{"id":"https://openalex.org/W4207015263","doi":"https://doi.org/10.3389/fimmu.2021.759389","title":"Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis","display_name":"Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis","publication_year":2022,"publication_date":"2022-01-24","ids":{"openalex":"https://openalex.org/W4207015263","doi":"https://doi.org/10.3389/fimmu.2021.759389","pmid":"https://pubmed.ncbi.nlm.nih.gov/35140707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8818777"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.759389","doi":"https://doi.org/10.3389/fimmu.2021.759389","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.759389","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2021.759389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070544601","display_name":"Laura Petrikowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Petrikowski","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]},{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083538213","display_name":"Sabrina Reinehr","orcid":"https://orcid.org/0000-0002-4770-0210","observed_orcids":["https://orcid.org/0000-0002-4770-0210"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabrina Reinehr","raw_affiliation_strings":["Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024409703","display_name":"Steffen Haupeltshofer","orcid":"https://orcid.org/0000-0002-7002-9760","observed_orcids":["https://orcid.org/0000-0002-7002-9760"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Haupeltshofer","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062488057","display_name":"Leonie Deppe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leonie Deppe","raw_affiliation_strings":["Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064567374","display_name":"Florian Graz","orcid":"https://orcid.org/0009-0001-5920-1363","observed_orcids":["https://orcid.org/0009-0001-5920-1363"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Graz","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]},{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008016806","display_name":"Ingo Kleiter","orcid":"https://orcid.org/0000-0002-8249-4408","observed_orcids":["https://orcid.org/0000-0002-8249-4408"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo Kleiter","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062491557","display_name":"H. Burkhard Dick","orcid":"https://orcid.org/0000-0001-7551-7395","observed_orcids":["https://orcid.org/0000-0001-7551-7395"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Burkhard Dick","raw_affiliation_strings":["Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062220148","display_name":"Ralf Gold","orcid":"https://orcid.org/0000-0002-7223-3052","observed_orcids":["https://orcid.org/0000-0002-7223-3052"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Gold","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083217479","display_name":"Simon Faissner","orcid":"https://orcid.org/0000-0002-3412-762X","observed_orcids":["https://orcid.org/0000-0002-3412-762X"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Simon Faissner","raw_affiliation_strings":["Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090060904","display_name":"Stephanie Carolin Joachim","orcid":"https://orcid.org/0000-0001-7056-0829","observed_orcids":["https://orcid.org/0000-0001-7056-0829"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stephanie C. Joachim","raw_affiliation_strings":["Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083217479","https://openalex.org/A5090060904"],"corresponding_institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I904495901"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":1999,"currency":"EUR","value_usd":2155},"fwci":1.502,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.81667117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"759389","last_page":"759389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromyelitis-optica-spectrum-disorder","display_name":"neuromyelitis optica spectrum disorder","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mogad","display_name":"MOGAD","score":0.7789999842643738},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/optic-nerve-demyelination","display_name":"optic nerve demyelination","score":0.9430000185966492},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.843999981880188},{"id":"https://openalex.org/keywords/microglia-macrophage-infiltration","display_name":"microglia/macrophage infiltration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.722000002861023},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.9319999814033508},{"id":"https://openalex.org/keywords/retinitis","display_name":"retinal inflammation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/photoreceptor-dysfunction","display_name":"photoreceptor