{"id":"https://openalex.org/W4210282981","doi":"https://doi.org/10.3390/ijms23031707","title":"Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa","display_name":"Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4210282981","doi":"https://doi.org/10.3390/ijms23031707","pmid":"https://pubmed.ncbi.nlm.nih.gov/35163629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8835995"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23031707","doi":"https://doi.org/10.3390/ijms23031707","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23031707","pdf_url":"https://www.mdpi.com/1422-0067/23/3/1707/pdf?version=1643727367","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/3/1707/pdf?version=1643727367","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030291891","display_name":"Nazia Afroze","orcid":"https://orcid.org/0000-0003-4623-8412","observed_orcids":["https://orcid.org/0000-0003-4623-8412"]},"institutions":[{"id":"https://openalex.org/I4405253056","display_name":"Manipal Academy of Higher Education, Dubai","ror":"https://ror.org/008qdx283","country_code":"AE","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4405253056"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Nazia Afroze","raw_affiliation_strings":["School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates","institution_ids":["https://openalex.org/I4405253056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068811021","display_name":"Sreepoorna Pramodh","orcid":"https://orcid.org/0000-0002-1478-338X","observed_orcids":["https://orcid.org/0000-0002-1478-338X"]},"institutions":[{"id":"https://openalex.org/I91044093","display_name":"Zayed University","ror":"https://ror.org/03snqfa66","country_code":"AE","type":"education","lineage":["https://openalex.org/I91044093"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Sreepoorna Pramodh","raw_affiliation_strings":["Department of Life and Environmental Sciences, College of Natural and Health Science, Zayed University, Dubai P.O. Box 19282, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-1478-338X","affiliations":[{"raw_affiliation_string":"Department of Life and Environmental Sciences, College of Natural and Health Science, Zayed University, Dubai P.O. Box 19282, United Arab Emirates","institution_ids":["https://openalex.org/I91044093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076159402","display_name":"Jasmin Shafarin","orcid":"https://orcid.org/0000-0002-8026-7340","observed_orcids":["https://orcid.org/0000-0002-8026-7340"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Jasmin Shafarin","raw_affiliation_strings":["College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069163485","display_name":"Khuloud Bajbouj","orcid":"https://orcid.org/0000-0001-7344-6095","observed_orcids":["https://orcid.org/0000-0001-7344-6095"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Khuloud Bajbouj","raw_affiliation_strings":["College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0001-7344-6095","affiliations":[{"raw_affiliation_string":"College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070877765","display_name":"Mawieh A. Hamad","orcid":"https://orcid.org/0000-0002-6769-1091","observed_orcids":["https://orcid.org/0000-0002-6769-1091"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mawieh Hamad","raw_affiliation_strings":["College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-6769-1091","affiliations":[{"raw_affiliation_string":"College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050499971","display_name":"Madhumitha Kedhari Sundaram","orcid":"https://orcid.org/0000-0002-5717-1789","observed_orcids":["https://orcid.org/0000-0002-5717-1789"]},"institutions":[{"id":"https://openalex.org/I4405253056","display_name":"Manipal Academy of Higher Education, Dubai","ror":"https://ror.org/008qdx283","country_code":"AE","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4405253056"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Madhumitha Kedhari Sundaram","raw_affiliation_strings":["School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-5717-1789","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates","institution_ids":["https://openalex.org/I4405253056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053008837","display_name":"Shafiul Haque","orcid":"https://orcid.org/0000-0002-2989-121X","observed_orcids":["https://orcid.org/0000-0002-2989-121X"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]},{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA","TR"],"is_corresponding":false,"raw_author_name":"Shafiul Haque","raw_affiliation_strings":["Faculty of Medicine, G\u00f6r\u00fckle Campus, Bursa Uluda\u011f University, Nil\u00fcfer 16059, Turkey","Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan P.O. Box 114, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-2989-121X","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, G\u00f6r\u00fckle Campus, Bursa Uluda\u011f University, Nil\u00fcfer 16059, Turkey","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan P.O. Box 114, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024145910","display_name":"Arif Hussain","orcid":"https://orcid.org/0000-0002-0851-4845","observed_orcids":["https://orcid.org/0000-0002-0851-4845"]},"institutions":[{"id":"https://openalex.org/I4405253056","display_name":"Manipal Academy of Higher Education, Dubai","ror":"https://ror.org/008qdx283","country_code":"AE","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4405253056"]}],"countries":["AE"],"is_corresponding":true,"raw_author_name":"Arif Hussain","raw_affiliation_strings":["School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-0851-4845","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Manipal Academy of Higher Education-Dubai Campus, Dubai P.O. Box 345050, United Arab Emirates","institution_ids":["https://openalex.org/I4405253056"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024145910"],"corresponding_institution_ids":["https://openalex.org/I4405253056"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":6.2349,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.98238411,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"23","issue":"3","first_page":"1707","last_page":"1707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fisetin","display_name":"fisetin","score":1.0},{"id":"https://openalex.org/keywords/flavonols","display_name":"flavonols","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8460000157356262},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.7850000262260437},{"id":"https://openalex.org/keywords/akt-pathway","display_name":"AKT pathway","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":1.0},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2777376040","wikidata":"https://www.wikidata.org/wiki/Q418384","display_name":"Fisetin","level":4,"score":0.9060337543487549},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6743284463882446},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5622966885566711},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5475770235061646},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.518733561038971},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5115178823471069},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5030278563499451},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4651300609111786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.462956964969635},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.4526410698890686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42652058601379395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39713922142982483},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.36743098497390747},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3385583758354187},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22603446245193481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15398162603378296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052721649408340454},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms23031707","doi":"https://doi.org/10.3390/ijms23031707","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23031707","pdf_url":"https://www.mdpi.com/1422-0067/23/3/1707/pdf?version=1643727367","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35163629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35163629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8835995","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8835995/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:778bfb05-0185-4400-9a42-dd3f7df2f27e","doi":null,"is_oa":true,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/778bfb05-0185-4400-9a42-dd3f7df2f27e/oai","pdf_url":"https://avesis.uludag.edu.tr/publication/details/778bfb05-0185-4400-9a42-dd3f7df2f27e/oai/document.pdf","source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1390f20a9d4845e58b8e4ef665218cd7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1390f20a9d4845e58b8e4ef665218cd7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 1707, p 1707 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23031707","doi":"https://doi.org/10.3390/ijms23031707","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23031707","pdf_url":"https://www.mdpi.com/1422-0067/23/3/1707/pdf?version=1643727367","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325295","display_name":"Zayed University","ror":"https://ror.org/03snqfa66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210282981.pdf","grobid_xml":"https://content.openalex.org/works/W4210282981.