{"id":"https://openalex.org/W4206264239","doi":"https://doi.org/10.3892/ijo.2022.5308","title":"Arsenic compounds induce apoptosis by activating the MAPK and caspase pathways in FaDu oral squamous carcinoma cells","display_name":"Arsenic compounds induce apoptosis by activating the MAPK and caspase pathways in FaDu oral squamous carcinoma cells","publication_year":2022,"publication_date":"2022-01-14","ids":{"openalex":"https://openalex.org/W4206264239","doi":"https://doi.org/10.3892/ijo.2022.5308","pmid":"https://pubmed.ncbi.nlm.nih.gov/35029282"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2022.5308","doi":"https://doi.org/10.3892/ijo.2022.5308","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5308","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5308/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5308/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102937574","display_name":"Su-Zhen Wu","orcid":"https://orcid.org/0000-0001-7513-073X","observed_orcids":["https://orcid.org/0000-0001-7513-073X"]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Su-Zhen Wu","raw_affiliation_strings":["Department of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079996432","display_name":"Yu-Yan Lan","orcid":"https://orcid.org/0000-0003-4436-2057","observed_orcids":["https://orcid.org/0000-0003-4436-2057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Yan Lan","raw_affiliation_strings":["Department of Nursing, Shu\u2011Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Shu\u2011Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan, R.O.C","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102254378","display_name":"Chiao\u2010Yun Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chiao-Yun Chu","raw_affiliation_strings":["Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110107299","display_name":"Yang-Kao Wang","orcid":"https://orcid.org/0000-0003-4887-5562","observed_orcids":["https://orcid.org/0000-0003-4887-5562"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yang-Kao Wang","raw_affiliation_strings":["Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042428551","display_name":"Yi-Ping Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ping Lee","raw_affiliation_strings":["Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072025450","display_name":"Hong Chang","orcid":"https://orcid.org/0000-0003-3494-5865","observed_orcids":["https://orcid.org/0000-0003-3494-5865"]},"institutions":[{"id":"https://openalex.org/I92582371","display_name":"Southern Taiwan University of Science and Technology","ror":"https://ror.org/0029n1t76","country_code":"TW","type":"education","lineage":["https://openalex.org/I92582371"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hong-Yi Chang","raw_affiliation_strings":["Department of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan, R.O.C","institution_ids":["https://openalex.org/I92582371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038332780","display_name":"Bu\u2010Miin Huang","orcid":"https://orcid.org/0000-0002-6966-832X","observed_orcids":["https://orcid.org/0000-0002-6966-832X"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bu-Miin Huang","raw_affiliation_strings":["Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8884,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.62738947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"60","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.33149999380111694,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.33149999380111694,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.19130000472068787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-compounds","display_name":"arsenic compounds","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sodium-arsenite","display_name":"sodium arsenite","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dimethylarsinic-acid","display_name":"dimethylarsinic acid","score":0.8579999804496765},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fadu-cells","display_name":"FaDu cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.7839999794960022},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.7960000038146973},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9789999723434448},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.843999981880188},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8870000243186951},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.7120000123977661},{"id":"https://openalex.org/keywords/intrinsic-and-extrinsic-apoptotic-pathways","display_name":"intrinsic