{"id":"https://openalex.org/W4200625596","doi":"https://doi.org/10.3390/ijms222413395","title":"Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions","display_name":"Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4200625596","doi":"https://doi.org/10.3390/ijms222413395","pmid":"https://pubmed.ncbi.nlm.nih.gov/34948191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8705584"},"language":"en","primary_location":{"id":"doi:10.3390/ijms222413395","doi":"https://doi.org/10.3390/ijms222413395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413395","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13395/pdf?version=1639455276","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/24/13395/pdf?version=1639455276","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060677753","display_name":"Veronika Ob\u0161ilov\u00e1","orcid":"https://orcid.org/0000-0003-4887-0323","observed_orcids":["https://orcid.org/0000-0003-4887-0323"]},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Veronika Obsilova","raw_affiliation_strings":["Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0003-4887-0323","affiliations":[{"raw_affiliation_string":"Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003943896","display_name":"Karol\u00edna Honzejkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Karolina Honzejkova","raw_affiliation_strings":["Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 12843 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 12843 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007535795","display_name":"Tom\u00e1\u0161 Ob\u0161il","orcid":"https://orcid.org/0000-0003-4602-1272","observed_orcids":["https://orcid.org/0000-0003-4602-1272"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Tomas Obsil","raw_affiliation_strings":["Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 12843 Prague, Czech Republic","Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0003-4602-1272","affiliations":[{"raw_affiliation_string":"Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 12843 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007535795","https://openalex.org/A5060677753"],"corresponding_institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210166371"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":1963,"currency":"EUR","value_usd":2117},"fwci":0.4842,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.41790349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"22","issue":"24","first_page":"13395","last_page":"13395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.22849999368190765,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ask1","display_name":"ASK1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/map3k","display_name":"MAP3K","score":0.8410000205039978},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.5189999938011169},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.703000009059906},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9580000042915344},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7200000286102295},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.48500001430511475},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.49399998784065247},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.9248843193054199},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6539278030395508},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.5605815649032593},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5005710124969482},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.47216886281967163},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46741199493408203},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.46379026770591736},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4607807695865631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45817941427230835},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4424901604652405},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.4361498951911926},{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.43346336483955383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40908247232437134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30838772654533386},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.2971266508102417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20666348934173584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11136078834533691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11053833365440369},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08692285418510437}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms222413395","doi":"https://doi.org/10.3390/ijms222413395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413395","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13395/pdf?version=1639455276","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:34948191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34948191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8705584","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8705584/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e190d9d55c5647beafae3a31b7274661","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e190d9d55c5647beafae3a31b7274661","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 13395, p 13395 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms222413395","doi":"https://doi.org/10.3390/ijms222413395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413395","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13395/pdf?version=1639455276","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1642742043","display_name":null,"funder_award_id":"67985823","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G2270324615","display_name":null,"funder_award_id":"67985823","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G2440933544","display_name":null,"funder_award_id":"1160120","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G2770096708","display_name":"Phosphorylation dependent regulation of human ubiquitin ligase NEDD4-2","funder_award_id":"GA20-00058S","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G3499615770","display_name":null,"funder_award_id":"RVO67985823","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G5128064691","display_name":null,"funder_award_id":"19-00121S and 20-00058S","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G5313543323","display_name":null,"funder_award_id":"RVO:67985823","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G7173107279","display_name":null,"funder_award_id":"67985823","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G813881031","display_name":"Molecular