{"id":"https://openalex.org/W4206950488","doi":"https://doi.org/10.1093/ecco-jcc/jjab232.021","title":"OP22 Antibody decay, T cell immunity and breakthrough infections following SARS-CoV-2 vaccination in infliximab- and vedolizumab-treated patients","display_name":"OP22 Antibody decay, T cell immunity and breakthrough infections following SARS-CoV-2 vaccination in infliximab- and vedolizumab-treated patients","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4206950488","doi":"https://doi.org/10.1093/ecco-jcc/jjab232.021","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9383218"},"language":"en","primary_location":{"id":"doi:10.1093/ecco-jcc/jjab232.021","doi":"https://doi.org/10.1093/ecco-jcc/jjab232.021","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjab232.021","pdf_url":null,"source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9383218/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054271143","display_name":"Simeng Lin","orcid":"https://orcid.org/0000-0002-4201-4879","observed_orcids":["https://orcid.org/0000-0002-4201-4879"]},"institutions":[{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Lin","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047522708","display_name":"Nicholas Alexander Kennedy","orcid":"https://orcid.org/0000-0003-4368-1961","observed_orcids":["https://orcid.org/0000-0003-4368-1961"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N A Kennedy","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078518078","display_name":"Aamir Saifuddin","orcid":"https://orcid.org/0000-0002-5888-5556","observed_orcids":["https://orcid.org/0000-0002-5888-5556"]},"institutions":[{"id":"https://openalex.org/I4210161740","display_name":"St Mark's Hospital","ror":"https://ror.org/05am5g719","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210161740"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Saifuddin","raw_affiliation_strings":["Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","St Marks Hospital and Academic Institute, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"St Marks Hospital and Academic Institute, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I4210161740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045290759","display_name":"Diana M\u016bnoz Sandoval","orcid":"https://orcid.org/0000-0001-8350-3989","observed_orcids":["https://orcid.org/0000-0001-8350-3989"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Mu\u00f1oz Sandoval","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044452613","display_name":"Catherine J. Reynolds","orcid":"https://orcid.org/0000-0002-1371-653X","observed_orcids":["https://orcid.org/0000-0002-1371-653X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C J Reynolds","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101611899","display_name":"Rocio Castro Seoane","orcid":"https://orcid.org/0000-0002-2938-3872","observed_orcids":["https://orcid.org/0000-0002-2938-3872"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R C Seoane","raw_affiliation_strings":["Imperial College London, Immunology and Inflammation, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Immunology and Inflammation, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113272631","display_name":"Sherine Hermangild Kottoor","orcid":"https://orcid.org/0009-0007-5987-406X","observed_orcids":["https://orcid.org/0009-0007-5987-406X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S H Kottoor","raw_affiliation_strings":["Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050022399","display_name":"Franziska P. Pieper","orcid":"https://orcid.org/0000-0002-4857-0518","observed_orcids":["https://orcid.org/0000-0002-4857-0518"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F P Pieper","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016984311","display_name":"Kai\u2010Min Lin","orcid":"https://orcid.org/0000-0003-2109-1530","observed_orcids":["https://orcid.org/0000-0003-2109-1530"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K M Lin","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005644642","display_name":"David K. Butler","orcid":"https://orcid.org/0000-0003-1882-8159","observed_orcids":["https://orcid.org/0000-0003-1882-8159"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D K Butler","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082782814","display_name":"Neil Chanchlani","orcid":"https://orcid.org/0000-0003-0207-6706","observed_orcids":["https://orcid.org/0000-0003-0207-6706"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Chanchlani","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108825887","display_name":"Rachel Nice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Nice","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Biochemistry- Exeter Clinical Laboratory International, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Biochemistry- Exeter Clinical Laboratory International, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030841755","display_name":"Desmond Chee","orcid":"https://orcid.org/0000-0003-3473-9447","observed_orcids":["https://orcid.org/0000-0003-3473-9447"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Chee","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069238850","display_name":"Claire Bewshea","orcid":"https://orcid.org/0000-0002-0965-9587","observed_orcids":["https://orcid.org/0000-0002-0965-9587"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Bewshea","raw_affiliation_strings":["University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045735248","display_name":"Malik Janjua","orcid":"https://orcid.org/0000-0002-3999-8555","observed_orcids":["https://orcid.org/0000-0002-3999-8555"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Janjua","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103163871","display_name":"Timothy James McDonald","orcid":"https://orcid.org/0000-0003-3559-6660","observed_orcids":["https://orcid.org/0000-0003-3559-6660"]},"institutions":[{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T J McDonald","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Biochemistry- Exeter Clinical Laboratory International, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Biochemistry- Exeter Clinical Laboratory International, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046490863","display_name":"Shaji Sebastian","orcid":"https://orcid.org/0000-0002-3670-6545","observed_orcids":["https://orcid.org/0000-0002-3670-6545"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]},{"id":"https://openalex.org/I69768126","display_name":"Hull York Medical School","ror":"https://ror.org/0003e4m70","country_code":"GB","type":"education","lineage":["https://openalex.org/I69768126"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Sebastian","raw_affiliation_strings":["Hull University Teaching Hospitals NHS Trust, Gastroenterology, Hull, United Kingdom","University of Hull, Hull York Medical School, Hull, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hull University Teaching Hospitals NHS Trust, Gastroenterology, Hull, United Kingdom","institution_ids":["https://openalex.org/I191240316"]},{"raw_affiliation_string":"University of Hull, Hull York Medical School, Hull, United Kingdom","institution_ids":["https://openalex.org/I191240316","https://openalex.org/I69768126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047051074","display_name":"James Leslie Alexander","orcid":"https://orcid.org/0000-0001-8542-327X","observed_orcids":["https://orcid.org/0000-0001-8542-327X"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J L Alexander","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, Gastroenterology, London, United Kingdom","Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]},{"raw_affiliation_string":"Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058358458","display_name":"Laura E. Constable","orcid":"https://orcid.org/0000-0003-1043-9888","observed_orcids":["https://orcid.org/0000-0003-1043-9888"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L Constable","raw_affiliation_strings":["Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666789","display_name":"James Christopher Lee","orcid":"https://orcid.org/0000-0001-5711-9385","observed_orcids":["https://orcid.org/0000-0001-5711-9385"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J C Lee","raw_affiliation_strings":["Royal Free London NHS Foundation Trust, Gastroenterology, London, United Kingdom","The Francis Crick Institute, Genetic Mechanisms of Disease Laboratory, London, United Kingdom","University of Cambridge, Cambridge Institute of Therapeutic Immunology and Infectious Disease- Jeffrey Cheah Biomedical Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free London NHS Foundation Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I169248724"]},{"raw_affiliation_string":"The Francis Crick Institute, Genetic Mechanisms of Disease Laboratory, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"University of Cambridge, Cambridge Institute of Therapeutic Immunology and Infectious Disease- Jeffrey Cheah Biomedical Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030321712","display_name":"Charles D Murray","orcid":"https://orcid.org/0000-0001-6736-1546","observed_orcids":["https://orcid.org/0000-0001-6736-1546"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C D Murray","raw_affiliation_strings":["Royal Free London NHS Foundation Trust, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free London NHS Foundation Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I169248724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040981628","display_name":"Ailsa L