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W177776831","https://openalex.org/W1602745681","https://openalex.org/W1772484437","https://openalex.org/W1987035130","https://openalex.org/W1990955264","https://openalex.org/W2000770184","https://openalex.org/W2003814325","https://openalex.org/W2004549986","https://openalex.org/W2010023860","https://openalex.org/W2012449154","https://openalex.org/W2017181626","https://openalex.org/W2020420780","https://openalex.org/W2034427923","https://openalex.org/W2036629112","https://openalex.org/W2042514640","https://openalex.org/W2043624712","https://openalex.org/W2051295838","https://openalex.org/W2053758678","https://openalex.org/W2072271791","https://openalex.org/W2077408869","https://openalex.org/W2081367726","https://openalex.org/W2086879676","https://openalex.org/W2106770132","https://openalex.org/W2128473487","https://openalex.org/W2131753291","https://openalex.org/W2134855813","https://openalex.org/W2149880101","https://openalex.org/W2162518284","https://openalex.org/W2164664027","https://openalex.org/W2218128634","https://openalex.org/W2238987536","https://openalex.org/W2250673102","https://openalex.org/W2312957701","https://openalex.org/W2329681473","https://openalex.org/W2417616494","https://openalex.org/W2510523517","https://openalex.org/W2510704354","https://openalex.org/W2552423477","https://openalex.org/W2570928071","https://openalex.org/W2584605683","https://openalex.org/W2756647112","https://openalex.org/W2765314233","https://openalex.org/W2767370630","https://openalex.org/W2783816949","https://openalex.org/W2799380905","https://openalex.org/W2804009539","https://openalex.org/W2881851781","https://openalex.org/W2883383051","https://openalex.org/W2899052178","https://openalex.org/W2903027734","https://openalex.org/W2914104637","https://openalex.org/W2917742246","https://openalex.org/W2917964400","https://openalex.org/W2923047376","https://openalex.org/W2923057410","https://openalex.org/W2942614275","https://openalex.org/W2943821970","https://openalex.org/W2944932175","https://openalex.org/W2966641116","https://openalex.org/W2969347269","https://openalex.org/W2969461921","https://openalex.org/W3005196658","https://openalex.org/W3042711809","https://openalex.org/W3092662532","https://openalex.org/W3117239808","https://openalex.org/W3119349610","https://openalex.org/W3138848156","https://openalex.org/W3165585845","https://openalex.org/W3169483605","https://openalex.org/W4294214970","https://openalex.org/W6676265842","https://openalex.org/W6729842162"],"related_works":["https://openalex.org/W2053758678","https://openalex.org/W2945596314","https://openalex.org/W2147327518","https://openalex.org/W2981884645","https://openalex.org/W1496852215","https://openalex.org/W3109281771","https://openalex.org/W2570928071","https://openalex.org/W2151207344","https://openalex.org/W2469322703","https://openalex.org/W4399055241"],"abstract_inverted_index":{"BACKGROUND:":[0],"Fisetin,":[1],"a":[2,11,233],"flavonol":[3],"profusely":[4],"found":[5,162],"in":[6,15,40,44],"vegetables":[7],"and":[8,47,58,71,92,94,99,102,117,122,125,142,158,169,180,186,198,220],"fruits,":[9],"exhibited":[10],"myriad":[12],"of":[13,36,67,80,82,155,178,189],"properties":[14],"preclinical":[16],"studies":[17,208],"to":[18,27,62,76,85,138,151,163,183],"impede":[19],"cancer":[20,95,190,215,238],"growth.":[21],"PURPOSE:":[22],"This":[23],"study":[24],"was":[25,161],"proposed":[26],"delineate":[28],"molecular":[29,38],"mechanisms":[30],"through":[31,223],"analysing":[32],"the":[33,64,78,146,167,176],"modulated":[34,108],"expression":[35,79,177],"various":[37,225],"targets":[39],"HeLa":[41],"cells":[42],"involved":[43],"proliferation,":[45,89,217],"apoptosis":[46,188,219],"inflammation.":[48],"METHODS:":[49],"MTT":[50],"assay,":[51],"flow":[52],"cytometry,":[53],"nuclear":[54],"morphology,":[55],"DNA":[56],"fragmentation":[57],"Annexin-Pi":[59],"were":[60,74],"performed":[61,75],"evaluate":[63],"anti-cancer":[65],"potential":[66],"fisetin.":[68],"Furthermore,":[69,105],"qPCR":[70],"proteome":[72],"profiler":[73],"analyse":[77],"variety":[81],"gene":[83,127],"related":[84],"cell":[86,88,140,216],"death,":[87],"oxidative":[90,196],"stress":[91,197],"inflammation":[93,200,222],"pathways.":[96,204],"RESULTS:":[97],"/M":[98],"increased":[100],"early":[101],"late":[103],"apoptosis.":[104,144],"fisetin":[106,174,211],"treatment":[107,193],"pro-apoptotic":[109],"genes":[110],"such":[111],"as":[112,232],"APAF1,":[113],"Bad,":[114],"Bax,":[115],"Bid":[116],"BIK":[118],"at":[119,135],"both":[120],"transcript":[121,168],"protein":[123,136,170],"levels":[124,137],"anti-apoptotic":[126],"Bcl-2,":[128],"BIRC8,":[129],"MCL-1,":[130],"XIAP/BIRC4,":[131],"Livin/BIRC7,":[132],"clap-2/BIRC3,":[133],"etc.":[134],"mitigate":[139],"proliferation":[141,185],"induce":[143],"Interestingly,":[145],"aforementioned":[147],"alterations":[148],"consequently":[149],"led":[150],"an":[152],"elevated":[153],"level":[154,171],"Caspase-3,":[156],"Caspase-8":[157],"Caspase-9,":[159],"which":[160],"be":[164,230],"consistent":[165],"with":[166],"expression.":[172],"Moreover,":[173],"downregulated":[175],"AKT":[179],"MAPK":[181],"pathways":[182,227],"avert":[184],"enhance":[187],"cells.":[191],"Fisetin":[192],"also":[194],"improves":[195],"alleviates":[199],"by":[201],"regulating":[202,224],"JAK-STAT/NF-kB":[203],"CONCLUSION:":[205],"Together,":[206],"these":[207],"established":[209],"that":[210,228],"deters":[212],"human":[213],"cervical":[214],"enhances":[218],"ameliorates":[221],"signalling":[226],"may":[229],"used":[231],"therapeutic":[234],"regime":[235],"for":[236],"better":[237],"management.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-02-08T00:00:00"}