{"id":"https://openalex.org/W4200577455","doi":"https://doi.org/10.3389/fnagi.2021.790926","title":"Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging","display_name":"Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4200577455","doi":"https://doi.org/10.3389/fnagi.2021.790926","pmid":"https://pubmed.ncbi.nlm.nih.gov/34975461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8714776"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2021.790926","doi":"https://doi.org/10.3389/fnagi.2021.790926","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.790926","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.790926/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.790926/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112388691","display_name":"Pei\u2010Lun Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei-Lun Kuo","raw_affiliation_strings":["Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057773277","display_name":"Ann Zenobia Moore","orcid":"https://orcid.org/0000-0002-1471-4253","observed_orcids":["https://orcid.org/0000-0002-1471-4253"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Zenobia Moore","raw_affiliation_strings":["Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102800323","display_name":"Frank Robert Lin","orcid":"https://orcid.org/0000-0002-6458-1196","observed_orcids":["https://orcid.org/0000-0002-6458-1196"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank R. Lin","raw_affiliation_strings":["Cochlear Center for Hearing and Public Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States","Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cochlear Center for Hearing and Public Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048196698","display_name":"Luigi Ferrucci","orcid":"https://orcid.org/0000-0002-6273-1613","observed_orcids":["https://orcid.org/0000-0002-6273-1613"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Luigi Ferrucci","raw_affiliation_strings":["Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048196698"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.0351,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86564299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"790926","last_page":"790926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.23989999294281006,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-age-acceleration","display_name":"epigenetic age acceleration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epigenetic-clocks","display_name":"epigenetic clocks","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hannum-clock","display_name":"Hannum clock","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.871999979019165},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dunedinpace","display_name":"DunedinPACE","score":0.7360000014305115},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4480000138282776},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7965985536575317},{"id":"https://openalex.org/C2779912225","wikidata":"https://www.wikidata.org/wiki/Q1756133","display_name":"Presbycusis","level":3,"score":0.7753893136978149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5632404685020447},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5011906623840332},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.48313114047050476},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.4828827679157257},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.4781511723995209},{"id":"https://openalex.org/C2779152698","wikidata":"https://www.wikidata.org/wiki/Q3095145","display_name":"Spiral ganglion","level":3,"score":0.4165991544723511},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3685632646083832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26701846718788147},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21632567048072815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0748395025730133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnagi.2021.790926","doi":"https://doi.org/10.3389/fnagi.2021.790926","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.790926","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.790926/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8714776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8714776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmid:34975461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34975461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:00b352b52bf9412c8daae1ad8d13337a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/00b352b52bf9412c8daae1ad8d13337a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2021.790926","doi":"https://doi.org/10.3389/fnagi.2021.790926","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.790926","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.790926/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310671","display_name":"Cochlear","ror":"https://ror.org/04hvmsy06"},{"id":"https://openalex.org/F4320332669","display_name":"Johns Hopkins Bloomberg School of Public Health","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200577455.pdf","grobid_xml":"https://content.openalex.org/works/W4200577455.