{"id":"https://openalex.org/W4205379571","doi":"https://doi.org/10.1182/blood.v128.22.2114.2114","title":"Renal Response in Patients with Relapsed Refractory Multiple Myeloma: Interim Data of a Large, Observational, Prospective Study","display_name":"Renal Response in Patients with Relapsed Refractory Multiple Myeloma: Interim Data of a Large, Observational, Prospective Study","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W4205379571","doi":"https://doi.org/10.1182/blood.v128.22.2114.2114"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.2114.2114","doi":"https://doi.org/10.1182/blood.v128.22.2114.2114","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2114.2114","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032722606","display_name":"Javier de la Rubia","orcid":"https://orcid.org/0000-0002-8354-768X","observed_orcids":["https://orcid.org/0000-0002-8354-768X"]},"institutions":[{"id":"https://openalex.org/I4210126200","display_name":"Hospital Universitario Doctor Peset","ror":"https://ror.org/03971n288","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210126200"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier De La Rubia","raw_affiliation_strings":["Hematology, Hospital Dr. Peset, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Dr. Peset, Valencia, Spain","institution_ids":["https://openalex.org/I4210126200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039935931","display_name":"Queralt Salas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210143012","display_name":"Duran i Reynals Hospital","ror":"https://ror.org/03qwghy04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210143012"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Queralt Salas","raw_affiliation_strings":["Institut Catal\u00e0 d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Catal\u00e0 d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147","https://openalex.org/I4210143012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036894659","display_name":"Enrique Morales","orcid":"https://orcid.org/0000-0002-5824-6973","observed_orcids":["https://orcid.org/0000-0002-5824-6973"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Morales","raw_affiliation_strings":["Hospital 12 de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital 12 de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110388448","display_name":"Esther Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149758","display_name":"Hospital Universitario De Cabue\u00f1es","ror":"https://ror.org/03yw66316","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210149758","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Gonz\u00e1lez","raw_affiliation_strings":["Hospital de Cabuenes, Asturias, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Cabuenes, Asturias, Spain","institution_ids":["https://openalex.org/I4210149758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089616302","display_name":"Mar\u00eda Soledad Dur\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Soledad Dur\u00e1n","raw_affiliation_strings":["Celgene S.L. Unipersonal, Madrid, Spain","Hospital Universitario Ciudad de Jaen, Jaen, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene S.L. Unipersonal, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Hospital Universitario Ciudad de Jaen, Jaen, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036725271","display_name":"Fernando Escalante","orcid":"https://orcid.org/0000-0003-4501-9066","observed_orcids":["https://orcid.org/0000-0003-4501-9066"]},"institutions":[{"id":"https://openalex.org/I4210160075","display_name":"Hospital Universitario de Le\u00f3n","ror":"https://ror.org/05gn84d31","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210160075"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando Escalante","raw_affiliation_strings":["Hospital De Leon, Leon, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital De Leon, Leon, Spain","institution_ids":["https://openalex.org/I4210160075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021328479","display_name":"Mercedes Gironella","orcid":"https://orcid.org/0000-0002-8106-8909","observed_orcids":["https://orcid.org/0000-0002-8106-8909"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Gironella","raw_affiliation_strings":["Hospital Universitari Vall d'Hebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari Vall d'Hebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068600380","display_name":"Tom\u00e1s Jos\u00e9 Gonz\u00e1lez\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0001-9575-1816","observed_orcids":["https://orcid.org/0000-0001-9575-1816","https://orcid.org/0000-0003-2458-2554"]},"institutions":[{"id":"https://openalex.org/I4210115949","display_name":"Hospital Universitario de Burgos","ror":"https://ror.org/01j5v0d02","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115949"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tom\u00e1s Jos\u00e9 