{"id":"https://openalex.org/W4200599016","doi":"https://doi.org/10.1093/noajnl/vdab159.070","title":"NI-7 Diffusion-weighted imaging for monitoring acute response and recurrence after photodynamic therapy in malignant gliomas","display_name":"NI-7 Diffusion-weighted imaging for monitoring acute response and recurrence after photodynamic therapy in malignant gliomas","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200599016","doi":"https://doi.org/10.1093/noajnl/vdab159.070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8648157"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdab159.070","doi":"https://doi.org/10.1093/noajnl/vdab159.070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.070","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537123/vdab159.070.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537123/vdab159.070.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113904522","display_name":"Yuichi Fujita","orcid":"https://orcid.org/0000-0002-1944-0925","observed_orcids":["https://orcid.org/0000-0002-1944-0925"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Fujita","raw_affiliation_strings":["Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013776345","display_name":"Hiroaki Nagashima","orcid":"https://orcid.org/0000-0003-0685-7382","observed_orcids":["https://orcid.org/0000-0003-0685-7382"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Nagashima","raw_affiliation_strings":["Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064521416","display_name":"Kazuhiro Tanaka","orcid":"https://orcid.org/0000-0001-5862-560X","observed_orcids":["https://orcid.org/0000-0001-5862-560X"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Tanaka","raw_affiliation_strings":["Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050883503","display_name":"Mitsuru Hashiguchi","orcid":"https://orcid.org/0000-0003-2405-0400","observed_orcids":["https://orcid.org/0000-0003-2405-0400"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Hashiguchi","raw_affiliation_strings":["Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103431709","display_name":"Tomoo Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoo Itoh","raw_affiliation_strings":["Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003564265","display_name":"Takashi Sasayama","orcid":"https://orcid.org/0000-0002-5593-9045","observed_orcids":["https://orcid.org/0000-0002-5593-9045"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sasayama","raw_affiliation_strings":["Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":{"value":2142,"currency":"USD","value_usd":2142},"apc_paid":{"value":2142,"currency":"USD","value_usd":2142},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"Supplement_6","first_page":"vi19","last_page":"vi19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.7300000190734863},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.7059999704360962},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/dissemination","display_name":"dissemination","score":0.4169999957084656},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8502955436706543},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8411973118782043},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8343826532363892},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6292465925216675},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.508454442024231},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.4835209846496582},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.4683137834072113},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.44386714696884155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2787918448448181},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/noajnl/vdab159.070","doi":"https://doi.org/10.1093/noajnl/vdab159.070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.070","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537123/vdab159.070.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8648157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8648157/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdab159.070","doi":"https://doi.org/10.1093/noajnl/vdab159.070","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.070","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537123/vdab159.070.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200599016.pdf","grobid_xml":"https://content.openalex.org/works/W4200599016.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3168671597","https://openalex.org/W2990859831","https://openalex.org/W6889928918","https://openalex.org/W4310765785","https://openalex.org/W2969997764","https://openalex.org/W2085270148","https://openalex.org/W2134609589","https://openalex.org/W7125615100","https://openalex.org/W2574441046","https://openalex.org/W2012939329"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Photodynamic":[2],"therapy":[3],"(PDT)":[4],"subsequent":[5],"to":[6,45,85,241,276],"surgical":[7],"tumor":[8],"removal":[9],"is":[10],"a":[11,59,223],"novel":[12],"light-activated":[13],"localized":[14],"treatment":[15],"for":[16,120],"malignant":[17,33,43,104,121,259],"glioma.":[18,34,105],"Although":[19],"PDT":[20,26,46,102,119,137,262],"provides":[21],"effective":[22],"local":[23,30,198,214,256,293],"control,":[24],"even":[25],"cannot":[27],"completely":[28],"suppress":[29],"recurrence":[31,100,146,199,204,237,257,294],"of":[32,42,155,165,286],"We":[35,130],"previously":[36],"reported":[37],"that":[38,67,219],"the":[39,87,90,139,145,163,166,177,191,265,273,284],"acute":[40,97,274],"response":[41,98,275],"glioma":[44,122,260],"could":[47,281],"be":[48],"detected":[49,161],"as":[50,95,272],"linear":[51,152],"hyperintense":[52,91,153,224,244,268],"signals":[53,154],"on":[54,93,134,158,226,229,246,249,270],"diffusion-weighted":[55],"imaging":[56],"(DWI)":[57],"and":[58,70,99,128,138,144,180,208],"decline":[60],"in":[61,103,182,200,205,210,258,264,283],"apparent":[62],"diffusion":[63],"coefficient":[64],"(ADC)":[65],"values":[66],"were":[68,160],"asymptomatic":[69],"transient.":[71],"However,":[72],"their":[73],"long-term":[74],"clinical":[75],"significance":[76],"has":[77],"not":[78,221,287],"yet":[79],"been":[80],"examined.":[81],"This":[82,278],"study":[83],"aimed":[84],"clarify":[86],"link":[88,140],"between":[89,126,141],"signal":[92,132,225,245,269],"DWI":[94,135,159,227,247,271],"an":[96],"after":[101,136,172,232,252,261,296],"Methods":[106],"Thirty":[107],"consecutive":[108],"patients":[109],"(16":[110],"men,":[111],"14":[112],"women;":[113],"median":[114],"age":[115],"60.5":[116],"years)":[117],"underwent":[118],"at":[123,162],"our":[124],"institution":[125],"2017":[127],"2020.":[129],"analyzed":[131],"changes":[133,175],"these":[142],"findings":[143],"pattern.":[147],"Results":[148],"In":[149],"all":[150],"patients,":[151,193],"5\u20137":[156],"mm":[157],"surface":[164],"resected":[167],"cavity":[168],"from":[169,217],"day":[170,230,250],"1":[171,206,231,251],"PDT.":[173,233,253,277,297],"These":[174],"matched":[176],"PDT-irradiated":[178,289],"area":[179,290],"disappeared":[181],"about":[183],"30":[184,192],"days":[185],"without":[186,267],"any":[187],"neurological":[188],"deterioration.":[189],"Of":[190],"19":[194],"(63%)":[195],"exhibited":[196],"recurrence:":[197],"10":[201],"(33%),":[202],"distant":[203,236],"(3%),":[207],"dissemination":[209,239],"8":[211],"(27%).":[212],"All":[213],"recurrences":[215],"arose":[216],"areas":[218,266],"did":[220],"show":[222],"obtained":[228,248],"Patients":[234],"with":[235],"or":[238],"tended":[240],"have":[242],"uninterrupted":[243],"Conclusion":[254],"The":[255],"occurred":[263],"characteristic":[279],"finding":[280],"aid":[282],"monitoring":[285],"only":[288],"but":[291],"also":[292],"site":[295]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-12-31T00:00:00"}