{"id":"https://openalex.org/W4200566305","doi":"https://doi.org/10.1080/01490451.2021.2005186","title":"Enhanced Anti-E. coli ST131 Metabolites Production by a Novel Streptomyces sp. CMB51 Strain Isolated from a Coal Mininig Soil Using Statistical Optimization","display_name":"Enhanced Anti-E. coli ST131 Metabolites Production by a Novel Streptomyces sp. CMB51 Strain Isolated from a Coal Mininig Soil Using Statistical Optimization","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200566305","doi":"https://doi.org/10.1080/01490451.2021.2005186"},"language":"en","primary_location":{"id":"doi:10.1080/01490451.2021.2005186","doi":"https://doi.org/10.1080/01490451.2021.2005186","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01490451.2021.2005186","pdf_url":null,"source":{"id":"https://openalex.org/S65040752","display_name":"Geomicrobiology Journal","issn_l":"0149-0451","issn":["0149-0451","1521-0529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geomicrobiology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033863734","display_name":"Ibtissem Djinni","orcid":"https://orcid.org/0000-0002-1485-8695","observed_orcids":["https://orcid.org/0000-0002-1485-8695"]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Ibtissem Djinni","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009625155","display_name":"Warda Djoudi","orcid":"https://orcid.org/0000-0001-8822-1921","observed_orcids":["https://orcid.org/0000-0001-8822-1921","https://orcid.org/0000-0002-9502-5192"]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Warda Djoudi","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048909844","display_name":"Nadia Harfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Nadia Harfi","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016139777","display_name":"Imene Stambouli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Imene Stambouli","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066051079","display_name":"Sara Khamtache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Sara Khamtache","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022494878","display_name":"Djaouida Makhlouf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Djaouida Makhlouf","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084165162","display_name":"Betitera Yanat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Betitera Yanat","raw_affiliation_strings":["Laboratoire de Biotechnologie V\u00e9g\u00e9tale et Ethnobotanique, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biotechnologie V\u00e9g\u00e9tale et Ethnobotanique, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064068769","display_name":"Samiha Souagui","orcid":"https://orcid.org/0000-0003-2472-8648","observed_orcids":["https://orcid.org/0000-0003-2472-8648"]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Samiha Souagui","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028036875","display_name":"Mouloud Kecha","orcid":"https://orcid.org/0000-0002-8836-3281","observed_orcids":["https://orcid.org/0000-0002-8836-3281"]},"institutions":[{"id":"https://openalex.org/I187560010","display_name":"University of B\u00e9ja\u00efa","ror":"https://ror.org/03yb2hp88","country_code":"DZ","type":"education","lineage":["https://openalex.org/I187560010"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Mouloud Kecha","raw_affiliation_strings":["Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, D\u00e9partement de Microbiologie, Universit\u00e9 de Bejaia, Bejaia, Algeria","institution_ids":["https://openalex.org/I187560010"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033863734"],"corresponding_institution_ids":["https://openalex.org/I187560010"],"apc_list":null,"apc_paid":null,"fwci":0.31,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.42934783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"39","issue":"1","first_page":"39","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-metabolites","display_name":"antimicrobial metabolites","score":0.7519999742507935},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.6620000004768372},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.8809999823570251},{"id":"https://openalex.org/keywords/response-surface-methodology","display_name":"response surface methodology","score":0.5090000033378601},{"id":"https://openalex.org/keywords/plackett-burman-design","display_name":"Plackett-Burman design","score":0.8230000138282776},{"id":"https://openalex.org/keywords/central-composite-design","display_name":"central composite design","score":0.8220000267028809},{"id":"https://openalex.org/keywords/16s-rrna-gene-identification","display_name":"16S rRNA identification","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.7544921636581421},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7084444761276245},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6787097454071045},{"id":"https://openalex.org/C2778169975","wikidata":"https://www.wikidata.org/wiki/Q130914","display_name":"Actinobacteria","level":4,"score":0.6635065078735352},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.6505899429321289},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5855592489242554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5597330927848816},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5584067106246948},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5529963970184326},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5422878861427307},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.4859093725681305},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.45840907096862793},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4466627836227417},{"id":"https://openalex.org/C143701427","wikidata":"https://www.wikidata.org/wiki/Q193566","display_name":"Incubation