{"id":"https://openalex.org/W4206397446","doi":"https://doi.org/10.1155/2022/9484217","title":"Kynurenine Pathway Metabolites as Biomarkers in Alzheimer\u2019s Disease","display_name":"Kynurenine Pathway Metabolites as Biomarkers in Alzheimer\u2019s Disease","publication_year":2022,"publication_date":"2022-01-19","ids":{"openalex":"https://openalex.org/W4206397446","doi":"https://doi.org/10.1155/2022/9484217","pmid":"https://pubmed.ncbi.nlm.nih.gov/35096208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8791723"},"language":"en","primary_location":{"id":"doi:10.1155/2022/9484217","doi":"https://doi.org/10.1155/2022/9484217","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/9484217","pdf_url":"https://downloads.hindawi.com/journals/dm/2022/9484217.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/dm/2022/9484217.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039407312","display_name":"Yuqing Liang","orcid":"https://orcid.org/0000-0001-8421-752X","observed_orcids":["https://orcid.org/0000-0001-8421-752X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Liang","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0001-8421-752X","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059616168","display_name":"Shan Xie","orcid":"https://orcid.org/0000-0002-7272-9381","observed_orcids":["https://orcid.org/0000-0002-7272-9381"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Xie","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0002-7272-9381","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064395618","display_name":"Yanyun He","orcid":"https://orcid.org/0000-0002-1130-0856","observed_orcids":["https://orcid.org/0000-0002-1130-0856"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyun He","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0002-1130-0856","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033956063","display_name":"Manru Xu","orcid":"https://orcid.org/0000-0001-8981-2141","observed_orcids":["https://orcid.org/0000-0001-8981-2141"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manru Xu","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0001-8981-2141","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056819882","display_name":"Xi Qiao","orcid":"https://orcid.org/0000-0001-6986-4059","observed_orcids":["https://orcid.org/0000-0001-6986-4059"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Qiao","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0001-6986-4059","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102903655","display_name":"Yue Hua Zhu","orcid":"https://orcid.org/0000-0003-4836-3241","observed_orcids":["https://orcid.org/0000-0003-4836-3241"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhu","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0003-4836-3241","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069045983","display_name":"Wenbin Wu","orcid":"https://orcid.org/0000-0001-8784-6137","observed_orcids":["https://orcid.org/0000-0001-8784-6137"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenbin Wu","raw_affiliation_strings":["Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China"],"raw_orcid":"https://orcid.org/0000-0001-8784-6137","affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069045983"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":1.1849,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.70967742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9089999794960022},{"id":"https://openalex.org/keywords/quinolinic-acid","display_name":"quinolinic acid","score":0.9259999990463257},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7839999794960022},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neuropathogenesis","display_name":"neuropathogenesis","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6723344326019287},{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.669231653213501},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.6369718909263611},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5511061549186707},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4865483343601227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.387143075466156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3861902356147766},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.20397189259529114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18903830647468567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18485313653945923},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017378","descriptor_name":"Quinolinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017378","descriptor_name":"Quinolinic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/9484217","doi":"https://doi.org/10.1155/2022/9484217","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/9484217","pdf_url":"https://downloads.hindawi.com/journals/dm/2022/9484217.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},{"id":"pmid:35096208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35096208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease markers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8791723","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8791723/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dis Markers","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b1c508ea578e4757b889eab6b7275f56","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b1c508ea578e4757b889eab6b7275f56","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Disease Markers, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/9484217","doi":"https://doi.org/10.1155/2022/9484217","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/9484217","pdf_url":"https://downloads.hindawi.com/journals/dm/2022/9484217.