{"id":"https://openalex.org/W4206201002","doi":"https://doi.org/10.1177/11795735211048045","title":"Channelopathy of Dravet Syndrome and Potential Neuroprotective Effects of Cannabidiol","display_name":"Channelopathy of Dravet Syndrome and Potential Neuroprotective Effects of Cannabidiol","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4206201002","doi":"https://doi.org/10.1177/11795735211048045","pmid":"https://pubmed.ncbi.nlm.nih.gov/34992485","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8724990"},"language":"en","primary_location":{"id":"doi:10.1177/11795735211048045","doi":"https://doi.org/10.1177/11795735211048045","is_oa":true,"landing_page_url":"https://doi.org/10.1177/11795735211048045","pdf_url":null,"source":{"id":"https://openalex.org/S4210217671","display_name":"Journal of Central Nervous System Disease","issn_l":"1179-5735","issn":["1179-5735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Central Nervous System Disease","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/11795735211048045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102735275","display_name":"Changqing Xu","orcid":"https://orcid.org/0000-0003-3268-4315","observed_orcids":["https://orcid.org/0000-0003-3268-4315"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Changqing Xu","raw_affiliation_strings":["Department of Child Health and the Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, USA"],"raw_orcid":"https://orcid.org/0000-0003-3268-4315","affiliations":[{"raw_affiliation_string":"Department of Child Health and the Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423547","display_name":"Yumin Zhang","orcid":"https://orcid.org/0000-0002-9806-4277","observed_orcids":["https://orcid.org/0000-0002-9806-4277"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yumin Zhang","raw_affiliation_strings":["Department of Anatomy, Physiology and Genetics; Department of Neuroscience, Uniformed Services University School of Medicine, Bethesda, MD, USA","Department of Anatomy, Physiology and Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Physiology and Genetics; Department of Neuroscience, Uniformed Services University School of Medicine, Bethesda, MD, USA","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Anatomy, Physiology and Genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043623030","display_name":"David Gozal","orcid":"https://orcid.org/0000-0001-8195-6036","observed_orcids":["https://orcid.org/0000-0001-8195-6036"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gozal","raw_affiliation_strings":["Department of Child Health and the Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child Health and the Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017888734","display_name":"Paul Richard Carney","orcid":"https://orcid.org/0000-0001-6248-1493","observed_orcids":["https://orcid.org/0000-0001-6248-1493"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Carney","raw_affiliation_strings":["Departments of Child Health and Neurology, School of Medicine, University of Missouri, Columbia, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Child Health and Neurology, School of Medicine, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017888734","https://openalex.org/A5102735275"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":{"value":1600,"currency":"USD","value_usd":1600},"fwci":0.2674,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.29626601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"11795735211048045","last_page":"11795735211048045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dravet-syndrome","display_name":"Dravet syndrome","score":1.0},{"id":"https://openalex.org/keywords/channelopathies","display_name":"channelopathies","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sodium-channelopathy","display_name":"sodium channelopathy","score":0.5609999895095825},{"id":"https://openalex.org/keywords/nav1-1","display_name":"Nav1.1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/scn1a","display_name":"SCN1A","score":0.9629999995231628},{"id":"https://openalex.org/keywords/scn1b","display_name":"SCN1B","score":0.9779999852180481},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.7910000085830688},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.7960000038146973},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hcn-channels","display_name":"HCN