{"id":"https://openalex.org/W4205565871","doi":"https://doi.org/10.1101/2022.01.07.475395","title":"Spread of New Mutations Through Space","display_name":"Spread of New Mutations Through Space","publication_year":2022,"publication_date":"2022-01-07","ids":{"openalex":"https://openalex.org/W4205565871","doi":"https://doi.org/10.1101/2022.01.07.475395"},"language":"en","primary_location":{"id":"doi:10.1101/2022.01.07.475395","doi":"https://doi.org/10.1101/2022.01.07.475395","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.07.475395","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/07/2022.01.07.475395.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/07/2022.01.07.475395.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023052755","display_name":"Kyle Shaw","orcid":"https://orcid.org/0000-0002-6479-8758","observed_orcids":["https://orcid.org/0000-0002-6479-8758"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kyle Shaw","raw_affiliation_strings":["Dept of Scientific Computing, Florida State University","Dept of Scientific Computing, Florid Stte University, Tllhssee FL"],"raw_orcid":"https://orcid.org/0000-0002-6479-8758","affiliations":[{"raw_affiliation_string":"Dept of Scientific Computing, Florida State University","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Dept of Scientific Computing, Florid Stte University, Tllhssee FL","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006699103","display_name":"Peter Beerli","orcid":"https://orcid.org/0000-0003-0947-5451","observed_orcids":["https://orcid.org/0000-0003-0947-5451"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Beerli","raw_affiliation_strings":["Dept of Scientific Computing, Florida State University","Dept of Scientific Computing, Florid Stte University, Tllhssee FL"],"raw_orcid":"https://orcid.org/0000-0003-0947-5451","affiliations":[{"raw_affiliation_string":"Dept of Scientific Computing, Florida State University","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Dept of Scientific Computing, Florid Stte University, Tllhssee FL","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023052755"],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-density","display_name":"population density","score":0.8420000076293945},{"id":"https://openalex.org/keywords/effective-population-size","display_name":"effective population size","score":0.7760000228881836},{"id":"https://openalex.org/keywords/spatial-population-genetics","display_name":"spatial population genetics","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dispersal","display_name":"dispersal","score":0.546999990940094},{"id":"https://openalex.org/keywords/neutral-mutations","display_name":"neutral mutations","score":0.8209999799728394},{"id":"https://openalex.org/keywords/diffusion-approximation","display_name":"diffusion approximation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/spatially-explicit-simulation","display_name":"spatially explicit simulation","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C47559259","wikidata":"https://www.wikidata.org/wiki/Q778143","display_name":"Biological dispersal","level":3,"score":0.6950017213821411},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6682577133178711},{"id":"https://openalex.org/C169733012","wikidata":"https://www.wikidata.org/wiki/Q1613416","display_name":"Population size","level":3,"score":0.6118173599243164},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5993486642837524},{"id":"https://openalex.org/C199733313","wikidata":"https://www.wikidata.org/wiki/Q22856","display_name":"Population density","level":3,"score":0.5769416689872742},{"id":"https://openalex.org/C3641667","wikidata":"https://www.wikidata.org/wiki/Q1295959","display_name":"Effective population size","level":4,"score":0.5336832404136658},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5131416916847229},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.46217599511146545},{"id":"https://openalex.org/C80990810","wikidata":"https://www.wikidata.org/wiki/Q486420","display_name":"Genetic drift","level":4,"score":0.454912930727005},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4496059715747833},{"id":"https://openalex.org/C2777027219","wikidata":"https://www.wikidata.org/wiki/Q1284190","display_name":"Constant (computer programming)","level":2,"score":0.4332540035247803},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4325272738933563},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.43104711174964905},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3302440047264099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3259740471839905},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2826457619667053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20319750905036926},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.16468891501426697},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.16455328464508057},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1484878659248352},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07214212417602539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.01.07.475395","doi":"https://doi.org/10.1101/2022.01.07.475395","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.07.475395","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/07/2022.01.07.475395.