{"id":"https://openalex.org/W4205205129","doi":"https://doi.org/10.3892/ijo.2022.5303","title":"Functional assessment of miR\u20111291 in colon cancer cells","display_name":"Functional assessment of miR\u20111291 in colon cancer cells","publication_year":2022,"publication_date":"2022-01-04","ids":{"openalex":"https://openalex.org/W4205205129","doi":"https://doi.org/10.3892/ijo.2022.5303","pmid":"https://pubmed.ncbi.nlm.nih.gov/34981812","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8759348"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2022.5303","doi":"https://doi.org/10.3892/ijo.2022.5303","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5303","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5303/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5303/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100365347","display_name":"Jiaqi Wang","orcid":"https://orcid.org/0000-0001-8841-0124","observed_orcids":["https://orcid.org/0000-0001-8841-0124","https://orcid.org/0009-0001-6668-3903","https://orcid.org/0000-0002-6548-0186"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiaqi Wang","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003041684","display_name":"Yuhki Yokoyama","orcid":"https://orcid.org/0000-0002-8542-8588","observed_orcids":["https://orcid.org/0000-0002-8542-8588"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuhki Yokoyama","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087134345","display_name":"Haruka Hirose","orcid":"https://orcid.org/0009-0007-3827-257X","observed_orcids":["https://orcid.org/0009-0007-3827-257X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Hirose","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103105936","display_name":"Yuki Shimomura","orcid":"https://orcid.org/0009-0006-8474-602X","observed_orcids":["https://orcid.org/0009-0006-8474-602X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Shimomura","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007956544","display_name":"Saki Bonkobara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saki Bonkobara","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075298201","display_name":"Hiroaki Itakura","orcid":"https://orcid.org/0000-0002-1039-8361","observed_orcids":["https://orcid.org/0000-0002-1039-8361"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Itakura","raw_affiliation_strings":["Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049117667","display_name":"Shihori Kouda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shihori Kouda","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090815270","display_name":"Yoshihiro Morimoto","orcid":"https://orcid.org/0000-0003-2687-9933","observed_orcids":["https://orcid.org/0000-0003-2687-9933"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Morimoto","raw_affiliation_strings":["Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045000295","display_name":"Kazumasa Minami","orcid":"https://orcid.org/0000-0002-3864-6478","observed_orcids":["https://orcid.org/0000-0002-3864-6478"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Minami","raw_affiliation_strings":["Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077310835","display_name":"Hidekazu Takahashi","orcid":"https://orcid.org/0000-0003-0779-407X","observed_orcids":["https://orcid.org/0000-0003-0779-407X","https://orcid.org/0000-0002-1023-9053","https://orcid.org/0000-0003-2878-5391"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidekazu Takahashi","raw_affiliation_strings":["Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009813235","display_name":"Satoshi Shibata","orcid":"https://orcid.org/0000-0002-9300-4494","observed_orcids":["https://orcid.org/0000-0002-9300-4494"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Shibata","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013781849","display_name":"Shogo Kobayashi","orcid":"https://orcid.org/0000-0002-8828-1067","observed_orcids":["https://orcid.org/0000-0002-8828-1067"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Kobayashi","raw_affiliation_strings":["Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University,Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University,Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013033064","display_name":"Mamoru Uemura","orcid":"https://orcid.org/0000-0001-6285-5619","observed_orcids":["https://orcid.org/0000-0001-6285-5619"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Uemura","raw_affiliation_strings":["Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077247642","display_name":"Susumu Tanaka","orcid":"https://orcid.org/0000-0003-4804-7839","observed_orcids":["https://orcid.org/0000-0003-4804-7839"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Tanaka","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113\u20118510, Japan","First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113\u20118510, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779371","display_name":"Xin Wu","orcid":"https://orcid.org/0000-0003-4972-7561","observed_orcids":["https://orcid.org/0000-0003-4972-7561"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xin Wu","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060197046","display_name":"Shinji Tanaka","orcid":"https://orcid.org/0000-0002-7718-3453","observed_orcids":["https://orcid.org/0000-0002-7718-3453"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Tanaka","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113\u20118510, Japan","First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113\u20118510, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067647817","display_name":"Masaki