dysfunction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pou4f1","display_name":"POU4F1","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7910000085830688},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.748173177242279},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.710943341255188},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.6208009719848633},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.6190984845161438},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5978087782859802},{"id":"https://openalex.org/C2779357208","wikidata":"https://www.wikidata.org/wiki/Q6947292","display_name":"Myelin oligodendrocyte glycoprotein","level":4,"score":0.5852782130241394},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.5523993968963623},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5204061269760132},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.5149972438812256},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4942488968372345},{"id":"https://openalex.org/C2781137167","wikidata":"https://www.wikidata.org/wiki/Q611458","display_name":"Neuromyelitis optica","level":3,"score":0.4804386794567108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47476792335510254},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.43550243973731995},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.43139705061912537},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.411063551902771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35290032625198364},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.32371091842651367},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30609261989593506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2692081332206726},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23985567688941956},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2222299873828888},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.1471690833568573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004679","descriptor_name":"Encephalomyelitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009471","descriptor_name":"Neuromyelitis Optica","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009902","descriptor_name":"Optic Neuritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020221","descriptor_name":"Optic Nerve Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063308","descriptor_name":"Myelin-Oligodendrocyte Glycoprotein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2021.759389","doi":"https://doi.org/10.3389/fimmu.2021.759389","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.759389","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8818777","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8818777/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8818777/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:35140707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35140707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:54ea4e1854b34b9f890379fbfcccec25","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/54ea4e1854b34b9f890379fbfcccec25","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2022)","raw_type":"article"},{"id":"pmh:oai:hss-opus.ub.ruhr-uni-bochum.de:8681","doi":null,"is_oa":true,"landing_page_url":"http://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/8681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400167","display_name":"Dokumentenrepositorium der RUB (Ruhr University Bochum)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I904495901","host_organization_name":"Ruhr University Bochum","host_organization_lineage":["https://openalex.org/I904495901"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.759389","doi":"https://doi.org/10.3389/fimmu.2021.759389","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.759389","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321959","display_name":"Gemeinn\u00fctzige Hertie-Stiftung","ror":"https://ror.org/03ak9vt35"},{"id":"https://openalex.org/F4320335219","display_name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum","ror":"https://ror.org/04tsk2644"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4207015263.pdf","grobid_xml":"https://content.openalex.org/works/W4207015263.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W238288757","https://openalex.org/W1634780921","https://openalex.org/W1967537890","https://openalex.org/W1968846399","https://openalex.org/W1983644479","https://openalex.org/W1986698112","https://openalex.org/W1992171452","https://openalex.org/W1992191441","https://openalex.org/W2007502293","https://openalex.org/W2021669785","https://openalex.org/W2029232806","https://openalex.org/W2031926147","https://openalex.org/W2037171954","https://openalex.org/W2044914889","https://openalex.org/W2048308751","https://openalex.org/W2056064381","https://openalex.org/W2057185572","https://openalex.org/W2057911576","https://openalex.org/W2064262911","https://openalex.org/W2086053219","https://openalex.org/W2094929674","https://