and extrinsic apoptotic pathways","score":0.7269999980926514},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.834399402141571},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5978922247886658},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5931646823883057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5647798180580139},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.5524024963378906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5501285195350647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5073005557060242},{"id":"https://openalex.org/C2779495234","wikidata":"https://www.wikidata.org/wiki/Q419586","display_name":"Sodium arsenite","level":3,"score":0.4963880181312561},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.450632780790329},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.4205038547515869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33482179045677185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3163599967956543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.233602374792099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2039394974708557},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0582522451877594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.2022.5308","doi":"https://doi.org/10.3892/ijo.2022.5308","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5308","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5308/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:35029282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35029282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2022.5308","doi":"https://doi.org/10.3892/ijo.2022.5308","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5308","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5308/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3279879736","display_name":"Epstein-Barr Virus Lytic Protein Rta Regulates Senescence-Associated Secretory Phenotype Genes to Promote Progression of Nasopharyngeal Carcinoma","funder_award_id":"MOST107-2320-B471-001","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8276640205","display_name":"The Role of Ron Receptor for Cancer Stem Cells in Hbv-Related Hepatocarcinogenesis under Hypoxia (Ii)( I )","funder_award_id":"MOST110-2314-B218-001","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320313851","display_name":"Shenzhen Polytechnic","ror":"https://ror.org/00d2w9g53"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206264239.pdf","grobid_xml":"https://content.openalex.org/works/W4206264239.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1595815978","https://openalex.org/W1607777232","https://openalex.org/W1667478348","https://openalex.org/W1967058574","https://openalex.org/W1970923300","https://openalex.org/W1973412670","https://openalex.org/W1974825648","https://openalex.org/W1976881265","https://openalex.org/W1976994092","https://openalex.org/W1977791393","https://openalex.org/W1978360956","https://openalex.org/W1979129905","https://openalex.org/W1982584241","https://openalex.org/W1989254646","https://openalex.org/W1992361007","https://openalex.org/W1995338674","https://openalex.org/W2003325519","https://openalex.org/W2004008931","https://openalex.org/W2005900169","https://openalex.org/W2006687288","https://openalex.org/W2011815881","https://openalex.org/W2023499824","https://openalex.org/W2024995224","https://openalex.org/W2025128734","https://openalex.org/W2038194286","https://openalex.org/W2040111088","https://openalex.org/W2042935092","https://openalex.org/W2044119772","https://openalex.org/W2045866866","https://openalex.org/W2047235581","https://openalex.org/W2047925472","https://openalex.org/W2059187014","https://openalex.org/W2059282715","https://openalex.org/W2059752816","https://openalex.org/W2061049714","https://openalex.org/W2072466513","https://openalex.org/W2074988455","https://openalex.org/W2084318835","https://openalex.org/W2086288597","https://openalex.org/W2093398266","https://openalex.org/W2099603517","https://openalex.org/W2101354010","https://openalex.org/W2102382046","https://openalex.org/W2106075350","https://openalex.org/W2111447964","https://openalex.org/W2131785771","https://openalex.org/W2134295452","https://openalex.org/W2142423276","https://openalex.org/W2143178808","https://openalex.org/W2159014565","https://openalex.org/W2161892620","https://openalex.org/W2162766713","https://openalex.org/W2163531798","https://openalex.org/W2165996931","https://openalex.org/W2169670265","https://openalex.org/W2172249201