{"id":"https://openalex.org/W4200569160","doi":"https://doi.org/10.7554/elife.72430.sa2","title":"Author response: Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages","display_name":"Author response: Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages","publication_year":2021,"publication_date":"2021-11-10","ids":{"openalex":"https://openalex.org/W4200569160","doi":"https://doi.org/10.7554/elife.72430.sa2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.72430.sa2","doi":"https://doi.org/10.7554/elife.72430.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72430.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.72430.sa2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060192149","display_name":"Marcia A. Munoz","orcid":"https://orcid.org/0000-0001-7603-0351","observed_orcids":["https://orcid.org/0000-0001-7603-0351"]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marcia A Munoz","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":"https://orcid.org/0000-0001-7603-0351","affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038086225","display_name":"Emma K. Fletcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Emma K Fletcher","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027370833","display_name":"Oliver P. Skinner","orcid":"https://orcid.org/0000-0003-0898-4131","observed_orcids":["https://orcid.org/0000-0003-0898-4131"]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Oliver P Skinner","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078004307","display_name":"Julie Jurczyluk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Julie Jurczyluk","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017032600","display_name":"Esther Kristianto","orcid":"https://orcid.org/0000-0001-8887-5175","observed_orcids":["https://orcid.org/0000-0001-8887-5175"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Esther Kristianto","raw_affiliation_strings":["Victor Chang Cardiac Research Institute Innovation Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute Innovation Centre","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034704867","display_name":"Mark P. Hodson","orcid":"https://orcid.org/0000-0002-5436-1886","observed_orcids":["https://orcid.org/0000-0002-5436-1886"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark P Hodson","raw_affiliation_strings":["School of Pharmacy, University of Queensland","Victor Chang Cardiac Research Institute Innovation Centre"],"raw_orcid":"https://orcid.org/0000-0002-5436-1886","affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Queensland","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Victor Chang Cardiac Research Institute Innovation Centre","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080904737","display_name":"Shuting Sun","orcid":"https://orcid.org/0000-0002-3635-9029","observed_orcids":["https://orcid.org/0000-0002-3635-9029"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210144182","display_name":"BioVinc (United States)","ror":"https://ror.org/04dk78q10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuting Sun","raw_affiliation_strings":["BioVinc","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioVinc","institution_ids":["https://openalex.org/I4210144182"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[{"id":"https://openalex.org/I4210144182","display_name":"BioVinc (United States)","ror":"https://ror.org/04dk78q10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank H Ebetino","raw_affiliation_strings":["BioVinc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioVinc","institution_ids":["https://openalex.org/I4210144182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051465312","display_name":"David R. Croucher","orcid":"https://orcid.org/0000-0003-4965-8674","observed_orcids":["https://orcid.org/0000-0003-4965-8674"]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David R Croucher","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":"https://orcid.org/0000-0003-4965-8674","affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076048446","display_name":"Philip M. Hansbro","orcid":"https://orcid.org/0000-0002-4741-3035","observed_orcids":["https://orcid.org/0000-0002-4741-3035"]},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Philip M Hansbro","raw_affiliation_strings":["Centre for Inflammation, Centenary Institute and University of Technology Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammation, Centenary Institute and University of Technology Sydney","institution_ids":["https://openalex.org/I114017466","https://openalex.org/I2800664540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081312172","display_name":"Michael J. Rogers","orcid":"https://orcid.org/0000-0002-1818-9249","observed_orcids":["https://orcid.org/0000-0002-1818-9249"]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael J Rogers","raw_affiliation_strings":["Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney"],"raw_orcid":"https://orcid.org/0000-0002-1818-9249","affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research and St Vincent\u2019s Clinical School, UNSW Sydney","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.4819999933242798},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":1.0},{"id":"https://openalex.org/keywords/early-immune-response","display_name":"early immune response","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.7020000219345093},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2779982574","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Mevalonate pathway","level":4,"score":0.7231571078300476},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.7004541754722595},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.4345090985298157},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4315446615219116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3726523518562317},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35157954692840576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32849812507629395},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.21039584279060364},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19449609518051147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16647112369537354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10463330149650574},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.0608467161655426},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.046580880880355835},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.72430.sa2","doi":"https://doi.org/10.7554/elife.72430.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72430.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.72430.sa2","doi":"https://doi.org/10.7554/elife.72430.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72430.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200501527","https://openalex.org/W6964789881","https://openalex.org/W2096648070","https://openalex.org/W2095070184","https://openalex.org/W2006203347","https://openalex.org/W2008279380","https://openalex.org/W4254586320","https://openalex.org/W2005039015","https://openalex.org/W2806783508","https://openalex.org/W2059086475"],"abstract_inverted_index":{"As":[0],"well":[1],"as":[2],"preventing":[3],"bone":[4],"loss,":[5],"bisphosphonate":[6],"drugs":[7],"may":[8],"boost":[9],"early":[10],"immune":[11],"responses":[12],"in":[13],"the":[14,26],"lung":[15],"by":[16],"acting":[17],"directly":[18],"on":[19],"alveolar":[20],"macrophages":[21],"that":[22],"form":[23],"one":[24],"of":[25,29],"first":[27],"lines":[28],"defence":[30],"against":[31],"infection.":[32]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2021-12-31T00:00:00"}
