{"id":"https://openalex.org/W4200564759","doi":"https://doi.org/10.1002/mco2.100","title":"Tumor metastasis: Mechanistic insights and therapeutic interventions","display_name":"Tumor metastasis: Mechanistic insights and therapeutic interventions","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200564759","doi":"https://doi.org/10.1002/mco2.100","pmid":"https://pubmed.ncbi.nlm.nih.gov/34977870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8706758"},"language":"en","primary_location":{"id":"doi:10.1002/mco2.100","doi":"https://doi.org/10.1002/mco2.100","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.100","pdf_url":null,"source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/mco2.100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100333907","display_name":"Mengmeng Liu","orcid":"https://orcid.org/0000-0002-0432-9386","observed_orcids":["https://orcid.org/0000-0002-0432-9386"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengmeng Liu","raw_affiliation_strings":["Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449595","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0001-8410-3549","observed_orcids":["https://orcid.org/0000-0001-8410-3549"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088393463","display_name":"Bu-Shu Xu","orcid":"https://orcid.org/0009-0001-0889-6169","observed_orcids":["https://orcid.org/0009-0001-0889-6169"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bushu Xu","raw_affiliation_strings":["Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100399153","display_name":"Xing Zhang","orcid":"https://orcid.org/0000-0003-2665-6940","observed_orcids":["https://orcid.org/0000-0003-2665-6940"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Zhang","raw_affiliation_strings":["Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100399153"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":1.9626,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.8989071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"4","first_page":"587","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anoikis-resistance","display_name":"anoikis resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9929999709129333},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cancer-dissemination","display_name":"cancer dissemination","score":0.5569999814033508},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metastasis-mechanisms","display_name":"metastasis mechanisms","score":0.7739999890327454},{"id":"https://openalex.org/keywords/metastasis-treatment","display_name":"metastasis treatment","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.8362205028533936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5966899991035461},{"id":"https://openalex.org/C152000582","wikidata":"https://www.wikidata.org/wiki/Q567522","display_name":"Anoikis","level":4,"score":0.5889465808868408},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.5800017714500427},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5468471050262451},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.531938374042511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5161062479019165},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5152140259742737},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.49348747730255127},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.47465020418167114},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4679020345211029},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.43941304087638855},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4243602752685547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23918044567108154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17512193322181702},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/mco2.100","doi":"https://doi.org/10.1002/mco2.100","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.100","pdf_url":null,"source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8706758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8706758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm (2020)","raw_type":"Text"},{"id":"pmid:34977870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34977870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2ab2b135c73451fbf8604be347f0389","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b2ab2b135c73451fbf8604be347f0389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MedComm, Vol 2, Iss 4, Pp 587-617 