{"id":"https://openalex.org/W4206207828","doi":"https://doi.org/10.1038/s41559-021-01615-9","title":"Spatial structure governs the mode of tumour evolution","display_name":"Spatial structure governs the mode of tumour evolution","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4206207828","doi":"https://doi.org/10.1038/s41559-021-01615-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/34949822"},"language":"en","primary_location":{"id":"doi:10.1038/s41559-021-01615-9","doi":"https://doi.org/10.1038/s41559-021-01615-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41559-021-01615-9","pdf_url":"https://www.nature.com/articles/s41559-021-01615-9.pdf","source":{"id":"https://openalex.org/S2764884935","display_name":"Nature Ecology & Evolution","issn_l":"2397-334X","issn":["2397-334X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Ecology & Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41559-021-01615-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103262257","display_name":"Robert Noble","orcid":"https://orcid.org/0000-0002-8057-4252","observed_orcids":["https://orcid.org/0000-0002-8057-4252"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I180825142","display_name":"City, University of London","ror":"https://ror.org/04489at23","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I180825142","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH","GB"],"is_corresponding":true,"raw_author_name":"Robert Noble","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. robert.noble@city.ac.uk","Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland. robert.noble@city.ac.uk","Department of Mathematics, City, University of London, London, UK. robert.noble@city.ac.uk","SIB Swiss Institute of Bioinformatics, Basel, Switzerland. robert.noble@city.ac.uk","Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8057-4252","affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. robert.noble@city.ac.uk","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland. robert.noble@city.ac.uk","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Mathematics, City, University of London, London, UK. robert.noble@city.ac.uk","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I180825142"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Basel, Switzerland. robert.noble@city.ac.uk","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068511226","display_name":"Dominik B\u00fcrri","orcid":"https://orcid.org/0000-0002-8131-9309","observed_orcids":["https://orcid.org/0000-0002-8131-9309"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominik Burri","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland","Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8131-9309","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067057282","display_name":"C\u00e9cile Le Sueur","orcid":"https://orcid.org/0000-0001-7114-3744","observed_orcids":["https://orcid.org/0000-0001-7114-3744"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Le Sueur","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021242323","display_name":"Jeanne Lemant","orcid":"https://orcid.org/0000-0003-1522-0025","observed_orcids":["https://orcid.org/0000-0003-1522-0025"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jeanne Lemant","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015942751","display_name":"Yannick Viossat","orcid":"https://orcid.org/0000-0003-1388-0599","observed_orcids":["https://orcid.org/0000-0003-1388-0599"]},"institutions":[{"id":"https://openalex.org/I171048554","display_name":"Centre de Recherche en Math\u00e9matiques de la D\u00e9cision","ror":"https://ror.org/03s0gj002","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I171048554","https://openalex.org/I2746051580","https://openalex.org/I4210141950","https://openalex.org/I56435720"]},{"id":"https://openalex.org/I56435720","display_name":"Universit\u00e9 Paris Dauphine-PSL","ror":"https://ror.org/052bz7812","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580","https://openalex.org/I56435720"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yannick Viossat","raw_affiliation_strings":["Ceremade, Universit\u00e9 Paris Dauphine-PSL, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1388-0599","affiliations":[{"raw_affiliation_string":"Ceremade, Universit\u00e9 Paris Dauphine-PSL, Paris, France","institution_ids":["https://openalex.org/I171048554","https://openalex.org/I56435720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073483894","display_name":"Jakob Nikolas Kather","orcid":"https://orcid.org/0000-0002-3730-5348","observed_orcids":["https://orcid.org/0000-0002-3730-5348"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob Nikolas Kather","raw_affiliation_strings":["Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3730-5348","affiliations":[{"raw_affiliation_string":"Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035497488","display_name":"Niko Beerenwinkel","orcid":"https://orcid.org/0000-0002-0573-6119","observed_orcids":["https://orcid.org/0000-0002-0573-6119"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Niko Beerenwinkel","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","SIB Swiss Institute of Bioinformatics, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","SIB Swiss Institute of Bioinformatics, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0573-6119","affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Basel, Switzerland. niko.beerenwinkel@bsse.ethz.ch","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5035497488","https://openalex.org/A5103262257"],"corresponding_institution_ids":["https://openalex.org/I124357947","https://openalex.org/I12708293","https://openalex.org/I180825142","https://openalex.org/I202697423","https://openalex.org/I35440088"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":{"value":11390,"currency":"USD","value_usd":11390},"fwci":6.5155,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.98478517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"2","first_page":"207","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-architecture","display_name":"tumor