{"id":"https://openalex.org/W4210264643","doi":"https://doi.org/10.1089/ten.tea.2021.0203","title":"In Vivo Delivery of M0, M1, and M2 Macrophage Subtypes via Genipin-Cross-Linked Collagen Biotextile","display_name":"In Vivo Delivery of M0, M1, and M2 Macrophage Subtypes via Genipin-Cross-Linked Collagen Biotextile","publication_year":2022,"publication_date":"2022-02-02","ids":{"openalex":"https://openalex.org/W4210264643","doi":"https://doi.org/10.1089/ten.tea.2021.0203","pmid":"https://pubmed.ncbi.nlm.nih.gov/35107345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469745"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2021.0203","doi":"https://doi.org/10.1089/ten.tea.2021.0203","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2021.0203","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000769878","display_name":"Ilaha Isali","orcid":"https://orcid.org/0000-0002-8100-0971","observed_orcids":["https://orcid.org/0000-0002-8100-0971"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilaha Isali","raw_affiliation_strings":["Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-8100-0971","affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005644749","display_name":"Phillip E. McClellan","orcid":"https://orcid.org/0000-0002-6151-5070","observed_orcids":["https://orcid.org/0000-0002-6151-5070"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip McClellan","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019428272","display_name":"Thomas R Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Wong","raw_affiliation_strings":["Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007867549","display_name":"Snigdha Cingireddi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snigdha Cingireddi","raw_affiliation_strings":["Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052863332","display_name":"Mukesh K. Jain","orcid":"https://orcid.org/0000-0001-9222-0761","observed_orcids":["https://orcid.org/0000-0001-9222-0761"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mukesh Jain","raw_affiliation_strings":["Harrington Discovery Institute and the Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, and the Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harrington Discovery Institute and the Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, and the Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024216881","display_name":"James Melvin Anderson","orcid":"https://orcid.org/0000-0003-2765-7996","observed_orcids":["https://orcid.org/0000-0003-2765-7996"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Anderson","raw_affiliation_strings":["Department of Biomedical Engineering, and Case Western Reserve University, Cleveland, Ohio, USA","Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, and Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112101580","display_name":"Adonis Hijaz","orcid":"https://orcid.org/0000-0003-0911-682X","observed_orcids":["https://orcid.org/0000-0003-0911-682X"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adonis Hijaz","raw_affiliation_strings":["Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078624568","display_name":"Ozan Akku\u015f","orcid":"https://orcid.org/0000-0003-3523-3421","observed_orcids":["https://orcid.org/0000-0003-3523-3421"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ozan Akkus","raw_affiliation_strings":["Department of Biomedical Engineering, and Case Western Reserve University, Cleveland, Ohio, USA","Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA","Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, and Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078624568"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":1.1862,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78128179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"28","issue":"15-16","first_page":"672","last_page":"684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.09769999980926514,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-subsets","display_name":"macrophage subsets","score":0.8560000061988831},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9359999895095825},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9470000267028809},{"id":"https://openalex.org/keywords/m0-macrophages","display_name":"M0 macrophages","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-delivery","display_name":"cell delivery","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.5809999704360962},{"id":"https://openalex.org/keywords/connective-tissue-regeneration","display_name":"connective tissue regeneration","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fibrous-capsule","display_name":"fibrous capsule","score":0.703000009059906},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.8130000233650208},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.6990000009536743},{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ym1","display_name":"Ym1","score":0.828000009059906},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2781438746","wikidata":"https://www.wikidata.org/wiki/Q1463401","display_name":"Genipin","level":3,"score":0.8369604349136353},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.6857230067253113},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.673513650894165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5512307286262512},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.524387538433075},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5084599256515503},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.49311086535453796},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48749756813049316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47403907775878906},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.4599676728248596},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4406808018684387},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.43734800815582275},{"id":"https://openalex.org/C170217031","wikidata":"https://www.wikidata.org/wiki/Q6725509","display_name":"Macrophage inflammatory