{"id":"https://openalex.org/W4205208809","doi":"https://doi.org/10.14233/ajchem.2022.23554","title":"Optimization and Evaluation of Piperine Loaded Herbosomes for their Antioxidant and Hepatoprotective Potential","display_name":"Optimization and Evaluation of Piperine Loaded Herbosomes for their Antioxidant and Hepatoprotective Potential","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4205208809","doi":"https://doi.org/10.14233/ajchem.2022.23554"},"language":"en","primary_location":{"id":"doi:10.14233/ajchem.2022.23554","doi":"https://doi.org/10.14233/ajchem.2022.23554","is_oa":true,"landing_page_url":"https://doi.org/10.14233/ajchem.2022.23554","pdf_url":null,"source":{"id":"https://openalex.org/S194824834","display_name":"Asian Journal of Chemistry","issn_l":"0970-7077","issn":["0970-7077","0975-427X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697052","host_organization_name":"ASIAN PUBLICATION CORPORATION","host_organization_lineage":["https://openalex.org/P4322697052"],"host_organization_lineage_names":["ASIAN PUBLICATION CORPORATION"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14233/ajchem.2022.23554","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080401743","display_name":"Gayatri Joshi","orcid":"https://orcid.org/0000-0003-3041-2893","observed_orcids":["https://orcid.org/0000-0003-3041-2893"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gayatri Joshi","raw_affiliation_strings":["Faculty of Pharmacy, IFTM University Moradabad-244102, India"],"raw_orcid":"https://orcid.org/0000-0003-3041-2893","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, IFTM University Moradabad-244102, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037267044","display_name":"Abhishek Tiwari","orcid":"https://orcid.org/0000-0003-1221-4754","observed_orcids":["https://orcid.org/0000-0003-1221-4754"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhishek Tiwari","raw_affiliation_strings":["Faculty of Pharmacy, IFTM University Moradabad-244102, India"],"raw_orcid":"https://orcid.org/0000-0003-1221-4754","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, IFTM University Moradabad-244102, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035673139","display_name":"Prashant Upadhyay","orcid":"https://orcid.org/0000-0003-1359-0145","observed_orcids":["https://orcid.org/0000-0003-1359-0145"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prashant Upadhyay","raw_affiliation_strings":["Faculty of Pharmacy, IFTM University Moradabad-244102, India"],"raw_orcid":"https://orcid.org/0000-0003-1359-0145","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, IFTM University Moradabad-244102, India","institution_ids":["https://openalex.org/I2801192375"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801192375"],"apc_list":null,"apc_paid":null,"fwci":0.291,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.407205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"34","issue":"2","first_page":"383","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.5189999938011169},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carbon-tetrachloride-hepatotoxicity","display_name":"carbon tetrachloride hepatotoxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.5619999766349792},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.828000009059906},{"id":"https://openalex.org/keywords/water-solubility-enhancement","display_name":"aqueous solubility enhancement","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lipid-vesicles","display_name":"lipid vesicles","score":0.3930000066757202},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.5870000123977661},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.9828073978424072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8843680024147034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49880146980285645},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.47705283761024475},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47659796476364136},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.46703124046325684},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.46365129947662354},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4034823775291443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24363192915916443},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12532386183738708},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14233/ajchem.2022.23554","doi":"https://doi.org/10.14233/ajchem.2022.23554","is_oa":true,"landing_page_url":"https://doi.org/10.14233/ajchem.2022.23554","pdf_url":null,"source":{"id":"https://openalex.org/S194824834","display_name":"Asian Journal of Chemistry","issn_l":"0970-7077","issn":["0970-7077","0975-427X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697052","host_organization_name":"ASIAN PUBLICATION CORPORATION","host_organization_lineage":["https://openalex.org/P4322697052"],"host_organization_lineage_names":["ASIAN PUBLICATION