{"id":"https://openalex.org/W4206377254","doi":"https://doi.org/10.3390/cells11030345","title":"Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart","display_name":"Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart","publication_year":2022,"publication_date":"2022-01-20","ids":{"openalex":"https://openalex.org/W4206377254","doi":"https://doi.org/10.3390/cells11030345","pmid":"https://pubmed.ncbi.nlm.nih.gov/35159152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8834511"},"language":"en","primary_location":{"id":"doi:10.3390/cells11030345","doi":"https://doi.org/10.3390/cells11030345","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11030345","pdf_url":"https://www.mdpi.com/2073-4409/11/3/345/pdf?version=1642744325","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/11/3/345/pdf?version=1642744325","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054198930","display_name":"Hanna Reuter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanna Reuter","raw_affiliation_strings":["Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000950875","display_name":"Birgit Perner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Perner","raw_affiliation_strings":["Core Facility Imaging, 07745 Jena, Germany","Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility Imaging, 07745 Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Florian Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Wahl","raw_affiliation_strings":["Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071490494","display_name":"Luise Rohde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luise Rohde","raw_affiliation_strings":["Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050788414","display_name":"Philipp Koch","orcid":"https://orcid.org/0000-0003-2825-7943","observed_orcids":["https://orcid.org/0000-0003-2825-7943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Koch","raw_affiliation_strings":["Core Facility Life Science Computing, 07735 Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2825-7943","affiliations":[{"raw_affiliation_string":"Core Facility Life Science Computing, 07735 Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016466390","display_name":"Marco Groth","orcid":"https://orcid.org/0000-0002-9199-8990","observed_orcids":["https://orcid.org/0000-0002-9199-8990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Groth","raw_affiliation_strings":["Core Facility DNA Sequencing, 07745 Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9199-8990","affiliations":[{"raw_affiliation_string":"Core Facility DNA Sequencing, 07745 Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057312613","display_name":"Katrin Buder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Buder","raw_affiliation_strings":["Core Service Histology/Pathology/EM, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Service Histology/Pathology/EM, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028310893","display_name":"Christoph Englert","orcid":"https://orcid.org/0000-0002-5931-3189","observed_orcids":["https://orcid.org/0000-0002-5931-3189"]},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph Englert","raw_affiliation_strings":["Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany","Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5931-3189","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Molecular Genetics Laboratory, Leibniz Institute on Aging\u2014Fritz Lipmann Institute (FLI), 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028310893"],"corresponding_institution_ids":["https://openalex.org/I4210127789","https://openalex.org/I76198965"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":1.7167,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.82445119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"345","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.8659999966621399},{"id":"https://openalex.org/keywords/zebrafish-heart","display_name":"zebrafish heart","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.8709999918937683},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8100000023841858},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cryoinjury","display_name":"cryoinjury","score":0.9390000104904175},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.973932147026062},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7237204313278198},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7089114785194397},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6443138122558594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6105226278305054},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5067716240882874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36587589979171753},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32157671451568604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3020648956298828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2924601435661316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2176722288131714},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12978610396385193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09841388463973999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07541602849960327}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/cells11030345","doi":"https://doi.org/10.3390/cells11030345","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11030345","pdf_url":"https://www.mdpi.com/2073-4409/11/3/345/pdf?version=1642744325","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmid:35159152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35159152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8834511","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8834511/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e3960da6af8b40f2a9d5f9255506b6e5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e3960da6af8b40f2a9d5f9255506b6e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 11, Iss 3, p 345 (2022)","raw_type":"article"},{"id":"pmh:oai:frl.publisso.de:frl:6475596","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/2073-4409/11/3/345#app1-cells-11-00345","pdf_url":null,"source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, 11(3):345","raw_type":"Zeitschriftenartikel"}],"best_oa_location":{"id":"doi:10.3390/cells11030345","doi":"https://doi.org/10.3390/cells11030345","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11030345","pdf_url":"https://www.mdpi.com/2073-4409/11/3/345/pdf?version=1642744325","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206377254.pdf","grobid_xml":"https://content.openalex.org/works/W4206377254.