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.01.07.475395","doi":"https://doi.org/10.1101/2022.01.07.475395","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.07.475395","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/07/2022.01.07.475395.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205565871.pdf","grobid_xml":"https://content.openalex.org/works/W4205565871.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1430512513","https://openalex.org/W1882056569","https://openalex.org/W1939346899","https://openalex.org/W1950384241","https://openalex.org/W1954298592","https://openalex.org/W1964151547","https://openalex.org/W1964768303","https://openalex.org/W2016404053","https://openalex.org/W2023829071","https://openalex.org/W2034954725","https://openalex.org/W2035939192","https://openalex.org/W2040948450","https://openalex.org/W2047417387","https://openalex.org/W2052672736","https://openalex.org/W2055254837","https://openalex.org/W2056035161","https://openalex.org/W2057724204","https://openalex.org/W2064357728","https://openalex.org/W2066347815","https://openalex.org/W2072706575","https://openalex.org/W2075041345","https://openalex.org/W2077462298","https://openalex.org/W2078352132","https://openalex.org/W2079949023","https://openalex.org/W2080068657","https://openalex.org/W2096697518","https://openalex.org/W2106948740","https://openalex.org/W2108169091","https://openalex.org/W2112299637","https://openalex.org/W2112348586","https://openalex.org/W2112390420","https://openalex.org/W2112937207","https://openalex.org/W2115212775","https://openalex.org/W2121729464","https://openalex.org/W2132542342","https://openalex.org/W2132718560","https://openalex.org/W2140447723","https://openalex.org/W2162248245","https://openalex.org/W2166321718","https://openalex.org/W2166415701","https://openalex.org/W2166999834","https://openalex.org/W2171188433","https://openalex.org/W2172960308","https://openalex.org/W2183897643","https://openalex.org/W2324705510","https://openalex.org/W2332905493","https://openalex.org/W2334642768","https://openalex.org/W2347059305","https://openalex.org/W2938656690","https://openalex.org/W2949069505","https://openalex.org/W2951309130","https://openalex.org/W2951621382","https://openalex.org/W2952559970","https://openalex.org/W3009544115","https://openalex.org/W3012987534","https://openalex.org/W3013574460","https://openalex.org/W3032942004","https://openalex.org/W4212975782","https://openalex.org/W4234195429","https://openalex.org/W4295978838"],"related_works":["https://openalex.org/W2148033515","https://openalex.org/W4285009798","https://openalex.org/W1973780630","https://openalex.org/W1894569600","https://openalex.org/W2946754261","https://openalex.org/W7212426528","https://openalex.org/W2020609600","https://openalex.org/W2099451110","https://openalex.org/W1553597362","https://openalex.org/W2122577020"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"terms":[2],"population":[3,6,40,52,57,97,110],"size":[4,41,58],"and":[5,67,114],"density":[7,25,98],"are":[8,16],"often":[9],"used":[10],"interchangeably,":[11],"when":[12],"in":[13,21,76,85,177],"fact":[14],"they":[15],"quite":[17],"different.":[18],"When":[19],"viewed":[20],"a":[22,34,48,73,89,106,117,148],"spatial":[23],"landscape,":[24],"is":[26,42,59,119],"defined":[27],"as":[28],"the":[29,44,55,63,100,123,127,144,158],"number":[30],"of":[31,37,47,102,160,162],"individuals":[32],"within":[33],"square":[35],"unit":[36],"distance,":[38],"while":[39,79,157],"simply":[43],"total":[45],"count":[46],"population.":[49],"In":[50],"discrete":[51],"genetics":[53],"models,":[54],"effective":[56],"known":[60],"to":[61,121,153],"influence":[62,84],"interaction":[64],"between":[65],"selection":[66,71],"random":[68,80],"drift":[69,81],"with":[70],"playing":[72],"larger":[74],"role":[75],"large":[77],"populations":[78],"has":[82],"more":[83,133],"smaller":[86],"populations.":[87,179],"Using":[88,109],"spatially":[90],"explicit":[91],"simulation":[92],"software":[93],"we":[94],"investigate":[95],"how":[96],"affects":[99],"flow":[101],"new":[103,128,172],"mutations":[104,174],"through":[105],"geographical":[107],"space.":[108],"density,":[111],"selectional":[112],"advantage,":[113],"dispersal":[115],"distributions,":[116],"model":[118],"developed":[120],"predict":[122],"speed":[124],"at":[125,146],"which":[126,147],"allele":[129,165],"will":[130],"travel,":[131],"obtaining":[132],"accurate":[134],"results":[135],"than":[136],"current":[137],"diffusion":[138],"approximations":[139],"provide.":[140],"We":[141,168],"note":[142],"that":[143,171],"rate":[145,159],"neutral":[149],"mutation":[150],"spreads":[151],"begins":[152],"decay":[154],"over":[155],"time":[156],"spread":[161,175],"an":[163],"advantageous":[164,173],"remains":[166],"constant.":[167],"also":[169],"show":[170],"faster":[176],"dense":[178]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-01-26T00:00:00"}