{"id":"https://openalex.org/W4200604636","doi":"https://doi.org/10.1021/acsomega.1c05297","title":"Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding","display_name":"Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding","publication_year":2021,"publication_date":"2021-12-14","ids":{"openalex":"https://openalex.org/W4200604636","doi":"https://doi.org/10.1021/acsomega.1c05297","pmid":"https://pubmed.ncbi.nlm.nih.gov/34984290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8717532"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.1c05297","doi":"https://doi.org/10.1021/acsomega.1c05297","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c05297","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsomega.1c05297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062624181","display_name":"Lori I. Robins","orcid":"https://orcid.org/0000-0003-4259-6642","observed_orcids":["https://orcid.org/0000-0003-4259-6642"]},"institutions":[{"id":"https://openalex.org/I4210138624","display_name":"University of Washington Bothell","ror":"https://ror.org/02ygzhr13","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138624"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lori I. Robins","raw_affiliation_strings":["Department of Physical Sciences, University of Washington Bothell, 18115 Campus Way NE, Bothell, Washington 98011, United States"],"raw_orcid":"https://orcid.org/0000-0003-4259-6642","affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, University of Washington Bothell, 18115 Campus Way NE, Bothell, Washington 98011, United States","institution_ids":["https://openalex.org/I4210138624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045794046","display_name":"Erika K. Keim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika K. Keim","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98195, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062592563","display_name":"Deborah B. Robins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deborah B. Robins","raw_affiliation_strings":["Issaquah High School, 700 2nd Ave SE, Issaquah, Washington 98027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Issaquah High School, 700 2nd Ave SE, Issaquah, Washington 98027, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028499054","display_name":"John Scott Edgar","orcid":"https://orcid.org/0000-0002-3783-205X","observed_orcids":["https://orcid.org/0000-0002-3783-205X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Edgar","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Washington, H172 Health Science Building, Seattle, Washington 98195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Washington, H172 Health Science Building, Seattle, Washington 98195, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076240640","display_name":"John Scott Meschke","orcid":"https://orcid.org/0000-0002-8983-9042","observed_orcids":["https://orcid.org/0000-0002-8983-9042"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Meschke","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98195, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034243534","display_name":"Philip R. Gafken","orcid":"https://orcid.org/0000-0001-6092-4828","observed_orcids":["https://orcid.org/0000-0001-6092-4828"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip R. Gafken","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102974202","display_name":"Jeffrey F. Williams","orcid":"https://orcid.org/0000-0001-6666-8722","observed_orcids":["https://orcid.org/0000-0001-6666-8722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey F. Williams","raw_affiliation_strings":["Briotech Inc., 14120 NE 200th St, Woodinville, Washington 98072, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Briotech Inc., 14120 NE 200th St, Woodinville, Washington 98072, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062624181"],"corresponding_institution_ids":["https://openalex.org/I4210138624"],"apc_list":{"value":1250,"currency":"USD","value_usd":1250},"apc_paid":{"value":1250,"currency":"USD","value_usd":1250},"fwci":0.7319,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65226874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"51","first_page":"35593","last_page":"35599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/hypochlorous-acid","display_name":"hypochlorous acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hypobromous-acid","display_name":"hypobromous acid","score":0.8519999980926514},{"id":"https://openalex.org/keywords/n-chlorotaurine","display_name":"N-chlorotaurine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reactive-halogen-species","display_name":"reactive halogen species","score":0.5860000252723694},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.906000018119812},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2780908991","wikidata":"https://www.wikidata.org/wiki/Q407318","display_name":"Hypochlorous acid","level":2,"score":0.9570307731628418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.669857919216156},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6224770545959473},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5958074331283569},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4836462736129761},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4560711979866028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4363314211368561},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4279767870903015},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42226219177246094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37612733244895935},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3474551737308502},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20471584796905518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17550453543663025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1644645631313324},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1021/acsomega.1c05297","doi":"https://doi.org/10.1021/acsomega.1c05297","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c05297","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2021-s68cw","doi":"https://doi.org/10.26434/chemrxiv-2021-s68cw","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2021-s68cw","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60cec8aa2616113e7f8b4ca5/original/modification-of-il-6-by-hypochlorous-acid-effects-on-receptor-binding-and-possible-role-in-treatment-of-covid-19.