{"id":"https://openalex.org/W4205337170","doi":"https://doi.org/10.1542/peds.10.4.397","title":"FURTHER STUDIES ON THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA WITH CORTISONE","display_name":"FURTHER STUDIES ON THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA WITH CORTISONE","publication_year":1952,"publication_date":"1952-10-01","ids":{"openalex":"https://openalex.org/W4205337170","doi":"https://doi.org/10.1542/peds.10.4.397","mag":"1542533777","pmid":"https://pubmed.ncbi.nlm.nih.gov/13003386"},"language":"en","primary_location":{"id":"doi:10.1542/peds.10.4.397","doi":"https://doi.org/10.1542/peds.10.4.397","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.10.4.397","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113666012","display_name":"John F. Crigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN F. CRIGLER","raw_affiliation_strings":["The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087412257","display_name":"Samuel H. Silverman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SAMUEL H. SILVERMAN","raw_affiliation_strings":["The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109908315","display_name":"Lawson Wilkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAWSON WILKINS","raw_affiliation_strings":["The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0906,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.96930764,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"4","first_page":"397","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":1.0},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9570000171661377},{"id":"https://openalex.org/keywords/compound-e","display_name":"compound E","score":0.8500000238418579},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/compound-b","display_name":"compound B","score":0.9879999756813049},{"id":"https://openalex.org/keywords/electrolyte-metabolism","display_name":"electrolyte metabolism","score":0.753000020980835},{"id":"https://openalex.org/keywords/sodium-retention","display_name":"sodium retention","score":0.9620000123977661},{"id":"https://openalex.org/keywords/adrenal-suppression","display_name":"adrenal suppression","score":0.6200000047683716},{"id":"https://openalex.org/keywords/urinary-17-ketosteroids","display_name":"urinary 17-ketosteroids","score":0.906000018119812},{"id":"https://openalex.org/keywords/deoxycorticosterone-acetate","display_name":"desoxycorticosterone acetate","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.6930000185966492},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.34700000286102295},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.9685662984848022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8943177461624146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.690389096736908},{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.6577458381652832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6551002860069275},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6194764375686646},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4941888153553009},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.4892899692058563},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1412642002105713},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1542/peds.10.4.397","doi":"https://doi.org/10.1542/peds.10.4.397","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.10.4.397","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:13003386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13003386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Journal Article"},{"id":"mag:1542533777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13003386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1542533777","https://openalex.org/W1863112020","https://openalex.org/W1969806517","https://openalex.org/W2113278045","https://openalex.org/W2020034028","https://openalex.org/W2268998068","https://openalex.org/W2411218229","https://openalex.org/W2003903123","https://openalex.org/W2020545581","https://openalex.org/W2068683100"],"abstract_inverted_index":{"Three":[0],"cases":[1],"of":[2,23,34,51,61,80,82,95,102,115,129],"congenital":[3],"adrenal":[4,53,117],"hyperplasia":[5],"with":[6,118],"disturbed":[7],"electrolyte":[8,41,75,86],"metabolism,":[9],"followed":[10],"for":[11],"14":[12],"to":[13,121],"20":[14],"months,":[15],"have":[16,43],"been":[17,44],"reported":[18],"in":[19,107,135],"detail.":[20],"The":[21,77,100,126],"effects":[22],"cortisone":[24,83,119],"(compound":[25,29],"E)":[26],"and":[27,38],"corticosterone":[28],"B)":[30],"on":[31,39,84],"the":[32,35,40,52,58,74,85,92,108,116],"suppression":[33,50,114],"abnormal":[36],"adrenals":[37],"disturbance":[42],"discussed.":[45,89],"Cortisone":[46],"produces":[47],"more":[48],"marked":[49],"overactivity/mg.":[54],"(as":[55],"measured":[56],"by":[57],"urinary":[59],"excretion":[60],"17-KS),":[62],"but":[63],"less":[64],"sodium":[65],"retention":[66],"than":[67],"corticosterone.":[68],"Both":[69],"steroids,":[70],"however,":[71,131],"significantly":[72],"improve":[73],"abnormality.":[76],"possible":[78],"mechanism":[79],"action":[81],"metabolism":[87],"is":[88,111],"Suggestions":[90],"concerning":[91],"therapeutic":[93],"management":[94],"these":[96],"patients":[97],"are":[98],"offered.":[99],"use":[101],"adequate":[103],"NaCl":[104],"without":[105],"DCA":[106,124],"initial":[109],"treatment":[110],"emphasized,":[112],"since":[113],"seems":[120],"alter":[122],"materially":[123],"requirement.":[125],"final":[127],"combination":[128],"therapy,":[130],"must":[132],"be":[133],"decided":[134],"each":[136],"patient":[137],"individually.":[138]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-01-25T00:00:00"}