basis of the 14-3-3 protein-dependent regulation of protein kinase activity","funder_award_id":"GA19-00121S","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200625596.pdf","grobid_xml":"https://content.openalex.org/works/W4200625596.grobid-xml"},"referenced_works_count":115,"referenced_works":["https://openalex.org/W1861665996","https://openalex.org/W1864228662","https://openalex.org/W1963915974","https://openalex.org/W1967447462","https://openalex.org/W1969268163","https://openalex.org/W1969419810","https://openalex.org/W1976852960","https://openalex.org/W1976957140","https://openalex.org/W1988625266","https://openalex.org/W1988656758","https://openalex.org/W1990847293","https://openalex.org/W1996822245","https://openalex.org/W1997195377","https://openalex.org/W2005341765","https://openalex.org/W2006619267","https://openalex.org/W2008872627","https://openalex.org/W2009256889","https://openalex.org/W2016554175","https://openalex.org/W2019023506","https://openalex.org/W2030247471","https://openalex.org/W2031154171","https://openalex.org/W2032421282","https://openalex.org/W2034580062","https://openalex.org/W2034978016","https://openalex.org/W2035872178","https://openalex.org/W2039414145","https://openalex.org/W2040394896","https://openalex.org/W2040895064","https://openalex.org/W2044070436","https://openalex.org/W2044945534","https://openalex.org/W2045969244","https://openalex.org/W2053362879","https://openalex.org/W2064122617","https://openalex.org/W2066985195","https://openalex.org/W2067665631","https://openalex.org/W2069123208","https://openalex.org/W2072276918","https://openalex.org/W2074037753","https://openalex.org/W2075352286","https://openalex.org/W2077498058","https://openalex.org/W2087290732","https://openalex.org/W2089427155","https://openalex.org/W2092510449","https://openalex.org/W2095407717","https://openalex.org/W2107835713","https://openalex.org/W2109679459","https://openalex.org/W2112202302","https://openalex.org/W2114360920","https://openalex.org/W2115205812","https://openalex.org/W2118808586","https://openalex.org/W2121000910","https://openalex.org/W2123619341","https://openalex.org/W2124557239","https://openalex.org/W2127690195","https://openalex.org/W2129070184","https://openalex.org/W2130191536","https://openalex.org/W2134829539","https://openalex.org/W2137122673","https://openalex.org/W2138333784","https://openalex.org/W2139785972","https://openalex.org/W2140912550","https://openalex.org/W2141321721","https://openalex.org/W2147309521","https://openalex.org/W2147345880","https://openalex.org/W2149278793","https://openalex.org/W2159574886","https://openalex.org/W2162690000","https://openalex.org/W2164552220","https://openalex.org/W2164794447","https://openalex.org/W2167575664","https://openalex.org/W2172178194","https://openalex.org/W2204172854","https://openalex.org/W2260086521","https://openalex.org/W2289373951","https://openalex.org/W2308875595","https://openalex.org/W2322088624","https://openalex.org/W2512835781","https://openalex.org/W2515991216","https://openalex.org/W2519061472","https://openalex.org/W2527212756","https://openalex.org/W2553287023","https://openalex.org/W2566220566","https://openalex.org/W2589734336","https://openalex.org/W2594325929","https://openalex.org/W2615779840","https://openalex.org/W2617998463","https://openalex.org/W2751439113","https://openalex.org/W2754550313","https://openalex.org/W2765912299","https://openalex.org/W2766100828","https://openalex.org/W2766294138","https://openalex.org/W2767059632","https://openalex.org/W2770340841","https://openalex.org/W2790909277","https://openalex.org/W2792197142","https://openalex.org/W2869751739","https://openalex.org/W2892835514","https://openalex.org/W2908385598","https://openalex.org/W2972545838","https://openalex.org/W2981186399","https://openalex.org/W3006436501","https://openalex.org/W3011737582","https://openalex.org/W3019157606","https://openalex.org/W3063760387","https://openalex.org/W3083930173","https://openalex.org/W3091142172","https://openalex.org/W3112948680","https://openalex.org/W3128333234","https://openalex.org/W3158365676","https://openalex.org/W3161373196","https://openalex.org/W3180092645","https://openalex.org/W3188037344","https://openalex.org/W3190143179","https://openalex.org/W3194513679","https://openalex.org/W4211123396"],"related_works":["https://openalex.org/W4411329362","https://openalex.org/W2100957071","https://openalex.org/W7100354102","https://openalex.org/W3006436501","https://openalex.org/W4387806687","https://openalex.org/W2318173209","https://openalex.org/W3019157606","https://openalex.org/W2979504845","https://openalex.org/W1998401471","https://openalex.org/W1966148531"],"abstract_inverted_index":{"Apoptosis":[0],"signal-regulating":[1],"kinase":[2,11,12,13],"(ASK)":[3],"1,":[4],"a":[5,30,116],"member":[6],"of":[7,65,92,108,149],"the":[8,63,147],"mitogen-activated":[9],"protein":[10],"(MAP3K)":[14],"family,":[15],"modulates":[16],"diverse":[17],"responses":[18],"to":[19,50,82],"oxidative":[20],"and":[21,26,41,46,54,59,73,76,86,94,135],"endoplasmic":[22],"reticulum":[23],"(ER)":[24],"stress":[25,33],"calcium":[27],"influx.":[28],"As":[29],"crucial":[31],"cellular":[32],"sensor,":[34],"ASK1":[35,133,144],"activates":[36],"c-Jun":[37],"N-terminal":[38],"kinases":[39,96],"(JNKs)":[40],"p38":[42,95],"MAPKs.":[43],"Their":[44],"excessive":[45],"sustained":[47],"activation":[48],"leads":[49],"cell":[51],"death,":[52],"inflammation":[53],"fibrosis":[55],"in":[56,62,80,138,146],"various":[57,139],"tissues":[58],"is":[60],"implicated":[61],"development":[64],"many":[66],"neurological":[67],"disorders,":[68],"such":[69,122],"as":[70,115],"Alzheimer's,":[71],"Parkinson's":[72],"Huntington":[74],"disease":[75],"amyotrophic":[77],"lateral":[78],"sclerosis,":[79],"addition":[81],"cardiovascular":[83],"diseases,":[84,140],"diabetes":[85],"cancer.":[87],"However,":[88],"currently":[89],"available":[90],"inhibitors":[91],"JNK":[93],"either":[97],"lack":[98],"efficacy":[99],"or":[100],"have":[101],"undesirable":[102],"side":[103],"effects.":[104],"Therefore,":[105],"targeted":[106],"inhibition":[107,145],"their":[109],"upstream":[110],"activator,":[111],"ASK1,":[112],"stands":[113],"out":[114],"promising":[117],"therapeutic":[118],"strategy":[119],"for":[120,143],"treating":[121],"severe":[123],"pathological":[124],"conditions.":[125],"This":[126],"review":[127],"summarizes":[128],"recent":[129],"structural":[130],"findings":[131],"on":[132],"regulation":[134],"its":[136],"role":[137],"highlighting":[141],"prospects":[142],"treatment":[148],"these":[150],"pathologies.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}