channels","score":0.9440000057220459},{"id":"https://openalex.org/keywords/excitation-inhibition-balance","display_name":"excitation-inhibition balance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.828000009059906},{"id":"https://openalex.org/keywords/anticonvulsant-mechanism","display_name":"anticonvulsant mechanism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2780623815","wikidata":"https://www.wikidata.org/wiki/Q1255956","display_name":"Dravet syndrome","level":3,"score":0.936956524848938},{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.7950876951217651},{"id":"https://openalex.org/C2777989426","wikidata":"https://www.wikidata.org/wiki/Q2936142","display_name":"Channelopathy","level":2,"score":0.7217546701431274},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5535696148872375},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5153462290763855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49252423644065857},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4643360376358032},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.41680964827537537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35127413272857666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3047371506690979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19789624214172363},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.09566804766654968},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.06810984015464783},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0671546459197998},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/11795735211048045","doi":"https://doi.org/10.1177/11795735211048045","is_oa":true,"landing_page_url":"https://doi.org/10.1177/11795735211048045","pdf_url":null,"source":{"id":"https://openalex.org/S4210217671","display_name":"Journal of Central Nervous System Disease","issn_l":"1179-5735","issn":["1179-5735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Central Nervous System Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8724990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8724990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cent Nerv Syst Dis","raw_type":"Text"},{"id":"pmid:34992485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34992485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of central nervous system disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:db09b0d1bc124e88bbd8f777de34ff14","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db09b0d1bc124e88bbd8f777de34ff14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Central Nervous System Disease, Vol 13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/11795735211048045","doi":"https://doi.org/10.1177/11795735211048045","is_oa":true,"landing_page_url":"https://doi.org/10.1177/11795735211048045","pdf_url":null,"source":{"id":"https://openalex.org/S4210217671","display_name":"Journal of Central Nervous System Disease","issn_l":"1179-5735","issn":["1179-5735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Central Nervous System Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":179,"referenced_works":["https://openalex.org/W185450831","https://openalex.org/W1548374789","https://openalex.org/W1558757561","https://openalex.org/W1562827635","https://openalex.org/W1564863670","https://openalex.org/W1587964038","https://openalex.org/W1629231131","https://openalex.org/W1806230115","https://openalex.org/W1819429514","https://openalex.org/W1827468191","https://openalex.org/W1865383866","https://openalex.org/W1873975405","https://openalex.org/W1964533239","https://openalex.org/W1970292539","https://openalex.org/W1974841170","https://openalex.org/W1976688814","https://openalex.org/W1977183929","https://openalex.org/W1978437325","https://openalex.org/W1979612107","https://openalex.org/W1980176764","https://openalex.org/W1983187084","https://openalex.org/W1985940938","https://openalex.org/W1986761885","https://openalex.org/W1989026211","https://openalex.org/W1991286554","https://openalex.org/W1991633373","https://openalex.org/W1991673195","https://openalex