{"id":"https://openalex.org/W4205702156","doi":"https://doi.org/10.1016/j.celrep.2021.110090","title":"Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function","display_name":"Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4205702156","doi":"https://doi.org/10.1016/j.celrep.2021.110090","pmid":"https://pubmed.ncbi.nlm.nih.gov/35021075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10258816"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2021.110090","doi":"https://doi.org/10.1016/j.celrep.2021.110090","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110090","pdf_url":"http://www.cell.com/article/S2211124721015813/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124721015813/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013795864","display_name":"Md Masud Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Masud Alam","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042752501","display_name":"De Yang","orcid":"https://orcid.org/0000-0001-6705-8504","observed_orcids":["https://orcid.org/0000-0001-6705-8504"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"De Yang","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Electronic address: yangd@mail.nih.gov","Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Electronic address: yangd@mail.nih.gov","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456713","display_name":"Xiaoqing Li","orcid":"https://orcid.org/0000-0002-9815-6040","observed_orcids":["https://orcid.org/0000-0002-9815-6040","https://orcid.org/0009-0002-6630-8529"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Qing Li","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409631","display_name":"Jia Liu","orcid":"https://orcid.org/0000-0001-5745-8141","observed_orcids":["https://orcid.org/0000-0001-5745-8141"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Liu","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006381802","display_name":"Timothy Carrel Back","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Carrel Back","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068884752","display_name":"Anna L. Trivett","orcid":"https://orcid.org/0000-0001-7143-105X","observed_orcids":["https://orcid.org/0000-0001-7143-105X"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Trivett","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072164441","display_name":"Baktiar O. Karim","orcid":"https://orcid.org/0000-0001-9604-9762","observed_orcids":["https://orcid.org/0000-0001-9604-9762"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baktiar Karim","raw_affiliation_strings":["Molecular Histopathology Laboratory, Leidos Biomedical Research, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":"https://orcid.org/0000-0001-9604-9762","affiliations":[{"raw_affiliation_string":"Molecular Histopathology Laboratory, Leidos Biomedical Research, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065436326","display_name":"Denise Barbut","orcid":"https://orcid.org/0000-0002-0181-3818","observed_orcids":["https://orcid.org/0000-0002-0181-3818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Barbut","raw_affiliation_strings":["Enterin Research Institute, Philadelphia, PA 19103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterin Research Institute, Philadelphia, PA 19103, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033473134","display_name":"MICHAEL A. ZASLOFF","orcid":"https://orcid.org/0000-0002-1453-9328","observed_orcids":["https://orcid.org/0000-0002-1453-9328"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Zasloff","raw_affiliation_strings":["Enterin Research Institute, Philadelphia, PA 19103, USA; MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC 20007, USA","Enterin Research Institute, Philadelphia, PA 19103, USA","MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC 20007, USA"],"raw_orcid":"https://orcid.org/0000-0002-1453-9328","affiliations":[{"raw_affiliation_string":"Enterin Research Institute, Philadelphia, PA 19103, USA; MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I2802534011"]},{"raw_affiliation_string":"Enterin Research Institute, Philadelphia, PA 19103, USA","institution_ids":[]},{"raw_affiliation_string":"MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joost J. Oppenheim","raw_affiliation_strings":["Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Electronic address: oppenhej@mail.nih.gov","Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Electronic address: oppenhej@mail.nih.gov","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Cellular Immunology Section, Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5042240287","https://openalex.org/A5042752501"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":11.312,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.99057169,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"38","issue":"2","first_page":"110090","last_page":"110090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bacterial-peptidoglycan","display_name":"bacterial peptidoglycan","score":0.7919999957084656},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7170000076293945},{"id":"https://openalex.org/keywords/antigen-specific-immune-response","display_name":"antigen-specific immune response","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neurotropic-viral-infection","display_name":"neurotropic viral infection","score":0.746999979019165},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.791537344455719},{"id":"https://openalex.org/C2778826181","wikidata":"https://www.wikidata.org/wiki/Q3310538","display_name":"Culprit","level":3,"score":0.7217543125152588},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.718498945236206},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.682831346988678},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5000410079956055},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49297308921813965},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47915905714035034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42890113592147827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.388634592294693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32265958189964294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21949905157089233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21927446126937866},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2021.110090","doi":"https://doi.org/10.1016/j.celrep.2021.110090","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110090","pdf_url":"http://www.cell.com/article/S2211124721015813/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:35021075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35021075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10258816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10258816","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10258816/pdf/nihms-1903676.