Gonz\u00e1lez-L\u00f3pez","raw_affiliation_strings":["Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain","institution_ids":["https://openalex.org/I4210115949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081162336","display_name":"Rafael Duro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090436","display_name":"Hospital Universitario Virgen Macarena","ror":"https://ror.org/016p83279","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210090436"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Duro","raw_affiliation_strings":["Hospital Universitario Virgen de Macare, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Virgen de Macare, Sevilla, Spain","institution_ids":["https://openalex.org/I4210090436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110351528","display_name":"Manuel P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel P\u00e9rez","raw_affiliation_strings":["Clinico Universitario de Santiago de Com, Sanatiago De Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinico Universitario de Santiago de Com, Sanatiago De Compostela, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111994217","display_name":"Paz Ribas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126200","display_name":"Hospital Universitario Doctor Peset","ror":"https://ror.org/03971n288","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210126200"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paz Ribas","raw_affiliation_strings":["Hematology, Hospital Dr. Peset, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Dr. Peset, Valencia, Spain","institution_ids":["https://openalex.org/I4210126200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032940393","display_name":"Maria-Elena Cabezudo","orcid":"https://orcid.org/0000-0002-4758-5152","observed_orcids":["https://orcid.org/0000-0002-4758-5152"]},"institutions":[{"id":"https://openalex.org/I4210091043","display_name":"Althaia","ror":"https://ror.org/00bxg8434","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210091043"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Cabezudo","raw_affiliation_strings":["Hospital Althaia de Manresa, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Althaia de Manresa, Barcelona, Spain","institution_ids":["https://openalex.org/I4210091043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080067623","display_name":"Rafael Lluch","orcid":"https://orcid.org/0000-0003-1358-5186","observed_orcids":["https://orcid.org/0000-0003-1358-5186"]},"institutions":[{"id":"https://openalex.org/I4210094134","display_name":"Hospital de La Ribera","ror":"https://ror.org/00qnmxq60","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Lluch","raw_affiliation_strings":["Hospital de Alzira/Hospital de La Ribera, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Alzira/Hospital de La Ribera, Valencia, Spain","institution_ids":["https://openalex.org/I4210094134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015345218","display_name":"Ignacio Espa\u00f1ol","orcid":"https://orcid.org/0000-0001-5145-7711","observed_orcids":["https://orcid.org/0000-0001-5145-7711"]},"institutions":[{"id":"https://openalex.org/I4210146010","display_name":"Santa Luc\u00eda University General Hospital","ror":"https://ror.org/051fvq837","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210146010"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignacio Espa\u00f1ol","raw_affiliation_strings":["Hospital Santa Lucia, Cartagena, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Santa Lucia, Cartagena, Murcia, Spain","institution_ids":["https://openalex.org/I4210146010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058537512","display_name":"Valent\u00edn Caba\u00f1as","orcid":"https://orcid.org/0000-0002-6248-2549","observed_orcids":["https://orcid.org/0000-0002-6248-2549"]},"institutions":[{"id":"https://openalex.org/I4210146619","display_name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria","ror":"https://ror.org/053j10c72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210146619"]},{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]},{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Valentin Caba\u00f1as","raw_affiliation_strings":["University Hospital Virgen de la Arrixaca, IMIB-Arrixaca, Murcia University, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Virgen de la Arrixaca, IMIB-Arrixaca, Murcia University, Murcia, Spain","institution_ids":["https://openalex.org/I4210146619","https://openalex.org/I4210150677","https://openalex.org/I80180929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111684606","display_name":"Ricardo Garc\u00eda\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-3201-3909","observed_orcids":["https://orcid.org/0000-0003-3201-3909"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricardo Garc\u00eda-Mu\u00f1oz","raw_affiliation_strings":["Hospital San Pedro, Logrono, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital San Pedro, Logrono, Spain","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose Antonio M\u00e1rquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092871","display_name":"Hospital