Hart","orcid":"https://orcid.org/0000-0002-7141-6076","observed_orcids":["https://orcid.org/0000-0002-7141-6076"]},"institutions":[{"id":"https://openalex.org/I4210161740","display_name":"St Mark's Hospital","ror":"https://ror.org/05am5g719","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210161740"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A L Hart","raw_affiliation_strings":["St Marks Hospital and Academic Institute, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Marks Hospital and Academic Institute, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I4210161740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031136418","display_name":"Peter Miles Irving","orcid":"https://orcid.org/0000-0003-0972-8148","observed_orcids":["https://orcid.org/0000-0003-0972-8148"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P M Irving","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, Gastroenterology, London, United Kingdom","King\u2019s College London, School of Immunology & Microbial Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]},{"raw_affiliation_string":"King\u2019s College London, School of Immunology & Microbial Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026906368","display_name":"Gareth\u2010Rhys Jones","orcid":"https://orcid.org/0000-0001-7355-2357","observed_orcids":["https://orcid.org/0000-0001-7355-2357"]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I4210151647","display_name":"Centre for Inflammation Research","ror":"https://ror.org/05wcr1b38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210151647","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G R Jones","raw_affiliation_strings":["The University of Edinburgh, Centre for Inflammation Research- The Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom","Western General Hospital- NHS Lothian, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Edinburgh, Centre for Inflammation Research- The Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210151647","https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Western General Hospital- NHS Lothian, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I1324252669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043915683","display_name":"Klaartje Bel Kok","orcid":"https://orcid.org/0000-0002-5942-9149","observed_orcids":["https://orcid.org/0000-0002-5942-9149"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K B Kok","raw_affiliation_strings":["Barts and the London School of Medicine- Queen Mary, Centre for Immunobiology- Blizard Institute, London, United Kingdom","Royal London Hospital- Barts Health NHS Trust, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts and the London School of Medicine- Queen Mary, Centre for Immunobiology- Blizard Institute, London, United Kingdom","institution_ids":["https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Royal London Hospital- Barts Health NHS Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123498426","display_name":"C A Lamb","orcid":"https://orcid.org/0000-0002-7271-4956","observed_orcids":["https://orcid.org/0000-0002-7271-4956"]},"institutions":[{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C A Lamb","raw_affiliation_strings":["Newcastle University, Translational & Clinical Research Institute- Faculty of Medical Sciences, Newcastle upon Tyne, United Kingdom","Newcastle upon Tyne Hospitals NHS Foundation Trust, Gastroenterology, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle University, Translational & Clinical Research Institute- Faculty of Medical Sciences, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Newcastle upon Tyne Hospitals NHS Foundation Trust, Gastroenterology, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078976339","display_name":"Charlie W. Lees","orcid":"https://orcid.org/0000-0002-0732-8215","observed_orcids":["https://orcid.org/0000-0002-0732-8215"]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C W Lees","raw_affiliation_strings":["University of Edinburgh, Institute of Genetic and Molecular Medicine, Edinburgh, United Kingdom","Western General Hospital- NHS Lothian, Gastroenterology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Institute of Genetic and Molecular Medicine, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Western General Hospital- NHS Lothian, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I1324252669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009753247","display_name":"Daniel Martin Altmann","orcid":"https://orcid.org/0000-0002-2436-6192","observed_orcids":["https://orcid.org/0000-0002-2436-6192"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D M Altmann","raw_affiliation_strings":["Imperial College London, Immunology and Inflammation, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Immunology and