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2021.110090","doi":"https://doi.org/10.1016/j.celrep.2021.110090","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110090","pdf_url":"http://www.cell.com/article/S2211124721015813/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2157522431","display_name":"Role of T Regulatory Cell Suppression in Autoimmunity and Cancer","funder_award_id":"ZIABC010707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4382062407","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320315952","funder_display_name":"Leidos"},{"id":"https://openalex.org/G4585269469","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4988656331","display_name":null,"funder_award_id":"HHSN261200800001E.","funder_id":"https://openalex.org/F4320313762","funder_display_name":"Frederick National Laboratory for Cancer Research"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320313762","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209"},{"id":"https://openalex.org/F4320315952","display_name":"Leidos","ror":"https://ror.org/012cvds63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205702156.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1048390352","https://openalex.org/W1497894656","https://openalex.org/W1572033244","https://openalex.org/W1685173550","https://openalex.org/W1832148330","https://openalex.org/W1968077397","https://openalex.org/W1968251608","https://openalex.org/W1981424925","https://openalex.org/W1994190235","https://openalex.org/W2004465286","https://openalex.org/W2013331421","https://openalex.org/W2026717532","https://openalex.org/W2041134571","https://openalex.org/W2050805027","https://openalex.org/W2050991927","https://openalex.org/W2058894111","https://openalex.org/W2061995199","https://openalex.org/W2068714945","https://openalex.org/W2077881833","https://openalex.org/W2094697534","https://openalex.org/W2105515675","https://openalex.org/W2108802551","https://openalex.org/W2119014922","https://openalex.org/W2123431154","https://openalex.org/W2129751113","https://openalex.org/W2140296969","https://openalex.org/W2142483035","https://openalex.org/W2145736817","https://openalex.org/W2150594596","https://openalex.org/W2150656456","https://openalex.org/W2154737306","https://openalex.org/W2169759699","https://openalex.org/W2170293184","https://openalex.org/W2171373028","https://openalex.org/W2203342546","https://openalex.org/W2212998809","https://openalex.org/W2409435003","https://openalex.org/W2486618134","https://openalex.org/W2515734925","https://openalex.org/W2528438579","https://openalex.org/W2558041282","https://openalex.org/W2611740728","https://openalex.org/W2638382976","https://openalex.org/W2681281215","https://openalex.org/W2761905894","https://openalex.org/W2790416725","https://openalex.org/W2898567653","https://openalex.org/W2901221545","https://openalex.org/W2904408627","https://openalex.org/W2922333127","https://openalex.org/W2923824245","https://openalex.org/W2953534538","https://openalex.org/W2977455371","https://openalex.org/W2980273606","https://openalex.org/W2997629102","https://openalex.org/W3006477212","https://openalex.org/W4250295396","https://openalex.org/W6627014767","https://openalex.org/W6832261992"],"related_works":["https://openalex.org/W4313373274","https://openalex.org/W2681281215","https://openalex.org/W2752144640","https://openalex.org/W4319455993","https://openalex.org/W1480927111","https://openalex.org/W7134951692","https://openalex.org/W4313365859","https://openalex.org/W4210278145","https://openalex.org/W2912074117","https://openalex.org/W2964045944"],"abstract_inverted_index":{"Alpha-synuclein":[0],"(\u03b1S)":[1],"is":[2,27,49,70,80],"causally":[3],"involved":[4],"in":[5,15,32],"the":[6,33,83,95,116,127,133],"development":[7,84],"of":[8,37,54,74,85,118,136,140],"Parkinson":[9],"disease":[10],"(PD);":[11],"however,":[12],"its":[13],"role":[14],"normal":[16,87],"vertebrate":[17],"physiology":[18],"has":[19],"remained":[20],"unknown.":[21],"Recent":[22],"studies":[23],"demonstrate":[24],"that":[25,68,112,129],"\u03b1S":[26,48,63,69,79,119,130],"induced":[28],"by":[29],"noroviral":[30],"infection":[31],"enteric":[34],"nervous":[35,134],"system":[36,135],"children":[38],"and":[39,62,76,102],"protects":[40],"mice":[41],"against":[42],"lethal":[43],"neurotropic":[44],"viral":[45],"infection.":[46],"Additionally,":[47],"a":[50,71,86],"potent":[51],"chemotactic":[52],"activator":[53],"phagocytes.":[55],"In":[56],"this":[57],"report,":[58],"using":[59],"both":[60],"wild-type":[61],"knockout":[64],"mice,":[65],"we":[66,110],"show":[67,111],"critical":[72],"mediator":[73],"inflammatory":[75,88],"immune":[77,122],"responses.":[78],"required":[81,120],"for":[82,121],"response":[89],"to":[90],"bacterial":[91],"peptidoglycan":[92],"introduced":[93],"into":[94],"peritoneal":[96],"cavity":[97],"as":[98,100],"well":[99],"antigen-specific":[101],"T":[103],"cell":[104],"responses":[105],"following":[106],"intraperitoneal":[107],"immunization.":[108],"Furthermore,":[109],"neural":[113],"cells":[114],"are":[115],"sources":[117],"competence.":[123],"Our":[124],"report":[125],"supports":[126],"hypothesis":[128],"accumulates":[131],"within":[132],"PD":[137],"individuals":[138],"because":[139],"an":[141],"inflammatory/immune":[142],"response.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":20}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-01-26T00:00:00"}