{"id":"https://openalex.org/W4206228474","doi":"https://doi.org/10.18805/ag.df-393","title":"Investigating Field Efficacy and Safety of Conjunctival Brucella abortus S19 Vaccine in Cattle","display_name":"Investigating Field Efficacy and Safety of Conjunctival Brucella abortus S19 Vaccine in Cattle","publication_year":2022,"publication_date":"2022-01-16","ids":{"openalex":"https://openalex.org/W4206228474","doi":"https://doi.org/10.18805/ag.df-393"},"language":"en","primary_location":{"id":"doi:10.18805/ag.df-393","doi":"https://doi.org/10.18805/ag.df-393","is_oa":true,"landing_page_url":"https://doi.org/10.18805/ag.df-393","pdf_url":"https://arccarticles.s3.amazonaws.com/OnlinePublish/Final-article-attachemnt-with-doi-DF-393-6089603e9087340b9bdcbbb1.pdf","source":{"id":"https://openalex.org/S2764562560","display_name":"Agricultural Science Digest - A Research Journal","issn_l":"0253-150X","issn":["0253-150X","0976-0547"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324046968","host_organization_name":"Agricultural Research Communication Center","host_organization_lineage":["https://openalex.org/P4324046968"],"host_organization_lineage_names":["Agricultural Research Communication Center"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural Science Digest - A Research Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://arccarticles.s3.amazonaws.com/OnlinePublish/Final-article-attachemnt-with-doi-DF-393-6089603e9087340b9bdcbbb1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034396961","display_name":"Sevil Erdenli\u011f G\u00fcrbi\u0307lek","orcid":"https://orcid.org/0000-0002-0377-2650","observed_orcids":["https://orcid.org/0000-0002-0377-2650"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S. Erdenlig Gurbilek","raw_affiliation_strings":["Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059013854","display_name":"Mustafa Sencer KARAG\u00dcL","orcid":"https://orcid.org/0000-0001-7215-5229","observed_orcids":["https://orcid.org/0000-0001-7215-5229"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M.S. Karagul","raw_affiliation_strings":["Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041609141","display_name":"Ahmet Murat Saytekin","orcid":"https://orcid.org/0000-0001-7486-8054","observed_orcids":["https://orcid.org/0000-0001-7486-8054"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A.M. Saytekin","raw_affiliation_strings":["Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077228093","display_name":"Emin Ayhan Baklan","orcid":"https://orcid.org/0000-0001-5411-6234","observed_orcids":["https://orcid.org/0000-0001-5411-6234"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E.A. Baklan","raw_affiliation_strings":["Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076715498","display_name":"G\u00fclnur SA\u011eLAM","orcid":"https://orcid.org/0000-0001-7162-2577","observed_orcids":["https://orcid.org/0000-0001-7162-2577"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G. Saglam","raw_affiliation_strings":["Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kartepe Vocational School of Equine Science, Kocaeli University, Kartepe, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51826884"],"apc_list":null,"apc_paid":null,"fwci":0.5544,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57358756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":"Of","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brucellosis","display_name":"brucellosis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.9200000166893005},{"id":"https://openalex.org/keywords/conjunctival-vaccination","display_name":"conjunctival vaccination","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.718999981880188},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antibody-persistence","display_name":"antibody persistence","score":0.7089999914169312},{"id":"https://openalex.org/keywords/rose-bengal-test","display_name":"Rose Bengal test","score":0.699999988079071},{"id":"https://openalex.org/keywords/serum-agglutination-test","display_name":"serum agglutination test","score":0.9829999804496765},{"id":"https://openalex.org/keywords/complement-fixation-test","display_name":"complement fixation test","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mass-vaccination-program","display_name":"mass vaccination program","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.8517423868179321},{"id":"https://openalex.org/C2781429187","wikidata":"https://www.wikidata.org/wiki/Q156050","display_name":"Brucellosis","level":2,"score":0.8325974941253662},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.6673604846000671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6494752764701843},{"id":"https://openalex.org/C73878171","wikidata":"https://www.wikidata.org/wiki/Q5280305","display_name":"Direct agglutination test","level":4,"score":0.5553619861602783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5454382300376892},{"id":"https://openalex.org/C152669594","wikidata":"https://www.wikidata.org/wiki/Q904197","display_name":"Complement fixation test","level":4,"score":0.536942720413208},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5259671211242676},{"id":"https://openalex.org/C2780767784","wikidata":"https://www.wikidata.org/wiki/Q313358","display_name":"Brucella","level":3,"score":0.5059646964073181},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5057699680328369},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.45593541860580444},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37550318241119385},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36946946382522583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25248485803604126},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.07563990354537964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18805/ag.df-393","doi":"https://doi.org/10.18805/ag.df-393","is_oa":true,"landing_page_url":"https://doi.org/10.18805/ag.df-393","pdf_url":"https://arccarticles.s3.amazonaws.com/OnlinePublish/Final-article-attachemnt-with-doi-DF-393-6089603e9087340b9bdcbbb1.pdf","source":{"id":"https://openalex.org/S2764562560","display_name":"Agricultural Science Digest - A Research Journal","issn_l":"0253-150X","issn":["0253-150X","0976-0547"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324046968","host_organization_name":"Agricultural Research Communication Center","host_organization_lineage":["https://openalex.org/P4324046968"],"host_organization_lineage_names":["Agricultural Research Communication Center"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural Science Digest - A Research Journal","raw_type":"journal-article"},{"id":"pmh:86aeff53-5605-4c96-b852-00b4c95c211b","doi":null,"is_oa":false,"landing_page_url":"https://avesis.kocaeli.edu.tr/publication/details/86aeff53-5605-4c96-b852-00b4c95c211b/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055291","display_name":"Kocaeli \u00dcniversitesi - AVES\u0130S","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18805/ag.df-393","doi":"https://doi.org/10.18805/ag.df-393","is_oa":true,"landing_page_url":"https://doi.org/10.18805/ag.df-393","pdf_url":"https://arccarticles.s3.amazonaws.com/OnlinePublish/Final-article-attachemnt-with-doi-DF-393-6089603e9087340b9bdcbbb1.pdf","source":{"id":"https://openalex.org/S2764562560","display_name":"Agricultural Science Digest - A Research Journal","issn_l":"0253-150X","issn":["0253-150X","0976-0547"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324046968","host_organization_name":"Agricultural Research Communication Center","host_organization_lineage":["https://openalex.org/P4324046968"],"host_organization_lineage_names":["Agricultural Research Communication Center"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural Science Digest - A Research Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.5666999816894531,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206228474.pdf","grobid_xml":"https://content.openalex.org/works/W4206228474.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W23208488","https://openalex.org/W174031359","https://openalex.org/W226564798","https://openalex.org/W2000073559","https://openalex.org/W2006587374","https://openalex.org/W2024820540","https://openalex.org/W2026706993","https://openalex.org/W2027456107","https://openalex.org/W2048691573","https://openalex.org/W2054305405","https://openalex.org/W2064284773","https://openalex.org/W2092214062","https://openalex.org/W2156404282","https://openalex.org/W2256530903","https://openalex.org/W2396087552","https://openalex.org/W2443806063","https://openalex.org/W2752033537","https://openalex.org/W2884251126","https://openalex.org/W2901304435","https://openalex.org/W2951663761","https://openalex.org/W3087377825","https://openalex.org/W4311842732"],"related_works":["https://openalex.org/W2051572610","https://openalex.org/W4406362427","https://openalex.org/W2897720428","https://openalex.org/W4416096182","https://openalex.org/W4213138903","https://openalex.org/W3216601646","https://openalex.org/W2910640686","https://openalex.org/W2886880820","https://openalex.org/W2752033537","https://openalex.org/W2397647558"],"abstract_inverted_index":{"Background:":[0],"Vaccination":[1],"is":[2,46,58],"the":[3,8,39,47,61,70,78,101,134,153,157,168,172,189,199,218],"most":[4,166],"fundamental":[5],"strategy":[6],"in":[7,24,27,35,44,145,165,203,208],"control":[9],"and":[10,66,123,205],"eradication":[11],"of":[12,38,55,63,95,136,139,149,156,167,191],"brucellosis.":[13],"Several":[14],"vaccination":[15,80,108],"programs":[16],"with":[17,91,100],"different":[18],"vaccines":[19,41],"have":[20],"been":[21],"carried":[22],"out":[23],"many":[25],"countries":[26],"which":[28],"brucellosis":[29,43],"continues":[30],"to":[31,59,77],"be":[32],"a":[33,92,146],"problem":[34],"livestock.":[36],"One":[37],"recommended":[40],"against":[42],"cattle":[45,88],"live":[48],"Brucella":[49,72,96],"abortus":[50,73,97],"S19":[51,74,98],"vaccine.":[52],"The":[53,104],"aim":[54],"this":[56,84,192,209],"study":[57,193,210],"evaluate":[60],"results":[62,190],"field":[64],"safety":[65],"efficacy":[67],"trials":[68],"for":[69,217],"conjunctival":[71,102],"vaccine":[75,99,140,200],"prior":[76],"mass":[79],"program.":[81],"Methods:":[82],"In":[83,187],"study,":[85],"81":[86],"female":[87],"were":[89],"vaccinated":[90],"reduced":[93],"dose":[94,204],"route.":[103],"immune":[105,161],"response":[106,162],"after":[107,177,185],"was":[109,131,142,163],"investigated":[110],"by":[111,170],"suggested":[112],"serological":[113,158,173],"tests;":[114],"namely,":[115],"Rose":[116],"Bengal":[117],"Plate":[118],"Test,":[119],"Serum":[120],"Agglutination":[121],"Test":[122],"Complement":[124],"Fixation":[125],"Test.":[126],"Result:":[127],"No":[128],"adverse":[129],"effect":[130],"observed":[132,143,164],"within":[133],"scope":[135],"safety.":[137],"Isolation":[138],"strain":[141],"only":[144],"milk":[147],"sample":[148],"lactating":[150],"animals.":[151,220],"Excluding":[152],"diagnosis":[154],"criteria":[155],"tests,":[159],"humoral":[160],"animals":[169],"all":[171],"tests":[174],"one":[175],"month":[176],"vaccination.":[178,186],"Antibody":[179],"levels":[180],"lasted":[181],"approximately":[182],"4":[183],"months":[184],"conclusion,":[188],"demonstrated":[194],"that":[195],"besides":[196],"vaccine-induced":[197],"antibodies,":[198],"including":[201],"changes":[202],"administration":[206],"way":[207],"did":[211],"not":[212],"cause":[213],"any":[214],"significant":[215],"risks":[216],"target":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-01-26T00:00:00"}