{"id":"https://openalex.org/W42035223","doi":null,"title":"The impact of CO2 on inorganic carbon supply and pH homeostasis in Corynebacterium glutamicum","display_name":"The impact of CO2 on inorganic carbon supply and pH homeostasis in Corynebacterium glutamicum","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W42035223","mag":"42035223"},"language":"en","primary_location":{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:5545","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/5545/1/DissertationKatjaKirsch.pdf","pdf_url":"https://kups.ub.uni-koeln.de/5545/1/DissertationKatjaKirsch.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044581776","display_name":"Katja Meike Kirsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katja Meike Kirsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044581776"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.06549999862909317,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corynebacterium-glutamicum","display_name":"Corynebacterium glutamicum","score":1.0},{"id":"https://openalex.org/keywords/carbon-dioxide","display_name":"carbon dioxide","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ph-homeostasis","display_name":"pH homeostasis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bicarbonate","display_name":"bicarbonate","score":0.7670000195503235},{"id":"https://openalex.org/keywords/co2-concentrating-mechanism","display_name":"CO2-concentrating mechanism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/synechocystis-sp-pcc-6803","display_name":"Synechocystis sp. PCC 6803","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pyruvate-carboxylation","display_name":"pyruvate carboxylation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/terminal-oxidase","display_name":"terminal oxidase","score":0.7929999828338623},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/phluorin","display_name":"pHluorin","score":0.824999988079071},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.6850000023841858},{"id":"https://openalex.org/keywords/l-glutamate-production","display_name":"L-glutamate production","score":0.8169999718666077},{"id":"https://openalex.org/keywords/l-lysine-production","display_name":"L-lysine production","score":0.902999997138977},{"id":"https://openalex.org/keywords/deletion-mutants","display_name":"deletion mutants","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.9753755331039429},{"id":"https://openalex.org/C24428623","wikidata":"https://www.wikidata.org/wiki/Q901081","display_name":"Carboxylation","level":3,"score":0.6891993880271912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6568566560745239},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.6086560487747192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5967260003089905},{"id":"https://openalex.org/C145597803","wikidata":"https://www.wikidata.org/wiki/Q97704244","display_name":"Total inorganic carbon","level":3,"score":0.5006959438323975},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.467204749584198},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.45261627435684204},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.27105170488357544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703841030597687},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.241644024848938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1308613419532776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11672484874725342},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07828530669212341}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:5545","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/5545/1/DissertationKatjaKirsch.pdf","pdf_url":"https://kups.ub.uni-koeln.de/5545/1/DissertationKatjaKirsch.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"mag:42035223","doi":null,"is_oa":false,"landing_page_url":"http://kups.ub.uni-koeln.de/5545/1/DissertationKatjaKirsch.