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1547644703","https://openalex.org/W1580695685","https://openalex.org/W1669479280","https://openalex.org/W1772653906","https://openalex.org/W1921187749","https://openalex.org/W1969038150","https://openalex.org/W1971012459","https://openalex.org/W1980285125","https://openalex.org/W1981118528","https://openalex.org/W1983581444","https://openalex.org/W2005400104","https://openalex.org/W2007263769","https://openalex.org/W2012016911","https://openalex.org/W2020541351","https://openalex.org/W2022287530","https://openalex.org/W2026812193","https://openalex.org/W2028460986","https://openalex.org/W2029286176","https://openalex.org/W2035375803","https://openalex.org/W2035618305","https://openalex.org/W2047286882","https://openalex.org/W2052003865","https://openalex.org/W2055004906","https://openalex.org/W2063319656","https://openalex.org/W2066279279","https://openalex.org/W2069146691","https://openalex.org/W2076973648","https://openalex.org/W2081527689","https://openalex.org/W2083560142","https://openalex.org/W2085320324","https://openalex.org/W2093355627","https://openalex.org/W2095498253","https://openalex.org/W2099997602","https://openalex.org/W2101986300","https://openalex.org/W2112857608","https://openalex.org/W2114360920","https://openalex.org/W2114375142","https://openalex.org/W2115852450","https://openalex.org/W2126525177","https://openalex.org/W2126747203","https://openalex.org/W2137014806","https://openalex.org/W2138207763","https://openalex.org/W2146103737","https://openalex.org/W2149161770","https://openalex.org/W2152663152","https://openalex.org/W2155490506","https://openalex.org/W2156369645","https://openalex.org/W2159872670","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2697082363","https://openalex.org/W2748775553","https://openalex.org/W2753518299","https://openalex.org/W2776266935","https://openalex.org/W2783036593","https://openalex.org/W2887449534","https://openalex.org/W2888686134","https://openalex.org/W2898819475","https://openalex.org/W2963132995","https://openalex.org/W2966831529","https://openalex.org/W2972325539","https://openalex.org/W2979123438","https://openalex.org/W2997366069","https://openalex.org/W3000502359","https://openalex.org/W3004210336","https://openalex.org/W3024854663","https://openalex.org/W3086660393","https://openalex.org/W3102558410","https://openalex.org/W3110434992"],"related_works":["https://openalex.org/W3022181472","https://openalex.org/W1460862465","https://openalex.org/W3174148568","https://openalex.org/W4404950083","https://openalex.org/W2011139490","https://openalex.org/W753899266","https://openalex.org/W2026812193","https://openalex.org/W2066279279","https://openalex.org/W2697082363","https://openalex.org/W2491831296"],"abstract_inverted_index":{"Age-associated":[0],"organ":[1],"failure":[2],"and":[3,21,75,89,124,143,179],"degenerative":[4],"diseases":[5],"have":[6,35,60],"a":[7,51,181],"major":[8],"impact":[9],"on":[10,56],"human":[11],"health.":[12],"Cardiovascular":[13],"dysfunction":[14],"has":[15,48],"an":[16,100,172],"increasing":[17],"prevalence":[18],"with":[19,127],"age":[20],"is":[22,140],"one":[23],"of":[24,28,39,73,102],"the":[25,43,62,68,81,108,134,152,176,187],"leading":[26],"causes":[27],"death.":[29],"In":[30,45],"contrast":[31],"to":[32,93,137],"humans,":[33],"zebrafish":[34,47,77,110,177],"extraordinary":[36],"regeneration":[37],"capacities":[38],"complex":[40],"organs":[41],"including":[42],"heart.":[44],"addition,":[46],"recently":[49],"become":[50],"model":[52],"organism":[53],"in":[54,86,107,118,147,151,159,175,183,186],"research":[55],"aging.":[57,96],"Here,":[58],"we":[59],"compared":[61],"ventricular":[63],"transcriptome":[64],"as":[65,67,84],"well":[66],"regenerative":[69,135,184],"capacity":[70],"after":[71],"cryoinjury":[72],"old":[74,87,109,148,160],"young":[76],"hearts.":[78],"We":[79],"identified":[80],"immune":[82,103,113],"system":[83],"activated":[85],"ventricles":[88],"found":[90],"muscle":[91],"organization":[92],"deteriorate":[94],"upon":[95],"Our":[97,129],"data":[98,130,170],"show":[99],"accumulation":[101],"cells,":[104],"mostly":[105],"macrophages,":[106],"ventricle.":[111],"Those":[112],"cells":[114],"not":[115],"only":[116],"increased":[117],"numbers":[119],"but":[120],"also":[121],"showed":[122],"morphological":[123],"behavioral":[125],"changes":[126],"age.":[128],"further":[131],"suggest":[132,180],"that":[133],"response":[136,185],"cardiac":[138],"injury":[139],"generally":[141],"impaired":[142],"much":[144],"more":[145],"variable":[146],"fish.":[149],"Collagen":[150],"wound":[153],"area":[154],"was":[155],"already":[156],"significantly":[157],"enriched":[158],"fish":[161],"at":[162],"7":[163],"days":[164],"post":[165],"injury.":[166],"Taken":[167],"together,":[168],"these":[169],"indicate":[171],"'inflammaging'-like":[173],"process":[174],"heart":[178],"change":[182],"old.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-01-25T00:00:00"}