protein","level":4,"score":0.41252899169921875},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.3556968569755554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3426128029823303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30760031938552856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25030094385147095},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.24855664372444153},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.21544069051742554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18911141157150269},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13812604546546936},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08348286151885986},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D039823","descriptor_name":"Iridoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/ten.tea.2021.0203","doi":"https://doi.org/10.1089/ten.tea.2021.0203","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2021.0203","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9469745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},{"id":"pmid:35107345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35107345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9469745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9469745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4910970435","display_name":"Training Program in Musculoskeletal Research","funder_award_id":"T32AR007505","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7231890474","display_name":"Immunoregenerative treatment of Stress Urinary Incontinence by Autologous Macrophage Therapy","funder_award_id":"R21HD095439","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1518095394","https://openalex.org/W1573088438","https://openalex.org/W1918968064","https://openalex.org/W1966504316","https://openalex.org/W2005575042","https://openalex.org/W2021316750","https://openalex.org/W2023591638","https://openalex.org/W2044242789","https://openalex.org/W2051278851","https://openalex.org/W2054019283","https://openalex.org/W2054472394","https://openalex.org/W2055901626","https://openalex.org/W2077796307","https://openalex.org/W2080229416","https://openalex.org/W2083876822","https://openalex.org/W2092075198","https://openalex.org/W2118329039","https://openalex.org/W2124672774","https://openalex.org/W2138475873","https://openalex.org/W2147517074","https://openalex.org/W2151035991","https://openalex.org/W2159146836","https://openalex.org/W2165909284","https://openalex.org/W2167830630","https://openalex.org/W2174617543","https://openalex.org/W2220782041","https://openalex.org/W2234275440","https://openalex.org/W2407926544","https://openalex.org/W2414701500","https://openalex.org/W2531256915","https://openalex.org/W2590029470","https://openalex.org/W2616793840","https://openalex.org/W2781853139","https://openalex.org/W2807906301","https://openalex.org/W2912502989","https://openalex.org/W3013522609","https://openalex.org/W3060906788","https://openalex.org/W3094314302","https://openalex.org/W3176608137","https://openalex.org/W3179361287"],"related_works":["https://openalex.org/W3176608137","https://openalex.org/W4402653988","https://openalex.org/W6911072665","https://openalex.org/W2292680702","https://openalex.org/W3146582890","https://openalex.org/W4237834241","https://openalex.org/W1999579326","https://openalex.org/W2525531941","https://openalex.org/W3192205561","https://openalex.org/W2903506471"],"abstract_inverted_index":{"Developing":[0],"strategies":[1,209],"to":[2,12,25,34,228,266],"regulate":[3],"the":[4,13,32,84,123,150,162,174],"immune":[5],"response":[6,58],"poses":[7],"significant":[8,219],"challenges":[9],"with":[10,69,221],"respect":[11],"clinical":[14],"translation":[15],"of":[16,40,46,63,72,79,88,105,112,161,196,248],"tissue-engineered":[17,302],"scaffolds.":[18],"Prominent":[19],"advancements":[20],"have":[21],"been":[22],"made":[23],"relating":[24],"macrophage-based":[26],"therapies":[27],"and":[28,38,55,59,75,99,102,118,144,170,176,184,191,206,234,241,244,270,273,277,291],"biomaterials.":[29],"Macrophages":[30,217],"exhibit":[31,218],"potential":[33],"influence":[35],"healing":[36,47,57,243,293],"trajectory,":[37],"predominance":[39],"particular":[41],"subtypes":[42],"during":[43],"early":[44],"onset":[45],"influences":[48],"repair":[49,205],"outcomes.":[50],"This":[51,186],"study":[52,187],"evaluated":[53],"short-":[54],"long-term":[56],"postoperative":[60],"mechanical":[61,171,279],"properties":[62,172,280],"genipin-cross-linked,":[64],"electrochemically":[65],"aligned":[66],"collagen":[67,131,157,163,201,262,285],"biotextiles":[68,132,202,263,286],"comparative":[70],"administration":[71],"M0,":[73,268],"M1,":[74,269],"M2":[76,89,129,165,197,271],"subtypes.":[77],"Irrespective":[78],"macrophage":[80,166],"subtype":[81],"seeded,":[82],"all":[83,122],"groups":[85,124],"demonstrated":[86],"existence":[87],"macrophages":[90,198,249,272],"at":[91,173],"both":[92,126],"time":[93,127],"points":[94],"as":[95,108,139,179,250],"typified":[96],"by":[97,110,181],"arginase":[98],"Ym-1":[100],"expressions,":[101],"distinct":[103],"absence":[104],"M1":[106],"macrophages,":[107],"indicated":[109,180],"lack":[111],"inducible":[113],"nitric":[114],"oxide":[115],"synthase":[116],"(iNOS)":[117],"interleukin-1\u03b2":[119],"expression":[120],"in":[121,281],"for":[125,203,253,311],"points.":[128],"macrophage-seeded":[130],"revealed":[133],"promising":[134],"host":[135],"tissue":[136,147,175,204,213,242,254,275],"responses,":[137],"such":[138],"reduced":[140,288],"fibrous":[141,289],"capsule":[142,290],"thickness":[143],"minimal":[145],"granulation":[146],"formation.":[148],"Furthermore,":[149],"M2-seeded":[151,284],"group":[152],"displayed":[153],"more":[154],"abundant":[155],"interstitial":[156],"deposition":[158],"following":[159,194],"degradation":[160],"threads.":[164],"supplementation":[167],"improved":[168,189],"structural":[169,314],"cellular":[177],"level":[178],"increased":[182],"modulus":[183],"stiffness.":[185],"demonstrates":[188],"biomechanical":[190],"histological":[192],"outcomes":[193,296],"incorporation":[195],"into":[199],"genipin-cross-linked":[200,261],"offers":[207],"future":[208],"focused":[210],"on":[211,300],"connective":[212],"regeneration.":[214,245],"Impact":[215],"statement":[216],"plasticity":[220],"complex":[222],"phenotypes":[223],"ranging":[224],"from":[225],"proinflammatory":[226],"(M1)":[227],"proregenerative":[229],"(M2).":[230],"They":[231],"release":[232],"cytokines":[233],"chemokines":[235],"governing":[236],"immunological":[237],"stability,":[238],"inflammation":[239],"resolution,":[240],"However,":[246],"utilization":[247],"therapeutic":[251,309],"tools":[252],"engineering":[255],"remains":[256],"limited.":[257],"In":[258],"this":[259],"study,":[260],"were":[264],"employed":[265],"deliver":[267],"evaluate":[274],"responses":[276],"postsurgical":[278],"vivo":[282],".":[283],"showed":[287],"favorable":[292],"response.":[294],"These":[295],"shed":[297],"new":[298],"light":[299],"designing":[301],"constructs":[303],"that":[304],"offer":[305],"a":[306],"novel":[307],"cell-based":[308],"approach":[310],"applications":[312],"requiring":[313],"augmentation.":[315]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-02-08T00:00:00"}
