{"id":"https://openalex.org/W4206649404","doi":"https://doi.org/10.3410/f.1025852.309832","title":"Faculty Opinions recommendation of Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space.","display_name":"Faculty Opinions recommendation of Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space.","publication_year":2005,"publication_date":"2005-05-15","ids":{"openalex":"https://openalex.org/W4206649404","doi":"https://doi.org/10.3410/f.1025852.309832"},"language":"en","primary_location":{"id":"doi:10.3410/f.1025852.309832","doi":"https://doi.org/10.3410/f.1025852.309832","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1025852.309832","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016723424","display_name":"Richard J. Youle","orcid":"https://orcid.org/0000-0001-9117-5241","observed_orcids":["https://orcid.org/0000-0001-9117-5241"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Youle","raw_affiliation_strings":["Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016723424"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis-inducing-factor","display_name":"apoptosis-inducing factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intermembrane-space","display_name":"intermembrane space","score":0.8650000095367432},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-protein-processing","display_name":"mitochondrial protein processing","score":0.5419999957084656},{"id":"https://openalex.org/keywords/flavoprotein","display_name":"flavoprotein","score":0.625},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/mitochondrial-protease","display_name":"mitochondrial protease","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C186850619","wikidata":"https://www.wikidata.org/wiki/Q1425206","display_name":"Intermembrane space","level":5,"score":0.9690871834754944},{"id":"https://openalex.org/C95580263","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrial intermembrane space","level":5,"score":0.9611040353775024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7193425893783569},{"id":"https://openalex.org/C172043667","wikidata":"https://www.wikidata.org/wiki/Q4780529","display_name":"Apoptosis-inducing factor","level":5,"score":0.6807237863540649},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6693645715713501},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5813671350479126},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.5407298803329468},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4972403347492218},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4539799392223358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4173440635204315},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4164292812347412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.370233416557312},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.34259775280952454},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.31186285614967346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2413245141506195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.1025852.309832","doi":"https://doi.org/10.3410/f.1025852.309832","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1025852.309832","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1000084","https://openalex.org/W53848852","https://openalex.org/W1937544647","https://openalex.org/W1966798559","https://openalex.org/W2006211612","https://openalex.org/W2012842274","https://openalex.org/W2013065884","https://openalex.org/W2029502542","https://openalex.org/W2032444047","https://openalex.org/W2042409437","https://openalex.org/W2068890239","https://openalex.org/W2079676584","https://openalex.org/W2083255536","https://openalex.org/W2087877138","https://openalex.org/W2102443458","https://openalex.org/W2103313412","https://openalex.org/W2123671636","https://openalex.org/W2134738066","https://openalex.org/W2144004362","https://openalex.org/W2147787249","https://openalex.org/W2155089409","https://openalex.org/W2159650080","https://openalex.org/W2318252390"],"related_works":["https://openalex.org/W2028925334","https://openalex.org/W2127324182","https://openalex.org/W2011751868","https://openalex.org/W1985079080","https://openalex.org/W2363998416","https://openalex.org/W2387838072","https://openalex.org/W4249097710","https://openalex.org/W2125536365","https://openalex.org/W2159650080","https://openalex.org/W2000142329"],"abstract_inverted_index":{"Apoptosis-inducing":[0],"factor":[1],"(AIF)":[2],"is":[3,9,29,46,60,155],"a":[4,61,124,151],"mitochondrial":[5],"intermembrane":[6,79,98,137],"flavoprotein":[7],"that":[8,27,57,117,154],"translocated":[10],"to":[11,16,48,70,77,89],"the":[12,49,67,71,74,78,97,101,105,129,136,142,148],"nucleus":[13],"in":[14,96,135,160],"response":[15],"proapoptotic":[17,158],"stimuli,":[18],"where":[19,44],"it":[20,45],"induces":[21],"nuclear":[22],"apoptosis.":[23],"Here":[24],"we":[25],"show":[26],"AIF":[28,59,88,118],"synthesized":[30],"as":[31],"an":[32,37,90],"approximately":[33,50,91],"67-kDa":[34],"preprotein":[35],"with":[36,66],"N-terminal":[38],"extension":[39],"and":[40,73,139],"imported":[41],"into":[42,104,141],"mitochondria,":[43],"processed":[47,102],"62-kDa":[51],"mature":[52,58,87],"form.":[53],"Topology":[54],"analysis":[55],"revealed":[56],"type-I":[62],"inner":[63,130],"membrane":[64,131],"protein":[65],"N-terminus":[68],"exposed":[69],"matrix":[72],"C-terminal":[75],"portion":[76],"space.":[80],"Upon":[81],"induction":[82],"of":[83,86,150],"apoptosis,":[84],"processing":[85,134],"57-kDa":[92],"form":[93,103],"occurred":[94],"caspase-independently":[95],"space,":[99],"releasing":[100],"cytoplasm.":[106,143],"Bcl-2":[107],"or":[108],"Bcl-XL":[109],"inhibited":[110],"both":[111],"these":[112],"events.":[113],"These":[114],"findings":[115],"indicate":[116],"release":[119],"from":[120,128],"mitochondria":[121],"occurs":[122],"by":[123,132,157],"two-step":[125],"process:":[126],"detachment":[127],"apoptosis-induced":[133],"space":[138],"translocation":[140],"The":[144],"results":[145],"also":[146],"suggest":[147],"presence":[149],"unique":[152],"protease":[153],"regulated":[156],"stimuli":[159],"caspase-independent":[161],"cell":[162],"death.":[163],"PMID:":[164],"15775970":[165]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-01-26T00:00:00"}