{"id":"https://openalex.org/W4206384403","doi":"https://doi.org/10.31590/ejosat.1044758","title":"RP-HPLC Method Development and Validation for Quantification of Fexofenadine in Pharmaceutical Products","display_name":"RP-HPLC Method Development and Validation for Quantification of Fexofenadine in Pharmaceutical Products","publication_year":2022,"publication_date":"2022-01-03","ids":{"openalex":"https://openalex.org/W4206384403","doi":"https://doi.org/10.31590/ejosat.1044758"},"language":"en","primary_location":{"id":"doi:10.31590/ejosat.1044758","doi":"https://doi.org/10.31590/ejosat.1044758","is_oa":true,"landing_page_url":"https://doi.org/10.31590/ejosat.1044758","pdf_url":"https://dergipark.org.tr/en/download/article-file/2153828","source":{"id":"https://openalex.org/S4210197137","display_name":"European Journal of Science and Technology","issn_l":"2148-2683","issn":["2148-2683"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327628574","host_organization_name":"European Journal of Science and Technology","host_organization_lineage":["https://openalex.org/P4327628574"],"host_organization_lineage_names":["European Journal of Science and Technology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/2153828","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041468736","display_name":"Erten Akbel","orcid":"https://orcid.org/0000-0002-6954-3658","observed_orcids":["https://orcid.org/0000-0002-6954-3658"]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erten AKBEL","raw_affiliation_strings":["Faculty of Health Sciences, U\u015fak University, U\u015fak, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, U\u015fak University, U\u015fak, Turkey,","institution_ids":["https://openalex.org/I204585392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027872759","display_name":"\u0130brahim Bulduk","orcid":"https://orcid.org/0000-0001-6172-7738","observed_orcids":["https://orcid.org/0000-0001-6172-7738"]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130brahim BULDUK","raw_affiliation_strings":["Faculty of Health Sciences, U\u015fak University, U\u015fak, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, U\u015fak University, U\u015fak, Turkey,","institution_ids":["https://openalex.org/I204585392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204585392"],"apc_list":null,"apc_paid":null,"fwci":0.2653,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.34137994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fexofenadine","display_name":"fexofenadine","score":1.0},{"id":"https://openalex.org/keywords/rp-hplc-method-development","display_name":"RP-HPLC method development","score":0.8619999885559082},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pharmaceutical-preparations","display_name":"pharmaceutical preparations","score":0.5220000147819519},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2776711289","wikidata":"https://www.wikidata.org/wiki/Q415122","display_name":"Fexofenadine","level":2,"score":0.9763403534889221},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.792112410068512},{"id":"https://openalex.org/C51989270","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Relative standard deviation","level":3,"score":0.64234459400177},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.6266680359840393},{"id":"https://openalex.org/C77170095","wikidata":"https://www.wikidata.org/wiki/Q1753188","display_name":"Linearity","level":2,"score":0.5622506737709045},{"id":"https://openalex.org/C202799725","wikidata":"https://www.wikidata.org/wiki/Q272035","display_name":"Accuracy and precision","level":2,"score":0.550417423248291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47175151109695435},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.46699514985084534},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.44940513372421265},{"id":"https://openalex.org/C22679943","wikidata":"https://www.wikidata.org/wiki/Q159375","display_name":"Standard deviation","level":2,"score":0.4230997562408447},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.42032676935195923},{"id":"https://openalex.org/C2992520659","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatographic separation","level":3,"score":0.41334858536720276},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.4130077362060547},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3739738464355469},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.3453376889228821},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18864870071411133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06528553366661072},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.05607163906097412},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.05114346742630005},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31590/ejosat.1044758","doi":"https://doi.org/10.31590/ejosat.1044758","is_oa":true,"landing_page_url":"https://doi.org/10.31590/ejosat.1044758","pdf_url":"https://dergipark.org.tr/en/download/article-file/2153828","source":{"id":"https://openalex.org/S4210197137","display_name":"European