{"id":"https://openalex.org/W4206337285","doi":"https://doi.org/10.3390/pharmaceutics14020244","title":"Model-Based Equivalent Dose Optimization to Develop New Donepezil Patch Formulation","display_name":"Model-Based Equivalent Dose Optimization to Develop New Donepezil Patch Formulation","publication_year":2022,"publication_date":"2022-01-20","ids":{"openalex":"https://openalex.org/W4206337285","doi":"https://doi.org/10.3390/pharmaceutics14020244","pmid":"https://pubmed.ncbi.nlm.nih.gov/35213976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8880217"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14020244","doi":"https://doi.org/10.3390/pharmaceutics14020244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14020244","pdf_url":"https://www.mdpi.com/1999-4923/14/2/244/pdf?version=1643292558","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/2/244/pdf?version=1643292558","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102984342","display_name":"Woo Jin Jung","orcid":"https://orcid.org/0000-0001-7806-597X","observed_orcids":["https://orcid.org/0000-0001-7806-597X"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woojin Jung","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028263789","display_name":"Heeyoon Jung","orcid":"https://orcid.org/0009-0003-1246-7994","observed_orcids":["https://orcid.org/0009-0003-1246-7994"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Heeyoon Jung","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013503558","display_name":"Ngoc\u2010Anh Thi Vu","orcid":"https://orcid.org/0000-0003-0106-4607","observed_orcids":["https://orcid.org/0000-0003-0106-4607"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ngoc-Anh Thi Vu","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055083229","display_name":"Gwanyoung Kim","orcid":"https://orcid.org/0009-0006-4528-2816","observed_orcids":["https://orcid.org/0009-0006-4528-2816"]},"institutions":[{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwan-Young Kim","raw_affiliation_strings":["Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007792466","display_name":"Gyoung-Won Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gyoung-Won Kim","raw_affiliation_strings":["Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022293663","display_name":"Jung\u2010woo Chae","orcid":"https://orcid.org/0000-0001-6026-7063","observed_orcids":["https://orcid.org/0000-0001-6026-7063"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung-woo Chae","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6026-7063","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016783011","display_name":"Tae\u2010Heon Kim","orcid":"https://orcid.org/0000-0003-3320-7203","observed_orcids":["https://orcid.org/0000-0003-3320-7203"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]},{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taeheon Kim","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Life Science Research Institute, Daewoong Pharmaceuticals, Yongin-si 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026070944","display_name":"Hwi\u2010yeol Yun","orcid":"https://orcid.org/0000-0001-8793-2449","observed_orcids":["https://orcid.org/0000-0001-8793-2449"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hwi-yeol Yun","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"],"raw_orcid":"https://orcid.org/0000-0001-8793-2449","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016783011","https://openalex.org/A5022293663","https://openalex.org/A5026070944"],"corresponding_institution_ids":["https://openalex.org/I196345858","https://openalex.org/I47141704"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.9452,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69063743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"2","first_page":"244","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.2240000069141388,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.9750000238418579},{"id":"https://openalex.org/keywords/equivalent-dose","display_name":"equivalent dose","score":0.6480000019073486},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.8460000157356262},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.7570000290870667},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.7179999947547913},{"id":"https://openalex.org/keywords/oral-formulations","display_name":"oral dosage forms","score":0.46700000762939453},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.574999988079071},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.8638478517532349},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.8225201368331909},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7361437678337097},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.7170629501342773},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5487372279167175},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4917323887348175},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46144479513168335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3575793504714966},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3537359833717346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10217845439910889},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics14020244","doi":"https://doi.org/10.3390/pharmaceutics14020244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14020244","pdf_url":"https://www.mdpi.com/1999-4923/14/2/244/pdf?version=1643292558","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:35213976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35213976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8880217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8880217/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8141deb41a814ca69a621e528cf1d3ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8141deb41a814ca69a621e528cf1d3ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 