{"id":"https://openalex.org/W4206474591","doi":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","title":"APRI and FIB-4 performance to assess liver fibrosis against predefined Fibroscan values in chronic hepatitis C virus infection","display_name":"APRI and FIB-4 performance to assess liver fibrosis against predefined Fibroscan values in chronic hepatitis C virus infection","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4206474591","doi":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","pmid":"https://pubmed.ncbi.nlm.nih.gov/35136771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8797084"},"language":"en","primary_location":{"id":"doi:10.4103/jfmpc.jfmpc_666_21","doi":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062109805","display_name":"Sumit Rungta","orcid":"https://orcid.org/0000-0003-3599-1388","observed_orcids":["https://orcid.org/0000-0003-3599-1388"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumit Rungta","raw_affiliation_strings":["Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588072","display_name":"Shweta Kumari","orcid":"https://orcid.org/0000-0002-4552-6300","observed_orcids":["https://orcid.org/0000-0002-4552-6300"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shweta Kumari","raw_affiliation_strings":["Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072439021","display_name":"Amar Deep","orcid":"https://orcid.org/0000-0002-8253-5169","observed_orcids":["https://orcid.org/0000-0002-8253-5169"]},"institutions":[{"id":"https://openalex.org/I186246823","display_name":"University of Lucknow","ror":"https://ror.org/03bdeag60","country_code":"IN","type":"education","lineage":["https://openalex.org/I186246823"]},{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amar Deep","raw_affiliation_strings":["Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India","Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]},{"raw_affiliation_string":"Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I186246823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027630511","display_name":"Kamlendra Verma","orcid":"https://orcid.org/0000-0002-1729-6341","observed_orcids":["https://orcid.org/0000-0002-1729-6341"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kamlendra Verma","raw_affiliation_strings":["Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075566188","display_name":"Suchit Swaroop","orcid":"https://orcid.org/0000-0001-5142-5875","observed_orcids":["https://orcid.org/0000-0001-5142-5875"]},"institutions":[{"id":"https://openalex.org/I186246823","display_name":"University of Lucknow","ror":"https://ror.org/03bdeag60","country_code":"IN","type":"education","lineage":["https://openalex.org/I186246823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suchit Swaroop","raw_affiliation_strings":["Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I186246823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027630511"],"corresponding_institution_ids":["https://openalex.org/I280994"],"apc_list":{"value":450,"currency":"USD","value_usd":450},"apc_paid":{"value":450,"currency":"USD","value_usd":450},"fwci":3.9629,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94945093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"10","issue":"11","first_page":"4082","last_page":"4088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9169999957084656},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/fib-4-index","display_name":"FIB-4","score":0.9020000100135803},{"id":"https://openalex.org/keywords/fibroscan","display_name":"FibroScan","score":0.8080000281333923},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-assessment","display_name":"noninvasive fibrosis assessment","score":0.9470000267028809},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.48500001430511475},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"receiver operating characteristic","score":0.47699999809265137},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.945900022983551},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7704064249992371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7144736051559448},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6927844882011414},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6212546229362488},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5337544083595276},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5272276401519775},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.4669761657714844},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4657403230667114},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4598373770713806},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.456880658864975},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.4493754208087921},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.4310513138771057},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.43097367882728577},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.32492682337760925},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.08989217877388},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/jfmpc.jfmpc_666_21","doi":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8797084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8797084","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Family