{"id":"https://openalex.org/W4205899298","doi":"https://doi.org/10.3389/fcell.2022.777887","title":"Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia","display_name":"Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia","publication_year":2022,"publication_date":"2022-01-21","ids":{"openalex":"https://openalex.org/W4205899298","doi":"https://doi.org/10.3389/fcell.2022.777887","pmid":"https://pubmed.ncbi.nlm.nih.gov/35127681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8815032"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2022.777887","doi":"https://doi.org/10.3389/fcell.2022.777887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.777887","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2022.777887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016740718","display_name":"Paul P. R. Iyyanar","orcid":"https://orcid.org/0000-0003-0327-5395","observed_orcids":["https://orcid.org/0000-0003-0327-5395"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul P. R. Iyyanar","raw_affiliation_strings":["Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002266768","display_name":"Zhaoming Wu","orcid":"https://orcid.org/0000-0002-0131-2423","observed_orcids":["https://orcid.org/0000-0002-0131-2423"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoming Wu","raw_affiliation_strings":["Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019190546","display_name":"Yu Lan","orcid":"https://orcid.org/0000-0001-5611-3600","observed_orcids":["https://orcid.org/0000-0001-5611-3600"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Lan","raw_affiliation_strings":["Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009851124","display_name":"Yueh\u2010Chiang Hu","orcid":"https://orcid.org/0000-0002-7992-0525","observed_orcids":["https://orcid.org/0000-0002-7992-0525"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yueh-Chiang Hu","raw_affiliation_strings":["Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050198479","display_name":"Rulang Jiang","orcid":"https://orcid.org/0000-0001-7842-4696","observed_orcids":["https://orcid.org/0000-0001-7842-4696"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rulang Jiang","raw_affiliation_strings":["Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050198479"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.1652,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92643384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"10","issue":null,"first_page":"777887","last_page":"777887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alx1","display_name":"ALX1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/frontonasal-dysplasia","display_name":"frontonasal dysplasia","score":0.906000018119812},{"id":"https://openalex.org/keywords/craniofacial-abnormalities","display_name":"craniofacial anomalies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/microphthalmia","display_name":"microphthalmia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alae-nasi","display_name":"alae nasi","score":0.7089999914169312},{"id":"https://openalex.org/keywords/periocular-mesenchyme","display_name":"periocular mesenchyme","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neural-crest-cells","display_name":"neural crest cells","score":0.6800000071525574},{"id":"https://openalex.org/keywords/pitx2","display_name":"PITX2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pax7","display_name":"Pax7","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lhx6","display_name":"Lhx6","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lhx8","display_name":"Lhx8","score":1.0},{"id":"https://openalex.org/keywords/alx4","display_name":"ALX4","score":0.9509999752044678},{"id":"https://openalex.org/keywords/crispr-cas9-mouse-model","display_name":"CRISPR/Cas9 mouse model","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.763922929763794},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.7584389448165894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.583010196685791},{"id":"https://openalex.org/C2778951934","wikidata":"https://www.wikidata.org/wiki/Q5182137","display_name":"Craniofacial abnormality","level":3,"score":0.5435488224029541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4753377437591553},{"id":"https://openalex.org/C2908871479","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental genetics","level":4,"score":0.4687505066394806},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.448147714138031},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.44422852993011475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4185492992401123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37401247024536133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11882203817367554},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.08912539482116699}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2022.777887","doi":"https://doi.org/10.3389/fcell.2022.777887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.777887","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8815032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8815032","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:35127681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35127681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b6733fcf2dc940bdb87c0d4fae18141a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b6733fcf2dc940bdb87c0d4fae18141a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2022.777887","doi":"https://doi.org/10.3389/fcell.2022.777887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.777887","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.550000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3318968210","display_name":"Mandible