de Basurto","ror":"https://ror.org/00j4pze04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210092871","https://openalex.org/I4210125364"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Antonio M\u00e1rquez","raw_affiliation_strings":["Hospital de Basurto, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Basurto, Bilbao, Spain","institution_ids":["https://openalex.org/I4210092871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109383058","display_name":"Marta Duran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Duran","raw_affiliation_strings":["Celgene S.L. Unipersonal, Madrid, Spain","Hospital Universitario Ciudad de Jaen, Jaen, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene S.L. Unipersonal, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Hospital Universitario Ciudad de Jaen, Jaen, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Javier Soriano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Soriano","raw_affiliation_strings":["Celgene S.L. Unipersonal, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene S.L. Unipersonal, Madrid, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110734715","display_name":"Antoni Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050926","display_name":"Hospital Universitari Arnau de Vilanova","ror":"https://ror.org/01p3tpn79","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050926","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antoni Garc\u00eda","raw_affiliation_strings":["Hospital Universitari Arnau de Vilanova, Lleida, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari Arnau de Vilanova, Lleida, Spain","institution_ids":["https://openalex.org/I2802050926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":"22","first_page":"2114","last_page":"2114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.968999981880188},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/renal-response","display_name":"renal response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cockcroft-gault-equation","display_name":"Cockcroft-Gault formula","score":0.902999997138977},{"id":"https://openalex.org/keywords/mdrd-equation","display_name":"MDRD equation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.41200000047683716},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8059999942779541},{"id":"https://openalex.org/keywords/health-resource-utilization","display_name":"health resource utilization","score":0.6940000057220459},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.36800000071525574},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5630000233650208},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5040000081062317},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8723978400230408},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6731345653533936},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.6006754636764526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5883623957633972},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5507732629776001},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.4696969985961914},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.44892168045043945},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.42676201462745667},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.42236292362213135},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3527413606643677},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3404134511947632},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.2114.2114","doi":"https://doi.org/10.1182/blood.v128.22.2114.2114","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2114.2114","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979382942","https://openalex.org/W3214511984","https://openalex.org/W2331788344","https://openalex.org/W2588556053","https://openalex.org/W4405165499","https://openalex.org/W7116690249","https://openalex.org/W2550893813","https://openalex.org/W2497657103","https://openalex.org/W4226007718","https://openalex.org/W2554707931"],"abstract_inverted_index":{"Abstract":[0],"Introduction:Renal":[1],"impairment":[2],"(RI)":[3],"is":[4,38,62],"a":[5,300,319,421],"common":[6],"complication":[7],"of":[8,14,25,33,45,134,163,216,260,316,423,447,478,514],"multiple":[9],"myeloma":[10],"(MM).":[11],"Almost":[12],"20%":[13],"patients":[15,317],"(pts)":[16],"present":[17,124],"with":[18,47,54,71,96,299,405,460,464,469,483,516],"RI":[19,29,74,287,297,486,510],"at":[20,452],"diagnosis,":[21],"while":[22,343],"approximately":[23,512],"40%-50%":[24],"pts":[26,46,70,95,178,242,387,430,448,482],"will":[27],"develop":[28],"during":[30],"the":[31,42,91,135,158,196,285,295,306,340,347,436,494],"course":[32],"their":[34],"disease.":[35],"However,":[36],"there":[37,378],"little":[39],"information":[40],"on":[41],"renal":[43,88,174,320,323,328,334,363,407,521],"response":[44,89,114,321,325,330,336,364,413,438],"relapsed":[48],"refractory":[49],"MM":[50,113,144,411],"(RRMM)":[51],"receiving":[52,388,431,449],"treatment":[53],"new":[55],"drugs":[56],"in":[57,69,94,165,190,195,284,294,383,481,499,502,511,520],"clinical":[58,376,500],"practice.":[59],"Aims:":[60],"This":[61],"an":[63,77,127],"observational,":[64],"prospective,":[65],"multicenter":[66],"study":[67,480],"conducted":[68],"RRMM":[72,484],"and":[73,119,143,161,202,226,253,266,276,289,308,332,356,375,390,398,433,442,466,485,490,526],"(defined":[75],"as":[76],"estimated":[78],"glomerular":[79],"filtration":[80],"rate":[81,414],"[eGFR]":[82],"<":[83,106],"50":[84],"mL/min)":[85,102,108],"to":[86,90,149,172,249,274,339,361],"evaluate":[87],"administered":[92,211],"therapy":[93],"moderate":[97,201,286],"(creatinine":[98],"clearance":[99],"[CrCl]":[100],"30-50":[101],"or":[103],"severe":[104,206,296],"(CrCl":[105],"30":[107],"RI.":[109],"Secondary":[110],"objectives":[111],"include":[112],"rate,":[115],"overall":[116,410,437],"survival,":[117],"safety,":[118],"health":[120],"resource":[121],"utilization.":[122],"We":[123],"results":[125,477],"from":[126],"interim":[128],"analysis":[129],"4":[130],"mos":[131,235,367,425,459,463,468],"after":[132,420],"completion":[133],"inclusion":[136],"period":[137],"(cutoff:":[138],"June":[139],"13,":[140],"2016).":[141],"Methods:Renal":[142],"responses":[145,344],"were":[146,170,193,212,262,350,379,401,440],"evaluated":[147],"according":[148,273,338],"International":[150],"Myeloma":[151],"Working":[152],"Group":[153],"criteria.":[154],"Both":[155],"eGFR":[156,272],"by":[157,346],"Cockroft-Gault":[159],"(CG)":[160],"Modification":[162],"Diet":[164],"Renal":[166],"Disease":[167],"(MDRD)":[168],"formulas":[169,278],"compared":[171],"analyze":[173],"response.":[175,408],"Results:Overall,":[176],"312":[177],"(mean":[179],"\u00b1":[180,184],"SD":[181],"age":[182],"75":[183],"9":[185],"yrs,":[186],"50%":[187],"male,":[188],"57%":[189],"first":[191],"relapse)":[192],"included":[194],"study;":[197],"217":[198],"(70%)":[199],"had":[200,205,318],"95":[203],"(30%)":[204],"RI,":[207],"respectively.":[208],"Anti-myeloma":[209],"therapies":[210,471,492,507],"lenalidomide":[213],"(LEN;":[214],"35%":[215],"pts),":[217],"bortezomib":[218],"(BORT;":[219],"21%),":[220],"different":[221],"chemotherapy":[222],"regimens":[223,495],"(CT;":[224],"22%),":[225],"other":[227],"non-CT":[228],"treatments":[229,392],"(22%).":[230],"Median":[231,359],"follow-up":[232],"was":[233,279,365,417,457],"7":[234],"(range,":[236,368,426],"0-39":[237],"mos).":[238,370,428],"To":[239],"date,":[240],"123":[241],"(39%)":[243],"have":[244,255],"discontinued":[245],"treatment,":[246],"12%":[247],"due":[248],"adverse":[250],"events":[251],"(AEs),":[252],"37%":[254],"died.":[256],"The":[257,269,409],"main":[258],"causes":[259],"death":[261],"disease":[263],"progression":[264],"(8.3%)":[265],"infections":[267],"(6.4%).":[268],"mean":[270],"baseline":[271],"CG":[275,307,341],"MDRD":[277,309,348],"38.7/41.7":[280],"(\u00b1":[281,291],"8.5/11.8)":[282],"mL/min":[283,293],"subgroup":[288],"20.3/20.1":[290],"8.0/10.1)":[292],"group,":[298],"strong":[301],"correlation":[302],"(coefficient":[303],"0.91)":[304],"between":[305,386,524],"eGFR.":[310],"Overall,":[311,505],"13.5%":[312],"(95%":[313],"CI,":[314],"9.7%-17.2%)":[315],"(5.8%":[322],"complete":[324],"[renalCR],":[326],"0.3%":[327,354],"partial":[329],"[renalPR],":[331],"7.4%":[333],"minor":[335],"[renalMR])":[337],"formula":[342],"measured":[345],"formula,":[349],"17.3%":[351],"(9.9%":[352],"renalCR,":[353],"renalPR,":[355],"7.1%":[357],"renalMR).":[358],"time":[360],"best":[362],"1.8":[366],"0.5-8.9":[369],"After":[371],"adjusting":[372],"for":[373],"demographic":[374],"characteristics,":[377],"no":[380,517],"significant":[381],"differences":[382,518],"GFR":[384],"improvement":[385,523],"LEN-":[389,489,525],"BORT-based":[391,491,527],"(P":[393,472],"=":[394,473],"0.706).":[395],"Arterial":[396],"hypertension":[397],"female":[399],"sex":[400],"statistically":[402],"significantly":[403],"associated":[404],"poor":[406],"efficacy":[412],"(\u2265":[415],"PR)":[416],"33.4%,":[418],"achieved":[419,451],"median":[422],"3.4":[424],"0.07-37.8":[427],"For":[429],"BORT":[432],"LEN,":[434],"respectively,":[435],"rates":[439],"43.5%":[441],"44.8%,":[443],"whereas":[444],"only":[445],"23%":[446],"CT":[450],"least":[453],"PR.":[454],"Progression-free":[455],"survival":[456],"13.3":[458],"LEN-based,":[461],"6.8":[462],"BORT-based,":[465],"7.5":[467],"CT-based":[470],"0.006).":[474],"Conclusions:":[475],"Preliminary":[476],"this":[479],"show":[487],"that":[488],"are":[493],"most":[496],"commonly":[497],"used":[498],"practice":[501],"these":[503,506],"pts.":[504],"can":[508],"improve":[509],"13%":[513],"cases,":[515],"seen":[519],"function":[522],"treatments.":[528],"Disclosures":[529],"De":[530],"La":[531],"Rubia:":[532],"Amgen,":[533],"Bristol":[534],"Myers,":[535],"Celgene,":[536],"Janssen:":[537],"Consultancy.":[538,540,543],"Morales:Celgene:":[539],"Garc\u00eda-Mu\u00f1oz:Celgene,":[541],"Roche:":[542],"Duran:Celgene:":[544],"Employment.":[545]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-01-25T00:00:00"}