architecture","score":0.8339999914169312},{"id":"https://openalex.org/keywords/spatial-structure","display_name":"spatial structure","score":0.9710000157356262},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/punctuated-evolution","display_name":"punctuated evolution","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neutral-evolution","display_name":"neutral evolution","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cell-dispersal","display_name":"cell dispersal","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6466613411903381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5749057531356812},{"id":"https://openalex.org/C47559259","wikidata":"https://www.wikidata.org/wiki/Q778143","display_name":"Biological dispersal","level":3,"score":0.5461318492889404},{"id":"https://openalex.org/C206175624","wikidata":"https://www.wikidata.org/wiki/Q595731","display_name":"Branching (polymer chemistry)","level":2,"score":0.5175489783287048},{"id":"https://openalex.org/C1570309","wikidata":"https://www.wikidata.org/wiki/Q1055017","display_name":"Neutral theory of molecular evolution","level":3,"score":0.5113682150840759},{"id":"https://openalex.org/C180916674","wikidata":"https://www.wikidata.org/wiki/Q3711935","display_name":"Diversification (marketing strategy)","level":2,"score":0.4501658082008362},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43690967559814453},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37692007422447205},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3525545597076416},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.33819112181663513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15565448999404907},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09305024147033691},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1038/s41559-021-01615-9","doi":"https://doi.org/10.1038/s41559-021-01615-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41559-021-01615-9","pdf_url":"https://www.nature.com/articles/s41559-021-01615-9.pdf","source":{"id":"https://openalex.org/S2764884935","display_name":"Nature Ecology & Evolution","issn_l":"2397-334X","issn":["2397-334X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Ecology & Evolution","raw_type":"journal-article"},{"id":"doi:10.1101/586735","doi":"https://doi.org/10.1101/586735","is_oa":true,"landing_page_url":"https://doi.org/10.1101/586735","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/04/13/586735.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:34949822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34949822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature ecology & evolution","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.city.ac.uk:27116","doi":null,"is_oa":false,"landing_page_url":"https://openaccess.city.ac.uk/view/creators_id/robert=2Enoble.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4306401940","display_name":"City Research Online (City University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I180825142","host_organization_name":"City, University of London","host_organization_lineage":["https://openalex.org/I180825142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8825284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8825284","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Ecol Evol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03522550v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03522550","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Ecology & Evolution, 2021, ⟨10.1038/s41559-021-01615-9⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:basepub.dauphine.psl.eu:123456789/22618","doi":null,"is_oa":true,"landing_page_url":"https://basepub.dauphine.psl.eu/handle/123456789/22618","pdf_url":null,"source":{"id":"https://openalex.org/S4306401007","display_name":"Base Institutionnelle de Recherche de l'universit\u00e9 Paris-Dauphine (BIRD) (University Paris-Dauphine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102197404","host_organization_name":"Universit\u00e9 Paris-Sud","host_organization_lineage":["https://openalex.org/I102197404"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article accept\u00e9 pour publication ou publi\u00e9"},{"id":"pmh:oai:publications.rwth-aachen.de:852001","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/852001","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature ecology & evolution 6(2), 207-217 (2022). doi:10.1038/s41559-021-01615-9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/522512","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/522512","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Ecology & Evolution, 6 (2)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.18154/rwth-conv-249089","doi":"https://doi.org/10.18154/rwth-conv-249089","is_oa":true,"landing_page_url":"https://doi.org/10.18154/rwth-conv-249089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.3929/ethz-b-000522512","doi":"https://doi.org/10.3929/ethz-b-000522512","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000522512","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41559-021-01615-9","doi":"https://doi.org/10.1038/s41559-021-01615-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41559-021-01615-9","pdf_url":"https://www.nature.com/articles/s41559-021-01615-9.pdf","source":{"id":"https://openalex.org/S2764884935","display_name":"Nature Ecology & Evolution","issn_l":"2397-334X","issn":["2397-334X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Ecology & Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2461366450","display_name":null,"funder_award_id":"691906","funder_id":"https://openalex.org/F4320324232","funder_display_name":"RWTH Aachen University"},{"id":"https://openalex.org/G2947078389","display_name":"Arizona Cancer and Evolution Center (ACE)","funder_award_id":"U54CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320324232","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34"},{"id":"https://openalex.org/F4320327569","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4206207828.pdf","grobid_xml":"https://content.openalex.org/works/W4206207828.