Journal of Science and Technology","issn_l":"2148-2683","issn":["2148-2683"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327628574","host_organization_name":"European Journal of Science and Technology","host_organization_lineage":["https://openalex.org/P4327628574"],"host_organization_lineage_names":["European Journal of Science and Technology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1044758","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/ejosat/issue/67030/1044758","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Science and Technology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.31590/ejosat.1044758","doi":"https://doi.org/10.31590/ejosat.1044758","is_oa":true,"landing_page_url":"https://doi.org/10.31590/ejosat.1044758","pdf_url":"https://dergipark.org.tr/en/download/article-file/2153828","source":{"id":"https://openalex.org/S4210197137","display_name":"European Journal of Science and Technology","issn_l":"2148-2683","issn":["2148-2683"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327628574","host_organization_name":"European Journal of Science and Technology","host_organization_lineage":["https://openalex.org/P4327628574"],"host_organization_lineage_names":["European Journal of Science and Technology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206384403.pdf","grobid_xml":"https://content.openalex.org/works/W4206384403.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W58805804","https://openalex.org/W60392183","https://openalex.org/W76807938","https://openalex.org/W1972141034","https://openalex.org/W1980421164","https://openalex.org/W2006371585","https://openalex.org/W2040199048","https://openalex.org/W2042055937","https://openalex.org/W2054697139","https://openalex.org/W2071893313","https://openalex.org/W2081732518","https://openalex.org/W2095223153"],"related_works":["https://openalex.org/W60392183","https://openalex.org/W7217259545","https://openalex.org/W2071893313","https://openalex.org/W2591741281","https://openalex.org/W2183075239","https://openalex.org/W1988464240","https://openalex.org/W4385216653","https://openalex.org/W2110383845","https://openalex.org/W2026806831","https://openalex.org/W6931023381"],"abstract_inverted_index":{"Fexofenadine":[0],"belongs":[1],"to":[2,11,44,177,187],"the":[3,29,46,55,148,163],"antihistamine":[4],"family":[5],"of":[6,32,59,75,84,102,109,144,165],"drugs.":[7],"It":[8],"is":[9],"used":[10,43,186],"treat":[12],"seasonal":[13],"allergic":[14],"rhinitis":[15],"symptoms.":[16],"In":[17],"this":[18],"study,":[19],"a":[20,80,88,141],"rapid,":[21],"simple":[22],"and":[23,36,61,111,113,127,167],"sensitive":[24],"liquid":[25],"chromatographic":[26,50,134],"method":[27,96,121,183],"for":[28],"quantitative":[30],"determination":[31],"fexofenadine":[33,189],"was":[34,42,52,92,151],"optimized":[35],"validated.":[37],"Agilent":[38],"Extend":[39],"C18":[40],"column":[41],"perform":[45],"separation.":[47],"The":[48,72,94,119,171,180],"optimum":[49],"separation":[51],"achieved":[53],"by":[54],"mobile":[56],"phase":[57],"consist":[58],"acetonitrile":[60],"20":[62],"mM":[63],"KH2PO4":[64],"solution":[65],"(pH":[66],"7.5)":[67],"in":[68,100,162,190],"35:65":[69],"ratios":[70],"respectively.":[71],"flow":[73],"rate":[74],"1.2":[76],"mL":[77],"min-1":[78],"with":[79],"standard":[81,157],"retention":[82],"time":[83],"3.5":[85],"min":[86],"at":[87],"wavelength":[89],"220":[90],"nm":[91],"optimized.":[93],"developed":[95,120],"has":[97,122],"been":[98],"validated":[99],"terms":[101],"their":[103],"linearity,":[104,125],"specificity,":[105],"precision,":[106,126],"accuracy,":[107],"limits":[108],"detection":[110],"quantification,":[112],"robustness":[114],"as":[115],"per":[116],"I.C.H.":[117],"guidelines.":[118],"shown":[123],"excellent":[124],"recovery.":[128],"There":[129],"were":[130,160],"no":[131],"spectral":[132],"or":[133],"interferences":[135],"from":[136,175],"non-medicinal":[137],"ingredients":[138],"found.":[139],"Within":[140],"concentration":[142],"range":[143],"10\u201360":[145],"g":[146],"mL-1,":[147],"correlation":[149],"coefficient":[150],"greater":[152],"than":[153],"0.999.":[154],"Low":[155],"relative":[156],"deviation":[158],"values":[159],"obtained":[161],"results":[164],"intra-day":[166],"inter-day":[168],"precision":[169],"tests.":[170],"method's":[172],"accuracy":[173],"ranged":[174],"99.45":[176],"100.52":[178],"%.":[179],"present":[181],"analytical":[182],"can":[184],"be":[185],"quantify":[188],"pharmaceutical":[191],"preparations.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-01-26T00:00:00"}