{"id":"https://openalex.org/W4205679347","doi":"https://doi.org/10.3390/ma15030797","title":"Sorption Studies of Tetracycline Antibiotics on Hydroxyapatite (001) Surface\u2014A First-Principles Insight","display_name":"Sorption Studies of Tetracycline Antibiotics on Hydroxyapatite (001) Surface\u2014A First-Principles Insight","publication_year":2022,"publication_date":"2022-01-21","ids":{"openalex":"https://openalex.org/W4205679347","doi":"https://doi.org/10.3390/ma15030797","pmid":"https://pubmed.ncbi.nlm.nih.gov/35160743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8836700"},"language":"en","primary_location":{"id":"doi:10.3390/ma15030797","doi":"https://doi.org/10.3390/ma15030797","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ma15030797","pdf_url":"https://www.mdpi.com/1996-1944/15/3/797/pdf?version=1642752805","source":{"id":"https://openalex.org/S18714766","display_name":"Materials","issn_l":"1996-1944","issn":["1996-1944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1996-1944/15/3/797/pdf?version=1642752805","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047126248","display_name":"Jiaming Song","orcid":"https://orcid.org/0000-0003-2402-3250","observed_orcids":["https://orcid.org/0000-0003-2402-3250"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaming Song","raw_affiliation_strings":["The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"],"raw_orcid":"https://orcid.org/0000-0003-2402-3250","affiliations":[{"raw_affiliation_string":"The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050988675","display_name":"Naiyu Cui","orcid":"https://orcid.org/0000-0003-0921-5633","observed_orcids":["https://orcid.org/0000-0003-0921-5633"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naiyu Cui","raw_affiliation_strings":["The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034521574","display_name":"Xuran Mao","orcid":"https://orcid.org/0000-0002-9607-4498","observed_orcids":["https://orcid.org/0000-0002-9607-4498"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuran Mao","raw_affiliation_strings":["The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"],"raw_orcid":"https://orcid.org/0000-0002-9607-4498","affiliations":[{"raw_affiliation_string":"The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082327488","display_name":"Qixuan Huang","orcid":"https://orcid.org/0009-0004-7137-1922","observed_orcids":["https://orcid.org/0009-0004-7137-1922","https://orcid.org/0000-0002-6470-0466"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qixuan Huang","raw_affiliation_strings":["The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074135764","display_name":"Eui\u2010Seok Lee","orcid":"https://orcid.org/0000-0002-1818-1140","observed_orcids":["https://orcid.org/0000-0002-1818-1140"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eui-Seok Lee","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031276162","display_name":"Heng Bo Jiang","orcid":"https://orcid.org/0000-0002-2514-2633","observed_orcids":["https://orcid.org/0000-0002-2514-2633"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hengbo Jiang","raw_affiliation_strings":["The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"],"raw_orcid":"https://orcid.org/0000-0002-2514-2633","affiliations":[{"raw_affiliation_string":"The Conversationalist Club, School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031276162","https://openalex.org/A5074135764"],"corresponding_institution_ids":["https://openalex.org/I197347611","https://openalex.org/I4210163399"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.1079,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72001298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"797","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10002","display_name":"Advanced Chemical Physics Studies","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/oxytetracycline","display_name":"oxytetracycline","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chlortetracycline","display_name":"chlortetracycline","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adsorption","display_name":"adsorption","score":0.5839999914169312},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.5389999747276306},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.7630000114440918},{"id":"https://openalex.org/keywords/adsorption-energy","display_name":"adsorption energy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/electrostatic-potential","display_name":"electrostatic potential","score":0.7609999775886536},{"id":"https://openalex.org/keywords/molecular-orbitals","display_name":"molecular orbitals","score":0.847000002861023},{"id":"https://openalex.org/keywords/charge-density-difference","display_name":"charge density difference","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hydroxyl-groups","display_name":"hydroxyl groups","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bone-disorders","display_name":"bone disease","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.7197636961936951},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.6116130352020264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5406008362770081},{"id":"https://openalex.org/C152365726","wikidata":"https://www.wikidata.org/wiki/Q1048589","display_name":"Density functional