period","level":3,"score":0.42637479305267334},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.33884885907173157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27993112802505493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23164072632789612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.197559654712677},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1772536039352417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/01490451.2021.2005186","doi":"https://doi.org/10.1080/01490451.2021.2005186","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01490451.2021.2005186","pdf_url":null,"source":{"id":"https://openalex.org/S65040752","display_name":"Geomicrobiology Journal","issn_l":"0149-0451","issn":["0149-0451","1521-0529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geomicrobiology Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321424","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","ror":"https://ror.org/01ejfgc23"},{"id":"https://openalex.org/F4320335007","display_name":"Direction G\u00e9n\u00e9rale de la Recherche Scientifique et du D\u00e9veloppement Technologique","ror":"https://ror.org/04jpfrv51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1523752572","https://openalex.org/W1969503463","https://openalex.org/W1973354211","https://openalex.org/W1974618838","https://openalex.org/W1980535445","https://openalex.org/W2006901874","https://openalex.org/W2037378264","https://openalex.org/W2046606957","https://openalex.org/W2072751268","https://openalex.org/W2073079522","https://openalex.org/W2088238875","https://openalex.org/W2091912663","https://openalex.org/W2096930675","https://openalex.org/W2129740570","https://openalex.org/W2132531447","https://openalex.org/W2140000624","https://openalex.org/W2144634347","https://openalex.org/W2167718088","https://openalex.org/W2171594527","https://openalex.org/W2178324140","https://openalex.org/W2285949578","https://openalex.org/W2338595164","https://openalex.org/W2411694425","https://openalex.org/W2582170541","https://openalex.org/W2609691463","https://openalex.org/W2620635074","https://openalex.org/W2798220052","https://openalex.org/W2884576567","https://openalex.org/W2904282688","https://openalex.org/W2947021121","https://openalex.org/W2962202409","https://openalex.org/W2979228428","https://openalex.org/W2990516012","https://openalex.org/W3042047911","https://openalex.org/W4205170784","https://openalex.org/W4251156702","https://openalex.org/W4298161061"],"related_works":["https://openalex.org/W2609691463","https://openalex.org/W2540585480","https://openalex.org/W2626814242","https://openalex.org/W4383877651","https://openalex.org/W2031690929","https://openalex.org/W7202162892","https://openalex.org/W2546642824","https://openalex.org/W1797672761","https://openalex.org/W3195908310","https://openalex.org/W4378189393"],"abstract_inverted_index":{"Actinobacteria":[0],"strains":[1],"isolated":[2],"from":[3],"coil":[4],"mining":[5],"soil":[6],"of":[7,128,135,144,149,167,179,193,196],"Bechar":[8],"region,":[9],"Algeria,":[10],"were":[11,95],"evaluated":[12],"for":[13,190],"their":[14],"antimicrobial":[15,34],"potential":[16],"against":[17,21,42],"pathogenic":[18],"germs":[19],"particularly":[20],"uropathogenic":[22],"multiresistant":[23],"Escherichia":[24],"coli":[25,44,130,198],"ST131.":[26],"Of":[27],"the":[28,69,122,126,136,176,194],"119":[29],"isolates,":[30],"82":[31],"exhibited":[32],"potent":[33],"properties.":[35],"The":[36,64,133,161,185],"strain":[37,79],"that":[38],"showed":[39],"maximum":[40,89],"inhibition":[41],"E.":[43],"ST131":[45,131,199],"was":[46,66,140,171,188],"further":[47,191],"screened":[48],"toward":[49],"nine":[50],"bacterial":[51],"pathogens":[52],"and":[53,59,81,103,111,116,156],"identified":[54],"based":[55],"on":[56],"morphological,":[57],"physiological":[58],"16S":[60],"rRNA":[61],"gene":[62],"sequencing.":[63],"isolate":[65],"related":[67],"to":[68,76],"genus":[70],"Streptomyces":[71,77,84],"with":[72,175],"99.46%":[73],"sequence":[74],"similarity":[75],"klenkii":[78],"S2704T":[80],"assigned":[82],"as":[83,121],"sp.":[85],"CMB51.":[86],"To":[87],"achieve":[88],"metabolites":[90],"production,":[91],"significant":[92,124],"process":[93],"parameters":[94],"optimized":[96,138],"through":[97],"response":[98],"surface":[99],"methodology":[100],"employing":[101],"Plackett\u2013Burman":[102],"Central":[104],"Composite":[105],"designs.":[106],"In":[107],"PBD":[108],"experiments,":[109],"starch":[110,142],"casein":[112,147],"concentrations,":[113],"incubation":[114,154],"time":[115,155],"initial":[117,158],"pH":[118,159],"value":[119,178],"emerged":[120],"most":[123],"affecting":[125],"output":[127],"anti-E.":[129,197],"activity.":[132],"composition":[134],"final":[137],"medium":[139],"soluble":[141],"concentration":[143,148],"5.31":[145],"g/L,":[146,151],"0.45":[150],"3":[152],"days":[153],"8.41":[157],"value.":[160],"optimization":[162],"resulted":[163],"an":[164],"antibacterial":[165],"activity":[166],"13":[168],"mm":[169,181],"which":[170],"in":[172],"close":[173],"accordance":[174],"predicted":[177],"13.60":[180],"recording":[182],"18.18%":[183],"increase.":[184],"chosen":[186],"method":[187],"efficient":[189],"investigations":[192],"production":[195],"metabolites.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}