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W121839966","https://openalex.org/W815962347","https://openalex.org/W1526705543","https://openalex.org/W1549619413","https://openalex.org/W1846418786","https://openalex.org/W1964154017","https://openalex.org/W1968657935","https://openalex.org/W1972180290","https://openalex.org/W2010873488","https://openalex.org/W2018463841","https://openalex.org/W2023560061","https://openalex.org/W2027861704","https://openalex.org/W2030563101","https://openalex.org/W2038268416","https://openalex.org/W2040458067","https://openalex.org/W2056099610","https://openalex.org/W2067256262","https://openalex.org/W2094647384","https://openalex.org/W2100024496","https://openalex.org/W2112192484","https://openalex.org/W2140080780","https://openalex.org/W2143468862","https://openalex.org/W2147247464","https://openalex.org/W2150575159","https://openalex.org/W2155418451","https://openalex.org/W2159382226","https://openalex.org/W2162248245","https://openalex.org/W2166641737","https://openalex.org/W2168901267","https://openalex.org/W2177689130","https://openalex.org/W2260951263","https://openalex.org/W2270865385","https://openalex.org/W2303551941","https://openalex.org/W2331613197","https://openalex.org/W2402730620","https://openalex.org/W2424353685","https://openalex.org/W2479347895","https://openalex.org/W2523689220","https://openalex.org/W2529657394","https://openalex.org/W2577286195","https://openalex.org/W2579382924","https://openalex.org/W2609243345","https://openalex.org/W2611387862","https://openalex.org/W2624281239","https://openalex.org/W2734638264","https://openalex.org/W2744373774","https://openalex.org/W2753965489","https://openalex.org/W2755261245","https://openalex.org/W2759206428","https://openalex.org/W2763367287","https://openalex.org/W2763498516","https://openalex.org/W2774281968","https://openalex.org/W2797282777","https://openalex.org/W2797542577","https://openalex.org/W2798825846","https://openalex.org/W2803133468","https://openalex.org/W2804079254","https://openalex.org/W2807580728","https://openalex.org/W2808042235","https://openalex.org/W2889558074","https://openalex.org/W2898969969","https://openalex.org/W2904525786","https://openalex.org/W2904624775","https://openalex.org/W2911710806","https://openalex.org/W2921148166","https://openalex.org/W2924124844","https://openalex.org/W2950181793","https://openalex.org/W2951391875","https://openalex.org/W2951890973","https://openalex.org/W2952481429","https://openalex.org/W2965204273","https://openalex.org/W2982587363","https://openalex.org/W2999681746","https://openalex.org/W3000527497","https://openalex.org/W3001381700","https://openalex.org/W3004647847","https://openalex.org/W3005234570","https://openalex.org/W3010545926","https://openalex.org/W3040113479","https://openalex.org/W3083938091","https://openalex.org/W3093815480","https://openalex.org/W3094983909","https://openalex.org/W3129959378","https://openalex.org/W3136769797","https://openalex.org/W3137654632","https://openalex.org/W3142063712","https://openalex.org/W3142571537","https://openalex.org/W3184200094","https://openalex.org/W4210516674","https://openalex.org/W4226236648","https://openalex.org/W4235071074","https://openalex.org/W4301482921"],"related_works":["https://openalex.org/W3193971388","https://openalex.org/W4388363453","https://openalex.org/W1974204627","https://openalex.org/W2001207513","https://openalex.org/W2835754784","https://openalex.org/W1998440774","https://openalex.org/W3112881275","https://openalex.org/W2896271600","https://openalex.org/W2745540247","https://openalex.org/W1972293988"],"abstract_inverted_index":{"Characterizing":[0],"the":[1,54,137],"mode-the":[2],"way,":[3],"manner":[4,132],"or":[5],"pattern-of":[6],"evolution":[7,93],"in":[8,40,148],"tumours":[9],"is":[10,33,50],"important":[11],"for":[12,101,124],"clinical":[13],"forecasting":[14,151],"and":[15,28,70,94,103,136,152],"optimizing":[16],"cancer":[17,125],"treatment.":[18],"Sequencing":[19],"studies":[20],"have":[21],"inferred":[22],"various":[23],"modes,":[24],"including":[25],"branching,":[26],"punctuated":[27],"neutral":[29,97],"evolution,":[30],"but":[31],"it":[32],"unclear":[34],"why":[35],"a":[36],"particular":[37],"pattern":[38],"predominates":[39],"any":[41],"given":[42],"tumour.":[43],"Here":[44],"we":[45,113],"propose":[46],"that":[47,115],"tumour":[48,84,154],"architecture":[49],"key":[51],"to":[52,144],"explaining":[53],"variety":[55],"of":[56,133,139],"observed":[57],"genetic":[58],"patterns.":[59],"We":[60],"examine":[61],"this":[62],"hypothesis":[63],"using":[64],"spatially":[65],"explicit":[66],"population":[67],"genetics":[68],"models":[69],"demonstrate":[71],"that,":[72],"within":[73],"biologically":[74],"relevant":[75],"parameter":[76],"ranges,":[77],"different":[78],"spatial":[79,129],"structures":[80],"can":[81],"generate":[82],"four":[83],"evolutionary":[85,106],"modes:":[86],"rapid":[87],"clonal":[88],"expansion,":[89],"progressive":[90],"diversification,":[91],"branching":[92],"effectively":[95],"almost":[96],"evolution.":[98,155],"Quantitative":[99],"indices":[100],"describing":[102],"classifying":[104],"these":[105,111],"modes":[107],"are":[108,119,142],"presented.":[109],"Using":[110],"indices,":[112],"show":[114],"our":[116],"model":[117],"predictions":[118],"consistent":[120],"with":[121,127],"empirical":[122],"observations":[123],"types":[126],"corresponding":[128],"structures.":[130],"The":[131],"cell":[134],"dispersal":[135],"range":[138],"cell-cell":[140],"interactions":[141],"found":[143],"be":[145],"essential":[146],"factors":[147],"accurately":[149],"characterizing,":[150],"controlling":[153]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2022-01-25T00:00:00"}