Inflammation, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009824484","display_name":"Rosemary Jane Boyton","orcid":"https://orcid.org/0000-0002-5608-0797","observed_orcids":["https://orcid.org/0000-0002-5608-0797"]},"institutions":[{"id":"https://openalex.org/I2800036501","display_name":"Royal Brompton & Harefield NHS Foundation Trust","ror":"https://ror.org/02218z997","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501"]},{"id":"https://openalex.org/I2802782613","display_name":"Harefield Hospital","ror":"https://ror.org/04fwa4t58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I2802782613"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R J Boyton","raw_affiliation_strings":["Imperial College London, Infectious Disease, London, United Kingdom","Royal Brompton Hospital and Harefield Hospitals, Lung Division, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Infectious Disease, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Royal Brompton Hospital and Harefield Hospitals, Lung Division, London, United Kingdom","institution_ids":["https://openalex.org/I2800036501","https://openalex.org/I2802782613","https://openalex.org/I4210096640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024002886","display_name":"James Goodhand","orcid":"https://orcid.org/0000-0003-3112-376X","observed_orcids":["https://orcid.org/0000-0003-3112-376X"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J R Goodhand","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059369253","display_name":"Nick Powell","orcid":"https://orcid.org/0000-0003-3231-6950","observed_orcids":["https://orcid.org/0000-0003-3231-6950"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Powell","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, Gastroenterology, London, United Kingdom","Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, Gastroenterology, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]},{"raw_affiliation_string":"Imperial College London, Metabolism- Digestion and Reproduction, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069067500","display_name":"Tariq Ahmad","orcid":"https://orcid.org/0000-0002-6058-5528","observed_orcids":["https://orcid.org/0000-0002-6058-5528"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2799452589","display_name":"Royal Devon & Exeter NHS Foundation Trust","ror":"https://ror.org/03085z545","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"id":"https://openalex.org/I4405257583","display_name":"Royal Devon University Healthcare NHS Foundation Trust","ror":"https://ror.org/05e5ahc59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405257583"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T Ahmad","raw_affiliation_strings":["Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2799452589","https://openalex.org/I4405257583"]},{"raw_affiliation_string":"University of Exeter, Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":26,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3881,"currency":"EUR","value_usd":4089},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"Supplement_1","first_page":"i023","last_page":"i025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.9240000247955322},{"id":"https://openalex.org/keywords/covid-19-breakthrough-infection","display_name":"COVID-19 breakthrough infection","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8542767763137817},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.8541973233222961},{"id":"https://openalex.org/C2776207728","wikidata":"https://www.wikidata.org/wiki/Q7918002","display_name":"Vedolizumab","level":4,"score":0.831917405128479},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6409100294113159},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6394988298416138},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.49852871894836426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4677450954914093},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4343090057373047},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4284956455230713},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.2799271047115326},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.26067110896110535},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17736834287643433}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ecco-jcc/jjab232.021","doi":"https://doi.org/10.1093/ecco-jcc/jjab232.021","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjab232.021","pdf_url":null,"source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9383218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9383218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Crohns Colitis","raw_type":"Text"},{"id":"pmh:oai:rde.dspace-express.com:11287/622389","doi":null,"is_oa":false,"landing_page_url":"https://rde.dspace-express.com/handle/11287/622389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401891","display_name":"Royal