.org/W1992661831","https://openalex.org/W1993938009","https://openalex.org/W2003403297","https://openalex.org/W2006288144","https://openalex.org/W2009844001","https://openalex.org/W2020505352","https://openalex.org/W2025431614","https://openalex.org/W2026551310","https://openalex.org/W2028053972","https://openalex.org/W2030623240","https://openalex.org/W2034651748","https://openalex.org/W2034785871","https://openalex.org/W2035699174","https://openalex.org/W2038964002","https://openalex.org/W2042186471","https://openalex.org/W2043006041","https://openalex.org/W2050962622","https://openalex.org/W2055600617","https://openalex.org/W2056531158","https://openalex.org/W2058766482","https://openalex.org/W2062518743","https://openalex.org/W2064222470","https://openalex.org/W2065906404","https://openalex.org/W2065972516","https://openalex.org/W2066210771","https://openalex.org/W2069656272","https://openalex.org/W2071885245","https://openalex.org/W2073533991","https://openalex.org/W2074144338","https://openalex.org/W2076319651","https://openalex.org/W2076398196","https://openalex.org/W2081700981","https://openalex.org/W2081984751","https://openalex.org/W2082433795","https://openalex.org/W2087381327","https://openalex.org/W2089314644","https://openalex.org/W2093473346","https://openalex.org/W2093537414","https://openalex.org/W2097194883","https://openalex.org/W2097891845","https://openalex.org/W2102037126","https://openalex.org/W2105423985","https://openalex.org/W2109321075","https://openalex.org/W2109946103","https://openalex.org/W2114251305","https://openalex.org/W2119071913","https://openalex.org/W2119507099","https://openalex.org/W2120773704","https://openalex.org/W2133923664","https://openalex.org/W2139411546","https://openalex.org/W2140968331","https://openalex.org/W2145455464","https://openalex.org/W2151323473","https://openalex.org/W2151546922","https://openalex.org/W2154765421","https://openalex.org/W2158282742","https://openalex.org/W2159213224","https://openalex.org/W2159332152","https://openalex.org/W2171597692","https://openalex.org/W2209781982","https://openalex.org/W2222191643","https://openalex.org/W2285926604","https://openalex.org/W2291928402","https://openalex.org/W2292040673","https://openalex.org/W2297366442","https://openalex.org/W2346609767","https://openalex.org/W2409651687","https://openalex.org/W2414143586","https://openalex.org/W2513406030","https://openalex.org/W2520865586","https://openalex.org/W2530807081","https://openalex.org/W2549204264","https://openalex.org/W2562272061","https://openalex.org/W2563036039","https://openalex.org/W2568338767","https://openalex.org/W2581622342","https://openalex.org/W2583598024","https://openalex.org/W2590287093","https://openalex.org/W2590568386","https://openalex.org/W2597981375","https://openalex.org/W2609649272","https://openalex.org/W2610381892","https://openalex.org/W2610741017","https://openalex.org/W2617831192","https://openalex.org/W2726304688","https://openalex.org/W2742158623","https://openalex.org/W2745227041","https://openalex.org/W2750692092","https://openalex.org/W2761862301","https://openalex.org/W2771245339","https://openalex.org/W2791515649","https://openalex.org/W2793002335","https://openalex.org/W2796552737","https://openalex.org/W2800285111","https://openalex.org/W2801464556","https://openalex.org/W2803860160","https://openalex.org/W2885328146","https://openalex.org/W2887582341","https://openalex.org/W2889799369","https://openalex.org/W2891640176","https://openalex.org/W2898326053","https://openalex.org/W2898642751","https://openalex.org/W2907719702","https://openalex.org/W2915550239","https://openalex.org/W2924479049","https://openalex.org/W2935524849","https://openalex.org/W2943858522","https://openalex.org/W2946708385","https://openalex.org/W2955589096","https://openalex.org/W2958569275","https://openalex.org/W2963561896","https://openalex.org/W2965627648","https://openalex.org/W2972375604","https://openalex.org/W2975966003","https://openalex.org/W2979600693","https://openalex.org/W2980764484","https://openalex.org/W2989939721","https://openalex.org/W2990298651","https://openalex.org/W2995066388","https://openalex.org/W2995406730","https://openalex.org/W2995871106","https://openalex.org/W2996