{"id":"https://openalex.org/W4205768655","doi":"https://doi.org/10.1177/20597002211065855","title":"Longitudinal assessment of hemodynamic alterations after mild traumatic brain injury in adolescents: Selected case study review","display_name":"Longitudinal assessment of hemodynamic alterations after mild traumatic brain injury in adolescents: Selected case study review","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4205768655","doi":"https://doi.org/10.1177/20597002211065855"},"language":"en","primary_location":{"id":"doi:10.1177/20597002211065855","doi":"https://doi.org/10.1177/20597002211065855","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20597002211065855","pdf_url":null,"source":{"id":"https://openalex.org/S4210190985","display_name":"Journal of Concussion","issn_l":"2059-7002","issn":["2059-7002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Concussion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1177/20597002211065855","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011606501","display_name":"Corey M. Thibeault","orcid":"https://orcid.org/0000-0002-3916-901X","observed_orcids":["https://orcid.org/0000-0002-3916-901X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Corey M. Thibeault","raw_affiliation_strings":["NovaSignal Corp, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3916-901X","affiliations":[{"raw_affiliation_string":"NovaSignal Corp, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054260914","display_name":"Amber Y. Dorn","orcid":"https://orcid.org/0000-0002-3139-4183","observed_orcids":["https://orcid.org/0000-0002-3139-4183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber Y. Dorn","raw_affiliation_strings":["NovaSignal Corp, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovaSignal Corp, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shankar Radhakrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shankar Radhakrishnan","raw_affiliation_strings":["NovaSignal Corp, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovaSignal Corp, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004533048","display_name":"Robert Hamilton","orcid":"https://orcid.org/0000-0003-3372-5561","observed_orcids":["https://orcid.org/0000-0003-3372-5561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B. Hamilton","raw_affiliation_strings":["NovaSignal Corp, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovaSignal Corp, Los Angeles, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011606501"],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.1425,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37557615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-traumatic-brain-injury","display_name":"mild traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hemodynamic-changes","display_name":"hemodynamic changes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neurovascular-dysfunction","display_name":"neurovascular dysfunction","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cerebrovascular-reactivity","display_name":"cerebrovascular reactivity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pulsatility-index","display_name":"pulsatility index","score":0.6489999890327454},{"id":"https://openalex.org/keywords/injury-recovery","display_name":"injury recovery","score":0.7950000166893005},{"id":"https://openalex.org/keywords/concussion","display_name":"concussion","score":0.3930000066757202},{"id":"https://openalex.org/keywords/long-term-monitoring","display_name":"long-term monitoring","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8589141368865967},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.5700420141220093},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.5675686597824097},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5622499585151672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5525253415107727},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5208271741867065},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.399397075176239},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3935680091381073},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3779141306877136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32327038049697876},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19423270225524902},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13585445284843445},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/20597002211065855","doi":"https://doi.org/10.1177/20597002211065855","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20597002211065855","pdf_url":null,"source":{"id":"https://openalex.org/S4210190985","display_name":"Journal of Concussion","issn_l":"2059-7002","issn":["2059-7002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Concussion","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:48024545ebab4b888a0bb623205ae010","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/48024545ebab4b888a0bb623205ae010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Concussion, Vol 6 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/20597002211065855","doi":"https://doi.org/10.1177/20597002211065855","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20597002211065855","pdf_url":null,"source":{"id":"https://openalex.org/S4210190985","display_name":"Journal of Concussion","issn_l":"2059-7002","issn":["2059-7002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Concussion","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G168043794","display_name":"Advanced