Med Prim Care","raw_type":"Text"},{"id":"pmid:35136771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35136771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of family medicine and primary care","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b7aa71209ea449eb8e0d6b7970f9b9f0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b7aa71209ea449eb8e0d6b7970f9b9f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Family Medicine and Primary Care, Vol 10, Iss 11, Pp 4082-4088 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/jfmpc.jfmpc_666_21","doi":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jfmpc.jfmpc_666_21","pdf_url":null,"source":{"id":"https://openalex.org/S2764801637","display_name":"Journal of Family Medicine and Primary Care","issn_l":"2249-4863","issn":["2249-4863","2278-7135"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Family Medicine and Primary Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1963683487","https://openalex.org/W1977300462","https://openalex.org/W1993794153","https://openalex.org/W1997865776","https://openalex.org/W1999950621","https://openalex.org/W2040419521","https://openalex.org/W2060623167","https://openalex.org/W2063027176","https://openalex.org/W2064387090","https://openalex.org/W2077967017","https://openalex.org/W2079011170","https://openalex.org/W2088337379","https://openalex.org/W2129746841","https://openalex.org/W2134137011","https://openalex.org/W2172076494","https://openalex.org/W2181577365","https://openalex.org/W2564381838","https://openalex.org/W2756248449","https://openalex.org/W2796237581","https://openalex.org/W2809967189","https://openalex.org/W2963085893","https://openalex.org/W2992925996","https://openalex.org/W4211243282","https://openalex.org/W6765957737"],"related_works":["https://openalex.org/W4413012229","https://openalex.org/W4383955036","https://openalex.org/W4410048409","https://openalex.org/W3086532193","https://openalex.org/W4389860386","https://openalex.org/W2796237581","https://openalex.org/W3214217842","https://openalex.org/W2963085893","https://openalex.org/W1943774447","https://openalex.org/W2793390489"],"abstract_inverted_index":{"BACKGROUNDS":[0],"AND":[1],"AIMS:":[2],"Chronic":[3],"hepatitis":[4,117],"C":[5,118],"(CHC)":[6],"infection":[7],"can":[8],"leads":[9],"to":[10,72,81,100,142,156],"chronic":[11],"liver":[12,30,44,83,233,260],"disease,":[13],"fibrosis,":[14,182,189],"then":[15],"cirrhosis,":[16],"and,":[17],"finally,":[18],"hepatocellular":[19],"carcinoma":[20],"(HCC);":[21],"moreover,":[22],"it":[23,47],"is":[24,34,48,122],"the":[25,36,41,65,102,116,174,178,230],"most":[26],"common":[27],"indication":[28],"for":[29,40,148,204,212,216,255],"transplantation.":[31],"Liver":[32],"biopsy":[33],"still":[35],"gold":[37],"standard":[38],"method":[39],"staging":[42],"of":[43,67,106,173,259],"fibrosis":[45,84,207,234],"as":[46,60,235,237],"an":[49,256],"invasive":[50],"procedure":[51],"with":[52,115,220,251],"complications.":[53],"There":[54],"are":[55,63,77],"some":[56],"noninvasive":[57,79,253],"methods":[58],"such":[59],"fibroscan":[61,111],"that":[62,126],"now":[64],"investigation":[66],"choice;":[68],"FIB-4":[69,107,163,224],"and":[70,95,104,108,160,164,190,208,214,223],"aminotransferase":[71,88,91],"platelet":[73,93,161],"ratio":[74],"index":[75],"(APRI)":[76],"other":[78,252],"tools":[80],"assess":[82],"by":[85],"using":[86],"aspartate":[87],"(AST),":[89],"alanine":[90],"(ALT),":[92],"count,":[94],"age.":[96],"This":[97],"study":[98,125,179],"aims":[99],"evaluate":[101],"efficacy":[103],"performance":[105,227,239],"APRI":[109,165,213,222],"against":[110],"in":[112,129,135,177,228,240,249],"patients":[113,176,231],"infected":[114],"virus.":[119],"METHOD:":[120],"It":[121],"a":[123,130],"cross-sectional":[124],"was":[127,146,154],"conducted":[128],"tertiary":[131],"health":[132],"care":[133],"center":[134],"Uttar":[136],"Pradesh,":[137],"India,":[138],"from":[139,168],"January":[140,143],"2017":[141],"2020.":[144],"Fibroscan":[145],"done":[147],"all":[149],"patients.":[150],"A":[151],"blood":[152],"sample":[153],"used":[155,248],"determine":[157],"AST,":[158],"ALT,":[159],"count.":[162],"were":[166,210],"calculated":[167],"laboratory":[169],"data.":[170],"RESULT:":[171],"187":[172],"487":[175],"have":[180,184,187,192],"F0-F1":[181],"69":[183],"F2,":[185],"53":[186],"F3":[188],"178":[191],"cirrhosis.":[193],"Based":[194],"on":[195],"receiver":[196],"operating":[197],"characteristic":[198],"(ROC)":[199],"analysis,":[200],"single":[201],"optimum":[202],"cut-offs":[203],"diagnosing":[205],"significant":[206,242],"cirrhosis":[209],"1.2":[211],"2.25":[215],"FIB-4.":[217],"CONCLUSIONS:":[218],"Compared":[219],"Fibroscan,":[221],"showed":[225],"good":[226],"detecting":[229,241],"without":[232],"well":[236],"satisfactory":[238],"fibrosis.":[243,261],"These":[244],"scores":[245,254],"should":[246],"be":[247],"combination":[250],"accurate":[257],"assessment":[258]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-01-26T00:00:00"}