Mori","orcid":"https://orcid.org/0000-0001-7632-3875","observed_orcids":["https://orcid.org/0000-0001-7632-3875"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Mori","raw_affiliation_strings":["Tokai University, Graduate School of Medicine, Isehara, Kanagawa 259\u20111193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokai University, Graduate School of Medicine, Isehara, Kanagawa 259\u20111193, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069920480","display_name":"Hirofumi Yamamoto","orcid":"https://orcid.org/0000-0001-6959-9574","observed_orcids":["https://orcid.org/0000-0001-6959-9574"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Yamamoto","raw_affiliation_strings":["Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Division of Health Sciences, Osaka University, Suita, Osaka 565\u20110871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003041684"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":null,"apc_paid":null,"fwci":1.4969,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81734486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"60","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dclk1","display_name":"DCLK1","score":0.968999981880188},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7590000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9679999947547913},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":1.0},{"id":"https://openalex.org/keywords/tumor-sphere-formation","display_name":"tumor sphere formation","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6849520206451416},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6609064340591431},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6024099588394165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5616236329078674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5389296412467957},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5122846364974976},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44044363498687744},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43353572487831116},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4272151589393616},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42424774169921875},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.4231744706630707},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4124062955379486},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3867044448852539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20969057083129883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09958189725875854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060340315103530884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089742","descriptor_name":"Doublecortin-Like Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000089742","descriptor_name":"Doublecortin-Like Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3892/ijo.2022.5303","doi":"https://doi.org/10.3892/ijo.2022.5303","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5303","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5303/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:34981812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34981812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8759348","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8759348/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmh:oai:ir.library.osaka-u.ac.jp:11094/87941","doi":null,"is_oa":false,"landing_page_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/87941/32569_Abstract.pdf","pdf_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/87941/32569_Abstract.pdf","source":{"id":"https://openalex.org/S4306402540","display_name":"OUKA (Osaka University Knowledge Archive) (Osaka University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98285908","host_organization_name":"The University of Osaka","host_organization_lineage":["https://openalex.org/I98285908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral_Thesis"}],"best_oa_location":{"id":"doi:10.3892/ijo.2022.5303","doi":"https://doi.org/10.3892/ijo.2022.5303","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2022.5303","pdf_url":"https://www.spandidos-publications.com/10.3892/ijo.2022.5303/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3236859586","display_name":"Development of a novel nucleic acid medicine targeting cancer stem-related marker Dclk1","funder_award_id":"18K16361","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3344103006","display_name":"Application of multiplex genome editing technology to the development of CAR-T therapy for refractory cancer subtypes","funder_award_id":"20K21627","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3351051044","display_name":"Understanding cancer stem cells and targeting colorectal cancer stem cells for therapy via isolation using cellular characteristics","funder_award_id":"20K09056","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4497163137","display_name":"Clarification of diversity mechanisms for innovation of refractory cancer treatment","funder_award_id":"19H01055","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320318230","display_name":"Cancer Research Institute, Kanazawa University","ror":null},{"id":"https://openalex.org/F4320318231","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337550","display_name":"Jonsson Comprehensive Cancer Center","ror":"https://ror.org/046rm7j60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205205129.pdf","grobid_xml":"https://content.openalex.org/works/W4205205129.