{"id":"https://openalex.org/W4205909596","doi":"https://doi.org/10.3390/biomedicines10010120","title":"Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis","display_name":"Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis","publication_year":2022,"publication_date":"2022-01-06","ids":{"openalex":"https://openalex.org/W4205909596","doi":"https://doi.org/10.3390/biomedicines10010120","pmid":"https://pubmed.ncbi.nlm.nih.gov/35052799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8773316"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10010120","doi":"https://doi.org/10.3390/biomedicines10010120","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10010120","pdf_url":"https://www.mdpi.com/2227-9059/10/1/120/pdf?version=1641470724","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/1/120/pdf?version=1641470724","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044595479","display_name":"Joan Serrano","orcid":"https://orcid.org/0000-0001-6002-116X","observed_orcids":["https://orcid.org/0000-0001-6002-116X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Serrano","raw_affiliation_strings":["Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052851934","display_name":"Nishita N. Meshram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishita N. Meshram","raw_affiliation_strings":["Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079676024","display_name":"Mangala M. Soundarapandian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mangala M. Soundarapandian","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute, Lake Nona, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, Lake Nona, FL 32827, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kathleen R. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen R. Smith","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute, Lake Nona, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, Lake Nona, FL 32827, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044610010","display_name":"Carter Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carter Mason","raw_affiliation_strings":["Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ian S. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian S. Brown","raw_affiliation_strings":["Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014684613","display_name":"Bj\u00f6rn Tyrberg","orcid":"https://orcid.org/0000-0003-0976-1220","observed_orcids":["https://orcid.org/0000-0003-0976-1220"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Tyrberg","raw_affiliation_strings":["Department of Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0976-1220","affiliations":[{"raw_affiliation_string":"Department of Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035067005","display_name":"George A. Kyriazis","orcid":"https://orcid.org/0000-0001-9514-3482","observed_orcids":["https://orcid.org/0000-0001-9514-3482"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George A. Kyriazis","raw_affiliation_strings":["Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0001-9514-3482","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035067005"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":2.5917,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.88618501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharin","display_name":"saccharin","score":1.0},{"id":"https://openalex.org/keywords/sweet-taste-receptor","display_name":"sweet taste receptor","score":0.7279999852180481},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9169999957084656},{"id":"https://openalex.org/keywords/phospholipase-c-signaling","display_name":"phospholipase C signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/trpm5","display_name":"TRPM5","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.8100000023841858},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9139999747276306},{"id":"https://openalex.org/keywords/insulin-exocytosis","display_name":"insulin exocytosis","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C2779147919","wikidata":"https://www.wikidata.org/wiki/Q191381","display_name":"Saccharin","level":2,"score":0.8990313410758972},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.599250853061676},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5859768986701965},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5508188009262085},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5413725972175598},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5351083874702454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48361554741859436},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4785090982913971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47064322233200073},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.4575239419937134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45158323645591736},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.45093145966529846},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.43406766653060913},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41459885239601135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36030393838882446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17302468419075012},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1666298508644104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11497345566749573}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10010120","doi":"https://doi.org/10.3390/biomedicines10010120","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10010120","pdf_url":"https://www.mdpi.com/2227-9059/10/1/120/pdf?version=1641470724","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:35052799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35052799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8773316","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8773316/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8d0f5190def14045b4887e78ace6f7d6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d0f5190def14045b4887e78ace6f7d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 