2, p 244 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14020244","doi":"https://doi.org/10.3390/pharmaceutics14020244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14020244","pdf_url":"https://www.mdpi.com/1999-4923/14/2/244/pdf?version=1643292558","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4417577150","display_name":null,"funder_award_id":"2020-0-01441","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G4987328150","display_name":null,"funder_award_id":"2020-0-01441","funder_id":"https://openalex.org/F4320321204","funder_display_name":"Chungnam National University"}],"funders":[{"id":"https://openalex.org/F4320321204","display_name":"Chungnam National University","ror":"https://ror.org/0227as991"},{"id":"https://openalex.org/F4320324891","display_name":"Iran Telecommunication Research Center","ror":"https://ror.org/01a3g2z22"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206337285.pdf","grobid_xml":"https://content.openalex.org/works/W4206337285.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W409431921","https://openalex.org/W1994197596","https://openalex.org/W1997535977","https://openalex.org/W2014091144","https://openalex.org/W2032734052","https://openalex.org/W2037650041","https://openalex.org/W2050555966","https://openalex.org/W2055727638","https://openalex.org/W2057679568","https://openalex.org/W2081285591","https://openalex.org/W2100072124","https://openalex.org/W2272820937","https://openalex.org/W2300904943","https://openalex.org/W2612757474","https://openalex.org/W3007448056","https://openalex.org/W3023109855"],"related_works":["https://openalex.org/W3023109855","https://openalex.org/W409431921","https://openalex.org/W2897703800","https://openalex.org/W2630773495","https://openalex.org/W2000270712","https://openalex.org/W7096754105","https://openalex.org/W2371507188","https://openalex.org/W7156880217","https://openalex.org/W2369666139","https://openalex.org/W2152431737"],"abstract_inverted_index":{"Donepezil":[0],"patch":[1,166,201],"was":[2,33,65,78,94,142,169,183],"developed":[3],"to":[4,54,144,171,211,214],"replace":[5],"the":[6,13,56,123,135,140,156,180,192],"original":[7],"oral":[8,29],"formulation.":[9],"To":[10],"accurately":[11,121],"describe":[12],"pharmacokinetics":[14,124],"of":[15,105,125,134,164,199],"donepezil":[16,41,165,175,200],"and":[17,30,74,88,103,107,148,186],"investigate":[18],"compatible":[19],"doses":[20],"between":[21],"two":[22,118],"formulations,":[23],"a":[24,37,97,114],"population":[25],"pharmacokinetic":[26,181],"model":[27,116,141,182],"for":[28,59,150],"transdermal":[31],"patches":[32],"built":[34],"based":[35,95],"on":[36,96,155],"clinical":[38,219],"study.":[39],"Plasma":[40],"levels":[42],"were":[43,52,109,189],"analyzed":[44],"via":[45,80],"liquid":[46],"chromatography/tandem":[47],"mass":[48],"spectrometry.":[49],"Non-compartmental":[50],"analyses":[51],"performed":[53,66,213],"derive":[55],"initial":[57],"parameters":[58,104,188],"compartmental":[60],"analyses.":[61],"Compartmental":[62],"analysis":[63],"(CA)":[64],"with":[67],"NLME":[68],"software":[69],"NONMEM":[70],"assisted":[71],"by":[72,195],"Perl-speaks-NONMEM,":[73],"R.":[75],"Model":[76],"evaluation":[77],"proceeded":[79],"visual":[81],"predictive":[82],"checks":[83],"(VPC),":[84],"goodness-of-fit":[85],"(GOF)":[86],"plotting,":[87],"bootstrap":[89],"method.":[90],"The":[91],"bioequivalence":[92,152,157],"test":[93],"2":[98,100],"\u00d7":[99],"crossover":[101],"design,":[102],"AUC":[106],"Cmax":[108],"considered.":[110],"We":[111],"found":[112],"that":[113],"two-compartment":[115],"featuring":[117],"transit":[119],"compartments":[120],"describes":[122],"nine":[126],"subjects":[127],"administered":[128],"in":[129,208,218],"oral,":[130],"as":[131,133],"well":[132],"patch-dosed":[136],"subjects.":[137],"Through":[138],"evaluation,":[139],"proven":[143],"be":[145,203,212],"sufficiently":[146],"accurate":[147],"suitable":[149],"further":[151],"tests.":[153],"Based":[154],"test,":[158],"114":[159],"mg/101.3":[160],"cm2\u2013146":[161],"mg/129.8":[162],"cm2":[163],"per":[167,176],"week":[168],"equivalent":[170,197],"10":[172],"mg":[173],"PO":[174],"day.":[177],"In":[178],"conclusion,":[179],"successfully":[184],"developed,":[185],"acceptable":[187],"estimated.":[190],"However,":[191],"size":[193],"calculated":[194],"an":[196],"dose":[198],"could":[202],"rather":[204],"large.":[205],"Further":[206],"optimization":[207],"formulation":[209],"needs":[210],"find":[215],"appropriate":[216],"usability":[217],"situations.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-01-25T00:00:00"}