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W272253102","https://openalex.org/W1511804816","https://openalex.org/W1533127962","https://openalex.org/W1644113001","https://openalex.org/W1928972520","https://openalex.org/W1964081206","https://openalex.org/W1964298295","https://openalex.org/W1965049479","https://openalex.org/W1985458848","https://openalex.org/W2010160578","https://openalex.org/W2022010237","https://openalex.org/W2037322733","https://openalex.org/W2050112915","https://openalex.org/W2060389571","https://openalex.org/W2063703361","https://openalex.org/W2064027874","https://openalex.org/W2069250897","https://openalex.org/W2074210527","https://openalex.org/W2075300416","https://openalex.org/W2079148941","https://openalex.org/W2092513068","https://openalex.org/W2100963721","https://openalex.org/W2102032782","https://openalex.org/W2107277218","https://openalex.org/W2107518278","https://openalex.org/W2108516575","https://openalex.org/W2109920372","https://openalex.org/W2114360920","https://openalex.org/W2116511889","https://openalex.org/W2121697185","https://openalex.org/W2122991820","https://openalex.org/W2127783246","https://openalex.org/W2132500831","https://openalex.org/W2144351955","https://openalex.org/W2154515580","https://openalex.org/W2156381851","https://openalex.org/W2166529745","https://openalex.org/W2284683492","https://openalex.org/W2293390255","https://openalex.org/W2325887197","https://openalex.org/W2343186061","https://openalex.org/W2379221911","https://openalex.org/W2413289852","https://openalex.org/W2435549854","https://openalex.org/W2493436472","https://openalex.org/W2527163647","https://openalex.org/W2588025094","https://openalex.org/W2591596179","https://openalex.org/W2596618221","https://openalex.org/W2598830924","https://openalex.org/W2751215238","https://openalex.org/W2770576752","https://openalex.org/W2791656081","https://openalex.org/W2801437236","https://openalex.org/W2884097717","https://openalex.org/W2884620854","https://openalex.org/W2887726433","https://openalex.org/W2889646458","https://openalex.org/W2891686291","https://openalex.org/W2899123592","https://openalex.org/W2901728462","https://openalex.org/W2912470974","https://openalex.org/W2914101983","https://openalex.org/W2923287877","https://openalex.org/W2941363269","https://openalex.org/W2972914310","https://openalex.org/W2975071263","https://openalex.org/W2992558303","https://openalex.org/W2995139706","https://openalex.org/W3000732020","https://openalex.org/W3003614072","https://openalex.org/W3005744760","https://openalex.org/W3009472278","https://openalex.org/W3010560689","https://openalex.org/W3041438991","https://openalex.org/W3043187607","https://openalex.org/W3092004182","https://openalex.org/W3092618728","https://openalex.org/W3146360245","https://openalex.org/W3174416769","https://openalex.org/W4211199921","https://openalex.org/W6754785150","https://openalex.org/W6758945625"],"related_works":["https://openalex.org/W3110687388","https://openalex.org/W3168837956","https://openalex.org/W6912305529","https://openalex.org/W2760323384","https://openalex.org/W2902952542","https://openalex.org/W2801733459","https://openalex.org/W2756108718","https://openalex.org/W3139037000","https://openalex.org/W2227866773","https://openalex.org/W7214014416"],"abstract_inverted_index":{"miR\u20111291":[0,33,43,58,68,80,95,129,160,202,223],"exerts":[1],"an":[2,204],"anti\u2011tumor":[3,205],"effect":[4,31,206],"in":[5,17,34,88,117,136,146,173],"a":[6,151,226],"subset":[7],"of":[8,32,54,75,144,153,159,186,194],"human":[9],"carcinomas,":[10],"including":[11,211],"pancreatic":[12],"cancer.":[13],"However,":[14],"its":[15],"role":[16],"colorectal":[18],"cancer":[19,97,212],"(CRC)":[20],"is":[21],"largely":[22],"unknown.":[23],"In":[24],"the":[25,28,46,71,142,163,174,180,187,198],"present":[26],"study,":[27],"expression":[29,87],"and":[30,51,85,102,104,115,123,134,141,155,189,214],"CRC":[35,55,138],"cells":[36,90,119,148],"was":[37,40],"investigated.":[38],"It":[39],"identified":[41],"that":[42,67,91,201,222],"significantly":[44,169],"suppressed":[45,82,96],"proliferation,":[47],"invasion,":[48],"cell":[49,60,99,139,215],"mobility":[50,116],"colony":[52],"formation":[53],"cells.":[56],"Additionally,":[57,179],"induced":[59,130],"apoptosis.":[61],"A":[62],"luciferase":[63],"reporter":[64],"assay":[65],"revealed":[66],"directly":[69],"bound":[70],"3'\u2011untranslated":[72],"region":[73],"sequence":[74],"doublecortin\u2011like":[76],"kinase":[77],"1":[78],"(DCLK1).":[79],"also":[81,121],"DCLK1":[83,126,145],"mRNA":[84],"protein":[86,191],"HCT116":[89,118,147],"expressed":[92],"DCLK1.":[93],"Furthermore,":[94,128],"stem":[98],"markers":[100],"BMI1":[101],"CD133,":[103],"inhibited":[105,170],"sphere":[106,112],"formation.":[107],"The":[108,218],"inhibitory":[109],"effects":[110],"on":[111,162],"formation,":[113],"invasion":[114],"were":[120],"explored":[122],"verified":[124],"using":[125],"siRNAs.":[127],"CDK":[131],"inhibitors":[132],"p21WAF1/CIP1":[133,154,188],"p27KIP1":[135,190],"three":[137],"lines,":[140],"overexpression":[143],"led":[149],"to":[150],"decrease":[152],"p27KIP1.":[156],"Intravenous":[157],"administration":[158],"loaded":[161],"super":[164],"carbonate":[165],"apatite":[166],"delivery":[167],"system":[168],"tumor":[171],"growth":[172],"DLD\u20111":[175],"xenograft":[176],"mouse":[177],"model.":[178],"resultant":[181],"tumors":[182],"exhibited":[183],"significant":[184],"upregulation":[185],"with":[192],"treatment":[193],"miR\u20111291.":[195],"Taken":[196],"together,":[197],"results":[199],"indicated":[200],"served":[203],"by":[207],"modulating":[208],"multiple":[209],"functions,":[210],"stemness":[213],"cycle":[216],"regulation.":[217],"current":[219],"data":[220],"suggested":[221],"may":[224],"be":[225],"promising":[227],"nucleic":[228],"acid":[229],"medicine":[230],"against":[231],"CRC.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-01-26T00:00:00"}