morphological analysis of cerebral blood flow for acute concussion diagnosis and return-to-play determination","funder_award_id":"R44NS092209","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6804979332","display_name":null,"funder_award_id":"1R43NS092209-01","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W338840253","https://openalex.org/W640756945","https://openalex.org/W1981032387","https://openalex.org/W1984337466","https://openalex.org/W1997859463","https://openalex.org/W2004278956","https://openalex.org/W2012377231","https://openalex.org/W2018057471","https://openalex.org/W2021729083","https://openalex.org/W2021860986","https://openalex.org/W2035148376","https://openalex.org/W2040802080","https://openalex.org/W2043015474","https://openalex.org/W2059681201","https://openalex.org/W2064151279","https://openalex.org/W2068359292","https://openalex.org/W2069051455","https://openalex.org/W2073493999","https://openalex.org/W2076797635","https://openalex.org/W2088800239","https://openalex.org/W2098395168","https://openalex.org/W2116226259","https://openalex.org/W2121483768","https://openalex.org/W2122210698","https://openalex.org/W2129342530","https://openalex.org/W2129946383","https://openalex.org/W2132354501","https://openalex.org/W2136600894","https://openalex.org/W2199850701","https://openalex.org/W2208872697","https://openalex.org/W2470893332","https://openalex.org/W2627009404","https://openalex.org/W2754503302","https://openalex.org/W2784141060","https://openalex.org/W2792774700","https://openalex.org/W2795030658","https://openalex.org/W2795443373","https://openalex.org/W2911346462","https://openalex.org/W2937897671","https://openalex.org/W2946660018","https://openalex.org/W2997194847","https://openalex.org/W3003960040","https://openalex.org/W3005886788","https://openalex.org/W3094721569","https://openalex.org/W4210955011","https://openalex.org/W6912592130"],"related_works":["https://openalex.org/W2795443373","https://openalex.org/W2937897671","https://openalex.org/W7223206093","https://openalex.org/W2946660018","https://openalex.org/W3021655086","https://openalex.org/W2164856765","https://openalex.org/W2274780684","https://openalex.org/W4401432982","https://openalex.org/W4386847206","https://openalex.org/W2733394596"],"abstract_inverted_index":{"Alterations":[0],"in":[1,65,75,199,210,240,250],"the":[2,20,39,45,119,126,141,150,176,193,203,236],"neurovasculature":[3],"after":[4,42,110,227],"traumatic":[5,48],"brain":[6,49],"injury":[7],"(TBI)":[8],"represents":[9],"a":[10,76,82,97,104,116,232],"significant":[11],"sequelae.":[12],"However,":[13,130],"despite":[14],"theoretical":[15],"and":[16,72,217],"empirical":[17],"evidence":[18],"supporting":[19],"near-ubiquity":[21],"of":[22,37,85,99,107,128,143,205,220,238],"vascular":[23,40],"injury,":[24],"its":[25,245],"pathophysiology":[26],"remains":[27],"elusive.":[28],"Although":[29],"this":[30],"has":[31,60],"been":[32],"shown":[33],"for":[34,121,247],"all":[35],"grades":[36],"TBI,":[38],"changes":[41,198,243],"injuries":[43,50],"with":[44,118,161,212],"broad":[46],"mild":[47],"(mTBI)":[51],"classification,":[52],"remain":[53],"particularly":[54],"difficult":[55],"to":[56,146,174,181],"describe.":[57],"Our":[58],"group":[59],"previously":[61],"demonstrated":[62],"hemodynamic":[63,108],"alterations":[64],"mTBI":[66,182,229],"by":[67,96],"utilizing":[68],"transcranial":[69],"Doppler":[70],"ultrasound":[71],"cerebrovascular":[73],"reactivity":[74],"cross-sectional":[77],"study.":[78],"That":[79],"work":[80,154,223],"identified":[81],"phasic":[83],"progression":[84],"deviations":[86],"over":[87,125],"varying":[88],"days":[89],"post-injury.":[90],"These":[91],"phases":[92,142],"were":[93,208],"then":[94],"characterized":[95],"set":[98,114],"inverse":[100],"models":[101],"that":[102,147,191],"provided":[103],"hypothetical":[105],"process":[106],"dysfunction":[109,144,226],"mTBI.":[111,255],"This":[112,222],"model":[113],"provides":[115],"framework":[117],"potential":[120,246],"guiding":[122],"clinical":[123],"treatment":[124],"course":[127],"recovery.":[129,168,221],"it":[131],"is":[132],"still":[133],"unclear":[134],"if":[135],"individual":[136,159],"patients":[137,160],"will":[138],"progress":[139],"through":[140],"similar":[145],"found":[148,173],"at":[149],"population":[151,194],"level.":[152],"The":[153,197],"presented":[155],"here":[156],"explores":[157],"six":[158,185],"high-density":[162],"data":[163],"collected":[164],"during":[165],"their":[166],"post-injury":[167],"Breath-hold":[169],"index":[170],"(BHI)":[171],"was":[172],"be":[175,231],"most":[177],"robust":[178,233],"feature":[179],"related":[180],"longitudinally.":[183],"All":[184],"subjects":[186,211],"exhibited":[187],"BHI":[188],"recovery":[189,253],"curves":[190],"followed":[192],"model's":[195],"progression.":[196],"pulsatile":[200],"features":[201],"lacked":[202],"universality":[204],"BHI,":[206],"but":[207],"present":[209],"higher":[213],"self-reported":[214],"symptom":[215],"scores":[216],"longer":[218],"periods":[219],"suggests":[224],"neurovascular":[225],"an":[228],"may":[230],"phenomenon.":[234],"Additionally,":[235],"capabilities":[237],"TCD":[239],"capturing":[241],"these":[242],"highlights":[244],"aiding":[248],"clinicians":[249],"monitoring":[251],"patient's":[252],"post":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-01-26T00:00:00"}