427081","https://openalex.org/W2997044966","https://openalex.org/W2998799567","https://openalex.org/W2998879343","https://openalex.org/W2999994253","https://openalex.org/W3000551275","https://openalex.org/W3003169441","https://openalex.org/W3005027786","https://openalex.org/W3006374524","https://openalex.org/W3007522902","https://openalex.org/W3010613868","https://openalex.org/W3010758315","https://openalex.org/W3014648176","https://openalex.org/W3016673798","https://openalex.org/W3023821375","https://openalex.org/W3030769523","https://openalex.org/W3031017926","https://openalex.org/W3034006522","https://openalex.org/W3034559903","https://openalex.org/W3047090044","https://openalex.org/W3047235925","https://openalex.org/W3081439212","https://openalex.org/W3083976522","https://openalex.org/W3090326290","https://openalex.org/W3094060584","https://openalex.org/W3110512604","https://openalex.org/W3136041475","https://openalex.org/W3158042676","https://openalex.org/W3162811347","https://openalex.org/W3164471230","https://openalex.org/W3165713994"],"related_works":["https://openalex.org/W7025091039","https://openalex.org/W4407250244","https://openalex.org/W4388365773","https://openalex.org/W2513406030","https://openalex.org/W4409626330","https://openalex.org/W7214103077","https://openalex.org/W4391935957","https://openalex.org/W3023412379","https://openalex.org/W2790374720","https://openalex.org/W4206417596"],"abstract_inverted_index":{"Dravet":[0],"syndrome":[1],"(DS)":[2],"is":[3,91],"a":[4,98],"channelopathy,":[5],"neurodevelopmental,":[6],"epileptic":[7],"encephalopathy":[8],"characterized":[9],"by":[10],"seizures,":[11,23,25],"developmental":[12],"delay,":[13],"and":[14,29,34,56,63,75,118,131,150,158,181,205,217],"cognitive":[15],"impairment":[16],"that":[17],"includes":[18],"susceptibility":[19],"to":[20,45,82,93],"thermally":[21],"induced":[22],"spontaneous":[24],"ataxia,":[26],"circadian":[27],"rhythm":[28],"sleep":[30],"disorders,":[31],"autistic-like":[32],"behaviors,":[33],"premature":[35],"death.":[36],"More":[37],"than":[38],"80%":[39],"of":[40,85,111,129,134,147,154,179,190,192,215,222],"DS":[41,90,109,130,216,223],"cases":[42],"are":[43,68,139,183,196],"linked":[44],"mutations":[46,71],"in":[47,102,115,121,161,171,224],"genes":[48],"which":[49,58,208],"encode":[50,59],"voltage-gated":[51],"sodium":[52,164],"channel":[53],"subunits,":[54],"SCN1A":[55],"SCN1B,":[57],"the":[60,125,137,148,177,218,225],"Nav1.1\u03b1":[61],"subunit":[62],"Nav1.1\u03b21":[64],"subunit,":[65],"respectively.":[66],"There":[67],"other":[69],"gene":[70],"encoding":[72],"potassium,":[73,156],"calcium,":[74,157,204],"hyperpolarization-activated":[76],"cyclic":[77],"nucleotide-gated":[78],"(HCN)":[79],"channels":[80,138,160],"related":[81],"DS.":[83,186],"One-third":[84],"patients":[86],"have":[87],"pharmacoresistance":[88],"epilepsy.":[89],"unresponsive":[92],"standard":[94],"therapy.":[95],"Cannabidiol":[96],"(CBD),":[97],"non-psychoactive":[99],"phytocannabinoid":[100],"present":[101],"Cannabis,":[103],"has":[104],"been":[105],"introduced":[106],"for":[107],"treating":[108],"because":[110],"its":[112],"anticonvulsant":[113,194],"properties":[114],"animal":[116],"models":[117],"humans,":[119],"especially":[120,163,202],"pharmacoresistant":[122],"patients.":[123],"However,":[124],"etiological":[126],"channelopathiological":[127],"mechanism":[128,133,153],"action":[132,152],"CBD":[135,193],"on":[136,198,212],"unclear.":[140],"In":[141],"this":[142],"review,":[143],"we":[144],"summarize":[145],"evidence":[146],"direct":[149],"indirect":[151],"sodium,":[155,203],"HCN":[159],"DS,":[162],"subunits.":[165],"Some":[166],"channels'":[167],"loss-of-function":[168],"or":[169,173],"gain-of-function":[170],"inhibitory":[172,182],"excitatory":[174,180],"neurons":[175],"determine":[176],"balance":[178],"associated":[184],"with":[185],"A":[187],"great":[188],"variety":[189],"mechanisms":[191],"effects":[195],"focused":[197],"modulating":[199],"these":[200],"channels,":[201,207],"potassium":[206],"will":[209],"shed":[210],"light":[211],"ionic":[213],"channelopathy":[214],"precise":[219],"molecular":[220],"treatment":[221],"future.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-01-25T00:00:00"}