openalex.org/W2099249565","https://openalex.org/W2101662803","https://openalex.org/W2107604806","https://openalex.org/W2108411385","https://openalex.org/W2114525905","https://openalex.org/W2119987649","https://openalex.org/W2122237804","https://openalex.org/W2122743846","https://openalex.org/W2125411015","https://openalex.org/W2160413407","https://openalex.org/W2164266946","https://openalex.org/W2280077905","https://openalex.org/W2313613057","https://openalex.org/W2325038063","https://openalex.org/W2336534940","https://openalex.org/W2415086087","https://openalex.org/W2465147644","https://openalex.org/W2515927283","https://openalex.org/W2594676718","https://openalex.org/W2766374320","https://openalex.org/W2766696180","https://openalex.org/W2792123029","https://openalex.org/W2795024322","https://openalex.org/W2808307083","https://openalex.org/W2809271854","https://openalex.org/W2895290943","https://openalex.org/W2900889362","https://openalex.org/W2912449823","https://openalex.org/W2920543411","https://openalex.org/W2947182558","https://openalex.org/W2957170417","https://openalex.org/W2964450401","https://openalex.org/W2967983128","https://openalex.org/W2974018753","https://openalex.org/W2982768830","https://openalex.org/W2992065324","https://openalex.org/W2992998116","https://openalex.org/W2993468802","https://openalex.org/W3009516645","https://openalex.org/W3036134455","https://openalex.org/W3042842710","https://openalex.org/W3066200180","https://openalex.org/W3091931640","https://openalex.org/W3099226536","https://openalex.org/W3127928180","https://openalex.org/W3131366758","https://openalex.org/W3165949458","https://openalex.org/W3205545191","https://openalex.org/W4211254511","https://openalex.org/W4253961323"],"related_works":["https://openalex.org/W6922601383","https://openalex.org/W4220743860","https://openalex.org/W4403303540","https://openalex.org/W4383872582","https://openalex.org/W2957170417","https://openalex.org/W6891753110","https://openalex.org/W4389447950","https://openalex.org/W4409216821","https://openalex.org/W2145889968","https://openalex.org/W2047843073"],"abstract_inverted_index":{"Neuromyelitis":[0],"optica":[1],"spectrum":[2],"disorder":[3],"(NMOSD)":[4],"and":[5,21,36,62,74,79,85,88,103,146,161,174,189,193,215,230,236],"myelin":[6],"oligodendrocyte":[7],"glycoprotein-antibody-associated":[8],"disease":[9],"(MOGAD)":[10],"are":[11],"antibody":[12],"mediated":[13],"CNS":[14],"disorders":[15],"mostly":[16],"affecting":[17],"the":[18,29,39,91,104,165,190,201,205,218,242],"optic":[19,86,149,159,237],"nerve":[20,87,238],"spinal":[22],"cord":[23],"with":[24,114,239],"potential":[25],"severe":[26],"impact":[27],"on":[28],"visual":[30,40,219],"pathway.":[31,106,207],"Here,":[32],"we":[33,210],"investigated":[34],"inflammation":[35,214],"degeneration":[37,216],"of":[38,83,90,112,117,148,153,164,186,200,213,217,241],"system":[41,203,220],"in":[42,77,128,135,157,179,221,233],"a":[43,55,168,222],"spontaneous":[44,56,223],"encephalomyelitis":[45,58,113,224],"animal":[46],"model.":[47],"We":[48,195],"used":[49],"double-transgenic":[50],"(2D2/Th)":[51],"mice":[52,108,130],"which":[53],"develop":[54],"opticospinal":[57],"(OSE).":[59],"Retinal":[60],"morphology":[61],"its":[63],"function":[64],"were":[65,95],"evaluated":[66],"via":[67,93,131,204],"spectral":[68],"domain":[69],"optical":[70],"coherence":[71],"tomography":[72],"(SD-OCT)":[73],"electroretinography":[75],"(ERG)":[76],"6-":[78],"8-week-old":[80],"mice.":[81],"Immunohistochemistry":[82],"retina":[84,92,166,235],"examination":[89],"RT-qPCR":[94,182],"performed":[96],"using":[97],"markers":[98,188],"for":[99],"inflammation,":[100],"immune":[101],"cells":[102],"complement":[105,202,243],"OSE":[107,129,158,180],"showed":[109],"clinical":[110],"signs":[111],"an":[115,184,198],"incidence":[116],"75%":[118],"at":[119],"day":[120],"38.":[121],"A":[122],"progressive":[123],"retinal":[124,170],"thinning":[125],"was":[126,141,155],"detected":[127],"SD-OCT.":[132],"An":[133],"impairment":[134],"photoreceptor":[136],"signal":[137],"transmission":[138],"occurred.":[139],"This":[140],"accompanied":[142],"by":[143,227],"cellular":[144],"infiltration":[145],"demyelination":[147],"nerves.":[150],"The":[151],"number":[152,173],"microglia/macrophages":[154],"increased":[156],"nerves":[160],"retinas.":[162,181],"Analysis":[163],"revealed":[167,183],"reduced":[169],"ganglion":[171],"cell":[172],"downregulated":[175],"Pou4f1":[176],"mRNA":[177],"expression":[178],"elevation":[185],"microglia":[187],"cytokines":[191],"Tnfa":[192],"Tgfb.":[194],"also":[196],"documented":[197],"upregulation":[199],"classical":[206],"In":[208],"summary,":[209],"describe":[211],"characteristics":[212],"model,":[225],"characterized":[226],"coinciding":[228],"inflammatory":[229],"degenerative":[231],"mechanisms":[232],"both":[234],"involvement":[240],"system.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-01-26T00:00:00"}
