{"id":"https://openalex.org/W4200609820","doi":"https://doi.org/10.3390/ijms222413388","title":"Safety and Danger Considerations of Novel Treatments for Atopic Dermatitis in Context of Primary Cutaneous Lymphomas","display_name":"Safety and Danger Considerations of Novel Treatments for Atopic Dermatitis in Context of Primary Cutaneous Lymphomas","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4200609820","doi":"https://doi.org/10.3390/ijms222413388","pmid":"https://pubmed.ncbi.nlm.nih.gov/34948183","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8703592"},"language":"en","primary_location":{"id":"doi:10.3390/ijms222413388","doi":"https://doi.org/10.3390/ijms222413388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413388","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13388/pdf?version=1639973824","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/24/13388/pdf?version=1639973824","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000965204","display_name":"Karol Ko\u0142kowski","orcid":"https://orcid.org/0000-0001-5977-2126","observed_orcids":["https://orcid.org/0000-0001-5977-2126"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Karol Ko\u0142kowski","raw_affiliation_strings":["Dermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0001-5977-2126","affiliations":[{"raw_affiliation_string":"Dermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071957704","display_name":"Magdalena Trzeciak","orcid":"https://orcid.org/0000-0002-8206-8441","observed_orcids":["https://orcid.org/0000-0002-8206-8441"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Trzeciak","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8206-8441","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057886419","display_name":"Ma\u0142gorzata Soko\u0142owska\u2010Wojdy\u0142o","orcid":"https://orcid.org/0000-0002-7626-3689","observed_orcids":["https://orcid.org/0000-0002-7626-3689"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Soko\u0142owska-Wojdy\u0142o","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7626-3689","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000965204"],"corresponding_institution_ids":["https://openalex.org/I75124487"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.9076,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.67165835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"24","first_page":"13388","last_page":"13388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.25290000438690186,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/primary-cutaneous-lymphoma","display_name":"primary cutaneous lymphoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":0.9760000109672546},{"id":"https://openalex.org/keywords/upadacitinib","display_name":"upadacitinib","score":0.9490000009536743},{"id":"https://openalex.org/keywords/jak-stat-inhibitors","display_name":"JAK/STAT inhibitors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6980000138282776},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9929999709129333},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9829999804496765},{"id":"https://openalex.org/keywords/il-31","display_name":"IL-31","score":0.996999979019165},{"id":"https://openalex.org/keywords/biologic-safety","display_name":"biologic safety","score":0.6790000200271606},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tofacitinib","display_name":"tofacitinib","score":0.8360000252723694},{"id":"https://openalex.org/keywords/fda-warning","display_name":"FDA warning","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.9544715881347656},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8969582319259644},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.8370211124420166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.836058497428894},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.8333876132965088},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6460787057876587},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6128802299499512},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45395416021347046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30952733755111694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.281873494386673},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.09311774373054504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001384","descriptor_name":"Azetidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054446","descriptor_name":"Lymphoma, Primary Cutaneous Anaplastic Large Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms222413388","doi":"https://doi.org/10.3390/ijms222413388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413388","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13388/pdf?version=1639973824","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8703592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8703592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:34948183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34948183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:47b1a32bcef74baa8790591fe0da90e3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47b1a32bcef74baa8790591fe0da90e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 13388, p 13388 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms222413388","doi":"https://doi.org/10.3390/ijms222413388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413388","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13388/pdf?version=1639973824","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200609820.pdf","grobid_xml":"https://content.openalex.org/works/W4200609820.