","https://openalex.org/W2184391500","https://openalex.org/W2414237279","https://openalex.org/W2535734390","https://openalex.org/W2544788703","https://openalex.org/W2766031263","https://openalex.org/W2891508711","https://openalex.org/W2935699220","https://openalex.org/W2945413808","https://openalex.org/W2947738412","https://openalex.org/W3012638502","https://openalex.org/W3016836923","https://openalex.org/W3092231652","https://openalex.org/W3097853477","https://openalex.org/W3127037333","https://openalex.org/W3183580855","https://openalex.org/W3186268392","https://openalex.org/W3191792523","https://openalex.org/W3195498360","https://openalex.org/W3209537235","https://openalex.org/W6684266464","https://openalex.org/W6761763794","https://openalex.org/W6762412778","https://openalex.org/W6776606329"],"related_works":["https://openalex.org/W4311225709","https://openalex.org/W3092231652","https://openalex.org/W4402133432","https://openalex.org/W4244554688","https://openalex.org/W2388698223","https://openalex.org/W2137346704","https://openalex.org/W2380882598","https://openalex.org/W2116538092","https://openalex.org/W4293176062","https://openalex.org/W2085953479"],"abstract_inverted_index":{"For":[0],"a":[1,65,76,215],"number":[2],"of":[3,16,49,81,97,103,134,151,159,169,196,221,230,247,259,269,282,304,318],"years,":[4],"oral":[5,29,58,107,320],"cancer":[6,30,59,321],"has":[7,72],"remained":[8],"in":[9,60,100,218,224,295],"the":[10,46,79,95,101,157,167,194,204,219,225,231,245,257,260,266,280,296,300,302,305,316,330],"top":[11],"ten":[12],"most":[13],"common":[14],"types":[15],"cancer,":[17,104],"with":[18,34,57,112,138,209,253,291,311],"an":[19],"incidence":[20],"rate":[21,158],"that":[22,124,156,207,265,309],"is":[23,54,64],"steadily":[24],"increasing.":[25],"In":[26],"total,":[27],"~75%":[28],"cases":[31],"are":[32],"associated":[33,56],"lifestyle":[35],"factors,":[36],"including":[37],"uncontrolled":[38],"alcohol":[39],"consumption,":[40],"betel":[41,52],"and":[42,45,116,131,142,179,211,227,272,274,285,293,313,332],"tobacco":[43],"chewing,":[44],"excessive":[47],"use":[48],"tobacco.":[50],"Notably,":[51],"chewing":[53],"highly":[55],"Southeast":[61],"Asia.":[62],"Arsenic":[63],"key":[66],"environmental":[67],"toxicant;":[68],"however,":[69],"arsenic":[70,98,118,170,197,254],"trioxide":[71],"been":[73],"used":[74],"as":[75,166,278,327,329],"medicine":[77],"for":[78,146],"treatment":[80,102,137,208,252,290,310],"acute":[82],"promyelocytic":[83],"leukemia,":[84],"highlighting":[85],"its":[86],"anticancer":[87],"properties.":[88],"The":[89,121,149],"present":[90,306],"study":[91,307],"aimed":[92],"to":[93,175,181,191,214,243],"investigate":[94],"role":[96],"compounds":[99,171,198],"using":[105],"FaDu":[106,125,160,200,222,248,297,319],"squamous":[108],"carcinoma":[109],"cells":[110,126,223],"treated":[111],"sodium":[113],"arsenite":[114],"(NaAsO2)":[115],"dimethyl":[117],"acid":[119],"(DMA).":[120],"results":[122,150,205,258,303],"demonstrated":[123,155],"exhibited":[127],"membrane":[128],"blebbing":[129],"phenomena":[130],"high":[132],"levels":[133,246,268,281],"apoptosis":[135,250,317],"following":[136,251,289],"10":[139,174],"\u00b5M":[140,177],"NaAsO2":[141,210,292,312],"1":[143,180],"mM":[144,183],"DMA":[145,212,294,314],"24":[147],"h.":[148],"cell":[152,161,201,232,249],"viability":[153],"assay":[154,239],"survival":[162],"was":[163,188,240],"markedly":[164],"reduced":[165],"concentration":[168],"increased":[172,288],"from":[173],"100":[176,182],"NaAsO2,":[178],"DMA.":[184],"Moreover,":[185],"flow":[186],"cytometry":[187],"carried":[189],"out":[190],"further":[192],"examine":[193],"effects":[195],"on":[199],"cycle":[202],"regulation;":[203],"revealed":[206,264,308],"led":[213],"significant":[216],"increase":[217],"percentage":[220],"sub\u2011G1":[226],"G2/M":[228],"phases":[229],"cycle.":[233],"An":[234],"Annexin":[235],"V/PI":[236],"double":[237],"staining":[238],"subsequently":[241],"performed":[242],"verify":[244],"compounds.":[255],"Furthermore,":[256],"western":[261],"blot":[262],"analyses":[263],"expression":[267],"caspase\u20118,":[270],"\u20119":[271],"\u20113,":[273],"poly":[275],"ADP\u2011ribose":[276],"polymerase,":[277],"well":[279,328],"phosphorylated":[283],"JNK":[284],"ERK1/2":[286],"were":[287],"cells.":[298],"On":[299],"whole,":[301],"promoted":[315],"cells,":[322],"by":[323],"activating":[324],"MAPK":[325],"pathways,":[326],"extrinsic":[331],"intrinsic":[333],"apoptotic":[334],"pathways.":[335]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-01-26T00:00:00"}
