{"id":"https://openalex.org/W4205226422","doi":"https://doi.org/10.3410/f.1048024.502450","title":"Faculty Opinions recommendation of Regulatory functions of nuclear hexokinase1 complex in glucose signaling.","display_name":"Faculty Opinions recommendation of Regulatory functions of nuclear hexokinase1 complex in glucose signaling.","publication_year":2006,"publication_date":"2006-11-23","ids":{"openalex":"https://openalex.org/W4205226422","doi":"https://doi.org/10.3410/f.1048024.502450"},"language":"en","primary_location":{"id":"doi:10.3410/f.1048024.502450","doi":"https://doi.org/10.3410/f.1048024.502450","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1048024.502450","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078963967","display_name":"Wolf Bernd Frommer","orcid":"https://orcid.org/0000-0001-6465-0115","observed_orcids":["https://orcid.org/0000-0001-6465-0115","https://orcid.org/0000-0002-7622-1139"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolf B Frommer","raw_affiliation_strings":["Institute for Molecular Physiology, Heinrich-Heine University of D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Physiology, Heinrich-Heine University of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078963967"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-signaling","display_name":"glucose signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8610000014305115},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6451185941696167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5369954109191895},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5369835495948792},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49451085925102234},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.4546353220939636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44718727469444275},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4306184649467468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4194050431251526},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.4172826111316681},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3835736811161041},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.303571879863739},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2589925527572632},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.22094446420669556}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.1048024.502450","doi":"https://doi.org/10.3410/f.1048024.502450","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1048024.502450","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071289410","https://openalex.org/W7096307841","https://openalex.org/W2140213301","https://openalex.org/W2012515588","https://openalex.org/W2030683211","https://openalex.org/W4224267601","https://openalex.org/W1607316646","https://openalex.org/W1989512080","https://openalex.org/W2608156916","https://openalex.org/W1975334887"],"abstract_inverted_index":{"Arabidopsis":[0],"hexokinase1":[1],"(HXK1)":[2],"is":[3],"a":[4,33,69,93,116],"glucose":[5,30,73,94,111],"sensor":[6],"that":[7,88,102],"integrates":[8],"nutrient":[9],"and":[10,17,38,53,64,83,100,123],"hormone":[11],"signals":[12],"to":[13,22],"govern":[14],"gene":[15,107],"expression":[16],"plant":[18],"growth":[19],"in":[20,118],"response":[21,74],"environmental":[23],"cues.":[24],"How":[25],"the":[26,48,54,77,89],"metabolic":[27,121],"enzyme":[28],"mediates":[29],"signaling":[31,95],"remains":[32],"mystery.":[34],"By":[35],"coupling":[36],"proteomic":[37],"binary-interaction":[39],"screens,":[40],"we":[41],"discover":[42],"two":[43],"nuclear-specific":[44],"HXK1":[45,78,91],"unconventional":[46],"partners:":[47],"vacuolar":[49],"H(+)-ATPase":[50],"B1":[51],"(VHA-B1)":[52],"19S":[55],"regulatory":[56],"particle":[57],"of":[58,72,110,125],"proteasome":[59],"subunit":[60],"(RPT5B).":[61],"Remarkably,":[62],"vha-B1":[63],"rpt5b":[65],"mutants":[66],"uniquely":[67],"share":[68],"broad":[70],"spectrum":[71],"defects":[75],"with":[76,98],"mutant":[79],"gin2":[80],"(glucose-insensitive2).":[81],"Genetic":[82],"chromatin":[84],"immunoprecipitation":[85],"analyses":[86],"suggest":[87],"nuclear":[90,132],"forms":[92],"complex":[96],"core":[97],"VHA-B1":[99],"RPT5B":[101],"directly":[103],"modulates":[104],"specific":[105],"target":[106],"transcription":[108],"independent":[109],"metabolism.":[112],"The":[113],"findings":[114],"support":[115],"model":[117],"which":[119],"conserved":[120],"enzymes":[122],"proteins":[124],"well-established":[126],"activities":[127],"may":[128],"perform":[129],"previously":[130],"unrecognized":[131],"functions.":[133],"PMID:":[134],"17081979":[135],"Funding":[136],"information":[137],"This":[138],"work":[139],"was":[140],"supported":[141],"by:":[142],"NIGMS":[143],"NIH":[144],"HHS,":[145],"United":[146],"States":[147],"Grant":[148],"ID:":[149],"R01":[150],"GM060493":[151]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-01-25T00:00:00"}