Development","funder_award_id":"R01DE027046","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4386860376","display_name":"Regulation of Craniofacial Development by ALX Transcription Factors","funder_award_id":"R01DE029417","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7607978485","display_name":null,"funder_award_id":"DE027046 DE029417","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1536035226","https://openalex.org/W1655316363","https://openalex.org/W1751067545","https://openalex.org/W1892875901","https://openalex.org/W1963761224","https://openalex.org/W1968308978","https://openalex.org/W1974853891","https://openalex.org/W1984667030","https://openalex.org/W1986872576","https://openalex.org/W1987960325","https://openalex.org/W1997441621","https://openalex.org/W2003426511","https://openalex.org/W2004657398","https://openalex.org/W2014104304","https://openalex.org/W2025065961","https://openalex.org/W2040878784","https://openalex.org/W2045124365","https://openalex.org/W2054059968","https://openalex.org/W2054486613","https://openalex.org/W2055557564","https://openalex.org/W2059124791","https://openalex.org/W2070270500","https://openalex.org/W2076244785","https://openalex.org/W2089549631","https://openalex.org/W2100942747","https://openalex.org/W2104010513","https://openalex.org/W2112149426","https://openalex.org/W2117237066","https://openalex.org/W2117616398","https://openalex.org/W2119287599","https://openalex.org/W2127112569","https://openalex.org/W2132372281","https://openalex.org/W2137075959","https://openalex.org/W2138305701","https://openalex.org/W2147751620","https://openalex.org/W2148037744","https://openalex.org/W2148677963","https://openalex.org/W2170038237","https://openalex.org/W2186560096","https://openalex.org/W2232166712","https://openalex.org/W2461013690","https://openalex.org/W2474020573","https://openalex.org/W2540759644","https://openalex.org/W2570307402","https://openalex.org/W2768883110","https://openalex.org/W2769320453","https://openalex.org/W2896045584","https://openalex.org/W3084574727","https://openalex.org/W3128306721","https://openalex.org/W3137345948","https://openalex.org/W3164692211","https://openalex.org/W4244867888","https://openalex.org/W4255705162","https://openalex.org/W6675226719"],"related_works":["https://openalex.org/W2119287599","https://openalex.org/W2942699586","https://openalex.org/W2089549631","https://openalex.org/W2800960368","https://openalex.org/W7128597899","https://openalex.org/W7136355120","https://openalex.org/W4211052794","https://openalex.org/W3084574727","https://openalex.org/W7207640220","https://openalex.org/W3168529613"],"abstract_inverted_index":{"Loss":[0],"of":[1,31,38,66,94,96,130,136,158,164,166,172,188,221,238],"ALX1":[2,39,189,222],"function":[3,187],"causes":[4,208],"the":[5,18,23,36,50,84,97,144,173,181,192,235],"frontonasal":[6,42,113,123,159,193,228],"dysplasia":[7],"syndrome":[8],"FND3,":[9],"characterized":[10,48],"by":[11,148,198],"severe":[12],"facial":[13],"clefting":[14,91],"and":[15,92,99,122,133,141,168,178,211,227],"microphthalmia.":[16],"Whereas":[17],"laboratory":[19],"mouse":[20,41,56,80],"has":[21],"been":[22,46],"preeminent":[24],"animal":[25],"model":[26,81],"for":[27],"studying":[28],"developmental":[29,138],"mechanisms":[30,237],"human":[32],"craniofacial":[33,86],"birth":[34],"defects,":[35],"roles":[37,220],"in":[40,112,143,180,190,223],"development":[43,95,226],"have":[44,76],"not":[45],"well":[47],"because":[49],"only":[51],"previously":[52,218],"reported":[53],"Alx1":[54,108],"mutant":[55],"line":[57],"exhibited":[58,127,156],"acrania":[59],"due":[60],"to":[61,120],"a":[62,200,209],"genetic":[63],"background-dependent":[64],"failure":[65],"cranial":[67],"neural":[68,114],"tube":[69],"closure.":[70],"Using":[71],"CRISPR/Cas9-mediated":[72],"genome":[73],"editing,":[74],"we":[75],"generated":[77],"an":[78],"Alx1-deletion":[79],"that":[82,107,117],"recapitulates":[83],"FND":[85],"malformations,":[87],"including":[88],"median":[89],"orofacial":[90],"disruption":[93,157],"eyes":[98],"alae":[100],"nasi.":[101],"In":[102],"situ":[103],"hybridization":[104],"analysis":[105],"showed":[106],"is":[109,195],"strongly":[110],"expressed":[111],"crest":[115],"cells":[116],"give":[118],"rise":[119],"periocular":[121,131,145,224],"mesenchyme.":[124],"Alx1del/del":[125,154],"embryos":[126,155],"increased":[128],"apoptosis":[129],"mesenchyme":[132,160,175,194,225,229],"decreased":[134],"expression":[135,165,171],"ocular":[137],"regulators":[139,176],"Pitx2":[140],"Lmxb1":[142],"mesenchyme,":[146],"followed":[147],"defective":[149],"optic":[150],"stalk":[151],"morphogenesis.":[152],"Moreover,":[153],"identity,":[161],"with":[162],"loss":[163],"Pax7":[167],"concomitant":[169],"ectopic":[170],"jaw":[174],"Lhx6":[177],"Lhx8":[179],"developing":[182],"lateral":[183],"nasal":[184],"processes.":[185],"The":[186],"patterning":[191],"partly":[196],"complemented":[197],"ALX4,":[199],"paralogous":[201],"ALX":[202],"family":[203],"transcription":[204],"factor":[205],"whose":[206],"loss-of-function":[207],"milder":[210],"distinctive":[212],"FND.":[213,240],"Together,":[214],"these":[215],"data":[216],"uncover":[217],"unknown":[219],"patterning,":[230],"providing":[231],"novel":[232],"insights":[233],"into":[234],"pathogenic":[236],"ALX1-related":[239]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-01-26T00:00:00"}