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W82375399","https://openalex.org/W121422322","https://openalex.org/W134420286","https://openalex.org/W1238240961","https://openalex.org/W1487680459","https://openalex.org/W1523308556","https://openalex.org/W1539968788","https://openalex.org/W1540876114","https://openalex.org/W1563686976","https://openalex.org/W1565189292","https://openalex.org/W1576095742","https://openalex.org/W1822784150","https://openalex.org/W1843300456","https://openalex.org/W1951619777","https://openalex.org/W1966204475","https://openalex.org/W1969428539","https://openalex.org/W1970801110","https://openalex.org/W1978633908","https://openalex.org/W1979287129","https://openalex.org/W1979695024","https://openalex.org/W1979717194","https://openalex.org/W1980128234","https://openalex.org/W1983219311","https://openalex.org/W1985573305","https://openalex.org/W1985855050","https://openalex.org/W1986809046","https://openalex.org/W1986915415","https://openalex.org/W1987507393","https://openalex.org/W1988038203","https://openalex.org/W1988282969","https://openalex.org/W1994314761","https://openalex.org/W1995174494","https://openalex.org/W1995891287","https://openalex.org/W1997387703","https://openalex.org/W1999851893","https://openalex.org/W2002478327","https://openalex.org/W2003481405","https://openalex.org/W2004181413","https://openalex.org/W2006045560","https://openalex.org/W2006685379","https://openalex.org/W2010971306","https://openalex.org/W2016166286","https://openalex.org/W2019137903","https://openalex.org/W2020332438","https://openalex.org/W2025315918","https://openalex.org/W2025322665","https://openalex.org/W2026787289","https://openalex.org/W2030928483","https://openalex.org/W2031742115","https://openalex.org/W2033511085","https://openalex.org/W2034622002","https://openalex.org/W2035046825","https://openalex.org/W2036773557","https://openalex.org/W2038663142","https://openalex.org/W2040090482","https://openalex.org/W2041823495","https://openalex.org/W2044634803","https://openalex.org/W2044858769","https://openalex.org/W2045023958","https://openalex.org/W2049512829","https://openalex.org/W2049964985","https://openalex.org/W2052857942","https://openalex.org/W2053004479","https://openalex.org/W2057184572","https://openalex.org/W2057327357","https://openalex.org/W2057948506","https://openalex.org/W2058394206","https://openalex.org/W2062286240","https://openalex.org/W2063883386","https://openalex.org/W2069556271","https://openalex.org/W2073618740","https://openalex.org/W2073706566","https://openalex.org/W2077820538","https://openalex.org/W2079480917","https://openalex.org/W2080329944","https://openalex.org/W2082497364","https://openalex.org/W2086689771","https://openalex.org/W2087058811","https://openalex.org/W2094432186","https://openalex.org/W2099180070","https://openalex.org/W2100224938","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2105331181","https://openalex.org/W2105854932","https://openalex.org/W2111424774","https://openalex.org/W2115834151","https://openalex.org/W2118008650","https://openalex.org/W2118501705","https://openalex.org/W2120211414","https://openalex.org/W2123063363","https://openalex.org/W2123644846","https://openalex.org/W2127068865","https://openalex.org/W2128090435","https://openalex.org/W2128554689","https://openalex.org/W2128635872","https://openalex.org/W2136806453","https://openalex.org/W2136811206","https://openalex.org/W2138289353","https://openalex.org/W2139158688","https://openalex.org/W2144459968","https://openalex.org/W2144624514","https://openalex.org/W2144634347","https://openalex.org/W2145154689","https://openalex.org/W2145322972","https://openalex.org/W2145684516","https://openalex.org/W2146746846","https://openalex.org/W2146932847","https://openalex.org/W2147562407","https://openalex.org/W2148632523","https://openalex.org/W2149717752","https://openalex.org/W2150322385","https://openalex.org/W2150603220","https://openalex.org/W2151492773","https://openalex.org/W2151592915","https://openalex.org/W2153572376","https://openalex.org/W2156725813","https://openalex.org/W2156803384","https://openalex.org/W2157777339","https://openalex.org/W2161485399","https://openalex.org/W2161681336","https://openalex.org/W2162169192","https://openalex.org/W2162621033","https://openalex.org/W2163369626","https://openalex.org/W2164166017","https://openalex.org/W2164668875","https://openalex.org/W2166212205","https://openalex.org/W2166470414","https://openalex.org/W2168409343","https://openalex.org/W2169329760","https://openalex.org/W2170400465","https://openalex.org/W2173122004","https://openalex.org/W2186787587","https://openalex.org/W2479470317","https://openalex.org/W2978309922"],"related_works":["https://openalex.