{"id":"https://openalex.org/W4200601697","doi":"https://doi.org/10.2147/dddt.s333418","title":"Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS","display_name":"Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200601697","doi":"https://doi.org/10.2147/dddt.s333418","pmid":"https://pubmed.ncbi.nlm.nih.gov/35002223","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8722572"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s333418","doi":"https://doi.org/10.2147/dddt.s333418","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s333418","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77225","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=77225","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037498188","display_name":"Yingying He","orcid":"https://orcid.org/0000-0002-9007-5983","observed_orcids":["https://orcid.org/0000-0002-9007-5983"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingying He","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039072944","display_name":"Haozhen Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haozhen Zheng","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104021836","display_name":"Lanying Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lanying Zhong","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089929870","display_name":"Nijun Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nijun Zhong","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guiqing Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guiqing Wen","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713995","display_name":"Lisheng Wang","orcid":"https://orcid.org/0000-0001-8729-0423","observed_orcids":["https://orcid.org/0000-0001-8729-0423"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lisheng Wang","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100386224","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0003-1620-3825","observed_orcids":["https://orcid.org/0000-0003-1620-3825"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I117532281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037498188","https://openalex.org/A5039072944","https://openalex.org/A5089929870","https://openalex.org/A5100386224","https://openalex.org/A5100713995","https://openalex.org/A5104021836"],"corresponding_institution_ids":["https://openalex.org/I117532281"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":5.3675,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.95887861,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"Volume 15","issue":null,"first_page":"5165","last_page":"5178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huangqi-guizhi-wuwu-decoction","display_name":"Huangqi Guizhi Wuwu Decoction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9769999980926514},{"id":"https://openalex.org/keywords/active-ingredients","display_name":"active ingredients","score":0.6169999837875366},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation-reoxygenation","display_name":"oxygen-glucose deprivation/reoxygenation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/calycosin","display_name":"calycosin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/paeoniflorin","display_name":"paeoniflorin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/wogonin","display_name":"wogonin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/formononetin","display_name":"formononetin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9070000052452087},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C190409667","wikidata":"https://www.wikidata.org/wiki/Q1136912","display_name":"Decoction","level":2,"score":0.7591273784637451},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5305681228637695},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5203301906585693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5027403831481934},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.47218552231788635},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3783101737499237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3657519817352295},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35942432284355164},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.31195884943008423},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071939","descriptor_name":"Stroke Rehabilitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D052616","descriptor_name":"Solid Phase Extraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/dddt.s333418","doi":"https://doi.org/10.2147/dddt.s333418","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s333418","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77225","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmid:35002223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35002223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8722572","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8722572/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a4c97168ba13432186d53e60f4861775","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a4c97168ba13432186d53e60f4861775","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 