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W158917702","https://openalex.org/W1503465113","https://openalex.org/W1567692140","https://openalex.org/W1581519400","https://openalex.org/W1606487633","https://openalex.org/W1662170570","https://openalex.org/W1881313444","https://openalex.org/W1912366752","https://openalex.org/W1921757731","https://openalex.org/W1969324239","https://openalex.org/W1970220246","https://openalex.org/W1972059814","https://openalex.org/W1973596639","https://openalex.org/W1975014863","https://openalex.org/W1975202136","https://openalex.org/W1979420316","https://openalex.org/W1979572828","https://openalex.org/W1992025888","https://openalex.org/W1993759083","https://openalex.org/W1996869817","https://openalex.org/W1998453743","https://openalex.org/W1999804934","https://openalex.org/W2000722735","https://openalex.org/W2006159237","https://openalex.org/W2014729966","https://openalex.org/W2018911810","https://openalex.org/W2019019272","https://openalex.org/W2020971852","https://openalex.org/W2023064301","https://openalex.org/W2023632476","https://openalex.org/W2026800245","https://openalex.org/W2031254710","https://openalex.org/W2031676466","https://openalex.org/W2032152255","https://openalex.org/W2034138605","https://openalex.org/W2037351900","https://openalex.org/W2048282576","https://openalex.org/W2053344100","https://openalex.org/W2054821802","https://openalex.org/W2064517815","https://openalex.org/W2067032547","https://openalex.org/W2069290710","https://openalex.org/W2073503689","https://openalex.org/W2075455397","https://openalex.org/W2076046722","https://openalex.org/W2076582266","https://openalex.org/W2076870975","https://openalex.org/W2077513110","https://openalex.org/W2077529892","https://openalex.org/W2080425028","https://openalex.org/W2081003617","https://openalex.org/W2082514292","https://openalex.org/W2083631019","https://openalex.org/W2089291062","https://openalex.org/W2090152164","https://openalex.org/W2091203750","https://openalex.org/W2098319567","https://openalex.org/W2110754651","https://openalex.org/W2114964305","https://openalex.org/W2115966711","https://openalex.org/W2120793327","https://openalex.org/W2124450032","https://openalex.org/W2134041885","https://openalex.org/W2135049789","https://openalex.org/W2136669623","https://openalex.org/W2140448680","https://openalex.org/W2142728867","https://openalex.org/W2153959643","https://openalex.org/W2155969925","https://openalex.org/W2159808191","https://openalex.org/W2162357150","https://openalex.org/W2171010115","https://openalex.org/W2200308911","https://openalex.org/W2303093245","https://openalex.org/W2305188648","https://openalex.org/W2320804813","https://openalex.org/W2322853343","https://openalex.org/W2325441109","https://openalex.org/W2342374902","https://openalex.org/W2344408938","https://openalex.org/W2344634105","https://openalex.org/W2400154597","https://openalex.org/W2404165235","https://openalex.org/W2418796931","https://openalex.org/W2419661260","https://openalex.org/W2465649762","https://openalex.org/W2481496926","https://openalex.org/W2535405638","https://openalex.org/W2559769990","https://openalex.org/W2583095266","https://openalex.org/W2584816673","https://openalex.org/W2587153615","https://openalex.org/W2588589218","https://openalex.org/W2593200577","https://openalex.org/W2594033175","https://openalex.org/W2607408873","https://openalex.org/W2729207723","https://openalex.org/W2752127863","https://openalex.org/W2752670171","https://openalex.org/W2761369781","https://openalex.org/W2767327745","https://openalex.org/W2783616522","https://openalex.org/W2783829013","https://openalex.org/W2784010902","https://openalex.org/W2801081252","https://openalex.org/W2888088956","https://openalex.org/W2888531381","https://openalex.org/W2891425021","https://openalex.org/W2902280735","https://openalex.org/W2909964376","https://openalex.org/W2919024003","https://openalex.org/W2942810024","https://openalex.org/W2943067963","https://openalex.org/W2949623374","https://openalex.org/W2962823845","https://openalex.org/W2969216821","https://openalex.org/W2972790514","https://openalex.org/W2988773944","https://openalex.org/W2990130911","https://openalex.org/W3003334583","https://openalex.org/W3004398344","https://openalex.org/W3008661668","https://openalex.org/W3009665278","https://openalex.org/W3011879699","https://openalex.org/W3013253836","https://openalex.org