{"id":"https://openalex.org/W4205109986","doi":"https://doi.org/10.1016/j.genrep.2021.101484","title":"Involvement of APOE polymorphism in Alzheimer's disease susceptibility and Donepezil response in Moroccan patients","display_name":"Involvement of APOE polymorphism in Alzheimer's disease susceptibility and Donepezil response in Moroccan patients","publication_year":2022,"publication_date":"2022-01-13","ids":{"openalex":"https://openalex.org/W4205109986","doi":"https://doi.org/10.1016/j.genrep.2021.101484"},"language":"en","primary_location":{"id":"doi:10.1016/j.genrep.2021.101484","doi":"https://doi.org/10.1016/j.genrep.2021.101484","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.genrep.2021.101484","pdf_url":null,"source":{"id":"https://openalex.org/S2765063225","display_name":"Gene Reports","issn_l":"2452-0144","issn":["2452-0144"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085253223","display_name":"Sara Ben Halla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Sara Ben Halla","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030646","display_name":"Amal Tazzite","orcid":"https://orcid.org/0000-0002-9179-2650","observed_orcids":["https://orcid.org/0000-0002-9179-2650"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Amal Tazzite","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075742270","display_name":"Boucha\u00efb Gazzaz","orcid":"https://orcid.org/0000-0001-6102-2148","observed_orcids":["https://orcid.org/0000-0001-6102-2148"]},"institutions":[{"id":"https://openalex.org/I4210140404","display_name":"Laboratoire de Recherche et d\u2019Analyses M\u00e9dicales de la Fraternelle de la Gendarmerie Royale","ror":"https://ror.org/031y5ny63","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210140404"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Boucha\u00efb Gazzaz","raw_affiliation_strings":["Genetics Analysis Institute, Royal gendarmerie, Rabat, Morocco","Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Analysis Institute, Royal gendarmerie, Rabat, Morocco","institution_ids":["https://openalex.org/I4210140404"]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005920117","display_name":"Bouchra El Moutawakil","orcid":"https://orcid.org/0009-0004-1208-8449","observed_orcids":["https://orcid.org/0009-0004-1208-8449"]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Bouchra El Moutawakil","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","Neurology Department, IBN ROCHD University Hospital, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"Neurology Department, IBN ROCHD University Hospital, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022651643","display_name":"Hind Dehbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hind Dehbi","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","Laboratory of Medical Genetics, IBN ROCHD University Hospital, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"Laboratory of Medical Genetics, IBN ROCHD University Hospital, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085253223","https://openalex.org/A5110030646"],"corresponding_institution_ids":["https://openalex.org/I99297268"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":null,"fwci":0.1726,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.33135757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"26","issue":null,"first_page":"101484","last_page":"101484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.7789999842643738},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8119999766349792},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8880000114440918},{"id":"https://openalex.org/keywords/apoe-epsilon2-allele","display_name":"APOE \u03b52 allele","score":0.8429999947547913},{"id":"https://openalex.org/keywords/apoe-epsilon4-genotype","display_name":"APOE \u03b54 genotype","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.6959999799728394},{"id":"https://openalex.org/keywords/moroccan-patients","display_name":"Moroccan patients","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.9085718393325806},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7679498195648193},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.7544888257980347},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7215299606323242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6839197874069214},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5877460241317749},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5216310620307922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5050988793373108},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.49785566329956055},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.455933541059494},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.43777209520339966},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41085323691368103},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33990854024887085},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.32921987771987915},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2822052836418152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27926820516586304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2720383405685425},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0490591824054718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.045413970947265625}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.genrep.2021.101484","doi":"https://doi.org/10.1016/j.genrep.2021.101484","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.genrep.2021.101484","pdf_url":null,"source":{"id":"https://openalex.org/S2765063225","display_name":"Gene Reports","issn_l":"2452-0144","issn":["2452-0144"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Reports","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1838193685","https://openalex.org/W1904458203","https://openalex.org/W1972488785","https://openalex.org/W1977511373","https://openalex.org/W1977780737","https://openalex.org/W1981594738","https://openalex.org/W2018780010","https://openalex.org/W2027564700","https://openalex.org/W2036433997","https://openalex.org/W2040939766","https://openalex.org/W2054879352","https://openalex.org/W2070434480","https://openalex.org/W2072150523","https://openalex.org/W2079482822","https://openalex.org/W2085139257","https://openalex.org/W2092796376","https://openalex.org/W2107094473","https://openalex.org/W2117425956","https://openalex.org/W2223259072","https://openalex.org/W2233504250","https://openalex.org/W2263319273","https://openalex.org/W2463737913","https://openalex.org/W2514770153","https://openalex.org/W2529049741","https://openalex.org/W2608764790","https://openalex.org/W2745657465","https://openalex.org/W2883974615","https://openalex.org/W2902047993","https://openalex.org/W2910395930","https://openalex.org/W2944048797","https://openalex.org/W2965401191","https://openalex.org/W3011971211","https://openalex.org/W3036464226","https://openalex.org/W4211072901","https://openalex.org/W6668629168","https://openalex.org/W6789327681"],"related_works":["https://openalex.org/W2079482822","https://openalex.org/W2965104811","https://openalex.org/W2223259072","https://openalex.org/W2414658991","https://openalex.org/W2085139257","https://openalex.org/W1981613830","https://openalex.org/W2343183508","https://openalex.org/W2381046997","https://openalex.org/W2027564700","https://openalex.org/W2463737913"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-01-26T00:00:00"}