CORPORATION"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14233/ajchem.2022.23554","doi":"https://doi.org/10.14233/ajchem.2022.23554","is_oa":true,"landing_page_url":"https://doi.org/10.14233/ajchem.2022.23554","pdf_url":null,"source":{"id":"https://openalex.org/S194824834","display_name":"Asian Journal of Chemistry","issn_l":"0970-7077","issn":["0970-7077","0975-427X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697052","host_organization_name":"ASIAN PUBLICATION CORPORATION","host_organization_lineage":["https://openalex.org/P4322697052"],"host_organization_lineage_names":["ASIAN PUBLICATION CORPORATION"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1417291594","https://openalex.org/W2006447847","https://openalex.org/W2020143653","https://openalex.org/W2020778508","https://openalex.org/W2044407233","https://openalex.org/W2053002347","https://openalex.org/W2054359817","https://openalex.org/W2080929388","https://openalex.org/W2094047296","https://openalex.org/W2273780641","https://openalex.org/W2551154560","https://openalex.org/W2563032789","https://openalex.org/W2985341081","https://openalex.org/W3081687356","https://openalex.org/W3090898565","https://openalex.org/W4402540030","https://openalex.org/W6600383830"],"related_works":["https://openalex.org/W3093397983","https://openalex.org/W2046271704","https://openalex.org/W2062983328","https://openalex.org/W1416886033","https://openalex.org/W4315926320","https://openalex.org/W7167837093","https://openalex.org/W7163342613","https://openalex.org/W2312822226","https://openalex.org/W4417329579","https://openalex.org/W2143948414"],"abstract_inverted_index":{"Piperine":[0],"is":[1],"classified":[2],"as":[3],"a":[4,20,71,77,133,169,204],"class":[5],"II":[6],"drug":[7,86,229,232],"in":[8,32,110],"the":[9,28,121,138,141,154,189,195,198,213,218,224,251],"biopharmaceutical":[10],"classification":[11],"system":[12],"due":[13],"to":[14,26,44,101,168,257],"its":[15],"low":[16],"aqueous":[17],"solubility.":[18],"As":[19],"result,":[21],"piperine":[22,38,81,150],"herbosomes":[23],"were":[24,42,93,186,215,249],"created":[25],"improve":[27],"dissolution":[29],"rate":[30,88],"and":[31,39,60,70,89,99,106,212,231,246,272,277,292],"vivo":[33],"liver":[34],"protecting":[35],"activity":[36],"of":[37,55,74,80,143,148,162,175,183,191,208],"physico-chemical":[40],"characteristics":[41],"used":[43],"confirm":[45],"herbosome":[46],"formation.":[47],"The":[48,145],"piperine-herbosome":[49,67,116],"formulation":[50,68,117,170,222,279],"revealed":[51],"spherical":[52],"particle":[53],"size":[54],"all":[56,96],"formulations":[57,97],"from":[58],"P1-P10":[59],"found142.4":[61],"\u00b1":[62,104,108,164,177,261,265,269,274,281,285,289,294],"0.98":[63],"nm":[64],"for":[65,95,114,188],"best":[66,115,225],"(P2)":[69],"PDI":[72],"value":[73,161,174],"0.237,":[75],"indicating":[76],"homogeneous":[78],"population":[79],"loaded":[82],"vesicles.":[83],"In":[84,255],"vitro":[85],"release":[87],"percent":[90],"entrapment":[91],"efficiency":[92],"determined":[94,152],"P1-P25":[98],"found":[100],"be":[102],"95.306":[103],"0.21":[105],"97.306":[107],"0.65":[109],"12":[111],"h,":[112],"respectively":[113],"(P2).":[118],"It":[119],"exemplifies":[120],"complex\u2019s":[122],"long-term":[123],"releasing":[124],"capability.":[125],"This":[126,221],"information":[127],"suggests":[128],"that":[129],"it":[130],"may":[131],"have":[132],"longer":[134],"retention":[135],"time":[136],"inside":[137],"body,":[139],"extending":[140],"duration":[142],"effect.":[144],"antioxidant":[146],"potential":[147],"pure":[149],"was":[151,200],"using":[153],"DPPH":[155],"scavenging":[156],"method,":[157],"with":[158,171],"an":[159,172],"IC50":[160,173],"107.59":[163],"0.11":[165],"g/mL":[166],"compared":[167],"93.926":[176],"0.03":[178],"g/mL.":[179],"Swiss":[180],"albino":[181],"mice":[182],"either":[184],"sex":[185],"utilized":[187],"evaluation":[190],"hepatoprotective":[192],"activity.":[193],"On":[194],"8th":[196],"day,":[197],"hepatotoxicity":[199],"caused":[201],"by":[202],"giving":[203],"single":[205],"oral":[206],"dosage":[207],"CCl4":[209],"(0.5":[210],"mL)":[211],"parameters":[214],"evaluated":[216],"on":[217,228],"9th":[219],"day.":[220],"has":[223],"optimized":[226],"based":[227],"content":[230],"entrapment.":[233],"Serum":[234],"glutamic":[235],"oxaloacetic":[236],"transaminase":[237,241],"(SGOT),":[238],"serum":[239],"glutamic-pyruvic":[240],"(SGPT),":[242],"alkaline":[243],"phosphatase":[244],"(ALP)":[245],"total":[247],"bilirubin":[248],"among":[250],"biochemical":[252],"markers":[253],"measured.":[254],"comparison":[256],"normal":[258],"control":[259],"(161":[260],"0.31":[262],"IU/L,":[263,267,283,287],"52.78":[264],"0.28":[266],"121.12":[268],"0.14":[270],"IU/L":[271,291,296],"0.633":[273],"1.44":[275],"IU/L)":[276],"P2":[278],"(163.23":[280],"0.49":[282],"66.9":[284],"0.05":[286],"128.3":[288],"1.15":[290],"0.645":[293],"0.67":[295],"respectively).":[297]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2022-01-25T00:00:00"}
