{"id":"https://openalex.org/W4205207116","doi":"https://doi.org/10.1115/imece1999-0398","title":"The Effects of Osmotic Pressure on the Viscoelastic and Physical Properties of Articular Chondrocytes","display_name":"The Effects of Osmotic Pressure on the Viscoelastic and Physical Properties of Articular Chondrocytes","publication_year":1999,"publication_date":"1999-11-14","ids":{"openalex":"https://openalex.org/W4205207116","doi":"https://doi.org/10.1115/imece1999-0398"},"language":"en","primary_location":{"id":"doi:10.1115/imece1999-0398","doi":"https://doi.org/10.1115/imece1999-0398","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece1999-0398","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioengineering","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090627153","display_name":"Farshid Guilak","orcid":"https://orcid.org/0000-0001-7380-0330","observed_orcids":["https://orcid.org/0000-0001-7380-0330"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farshid Guilak","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113589919","display_name":"H. Ping Ting\u2010Beall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ping Ting-Beall","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.47,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.91923077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"103","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-chondrocytes","display_name":"articular chondrocytes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/osmotic-pressure","display_name":"osmotic pressure","score":0.9900000095367432},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.871999979019165},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cartilage-matrix","display_name":"cartilage matrix","score":0.875},{"id":"https://openalex.org/keywords/mechanical-transduction","display_name":"mechanical signal transduction","score":0.906000018119812},{"id":"https://openalex.org/keywords/mechanical-properties-of-cells","display_name":"cell mechanical properties","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cartilage-mechanobiology","display_name":"cartilage mechanobiology","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.7848805785179138},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7775654792785645},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7662807703018188},{"id":"https://openalex.org/C9603476","wikidata":"https://www.wikidata.org/wiki/Q193135","display_name":"Osmotic pressure","level":2,"score":0.6283644437789917},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5540242195129395},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5459139347076416},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.5125696659088135},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5093339681625366},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4891496002674103},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4780997931957245},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.41823694109916687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4178353250026703},{"id":"https://openalex.org/C180016635","wikidata":"https://www.wikidata.org/wiki/Q2712821","display_name":"Compression (physics)","level":2,"score":0.41167575120925903},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3488216698169708},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3238357901573181},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17208975553512573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15814080834388733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1509728729724884},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13801607489585876},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.08980029821395874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06855598092079163},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/imece1999-0398","doi":"https://doi.org/10.1115/imece1999-0398","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece1999-0398","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioengineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031612910","https://openalex.org/W1990470530","https://openalex.org/W2260457320","https://openalex.org/W1640609258","https://openalex.org/W19624625","https://openalex.org/W2017692140","https://openalex.org/W2972145591","https://openalex.org/W4205733241","https://openalex.org/W2074158977","https://openalex.org/W4244270736"],"abstract_inverted_index":{"Abstract":[0],"Mechanical":[1],"stress":[2],"is":[3,40],"an":[4],"important":[5],"factor":[6],"in":[7,33,90,107],"the":[8,14,17,43,47,72,75,82,102,120,131,134,138],"regulation":[9],"of":[10,16,27,71,87,101,104,114,125,137],"chondrocyte":[11,139],"metabolism":[12,32],"and":[13,36,63,74,84,94,122,128],"maintenance":[15],"cartilage":[18,28],"extracellular":[19,48,76],"matrix.":[20,77],"Previous":[21],"studies":[22],"have":[23],"shown":[24,56],"that":[25,133],"compression":[26],"explants":[29],"alters":[30],"cellular":[31,52],"a":[34],"time-":[35],"spatially-varying":[37],"manner":[38],"which":[39,66],"correlated":[41],"with":[42],"mechanical":[44,93,108,135],"environment":[45],"within":[46],"matrix":[49],"[1].":[50],"Furthermore,":[51],"response":[53,91],"has":[54],"been":[55],"to":[57,69,92,118,129],"be":[58],"influenced":[59,141],"by":[60,142],"mechanical,":[61],"electrical,":[62],"physicochemical":[64,85,144],"events":[65,105],"are":[67,140],"coupled":[68],"deformation":[70],"cells":[73,89],"Therefore,":[78],"detailed":[79],"information":[80],"on":[81],"stress-strain":[83],"environments":[86],"individual":[88],"osmotic":[95,121],"stresses":[96],"would":[97],"improve":[98],"our":[99],"understanding":[100],"sequence":[103],"involved":[106],"signal":[109],"transduction":[110],"[2\u20134].":[111],"The":[112],"goal":[113],"this":[115],"study":[116],"was":[117],"quantify":[119],"viscoelastic":[123],"properties":[124,136],"isolated":[126],"chondrocytes":[127],"test":[130],"hypothesis":[132],"their":[143],"(osmotic)":[145],"environment.":[146]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-01-25T00:00:00"}