{"id":"https://openalex.org/W4207576","doi":null,"title":"Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy.","display_name":"Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy.","publication_year":1984,"publication_date":"1984-05-01","ids":{"openalex":"https://openalex.org/W4207576","mag":"4207576","pmid":"https://pubmed.ncbi.nlm.nih.gov/6232423"},"language":"en","primary_location":{"id":"pmid:6232423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6232423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074965208","display_name":"Fred J. Clubb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Clubb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021111883","display_name":"Sanford P. Bishop","orcid":"https://orcid.org/0000-0001-5539-1668","observed_orcids":["https://orcid.org/0000-0001-5539-1668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S P Bishop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2752,"has_fulltext":false,"cited_by_count":263,"citation_normalized_percentile":{"value":0.77810693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"5","first_page":"571","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiomyocyte-growth","display_name":"cardiomyocyte growth","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neonatal-rat-heart","display_name":"neonatal rat heart","score":0.6110000014305115},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tritiated-thymidine-labeling","display_name":"tritiated thymidine labeling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/mitotic-rate","display_name":"mitotic activity","score":0.878000020980835},{"id":"https://openalex.org/keywords/hyperplasia","display_name":"hyperplasia","score":0.578000009059906},{"id":"https://openalex.org/keywords/amitosis","display_name":"amitosis","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C143016879","wikidata":"https://www.wikidata.org/wiki/Q4914552","display_name":"Binucleated cells","level":5,"score":0.818568229675293},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.6820774078369141},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.6638368368148804},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6526159644126892},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.5207040905952454},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.5154789090156555},{"id":"https://openalex.org/C3018418570","wikidata":"https://www.wikidata.org/wiki/Q1729124","display_name":"Myocardial hypertrophy","level":3,"score":0.48601728677749634},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.46791818737983704},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46512719988822937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45084527134895325},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4375610947608948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.432033896446228},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38718992471694946},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.37584471702575684},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3636930286884308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34567344188690186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3356902003288269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2820975184440613},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.280294805765152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2552540898323059},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.18423718214035034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16419294476509094},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.16136667132377625},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006128","descriptor_name":"Growth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6232423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6232423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:4207576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6232423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1904488311","https://openalex.org/W1996607088","https://openalex.org/W1999875000","https://openalex.org/W2011770991","https://openalex.org/W2013192486","https://openalex.org/W2025693630","https://openalex.org/W2035495424","https://openalex.org/W2062489708","https://openalex.org/W2081191855","https://openalex.org/W2084981710","https://openalex.org/W2133799219","https://openalex.org/W2134855866","https://openalex.org/W2138131313","https://openalex.org/W2331356409","https://openalex.org/W2411147328","https://openalex.org/W2417691248"],"related_works":["https://openalex.org/W2003035943","https://openalex.org/W2057646444","https://openalex.org/W2029215269","https://openalex.org/W1985959222","https://openalex.org/W2134039588","https://openalex.org/W1837016407","https://openalex.org/W2082076982","https://openalex.org/W2408961876","https://openalex.org/W2057555039","https://openalex.org/W2466339923"],"abstract_inverted_index":{"The":[0],"purposes":[1],"of":[2,18,43,49,59,75,84,94,110,121,133,147,166,173,200,208,225,235,243,253,272,280,290],"this":[3,167],"study":[4,168],"were":[5,37,64,78,123,138,240],"to":[6,39,206,250],"characterize":[7],"myocardial":[8,21,29,51,60,82,100,114,148,153,174,201,238,258,274],"cell":[9,61,101,115],"growth":[10,172,281],"in":[11,20,53,176,217,228,283],"neonatal":[12,54,178,219,285],"rats":[13,55,67,85,122],"and":[14,46,91,136,194,287],"investigate":[15],"the":[16,25,41,47,92,107,171,177,218,230,236,270,284],"mechanism":[17],"binucleation":[19,248],"cells.":[22],"To":[23,112],"test":[24],"hypothesis":[26],"that":[27,170,242,269],"binucleated":[28,50,237,257,273],"cells":[30,52,83,149,175,202,239,259,275],"result":[31,289],"from":[32,66,80,155],"karyokinesis":[33],"without":[34,292],"cytokinesis,":[35],"experiments":[36],"designed":[38],"measure":[40],"rate":[42],"DNA":[44,116,215],"synthesis":[45,117,216],"percentage":[48],"during":[56],"growth.":[57],"Estimates":[58],"nuclear":[62],"divisions":[63],"obtained":[65],"pulsed":[68],"with":[69,129],"tritiated":[70,134,226],"thymidine":[71],"at":[72,87,125],"17":[73],"days":[74],"gestation.":[76],"Autoradiograms":[77],"prepared":[79,157],"isolated":[81],"killed":[86],"various":[88,126],"ages":[89],"postpartum,":[90,118],"number":[93],"developed":[95],"silver":[96],"halide":[97],"grains":[98],"over":[99,264],"nuclei":[102],"was":[103,150,203,213,247],"calculated.":[104],"This":[105],"estimated":[106],"mitotic":[108],"activity":[109],"nuclei.":[111],"determine":[113],"another":[119],"set":[120],"injected":[124],"time":[127],"periods":[128],"4":[130],"hourly":[131],"doses":[132],"thymidine,":[135],"hearts":[137],"fixed":[139],"by":[140,222],"perfusion":[141],"1":[142,159],"hour":[143],"later.":[144],"Labeling":[145],"index":[146],"calculated":[151],"(labeled/total":[152],"cells)":[154],"autoradiograms":[156],"on":[158],"micron":[160],"thick,":[161],"methacrylate-embedded":[162],"heart":[163],"cross-sections.":[164],"Results":[165],"indicated":[169],"period":[179],"can":[180],"be":[181],"divided":[182],"into":[183],"three":[184],"phases:":[185],"(a)":[186],"a":[187,191,196,288],"hyperplastic":[188],"phase,":[189,193],"(b)":[190],"transitional":[192],"(c)":[195],"hypertrophic":[197],"phase.":[198],"Binucleation":[199],"not":[204],"due":[205,249],"fusion":[207],"mononucleated":[209,244],"cells,":[210],"because":[211],"there":[212],"continued":[214,223],"hearts,":[220],"reflected":[221],"incorporation":[224],"thymidine;":[227],"addition,":[229],"grain":[231,262],"counts":[232,263],"per":[233],"nucleus":[234],"half":[241],"cells;":[245],"nor":[246],"amitotic":[251],"splitting":[252],"single":[254],"nuclei,":[255],"since":[256],"had":[260],"similar":[261],"each":[265],"nucleus.":[266],"We":[267],"conclude":[268],"formation":[271],"is":[276],"an":[277],"early":[278],"indicator":[279],"hypertrophy":[282],"rat":[286],"mitosis":[291],"cytokinesis.":[293]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
