{"id":"https://openalex.org/W4205338151","doi":"https://doi.org/10.1055/s-0041-1740512","title":"Effectiveness of 17-OHP for Prevention of Recurrent Preterm Birth: A Retrospective Cohort Study","display_name":"Effectiveness of 17-OHP for Prevention of Recurrent Preterm Birth: A Retrospective Cohort Study","publication_year":2021,"publication_date":"2021-12-31","ids":{"openalex":"https://openalex.org/W4205338151","doi":"https://doi.org/10.1055/s-0041-1740512","pmid":"https://pubmed.ncbi.nlm.nih.gov/34972229"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1740512","doi":"https://doi.org/10.1055/s-0041-1740512","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1740512","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057970778","display_name":"Blair Johnson Wylie","orcid":"https://orcid.org/0000-0003-4818-1050","observed_orcids":["https://orcid.org/0000-0003-4818-1050"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blair J. Wylie","raw_affiliation_strings":["Divisiont of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077007622","display_name":"Andrew L. Beam","orcid":"https://orcid.org/0000-0002-6657-2787","observed_orcids":["https://orcid.org/0000-0002-6657-2787"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew L. Beam","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts","Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091289985","display_name":"Joe B. Hakim","orcid":"https://orcid.org/0000-0002-2820-4932","observed_orcids":["https://orcid.org/0000-0002-2820-4932"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe B. Hakim","raw_affiliation_strings":["Department of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-2820-4932","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210092658","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Zhou","raw_affiliation_strings":["Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006217491","display_name":"Sonia Hern\u00e1ndez\u2013D\u0131\u0301az","orcid":"https://orcid.org/0000-0003-1458-7642","observed_orcids":["https://orcid.org/0000-0003-1458-7642"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia Hernandez-Diaz","raw_affiliation_strings":["Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033210935","display_name":"Jessica M. Hart","orcid":"https://orcid.org/0000-0001-8981-6038","observed_orcids":["https://orcid.org/0000-0001-8981-6038"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Hart","raw_affiliation_strings":["Divisiont of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3602,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60461494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"41","issue":"04","first_page":"405","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/17alpha-hydroxyprogesterone-caproate","display_name":"17-hydroxyprogesterone caproate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/recurrent-preterm-birth","display_name":"recurrent preterm birth","score":0.9129999876022339},{"id":"https://openalex.org/keywords/preterm-birth-prevention","display_name":"preterm birth prevention","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spontaneous-preterm-birth","display_name":"spontaneous preterm birth","score":0.8960000276565552},{"id":"https://openalex.org/keywords/treatment-effectiveness","display_name":"treatment effectiveness","score":0.578000009059906},{"id":"https://openalex.org/keywords/health-insurance-claims","display_name":"health insurance claims","score":0.8339999914169312},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.796999990940094},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9682192802429199},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.9058043956756592},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6766027808189392},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5869638323783875},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5655857920646667},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5313737392425537},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4666125178337097},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43458691239356995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20338132977485657}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006908","descriptor_name":"Hydroxyprogesterones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0041-1740512","doi":"https://doi.org/10.1055/s-0041-1740512","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1740512","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"journal-article"},{"id":"pmid:34972229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34972229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of perinatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","score":0.4399999976158142,"display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5276534766","display_name":"Predicting Pulmonary and Cardiac Morbidity in Preterm Infants with Deep Learning","funder_award_id":"K01HL141771","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1997569039","https://openalex.org/W2042751011","https://openalex.org/W2048986809","https://openalex.org/W2065614074","https://openalex.org/W2075719860","https://openalex.org/W2105665442","https://openalex.org/W2120179733","https://openalex.org/W2131812328","https://openalex.org/W2166266395","https://openalex.org/W2276408674","https://openalex.org/W2344784469","https://openalex.org/W2545458768","https://openalex.org/W2558201159","https://openalex.org/W2589773274","https://openalex.org/W2757213082","https://openalex.org/W2757419317","https://openalex.org/W2763917511","https://openalex.org/W2907015974","https://openalex.org/W2907279308","https://openalex.org/W2967432607","https://openalex.org/W2981584661","https://openalex.org/W3006680891","https://openalex.org/W3127749779","https://openalex.org/W4252694308"],"related_works":["https://openalex.org/W2781887992","https://openalex.org/W2109574741","https://openalex.org/W2758682068","https://openalex.org/W4301016516","https://openalex.org/W2130808186","https://openalex.org/W2589773274","https://openalex.org/W2007809723","https://openalex.org/W2967432607","https://openalex.org/W3122615996","https://openalex.org/W2944686451"],"abstract_inverted_index":{"OBJECTIVE:":[0],"17-\u03b1-hydroxyprogesterone":[1],"caproate":[2],"(17-OHP)":[3],"has":[4],"been":[5],"recommended":[6],"by":[7],"professional":[8],"societies":[9],"for":[10,85,136,157],"the":[11,32,36,86,137,160,165,190],"prevention":[12,138],"of":[13,38,50,67,88,134,139,180],"recurrent":[14,57,92,141],"preterm":[15,59,142],"birth,":[16],"but":[17],"subsequent":[18],"clinical":[19,41],"studies":[20],"have":[21],"reported":[22],"conflicting":[23],"efficacy":[24],"results.":[25],"This":[26],"study":[27],"aimed":[28],"to":[29,31,129,175,189],"contribute":[30],"evidence":[33],"base":[34],"regarding":[35],"effectiveness":[37],"17-OHP":[39,90,135,163,181],"in":[40,64,144,159,164],"practice":[42],"using":[43],"real-world":[44],"data.":[45],"STUDY":[46],"DESIGN:":[47],"A":[48],"total":[49],"4,422":[51],"individuals":[52],"meeting":[53],"inclusion":[54,191],"criteria":[55,192],"representing":[56],"spontaneous":[58,140],"birth":[60,143],"(sPTB)":[61],"were":[62,94,101],"identified":[63],"a":[65,131,177],"database":[66],"insurance":[68],"claims,":[69],"and":[70,76,81,193],"568":[71],"(12.8%)":[72],"received":[73],"17-OHP.":[74],"Crude":[75],"propensity":[77,110],"score-matched":[78],"recurrence":[79,99],"rates":[80,100],"risk":[82,156],"ratios":[83],"(RRs)":[84],"association":[87,114],"receiving":[89,162],"on":[91,182],"sPTB":[93,98,158],"calculated.":[95],"RESULTS:":[96],"Raw":[97],"higher":[102,155],"among":[103],"those":[104],"treated":[105],"versus":[106],"not":[107],"treated;":[108],"after":[109],"score":[111],"matching,":[112,171],"no":[113],"was":[115],"detected":[116],"(26.3":[117],"vs.":[118],"23.8%,":[119],"RR":[120],"=":[121],"1.1,":[122],"95%":[123],"CI:":[124],"0.9-1.4).":[125],"CONCLUSION:":[126],"We":[127,153],"failed":[128,174],"identify":[130,176],"beneficial":[132,178],"effect":[133,179],"our":[145],"observational,":[146],"U.S.":[147],"based":[148],"cohort.":[149],"KEY":[150],"POINTS:":[151],"\u00b7":[152,168,184],"observed":[154],"group":[161],"unmatched":[166],"analysis.":[167],"After":[169],"propensity-score":[170],"we":[172],"still":[173],"sPTB.":[183],"Sensitivity":[185],"analyses":[186],"demonstrated":[187],"robustness":[188],"modeling":[194],"assumptions..":[195]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-01-26T00:00:00"}