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3758545945","display_name":null,"funder_award_id":"2020YFC2003100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5513431361","display_name":null,"funder_award_id":"2020YFC2003104","funder_id":"https://openalex.org/F4320328111","funder_display_name":"Chengdu University"},{"id":"https://openalex.org/G5601084612","display_name":null,"funder_award_id":"2020YFC2003100","funder_id":"https://openalex.org/F4320328111","funder_display_name":"Chengdu University"},{"id":"https://openalex.org/G587161010","display_name":null,"funder_award_id":"QNXZ2018004","funder_id":"https://openalex.org/F4320328111","funder_display_name":"Chengdu University"},{"id":"https://openalex.org/G7698036313","display_name":null,"funder_award_id":"QNXZ2018004","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8231968953","display_name":null,"funder_award_id":"2019-YF09-00096-SN","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8332131193","display_name":null,"funder_award_id":"2020YFC2003104","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8489819382","display_name":null,"funder_award_id":"2019-YF09-00096-SN","funder_id":"https://openalex.org/F4320328111","funder_display_name":"Chengdu University"},{"id":"https://openalex.org/G999462211","display_name":null,"funder_award_id":"QNXZ2018004","funder_id":"https://openalex.org/F4320325093","funder_display_name":"Chengdu University of Traditional Chinese Medicine"}],"funders":[{"id":"https://openalex.org/F4320325093","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470"},{"id":"https://openalex.org/F4320328111","display_name":"Chengdu University","ror":"https://ror.org/034z67559"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206397446.pdf","grobid_xml":"https://content.openalex.org/works/W4206397446.grobid-xml"},"referenced_works_count":200,"referenced_works":["https://openalex.org/W114145985","https://openalex.org/W200884607","https://openalex.org/W1076432193","https://openalex.org/W1481597245","https://openalex.org/W1507305149","https://openalex.org/W1540470728","https://openalex.org/W1546992055","https://openalex.org/W1547937746","https://openalex.org/W1573025925","https://openalex.org/W1580382382","https://openalex.org/W1598480899","https://openalex.org/W1603819614","https://openalex.org/W1606036403","https://openalex.org/W1606950487","https://openalex.org/W1622777525","https://openalex.org/W1641831614","https://openalex.org/W1648903440","https://openalex.org/W1788048720","https://openalex.org/W1830769718","https://openalex.org/W1833773432","https://openalex.org/W1841085127","https://openalex.org/W1887681162","https://openalex.org/W1915977580","https://openalex.org/W1940795041","https://openalex.org/W1964595024","https://openalex.org/W1964640907","https://openalex.org/W1971547362","https://openalex.org/W1973807988","https://openalex.org/W1977407101","https://openalex.org/W1981537604","https://openalex.org/W1984584304","https://openalex.org/W1988691690","https://openalex.org/W1990286385","https://openalex.org/W1991052041","https://openalex.org/W1991576487","https://openalex.org/W1991795197","https://openalex.org/W1992925599","https://openalex.org/W1993293666","https://openalex.org/W1993571512","https://openalex.org/W1994611803","https://openalex.org/W1994997357","https://openalex.org/W1997503261","https://openalex.org/W1998142996","https://openalex.org/W2000183088","https://openalex.org/W2001819303","https://openalex.org/W2005359428","https://openalex.org/W2007820656","https://openalex.org/W2008249034","https://openalex.org/W2013236786","https://openalex.org/W2013898280","https://openalex.org/W2020882728","https://openalex.org/W2022395126","https://openalex.org/W2033290089","https://openalex.org/W2034912639","https://openalex.org/W2037047673","https://openalex.org/W2037599428","https://openalex.org/W2039013033","https://openalex.org/W2039980606","https://openalex.org/W2042341257","https://openalex.org/W2042493526","https://openalex.org/W2050216330","https://openalex.org/W2051353156","https://openalex.org/W2052322755","https://openalex.org/W2053875523","https://openalex.org/W2055909204","https://openalex.org/W2056081776","https://openalex.org/W2056492549","https://openalex.org/W2057095578","https://openalex.org/W2058834701","https://openalex.org/W2059197184","https://openalex.org/W2064018971","https://openalex.org/W2067145276","https://openalex.org/W2074274825","https://openalex.org/W2075010970","https://openalex.org/W2076249077","https://openalex.org/W2081747977","https://openalex.org/W2083949851","https://openalex.org/W2085595922","https://openalex.org/W2086208662","https://openalex.org/W2086261392","https://openalex.org/W2089874235","https://openalex.org/W2092735546","https://openalex.org/W2093100587","https://openalex.org/W2094628147","https://openalex.org/W2097112082","https://openalex.org/W2097144774","https://openalex.org/W2098613848","https://openalex.org/W2106981471","https://openalex.org/W2112175077","https://openalex.org/W2112219780","https://openalex.org/W2116784956","https://openalex.org/W2118804183","https://openalex.org/W2122836188","https://openalex.org/W2124707930","https://openalex.org/W2131685977","https://openalex.org/W2135892739","https://openalex.org/W2135955660","https://openalex.org/W2137182040","https://openalex.org/W2141195881","https://openalex.org/W2151104072","https://openalex.org/W2154565921","https://openalex.org/W2160877743","https://openalex.org/W2168912740","https://openalex.org/W2171668977","https://openalex.org/W2215675716","https://openalex.org/W2260534687","https://openalex.org/W2273585977","https://openalex.org/W2293113510","https://openalex.org/W2298656843","https://openalex.org/W2302151110","https://openalex.org/W2339856074","https://openalex.org/W2344365871","https://openalex.org/W2363424999","https://openalex.org/W2401414122","https://openalex.org/W2423144875","https://openalex.org/W2460405435","https://openalex.org/W2465699308","https://openalex.org/W2471743045","https://openalex.org/W2504229998","https://openalex.org/W2510451333","https://openalex.org/W2531162427","https://openalex.org/W2534771646","https://openalex.org/W2556618455","https://openalex.org/W2569496991","https://openalex.org/W2579935110","https://openalex.org/W2595826119","https://openalex.org/W2603228471","https://openalex.org/W2605569345","https://openalex.org/W2605574980","https://openalex.org/W2611002114","https://openalex.org/W2622807556","https://openalex.org/W2626924766","https://openalex.org/W2728505972","https://openalex.org/W2739055196","https://openalex.org/W2739923514","https://openalex.org/W2741386819","https://openalex.org/W2744015013","https://openalex.org/W2748212695","https://openalex.org/W2750394230","https://openalex.org/W2751316875","https://openalex.org/W2752798784","https://openalex.org/W2765902885","https://openalex.org/W2769465114","https://openalex.org/W2779643604","https://openalex.org/W2784429314","https://openalex.org/W2791854398","https://openalex.org/W2793877525","https://openalex.org/W2795614235","https://openalex.org/W2795720999","https://openalex.org/W2798054687","https://openalex.org/W2803960895","https://openalex.org/W2804597358","https://openalex.org/W2810902145","https://openalex.org/W2890118151","https://openalex.org/W2890394985","https://openalex.org/W2905698223","https://openalex.org/W2911147760","https://openalex.org/W2911185470","https://openalex.org/W2928372571","https://openalex.org/W2954406404","https://openalex.org/W2965429422","https://openalex.org/W2966777687","https://openalex.org/W2968070193","https://openalex.org/W2968954438","https://openalex.org/W2969940182","https://openalex.org/W2979510318","https://openalex.org/W2979942667","https://openalex.org/W2980215391","https://openalex.org/W2990097926","https://openalex.org/W2990312754","https://openalex.org/W2993986224","https://openalex.org/W2996426837","https://openalex.org/W3000157665","https://openalex.org/W3005054591","https://openalex.org/W3005301951","https://openalex.org/W3007394158","https://openalex.org/W3008056865","https://openalex.org/W3008243650","https://openalex.org/W3009619005","https://openalex.org/W3010891774","https://openalex.org/W3011845531","https://openalex.org/W3013912081","https://openalex.org/W3015388543","https://openalex.org/W3108308610","https://openalex.org/W3110893574","https://openalex.org/W3111509171","https://openalex.org/W3113246193","https://openalex.org/W3120802281","https://openalex.org/W3124013764","https://openalex.org/W3128820871","https://openalex.org/W3142533463","https://openalex.org/W3165442994","https://openalex.org/W3169360020","https://openalex.org/W3174667567","https://openalex.org/W3174682784","https://openalex.org/W3194032198","https://openalex.org/W3194316381","https://openalex.org/W3198221730","https://openalex.org/W3199877704","https://openalex.org/W4212867161"],"related_works":["https://openalex.org/W1973807988","https://openalex.org/W2166508115","https://openalex.org/W4410464448","https://openalex.org/W2928372571","https://openalex.org/W4210829204","https://openalex.org/W2889659746","https://openalex.org/W2094628147","https://openalex.org/W4297006551","https://openalex.org/W4312128763","https://openalex.org/W2751316875"],"abstract_inverted_index":{"),":[0],"and":[1,12,34,42,86,93,96,106,131,145,159],"other":[2,76],"pathological":[3],"changes":[4],"in":[5,26,40,53,66,126],"the":[6,27,45,67,79,91,102,118,122,138],"brain.":[7],"The":[8,31,150],"kynurenine":[9],"pathway":[10],"(KP)":[11],"several":[13],"of":[14,29,47,50,69,90,104,124,140],"its":[15],"metabolites,":[16,130],"especially":[17],"quinolinic":[18],"acid":[19],"(QA),":[20],"are":[21],"considered":[22],"to":[23,153,156],"be":[24],"involved":[25],"neuropathogenesis":[28],"AD.":[30,43,70,149,165],"important":[32],"metabolites":[33,52,60,74,95,120,142],"key":[35],"enzymes":[36],"show":[37],"significant":[38,128],"importance":[39],"neuroinflammation":[41,107,125],"Meanwhile,":[44],"discovery":[46],"changed":[48],"levels":[49],"KP":[51,59,73,119,129],"patients":[54,163],"with":[55,164],"AD":[56],"suggests":[57],"that":[58],"may":[61,109],"have":[62,110],"a":[63],"prominent":[64],"role":[65],"pathogenesis":[68],"Further,":[71],"some":[72],"exhibit":[75],"effects":[77],"on":[78,117],"brain,":[80],"such":[81],"as":[82,135,137,143],"oxidative":[83],"stress":[84],"regulation":[85],"neurotoxicity.":[87],"Both":[88],"analogs":[89],"neuroprotective":[92],"antineuroinflammation":[94],"small":[97],"molecule":[98],"enzyme":[99],"inhibitors":[100],"preventing":[101],"formation":[103],"neurotoxic":[105],"compounds":[108],"potential":[111],"therapeutic":[112,146,160],"significance.":[113],"This":[114],"review":[115],"focused":[116],"through":[121],"relationship":[123],"AD,":[127],"associated":[132],"molecular":[133],"mechanisms":[134],"well":[136],"utility":[139],"these":[141],"biomarkers":[144,158],"targets":[147,161],"for":[148,162],"objective":[151],"is":[152],"provide":[154],"references":[155],"find":[157]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-01-25T00:00:00"}