Devon and Exeter Research Repository (Royal Devon and Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801242002","host_organization_name":"Royal Devon and Exeter Hospital","host_organization_lineage":["https://openalex.org/I2801242002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9383218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9383218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Crohns Colitis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220846329","https://openalex.org/W3212824308","https://openalex.org/W3212993684","https://openalex.org/W3158750369","https://openalex.org/W4288443557","https://openalex.org/W4318577132","https://openalex.org/W3169068432","https://openalex.org/W7221643139","https://openalex.org/W3199488937","https://openalex.org/W4313069853"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Antibody":[2,237],"responses":[3,52,119,221,377],"following":[4,61,125,148,246,324],"SARS-CoV-2":[5,11,63,288,329,334,384],"infection":[6,60,355],"or":[7,105,231],"a":[8,30,81,99,149,192,325,348,379],"single-dose":[9],"of":[10,57,83,102,117,122,128,152,217,234,248,328,353,400],"vaccine":[12,118,182,330,372],"are":[13],"impaired":[14],"in":[15,74,137,143,214,223,241,307,341,351,382],"patients":[16,42,77,138,228,245,308],"with":[17,22,28,44,140,146,179,191,226,310,368],"inflammatory":[18],"bowel":[19],"disease":[20],"treated":[21,27,43,139,145,309],"anti-TNF":[23],"compared":[24,79,183,225],"to":[25,39,80,95,184,304,390],"those":[26,144],"vedolizumab,":[29,147],"gut-selective":[31],"anti-integrin":[32],"\u03b14\u03b27":[33],"monoclonal":[34],"antibody.":[35],"Here":[36],"we":[37,346],"sought":[38],"determine":[40],"if":[41],"infliximab":[45,141,311,401],"have":[46],"attenuated":[47],"serological":[48],"and":[49,53,120,163,265,301,378],"T":[50,113,219],"cell":[51,114,220],"an":[54],"increased":[55],"risk":[56,121],"breakthrough":[58,123,305,333,354,383],"COVID-19":[59],"primary":[62,88,394],"vaccination.":[64],"Methods":[65],"Anti-spike":[66],"(S)":[67],"receptor":[68],"binding":[69],"domain":[70],"(RBD)":[71],"antibody":[72,133,202,322,344,376,405],"concentration":[73,203],"2306":[75],"infliximab-treated":[76],"were":[78,111,135,210,290],"cohort":[82],"1045":[84],"vedolizumab-treated":[85,227,244],"patients.":[86],"Our":[87],"outcome":[89],"was":[90,188,239,366],"anti-S":[91,200,320,342,374,403],"RBD":[92,132,201,321,343,375,404],"antibodies":[93],"2":[94],"10":[96],"weeks":[97,251,259,269,277],"after":[98,229],"second":[100,150,326],"dose":[101,151,327],"the":[103,180,185,215,302,398],"BNT162b2":[104,153,181,249],"ChAdOx1":[106,164,186,266],"nCoV-19":[107,165,187,267],"vaccines.":[108],"Secondary":[109],"outcomes":[110],"anti-spike":[112,218],"responses,":[115],"durability":[116],"infections":[124,289],"two":[126,232],"doses":[127,233,395],"vaccine.":[129,236],"Results":[130],"Anti-S":[131],"concentrations":[134,323],"lower":[136],"than":[142,243,312],"(567.3":[154],"U/mL":[155,159,167,171],"[6.1]":[156],"vs":[157,169,257,275,295],"4601.1":[158],"[5.3],":[160],"p":[161,173,283,298,361],"<0.0001)":[162,174],"(183.9":[166],"[5.0]":[168],"789.4":[170],"[3.5],":[172],"vaccines":[175],"(Fig.":[176,207,317],"1).":[177],"Vaccination":[178],"independently":[189],"associated":[190,367],"3.7-fold":[193],"[95%":[194,252,260,270,278],"CI":[195,253,261,271,279,357],"3.30":[196],"\u2013":[197,255,263,273,281,359],"4.13]":[198],"higher":[199],"(p":[204,314],"<":[205,285],"0.0001)":[206],"2).":[208],"There":[209],"no":[211],"significant":[212],"differences":[213],"magnitude":[216],"observed":[222,347],"infliximab-":[224,242],"one":[230],"either":[235],"half-life":[238],"shorter":[240,306],"two-doses":[247],"(4.0":[250],"3.8":[254],"4.1]":[256],"7.2":[258],"6.8":[262],"7.6])":[264],"(5.3":[268],"5.1":[272],"5.5]":[274],"9.3":[276],"8.5":[280],"10.2],":[282],"value":[284],"0.0001).":[286],"Breakthrough":[287],"more":[291],"frequent":[292],"(5.8%":[293],"(202/3467)":[294],"3.9%":[296],"(66/1691),":[297],"=":[299,315,362],"0.0032)":[300],"time":[303],"vedolizumab":[313],"0.0023)":[316],"3).":[318],"Higher":[319],"protected":[331],"against":[332],"infection:":[335],"overall,":[336],"for":[337],"every":[338],"10-fold":[339],"rise":[340],"level":[345],"0.8-fold":[349],"reduction":[350],"odds":[352],"([95%":[356],"0.70":[358],"0.99],":[360],"0.035).":[363],"Conclusion":[364],"Infliximab":[365],"attenuated,":[369],"less":[370],"durable":[371],"induced":[373],"50%":[380],"increase":[381],"infection.":[385],"Further":[386],"follow-up":[387],"is":[388],"required":[389],"assess":[391],"whether":[392],"third":[393],"can":[396],"mitigate":[397],"effects":[399],"on":[402],"responses.":[406]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-01-26T00:00:00"}