org/W1983219311","https://openalex.org/W134420286","https://openalex.org/W2031742115","https://openalex.org/W2006566359","https://openalex.org/W2989571061","https://openalex.org/W2351009417","https://openalex.org/W2549171918","https://openalex.org/W2019802671","https://openalex.org/W1772450153","https://openalex.org/W7212059748"],"abstract_inverted_index":{"The":[0,230,243,279],"actinobacterium":[1],"C.":[2,58,165,207,216,258,294,382],"glutamicum":[3,166,217,295],"is":[4,9,34,44,79,94,200,250],"a":[5,68,101,158,179,260],"soil":[6],"bacterium":[7],"which":[8],"extensively":[10],"used":[11],"in":[12,15,64,133,206,215,237,381],"biotechnology,":[13],"especially":[14,81],"the":[16,35,54,74,119,134,162,173,191,254,268,274,282,288,291,313,322,327,341,348,352,361,368,371,377],"production":[17],"of":[18,25,37,40,57,89,154,161,176,190,195,232,245,257,267,281,293,312,321,326,334,337,340,347,354,370,378],"L-glutamate":[19],"and":[20,105,143,226,287],"L-lysine.":[21],"An":[22],"important":[23],"aspect":[24],"industrial":[26],"scale":[27],"fermentation":[28],"processes":[29],"with":[30,71],"high":[31],"cell":[32],"densities":[33],"formation":[36],"large":[38],"amounts":[39],"CO2.":[41],"Since":[42],"CO2":[43,90,132],"assumed":[45],"to":[46,91,114,124,140,157,202,296,307,345,363],"influence":[47],"inorganic":[48,72,204],"carbon":[49,192,205],"provision":[50],"as":[51,53,100],"well":[52],"internal":[55],"pH":[56,85,120,150,248,255,270,299,303,314,323,349,365,379],"glutamicum,":[59,208,259],"both":[60,335],"aspects":[61],"were":[62,210,317],"investigated":[63],"this":[65,128,188],"study.":[66],"For":[67],"sufficient":[69],"supply":[70,135],"carbon,":[73],"\u00df-type":[75],"carbonic":[76],"anhydrase":[77],"Bca":[78,110,155],"essential,":[80],"at":[82,301],"low":[83],"external":[84,302],"values,":[86],"since":[87],"conversion":[88],"bicarbonate":[92,183],"(HCO3-)":[93],"crucial":[95],"before":[96],"it":[97],"can":[98,169],"serve":[99],"substrate":[102],"for":[103,182,264],"PEP":[104],"pyruvate":[106],"carboxylation":[107],"reactions.":[108],"Although":[109,187],"activity":[111,231],"also":[112],"leads":[113,156,344],"an":[115],"accelerated":[116],"proton":[117],"formation,":[118],"homeostasis":[121,249,256,283,300,315,324,380],"seems":[122],"not":[123,138,359],"be":[125,170,235],"affected":[126],"by":[127,172,319],"enzyme.":[129],"Also,":[130],"elevated":[131,221],"air":[136],"did":[137],"lead":[139],"impaired":[141],"growth":[142,159,222],"showed":[144],"only":[145,211,355],"short":[146],"term":[147],"effects":[148],"on":[149,224,228,247,376],"homeostasis.":[151,366],"A":[152,331],"lack":[153,333],"deficit":[160],"deletion":[163,329],"mutant":[164],"\u0394bca.":[167],"This":[168],"compensated":[171],"heterologous":[174],"expression":[175],"genes":[177],"encoding":[178],"cyanobacterial":[180],"system":[181],"import,":[184],"called":[185],"SbtAB.":[186],"component":[189],"concentrating":[193],"mechanism":[194],"Synechocystis":[196],"sp.":[197],"PCC":[198],"6803":[199],"able":[201],"provide":[203],"there":[209],"slight":[212],"benefits":[213],"observed":[214,318],"wild":[218],"type,":[219],"including":[220],"rates":[223],"glucose":[225],"partly":[227],"pyruvate.":[229],"SbtAB":[233,246],"could":[234],"determined":[236,286],"uptake":[238],"measurements":[239],"using":[240,273],"radio-labelled":[241],"bicarbonate.":[242],"impact":[244],"negligible.":[251],"To":[252],"investigate":[253],"fluorescence":[261],"based":[262],"assay":[263],"online":[265],"detection":[266],"intracellular":[269],"was":[271,285],"established":[272],"ratiometric":[275],"GFP":[276],"variant":[277],"pHluorin.":[278],"dynamic":[280],"process":[284],"results":[289],"show":[290],"ability":[292,362],"perform":[297,364],"effective":[298],"values":[304],"from":[305],"6":[306],"8.5.":[308],"Various":[309],"possible":[310],"components":[311],"machinery":[316],"determination":[320],"capacity":[325],"according":[328],"mutants.":[330],"complete":[332],"branches":[336],"terminal":[338],"oxidases":[339],"respiratory":[342],"chain":[343],"collapse":[346],"homeostasis,":[350],"while":[351],"absence":[353,369],"one":[356],"branch":[357],"does":[358],"affect":[360],"Also":[367],"F(1)F(O)ATPase":[372],"has":[373],"no":[374],"effect":[375],"glutamicum.":[383]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2016-06-24T00:00:00"}
