{"id":"https://openalex.org/W42052472","doi":null,"title":"Similar immune profile in bipolar disorder and schizophrenia:selective increase in soluble tumor necrosis factor receptor 1 and von Willebrand factor","display_name":"Similar immune profile in bipolar disorder and schizophrenia:selective increase in soluble tumor necrosis factor receptor 1 and von Willebrand factor","publication_year":2009,"publication_date":"2009-04-20","ids":{"openalex":"https://openalex.org/W42052472","mag":"42052472"},"language":"en","primary_location":{"id":"mag:42052472","doi":null,"is_oa":false,"landing_page_url":"http://scnp.org/journal/index.php/SCNP/article/view/73","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021656534","display_name":"Sigrun Hope","orcid":"https://orcid.org/0000-0003-0115-5285","observed_orcids":["https://orcid.org/0000-0003-0115-5285"]},"institutions":[{"id":"https://openalex.org/I4210157351","display_name":"\u00d8stfold Hospital Trust","ror":"https://ror.org/04wpcxa25","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210123979","https://openalex.org/I4210157351"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Sigrun Hope","raw_affiliation_strings":["Sykehuset \u00d8stfold, DPS Edwin Ruud"],"raw_orcid":"https://orcid.org/0000-0003-0115-5285","affiliations":[{"raw_affiliation_string":"Sykehuset \u00d8stfold, DPS Edwin Ruud","institution_ids":["https://openalex.org/I4210157351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021656534"],"corresponding_institution_ids":["https://openalex.org/I4210157351"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00522193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.2281000018119812,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/soluble-tumor-necrosis-factor-receptor-1","display_name":"soluble tumor necrosis factor receptor 1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-1r1","display_name":"IL1R1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.953000009059906},{"id":"https://openalex.org/keywords/plasma-inflammatory-markers","display_name":"plasma inflammatory markers","score":0.6039999723434448},{"id":"https://openalex.org/keywords/severe-mental-illness","display_name":"severe mental illness","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.8417994976043701},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7576647996902466},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6034730076789856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5882535576820374},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.5825095772743225},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4945649802684784},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4839932918548584},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4471632242202759},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.438477098941803},{"id":"https://openalex.org/C3018432486","wikidata":"https://www.wikidata.org/wiki/Q7575316","display_name":"Schizophrenia spectrum","level":3,"score":0.41359996795654297},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40301400423049927},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.3977985978126526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39618155360221863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3831000328063965},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3381471037864685},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.27943411469459534},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2555898129940033},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.1609291434288025},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:42052472","doi":null,"is_oa":false,"landing_page_url":"http://scnp.org/journal/index.php/SCNP/article/view/73","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050584458","https://openalex.org/W2404665804","https://openalex.org/W2079187454","https://openalex.org/W2804188092","https://openalex.org/W2566625959","https://openalex.org/W2113964999","https://openalex.org/W1993178195","https://openalex.org/W2072328883","https://openalex.org/W2159732985","https://openalex.org/W3084838201"],"abstract_inverted_index":{"Alterations":[0],"in":[1,39,85,130,184,204],"the":[2,20,27,145,159,172,177,189],"inflammatory":[3,37],"system":[4],"have":[5],"been":[6,16],"associated":[7],"with":[8,24,82,95,140],"schizophrenia":[9,47,109,135],"and":[10,19,46,75,108,114,123,134,153,176],"mood":[11],"disorders.":[12,207],"Bipolar":[13],"disorder":[14,45,104,133],"has":[15],"less":[17],"studied,":[18],"literature":[21],"is":[22],"inconsistent":[23],"regard":[25],"to":[26,35,49,137],"specific":[28,197],"underlying":[29],"mechanisms.":[30],"The":[31,193],"study":[32],"aim":[33],"was":[34,80,162],"investigate":[36],"parameters":[38],"a":[40,86,163],"representative":[41],"sample":[42,90],"of":[43,55,91,121,169,199],"bipolar":[44,102,132],"compared":[48,136],"healthy":[50,115],"controls":[51],"in.":[52],"Results:Plasma":[53],"levels":[54,120],"soluble":[56],"tumor":[57],"necrosis":[58],"factor":[59,78],"receptor":[60,65],"1":[61,64,67],"(sTNFR1),":[62],"Interleukin":[63,69],"type":[66],"(ILR1),":[68],"6":[70],"(IL6),":[71],"high-sensitivity":[72],"CRP":[73],"(hs-CRP)":[74],"von":[76],"Willebrand":[77],"(vWf)":[79],"measured":[81],"ELISA":[83],"techniques":[84],"catchment":[87],"area":[88],"based":[89],"consecutively":[92],"referred":[93],"patients":[94],"severe":[96,205],"mental":[97,206],"disorders":[98],"(n=":[99],"443;":[100],"comprising":[101],"spectrum":[103,110],"(n":[105,111],"=":[106,112],"169)":[107],"274),":[113],"volunteers":[116],"(n=261)).":[117],"\u00c2":[118,179,192,208,209,210],"Plasma":[119],"sTNFR1":[122],"vWf":[124],"were":[125,181],"highly":[126],"statistically":[127,166],"significantly":[128],"increased":[129],"both":[131],"controls,":[138],"but":[139],"no":[141,182],"major":[142],"differences":[143,155,183],"between":[144,171,188],"two":[146,173],"diagnostic":[147,174],"groups.":[148,190],"Controlling":[149],"for":[150],"age,":[151],"gender":[152],"ethnical":[154],"did":[156],"not":[157],"affect":[158],"results.":[160],"There":[161,180],"trend":[164],"towards":[165],"significant":[167],"elevation":[168],"hs-CRP":[170],"groups":[175],"controls.":[178],"other":[185],"inflammation":[186,202],"factors":[187],"Conclusion:\u00c2":[191],"present":[194],"results":[195],"indicate":[196],"alterations":[198],"endothel":[200],"related":[201],"processes":[203]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}