1, p 120 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10010120","doi":"https://doi.org/10.3390/biomedicines10010120","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10010120","pdf_url":"https://www.mdpi.com/2227-9059/10/1/120/pdf?version=1641470724","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6986349248","display_name":null,"funder_award_id":"NIFA-2018-67001-28246","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G7026602474","display_name":"Ohio State University Neuroscience Center Core","funder_award_id":"P30NS104177","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8506791171","display_name":"Zeiss LSM 800 confocal microscope with Airyscan","funder_award_id":"1s10od026842-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000865330","display_name":"Michigan Diabetes Research Center (MDRC)","funder_award_id":"P30DK020572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000917872","display_name":"Receptor-mediated glucose sensing and skeletal muscle function","funder_award_id":"R01DK127444","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205909596.pdf","grobid_xml":"https://content.openalex.org/works/W4205909596.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1517377491","https://openalex.org/W1964304136","https://openalex.org/W1978845732","https://openalex.org/W1982365101","https://openalex.org/W1986785638","https://openalex.org/W1989947363","https://openalex.org/W1992332174","https://openalex.org/W2003351542","https://openalex.org/W2005094623","https://openalex.org/W2009566087","https://openalex.org/W2014488464","https://openalex.org/W2015463169","https://openalex.org/W2020053294","https://openalex.org/W2023939486","https://openalex.org/W2029653123","https://openalex.org/W2038561627","https://openalex.org/W2038573621","https://openalex.org/W2060980311","https://openalex.org/W2062188766","https://openalex.org/W2065518915","https://openalex.org/W2074092708","https://openalex.org/W2078800834","https://openalex.org/W2079106227","https://openalex.org/W2083831958","https://openalex.org/W2086339199","https://openalex.org/W2087355933","https://openalex.org/W2089913300","https://openalex.org/W2101841579","https://openalex.org/W2102893344","https://openalex.org/W2103354645","https://openalex.org/W2113055773","https://openalex.org/W2121704677","https://openalex.org/W2146182298","https://openalex.org/W2152289968","https://openalex.org/W2157649826","https://openalex.org/W2161088709","https://openalex.org/W2162535898","https://openalex.org/W2163903769","https://openalex.org/W2164075114","https://openalex.org/W2194931686","https://openalex.org/W2399759053","https://openalex.org/W2560741355","https://openalex.org/W2567497498","https://openalex.org/W2593318014","https://openalex.org/W2889541365","https://openalex.org/W2937460002","https://openalex.org/W3116831458","https://openalex.org/W3132371458","https://openalex.org/W3201294945","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W1982365101","https://openalex.org/W7098038273","https://openalex.org/W2607559883","https://openalex.org/W2163903769","https://openalex.org/W2593318014","https://openalex.org/W2155930086","https://openalex.org/W2541231122","https://openalex.org/W2099039337","https://openalex.org/W1978845732","https://openalex.org/W2076092771"],"abstract_inverted_index":{"BACKGROUND:":[0],"Saccharin":[1,137],"is":[2],"a":[3,8,69,86,157],"common":[4],"artificial":[5],"sweetener":[6],"and":[7,37,50,56,63,76,115,168],"bona":[9],"fide":[10],"ligand":[11],"for":[12,159],"sweet":[13],"taste":[14],"receptors":[15],"(STR).":[16],"STR":[17,36,61,150,172],"can":[18,30,91],"regulate":[19],"insulin":[20,32,93,142],"secretion":[21,33,94,143],"in":[22,48,51,54,173],"beta":[23],"cells,":[24],"so":[25],"we":[26],"investigated":[27],"whether":[28],"saccharin":[29,90,102,124,166],"stimulate":[31],"dependent":[34,95],"on":[35,96],"the":[38,66,83,104,107,116,145,148,161,169],"activation":[39,105,146],"of":[40,60,68,85,89,106,119,123,147,165,171],"phospholipase":[41],"C":[42],"(PLC)":[43],"signaling.":[44],"METHODS:":[45],"We":[46,80],"performed":[47],"vivo":[49],"vitro":[52],"approaches":[53],"mice":[55],"cells":[57],"with":[58],"loss-of-function":[59],"signaling":[62,71,109,151],"specifically":[64],"assessed":[65],"involvement":[67],"PLC":[70,108],"cascade":[72],"using":[73],"real-time":[74],"biosensors":[75],"calcium":[77,113],"imaging.":[78],"RESULTS:":[79],"found":[81],"that":[82],"ingestion":[84,138],"physiological":[87,154],"amount":[88],"potentiate":[92,141],"STR.":[97],"Similar":[98],"to":[99,112],"natural":[100],"sweeteners,":[101],"triggers":[103],"cascade,":[110],"leading":[111],"influx":[114],"vesicular":[117],"exocytosis":[118],"insulin.":[120],"The":[121],"effects":[122,155],"also":[125],"partially":[126],"require":[127],"transient":[128],"receptor":[129],"potential":[130,162],"cation":[131],"channel":[132],"M5":[133],"(TRPM5)":[134],"activity.":[135],"CONCLUSIONS:":[136],"may":[139],"transiently":[140],"through":[144],"canonical":[149],"pathway.":[152],"These":[153],"provide":[156],"framework":[158],"understanding":[160],"health":[163],"impact":[164],"use":[167],"contribution":[170],"peripheral":[174],"tissues.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-01-25T00:00:00"}