15, Pp 5165-5178 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/71916","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/identification-of-active-ingredients-of-huangqi-guizhi-wuwu-decoction--peer-reviewed-fulltext-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s333418","doi":"https://doi.org/10.2147/dddt.s333418","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s333418","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77225","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1400351264","display_name":null,"funder_award_id":"81373973","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6015233874","display_name":null,"funder_award_id":"81573872","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200601697.pdf","grobid_xml":"https://content.openalex.org/works/W4200601697.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1073992461","https://openalex.org/W1976851890","https://openalex.org/W2002490462","https://openalex.org/W2022953443","https://openalex.org/W2023125814","https://openalex.org/W2045360008","https://openalex.org/W2093175712","https://openalex.org/W2113978971","https://openalex.org/W2224008359","https://openalex.org/W2351673993","https://openalex.org/W2469801881","https://openalex.org/W2591786331","https://openalex.org/W2768928122","https://openalex.org/W2788048790","https://openalex.org/W2789293914","https://openalex.org/W2809040460","https://openalex.org/W2892656690","https://openalex.org/W2898289980","https://openalex.org/W2924756238","https://openalex.org/W2973046603","https://openalex.org/W2977136507","https://openalex.org/W2992133125","https://openalex.org/W2999362366","https://openalex.org/W3007450737","https://openalex.org/W3043752720","https://openalex.org/W4250941279"],"related_works":["https://openalex.org/W7140195688","https://openalex.org/W2977136507","https://openalex.org/W4387051947","https://openalex.org/W4383371511","https://openalex.org/W4415772189","https://openalex.org/W4413326018","https://openalex.org/W2582519800","https://openalex.org/W4386347268","https://openalex.org/W3184765148","https://openalex.org/W4417124676"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,50,62,186],"Chinese":[2,230],"medicine":[3],"Huangqi":[4],"Guizhi":[5],"Wuwu":[6],"Decoction":[7],"(HGWD)":[8],"has":[9],"been":[10],"reported":[11],"to":[12,35,83,112,177,192,201,223],"improve":[13],"the":[14,37,44,85,114,179,202],"clinical":[15],"symptoms":[16],"and":[17,42,58,71,104,148,169,175,207],"restore":[18],"nerve":[19],"function":[20],"after":[21,196],"ischemic":[22,197],"stroke;":[23],"however,":[24],"its":[25],"active":[26,119,226],"ingredients":[27,64,120],"are":[28],"not":[29],"well-determined.":[30],"Therefore,":[31],"this":[32],"study":[33,210],"aimed":[34],"investigate":[36,84],"bioactive":[38],"compounds":[39,126,153],"of":[40,47,87,117,188,190,204],"HGWD":[41,88,191],"explore":[43],"possible":[45],"mechanism":[46,187],"action.":[48],"METHODS:":[49],"methods,":[51],"including":[52],"live":[53],"HT22":[54,79,160],"cells,":[55],"solid-phase":[56],"extraction,":[57],"HPLC-MS/MS":[59,219],"were":[60,65,81,107,131],"utilized.":[61],"potential":[63,118,225],"identified":[66,132],"through":[67],"comparisons":[68],"with":[69,90,127,218],"literature":[70],"monomer":[72],"compounds.":[73],"Then,":[74],"oxygen-glucose":[75],"deprivation":[76],"reperfusion":[77],"(OGD/R)-treated":[78],"cells":[80],"utilized":[82],"effect":[86,157],"components":[89,227],"specific":[91,128],"binding":[92,129],"affinities.":[93],"Reactive":[94],"oxygen":[95],"species":[96],"(ROS),":[97],"superoxide":[98],"dismutase":[99],"(SOD),":[100],"lactate":[101],"dehydrogenase":[102],"(LDH),":[103],"Tunel":[105],"staining":[106],"used":[108],"as":[109,133],"testing":[110],"indexes":[111],"analyze":[113],"protective":[115,156],"effects":[116],"on":[121,158],"OGD/R-induced":[122],"damage.":[123],"RESULTS:":[124],"Eleven":[125],"affinities":[130],"calycosin-7-O-glucoside,":[134,163],"calycosin,":[135,164],"formononetin,":[136],"cinnamic":[137,139],"alcohol,":[138],"acid,":[140,143,145,167],"betaine,":[141],"dl-2-phenylpropionic":[142],"4-hydroxycinnamic":[144,166],"6-methylcoumarin,":[146],"wogonin,":[147,168],"paeoniflorin.":[149],"Among":[150],"them,":[151],"six":[152],"had":[154],"a":[155],"OGD/R-treated":[159],"cells.":[161],"Furthermore,":[162],"paeoniflorin,":[165],"formononetin":[170],"could":[171,220],"regulate":[172],"oxidative":[173,205],"stress":[174,206],"apoptosis":[176],"attenuate":[178],"cell":[180,213],"damage":[181],"caused":[182],"by":[183],"OGD/R.":[184],"CONCLUSION:":[185],"action":[189],"promote":[193],"neurological":[194],"recovery":[195],"stroke":[198],"was":[199],"related":[200],"regulation":[203],"apoptosis.":[208],"This":[209],"suggested":[211],"that":[212],"membrane":[214],"affinity":[215],"chromatography":[216],"combined":[217],"be":[221],"applied":[222],"screen":[224],"in":[228],"traditional":[229],"medicines":[231],"(TCM).":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}