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1974047233","https://openalex.org/W2080644309","https://openalex.org/W2101870168","https://openalex.org/W2121091193","https://openalex.org/W2171600170","https://openalex.org/W2508814107","https://openalex.org/W2808129762","https://openalex.org/W2892085335","https://openalex.org/W2909380116","https://openalex.org/W2912654909","https://openalex.org/W2949100461","https://openalex.org/W3008932332","https://openalex.org/W3012081632","https://openalex.org/W3022131036","https://openalex.org/W3046908609","https://openalex.org/W3116184317","https://openalex.org/W3138650208","https://openalex.org/W3158806857"],"related_works":["https://openalex.org/W7128027157","https://openalex.org/W7167788397","https://openalex.org/W3182320299","https://openalex.org/W7163358975","https://openalex.org/W4410641809","https://openalex.org/W7125749242","https://openalex.org/W4308072410","https://openalex.org/W7170155657","https://openalex.org/W2077856521","https://openalex.org/W4404671664"],"abstract_inverted_index":{"Objectives:":[0],"Age-related":[1],"hearing":[2,45,61,78,238],"loss":[3],"(ARHL)":[4],"is":[5,113,228],"highly":[6],"prevalent":[7],"among":[8],"older":[9],"adults,":[10],"but":[11],"the":[12,38,53,63,124,134,154,232,242],"potential":[13,233],"mechanisms":[14],"and":[15,35,44,59,76,103,130,151,200,239,248],"predictive":[16,30],"markers":[17],"for":[18,141,166,177,188,198,209],"ARHL":[19],"are":[20,86,222],"lacking.":[21],"Epigenetic":[22],"age":[23,42,57,88,94,97,128,219],"acceleration":[24,43,58,89,129,220],"has":[25],"been":[26],"shown":[27],"to":[28,51,122,230,240],"be":[29],"of":[31,67,106,237],"many":[32],"age-associated":[33],"diseases":[34],"mortality.":[36],"However,":[37],"association":[39,125],"between":[40,55,126,147,245],"epigenetic":[41,56,87,93,127,218],"remains":[46],"unknown.":[47],"Our":[48],"study":[49,214,231],"aims":[50],"investigate":[52,241],"relationship":[54,244],"audiometric":[60,77],"in":[62],"Baltimore":[64],"Longitudinal":[65],"Study":[66],"Aging":[68],"(BLSA).":[69],"Methods:":[70],"Participants":[71],"with":[72,224],"both":[73],"DNA":[74,246],"methylation":[75,247],"measurements":[79,221],"were":[80,157],"included.":[81],"The":[82,109,212],"main":[83,110],"independent":[84],"variables":[85],"measures,":[90],"including":[91],"intrinsic":[92],"acceleration\u2014\u201cIEAA,\u201d":[95],"Hannum":[96],"acceleration\u2014\u201cAgeAccelerationResidualHannum,\u201d":[98],"PhenoAge":[99],"acceleration\u2014\u201cAgeAccelPheno,\u201d":[100],"GrimAge":[101],"acceleration\u2014\u201cAgeAccelGrim,\u201d":[102],"methylation-based":[104],"pace":[105],"aging":[107],"estimation\u2014\u201cDunedinPoAm.\u201d":[108],"dependent":[111],"variable":[112],"speech-frequency":[114],"pure":[115],"tone":[116],"average.":[117],"Linear":[118],"regression":[119],"was":[120],"used":[121],"assess":[123],"hearing.":[131,225,249],"Results:":[132],"Among":[133],"236":[135],"participants":[136],"(52.5%":[137],"female),":[138],"after":[139],"adjusting":[140],"age,":[142],"sex,":[143],"race,":[144],"time":[145],"difference":[146],"measurements,":[148],"cardiovascular":[149,235],"factors,":[150],"smoking":[152],"history,":[153],"effect":[155],"sizes":[156],"0.11":[158],"995%":[159],"CI:":[160,171,182,192,203],"(\u20130.00,":[161],"0.23),":[162],"p":[163,174,185,195,206],"=":[164,175,186,196,207],"0.054]":[165],"Hannum\u2019s":[167],"clock,":[168,179],"0.08":[169],"[95%":[170,181,191,202],"(\u20130.03,":[172],"0.19),":[173],"0.143]":[176],"Horvath\u2019s":[178],"0.10":[180],"(\u20130.01,":[183],"0.21),":[184],"0.089]":[187],"PhenoAge,":[189],"0.20":[190],"(0.06,":[193],"0.33),":[194,205],"0.004]":[197],"GrimAge,":[199],"0.21":[201],"(0.09,":[204],"0.001]":[208],"DunedinPoAm.":[210],"Discussion:":[211],"present":[213],"suggests":[215],"that":[216],"some":[217],"associated":[223],"Future":[226],"research":[227],"needed":[229],"subclinical":[234],"causes":[236],"longitudinal":[243]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}