/W3013813365","https://openalex.org/W3015335355","https://openalex.org/W3016767547","https://openalex.org/W3025965449","https://openalex.org/W3026694855","https://openalex.org/W3032018657","https://openalex.org/W3036283516","https://openalex.org/W3036862512","https://openalex.org/W3037349633","https://openalex.org/W3039472607","https://openalex.org/W3040869725","https://openalex.org/W3041874564","https://openalex.org/W3042769795","https://openalex.org/W3044651017","https://openalex.org/W3087296239","https://openalex.org/W3087665791","https://openalex.org/W3089470786","https://openalex.org/W3090227268","https://openalex.org/W3091046625","https://openalex.org/W3091579342","https://openalex.org/W3092986070","https://openalex.org/W3093414992","https://openalex.org/W3093711947","https://openalex.org/W3097192879","https://openalex.org/W3103961004","https://openalex.org/W3108729787","https://openalex.org/W3110794513","https://openalex.org/W3115096572","https://openalex.org/W3117593172","https://openalex.org/W3118254650","https://openalex.org/W3120628765","https://openalex.org/W3129043732","https://openalex.org/W3129325639","https://openalex.org/W3134789419","https://openalex.org/W3135108405","https://openalex.org/W3136297743","https://openalex.org/W3149550392","https://openalex.org/W3150304305","https://openalex.org/W3151092943","https://openalex.org/W3154657415","https://openalex.org/W3156448761","https://openalex.org/W3156822772","https://openalex.org/W3156976560","https://openalex.org/W3159897478","https://openalex.org/W3164188014","https://openalex.org/W3164705475","https://openalex.org/W3168367048","https://openalex.org/W3169506694","https://openalex.org/W3170263128","https://openalex.org/W3172437444","https://openalex.org/W3176333981","https://openalex.org/W3177382246","https://openalex.org/W3179775266","https://openalex.org/W3186317220","https://openalex.org/W3189956257","https://openalex.org/W3193270512","https://openalex.org/W3193360717","https://openalex.org/W3194970552","https://openalex.org/W3198191732","https://openalex.org/W3201805538","https://openalex.org/W3206514850","https://openalex.org/W3207602622","https://openalex.org/W3208944142","https://openalex.org/W4230355606","https://openalex.org/W6681085416"],"related_works":["https://openalex.org/W4401662175","https://openalex.org/W4410729722","https://openalex.org/W4402976565","https://openalex.org/W4407064093","https://openalex.org/W7135195205","https://openalex.org/W7118129501","https://openalex.org/W4402104448","https://openalex.org/W7162955555","https://openalex.org/W4401373367","https://openalex.org/W4394008790"],"abstract_inverted_index":{"The":[0],"impact":[1,132],"of":[2,10,67,86,94,103,120,136,147,159,170,174],"new":[3],"and":[4,32,56,58,74,107,126,144],"emerging":[5],"therapies":[6],"on":[7,51,96,100,133,163],"the":[8,20,39,49,65,84,91,101,104,121,134,160,168,171],"microenvironment":[9],"primary":[11],"cutaneous":[12,137],"lymphomas":[13],"(PCLs)":[14],"has":[15],"been":[16],"recently":[17],"raised":[18],"in":[19,61,83,157,167,178],"literature.":[21],"Concomitantly,":[22],"novel":[23],"treatments":[24],"are":[25],"already":[26],"used":[27],"or":[28],"registered":[29],"(dupilumab,":[30,70,124],"upadacitinib)":[31],"others":[33,127],"seem":[34],"to":[35,38,47,63,152,189],"be":[36],"added":[37],"armamentarium":[40],"against":[41],"atopic":[42,87,175],"dermatitis.":[43,88],"Our":[44,115],"aim":[45],"was":[46],"review":[48],"literature":[50],"interleukins":[52],"4,":[53],"13,":[54],"22,":[55],"31,":[57],"JAK/STAT":[59],"pathways":[60],"PCLs":[62],"elucidate":[64],"safety":[66],"using":[68],"biologics":[69],"tralokinumab,":[71],"fezakinumab,":[72],"nemolizumab)":[73],"small":[75],"molecule":[76],"inhibitors":[77],"(upadacitinib,":[78],"baricitinib,":[79],"abrocitinib,":[80],"ruxolitinib,":[81],"tofacitinib)":[82],"treatment":[85],"We":[89],"summarized":[90],"current":[92],"state":[93],"knowledge":[95],"this":[97],"topic":[98],"based":[99],"search":[102],"PubMed":[105],"database":[106],"related":[108],"references":[109],"published":[110],"before":[111],"21":[112],"October":[113],"2021.":[114],"analysis":[116],"suggests":[117],"that":[118],"some":[119],"mentioned":[122],"agents":[123],"ruxolitinib)":[125],"may":[128],"have":[129],"a":[130,187,191,195],"direct":[131],"progression":[135,173],"lymphomas.":[138],"This":[139],"issue":[140],"requires":[141],"further":[142],"study":[143],"meticulous":[145],"monitoring":[146],"patients":[148,179],"receiving":[149],"these":[150],"drugs":[151],"ensure":[153],"their":[154],"safety,":[155],"especially":[156,177],"light":[158],"FDA":[161],"warning":[162],"tofacitinib.":[164],"In":[165],"conclusion,":[166],"case":[169],"rapid":[172],"dermatitis/eczema,":[176],"older":[180],"than":[181],"40":[182],"years":[183],"old,":[184],"there":[185],"is":[186],"necessity":[188],"perform":[190],"biopsy":[192],"followed":[193],"by":[194],"very":[196],"careful":[197],"pathological":[198],"examination.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}