theory","level":2,"score":0.5356131792068481},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.43966981768608093},{"id":"https://openalex.org/C2776671240","wikidata":"https://www.wikidata.org/wiki/Q411646","display_name":"Oxytetracycline","level":3,"score":0.4296039342880249},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.4186658263206482},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4134429395198822},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3558002710342407},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3464704751968384},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3444382846355438},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2630477547645569},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20763394236564636},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1796664595603943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11415570974349976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08965092897415161},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ma15030797","doi":"https://doi.org/10.3390/ma15030797","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ma15030797","pdf_url":"https://www.mdpi.com/1996-1944/15/3/797/pdf?version=1642752805","source":{"id":"https://openalex.org/S18714766","display_name":"Materials","issn_l":"1996-1944","issn":["1996-1944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials","raw_type":"journal-article"},{"id":"pmid:35160743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35160743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8836700","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8836700/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e2b725a306ca4fccb6d0d61b9d13c4ce","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e2b725a306ca4fccb6d0d61b9d13c4ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials, Vol 15, Iss 3, p 797 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ma15030797","doi":"https://doi.org/10.3390/ma15030797","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ma15030797","pdf_url":"https://www.mdpi.com/1996-1944/15/3/797/pdf?version=1642752805","source":{"id":"https://openalex.org/S18714766","display_name":"Materials","issn_l":"1996-1944","issn":["1996-1944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205679347.pdf","grobid_xml":"https://content.openalex.org/works/W4205679347.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1761183838","https://openalex.org/W1976161355","https://openalex.org/W1982231816","https://openalex.org/W1992696749","https://openalex.org/W1995536883","https://openalex.org/W1998837503","https://openalex.org/W2004806234","https://openalex.org/W2013095103","https://openalex.org/W2014680165","https://openalex.org/W2027432937","https://openalex.org/W2029667189","https://openalex.org/W2036065908","https://openalex.org/W2045068208","https://openalex.org/W2047336754","https://openalex.org/W2048709002","https://openalex.org/W2068554963","https://openalex.org/W2077697305","https://openalex.org/W2082445702","https://openalex.org/W2086957099","https://openalex.org/W2092157292","https://openalex.org/W2132525235","https://openalex.org/W2165181270","https://openalex.org/W2170340271","https://openalex.org/W2230785030","https://openalex.org/W2335598274","https://openalex.org/W2339664108","https://openalex.org/W2622290914","https://openalex.org/W2692515715","https://openalex.org/W2701735408","https://openalex.org/W2736222284","https://openalex.org/W2767424149","https://openalex.org/W2768054257","https://openalex.org/W2791336914","https://openalex.org/W2883763914","https://openalex.org/W2908581579","https://openalex.org/W2945367815","https://openalex.org/W2973338374","https://openalex.org/W3027308092","https://openalex.org/W3082221893","https://openalex.org/W3082299015","https://openalex.org/W3086729970","https://openalex.org/W3093496668","https://openalex.org/W3124338294","https://openalex.org/W3157226329","https://openalex.org/W3186282029","https://openalex.org/W4233730725"],"related_works":["https://openalex.org/W4388196817","https://openalex.org/W2279529017","https://openalex.org/W2963619378","https://openalex.org/W2066723180","https://openalex.org/W4414619943","https://openalex.org/W2007697964","https://openalex.org/W4283749366","https://openalex.org/W2580204877","https://openalex.org/W2289443668","https://openalex.org/W1989635007"],"abstract_inverted_index":{"Owing":[0],"to":[1,33,73,94,111,119,128,164],"the":[2,10,21,75,87,96,103,113,116,130,143,161,167,173,209],"limitations":[3],"of":[4,12,23,78,100,115,169,176,211],"traditional":[5],"systemic":[6],"drug":[7,35,63],"delivery":[8],"in":[9,183,202,207],"treatment":[11,212],"bone":[13,204],"diseases":[14,205],"with":[15,25,62],"side":[16],"effects":[17],"on":[18,49,102,181],"normal":[19],"cells,":[20],"selection":[22],"materials":[24],"high":[26],"affinities":[27,114],"for":[28,197],"bones,":[29],"as":[30,57,199],"targeting":[31],"ligands":[32,59,201],"modify":[34],"carriers,":[36],"has":[37,160],"become":[38],"an":[39,46],"important":[40],"research":[41],"topic.":[42],"Tetracyclines":[43],"(TCs)":[44],"have":[45],"adsorption":[47,107,174],"effect":[48],"hydroxyapatite":[50],"(HAp).":[51],"Thus,":[52,178],"they":[53],"can":[54],"be":[55],"used":[56,72,110],"bone-targeting":[58,200,216],"and":[60,83,91,135,142,206],"combined":[61],"carriers.":[64],"In":[65],"this":[66],"study,":[67],"density":[68,152],"functional":[69],"theory":[70],"is":[71,109,126,146],"analyze":[74],"interaction":[76,132],"mechanism":[77],"TC,":[79],"oxytetracycline":[80],"(OTC),":[81],"chlortetracycline,":[82],"HAp.":[84,120,136],"We":[85],"calculate":[86],"electrostatic":[88],"potential":[89],"(ESP)":[90],"molecular":[92],"orbitals":[93],"predict":[95],"possible":[97],"binding":[98,189],"sites":[99],"TCs":[101,118,134,141,198],"HAp":[104,144,165,182],"surface.":[105],"The":[106,137,155],"energy":[108],"compare":[112],"three":[117],"An":[121],"independent":[122],"gradient":[123],"model":[124],"analysis":[125],"performed":[127],"study":[129,192],"weak":[131],"between":[133,140],"coordination":[138],"bond":[139],"surface":[145],"evaluated":[147],"by":[148,213],"conducting":[149],"a":[150,184,194],"charge":[151],"difference":[153],"analysis.":[154],"results":[156],"show":[157],"that":[158],"OTC":[159,179],"highest":[162],"affinity":[163],"because":[166],"introduction":[168],"hydroxyl":[170],"groups":[171],"change":[172],"configuration":[175],"OTC.":[177],"adsorbed":[180],"broken-line":[185],"shape":[186],"exposes":[187],"more":[188],"sites.":[190],"This":[191],"provides":[193],"theoretical":[195],"basis":[196],"treating":[203],"improving":[208],"safety":[210],"selecting":[214],"different":[215],"ligands.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-01-26T00:00:00"}