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.33774/chemrxiv-2021-s68cw","doi":"https://doi.org/10.33774/chemrxiv-2021-s68cw","is_oa":true,"landing_page_url":"https://doi.org/10.33774/chemrxiv-2021-s68cw","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8717532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8717532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:34984290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34984290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7c6dc9ca327b4ce585bd8fc431a04f61","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c6dc9ca327b4ce585bd8fc431a04f61","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 6, Iss 51, Pp 35593-35599 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.1c05297","doi":"https://doi.org/10.1021/acsomega.1c05297","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c05297","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320334502","display_name":"University of Washington Bothell","ror":"https://ror.org/02ygzhr13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200604636.pdf","grobid_xml":"https://content.openalex.org/works/W4200604636.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W169983585","https://openalex.org/W989016558","https://openalex.org/W1586360287","https://openalex.org/W1843621178","https://openalex.org/W1895277992","https://openalex.org/W1968690534","https://openalex.org/W1970942128","https://openalex.org/W1971435128","https://openalex.org/W1972719386","https://openalex.org/W1984159370","https://openalex.org/W1989394769","https://openalex.org/W1999919534","https://openalex.org/W2005899936","https://openalex.org/W2014006305","https://openalex.org/W2015010038","https://openalex.org/W2017921966","https://openalex.org/W2025694904","https://openalex.org/W2030022020","https://openalex.org/W2051082122","https://openalex.org/W2051256601","https://openalex.org/W2056310181","https://openalex.org/W2062856009","https://openalex.org/W2064664882","https://openalex.org/W2071090314","https://openalex.org/W2072796605","https://openalex.org/W2072884289","https://openalex.org/W2075098204","https://openalex.org/W2076846032","https://openalex.org/W2083082623","https://openalex.org/W2083136355","https://openalex.org/W2087134134","https://openalex.org/W2088659912","https://openalex.org/W2117170204","https://openalex.org/W2122382610","https://openalex.org/W2151938701","https://openalex.org/W2172680325","https://openalex.org/W2314530439","https://openalex.org/W2338039337","https://openalex.org/W2474986619","https://openalex.org/W2582247657","https://openalex.org/W2589903025","https://openalex.org/W2763626562","https://openalex.org/W2810720197","https://openalex.org/W2996774789","https://openalex.org/W3003715287","https://openalex.org/W3008318402","https://openalex.org/W3012405893","https://openalex.org/W3014050022","https://openalex.org/W3015607499","https://openalex.org/W3017957088","https://openalex.org/W3025160648","https://openalex.org/W3042855511","https://openalex.org/W3045453828","https://openalex.org/W3086783775","https://openalex.org/W3091085673","https://openalex.org/W3092569618","https://openalex.org/W3107765474","https://openalex.org/W3134936424","https://openalex.org/W3176771029","https://openalex.org/W4230901874","https://openalex.org/W6807222815"],"related_works":["https://openalex.org/W3195828199","https://openalex.org/W3040956296","https://openalex.org/W3182038357","https://openalex.org/W3112153355","https://openalex.org/W3153638144","https://openalex.org/W4388302901","https://openalex.org/W3109708588","https://openalex.org/W4282585476","https://openalex.org/W2056310181","https://openalex.org/W3094644754"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Interleukin-6":[7],"(IL-6)":[8],"has":[9],"been":[10,177],"implicated":[11,178],"in":[12,57,64,77,119,179,198,221,232],"the":[13,102,141,152,183,199],"pathogenesis":[14],"of":[15,41,71,104,124,157,174,182,201],"inflammatory":[16],"events":[17],"including":[18],"those":[19],"seen":[20],"with":[21,38,84,216,229],"COVID-19":[22,233],"patients.":[23],"Positive":[24],"clinical":[25],"responses":[26],"to":[27,48,53,62,73,88,93,106,129,135,163],"monoclonal":[28],"antibodies":[29],"directed":[30],"against":[31],"IL-6":[32,52,72,105,126,217],"receptors":[33],"(IL-6Rs)":[34],"suggest":[35,187],"that":[36,140,188],"interference":[37],"IL-6-dependent":[39],"activation":[40],"pro-inflammatory":[42],"pathways":[43],"offers":[44],"a":[45,78,82,90],"useful":[46],"approach":[47],"therapy.":[49],"We":[50],"exposed":[51],"hypochlorous":[54],"acid":[55,112,166],"(HOCl)":[56],"vitro":[58],"at":[59,144],"concentrations":[60,145],"reported":[61],"develop":[63],"vivo":[65,120,222],".":[66,121],"After":[67],"HOCl":[68,190,207],"treatment,":[69],"binding":[70,181],"IL-6R":[74],"was":[75],"reduced":[76],"dose-dependent":[79],"manner":[80],"using":[81],"bioassay":[83],"human":[85],"cells":[86],"engineered":[87],"provide":[89],"luminescence":[91],"response":[92],"signal":[94],"transduction":[95],"upon":[96],"receptor":[97,180],"activation.":[98],"Similar":[99],"results":[100],"followed":[101],"exposure":[103],"N":[107],"-chlorotaurine":[108],"(NCT)":[109],"and":[110,170,191,208,210,218,234],"hypobromous":[111],"(HOBr),":[113],"two":[114,164],"other":[115,235],"reactive":[116],"species":[117],"produced":[118],"SDS-PAGE":[122],"analysis":[123],"HOCl-treated":[125],"showed":[127],"little":[128],"no":[130],"fragmentation":[131],"or":[132],"aggregation":[133],"up":[134,225],"1.75":[136,147],"mM":[137,148],"HOCl,":[138],"suggesting":[139],"modifications":[142],"induced":[143],"below":[146],"took":[149],"place":[150],"on":[151,205],"intact":[153],"protein.":[154],"Mass":[155],"spectrometry":[156],"trypsin-digested":[158],"fragments":[159],"identified":[160],"oxidative":[161],"changes":[162],"amino":[165],"residues,":[167],"methionine":[168],"161":[169],"tryptophan":[171],"157,":[172],"both":[173],"which":[175],"have":[176],"cytokine.":[184],"Our":[185],"findings":[186],"exogenous":[189],"NCT":[192],"might":[193],"bring":[194],"about":[195],"beneficial":[196],"effects":[197],"treatment":[200],"COVID-19.":[202],"Further":[203],"studies":[204],"how":[206],"HOBr":[209],"their":[211],"halogenated":[212],"amine":[213],"derivatives":[214],"interact":[215],"related":[219],"cytokines":[220],"may":[223],"open":[224],"alternative":[226],"therapeutic":[227],"interventions":[228],"these":[230],"compounds":[231],"hyperinflammatory":[236],"diseases.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}