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/mco2.100","doi":"https://doi.org/10.1002/mco2.100","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.100","pdf_url":null,"source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1297702955","display_name":null,"funder_award_id":"82072958","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2888585503","display_name":null,"funder_award_id":"2020M683119","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6659275059","display_name":null,"funder_award_id":"81772863","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":414,"referenced_works":["https://openalex.org/W161541381","https://openalex.org/W830230436","https://openalex.org/W983362279","https://openalex.org/W1269896974","https://openalex.org/W1523693806","https://openalex.org/W1551186235","https://openalex.org/W1775309324","https://openalex.org/W1849720919","https://openalex.org/W1879925438","https://openalex.org/W1903388451","https://openalex.org/W1904885158","https://openalex.org/W1905956901","https://openalex.org/W1908116487","https://openalex.org/W1964081206","https://openalex.org/W1964405387","https://openalex.org/W1969909442","https://openalex.org/W1970637701","https://openalex.org/W1971873096","https://openalex.org/W1971892663","https://openalex.org/W1975426777","https://openalex.org/W1976520103","https://openalex.org/W1979783084","https://openalex.org/W1984526943","https://openalex.org/W1985124617","https://openalex.org/W1985727076","https://openalex.org/W1987473368","https://openalex.org/W1989908520","https://openalex.org/W1991105254","https://openalex.org/W1992804143","https://openalex.org/W1996362044","https://openalex.org/W1996630132","https://openalex.org/W1997944395","https://openalex.org/W1998791089","https://openalex.org/W1998943082","https://openalex.org/W1999203398","https://openalex.org/W1999356404","https://openalex.org/W2001868807","https://openalex.org/W2003870059","https://openalex.org/W2007663061","https://openalex.org/W2007897263","https://openalex.org/W2008514427","https://openalex.org/W2009338130","https://openalex.org/W2010417415","https://openalex.org/W2010542459","https://openalex.org/W2014691022","https://openalex.org/W2015512331","https://openalex.org/W2016227239","https://openalex.org/W2016464470","https://openalex.org/W2016968561","https://openalex.org/W2019221616","https://openalex.org/W2024060067","https://openalex.org/W2025252202","https://openalex.org/W2027260842","https://openalex.org/W2027518405","https://openalex.org/W2028205153","https://openalex.org/W2033278321","https://openalex.org/W2037236573","https://openalex.org/W2041627592","https://openalex.org/W2044748328","https://openalex.org/W2048067731","https://openalex.org/W2049824915","https://openalex.org/W2050516456","https://openalex.org/W2055971882","https://openalex.org/W2058648826","https://openalex.org/W2059036087","https://openalex.org/W2059688175","https://openalex.org/W2060953438","https://openalex.org/W2062070329","https://openalex.org/W2064263210","https://openalex.org/W2067708052","https://openalex.org/W2067740832","https://openalex.org/W2069380387","https://openalex.org/W2070338369","https://openalex.org/W2074470232","https://openalex.org/W2076271925","https://openalex.org/W2078428458","https://openalex.org/W2078481843","https://openalex.org/W2079580613","https://openalex.org/W2082239705","https://openalex.org/W2083452155","https://openalex.org/W2084863590","https://openalex.org/W2087367170","https://openalex.org/W2089370460","https://openalex.org/W2089449542","https://openalex.org/W2092893236","https://openalex.org/W2093608608","https://openalex.org/W2093921289","https://openalex.org/W2094302288","https://openalex.org/W2096625946","https://openalex.org/W2097478351","https://openalex.org/W2097862336","https://openalex.org/W2099817731","https://openalex.org/W2101776780","https://openalex.org/W2101973145","https://openalex.org/W2102251969","https://openalex.org/W2104104624","https://openalex.org/W2104934425","https://openalex.org/W2104966044","https://openalex.org/W2106294189","https://openalex.org/W2107462637","https://openalex.org/W2111479290","https://openalex.org/W2112057120","https://openalex.org/W2114600625","https://openalex.org/W2116576993","https://openalex.org/W2117225762","https://openalex.org/W2117692326","https://openalex.org/W2119808986","https://openalex.org/W2121800941","https://openalex.org/W2125000296","https://openalex.org/W2127625280","https://openalex.org/W2128035403","https://openalex.org/W2128619556","https://openalex.org/W2129124145","https://openalex.org/W2130486170","https://openalex.org/W2132979301","https://openalex.org/W2135376666","https://openalex.org/W2140882198","https://openalex.org/W2140995313","https://openalex.org/W2141363604","https://openalex.org/W2141815918","https://openalex.org/W2142644858","https://openalex.org/W2146147581","https://openalex.org/W2147968481","https://openalex.org/W2149596433","https://openalex.org/W2151948621","https://openalex.org/W2153613808","https://openalex.org/W2156051913","https://openalex.org/W2156323704","https://openalex.org/W2157096314","https://openalex.org/W2157669002","https://openalex.org/W2157962067","https://openalex.org/W2158620813","https://openalex.org/W2158965678","https://openalex.org/W2159754384","https://openalex.org/W2159803625","https://openalex.org/W2165097920","https://openalex.org/W2165118132","https://openalex.org/W2166395246","https://openalex.org/W2166662937","https://openalex.org/W2168887286","https://openalex.org/W2169770122","https://openalex.org/W2187985754","https://openalex.org/W2193074466","https://openalex.org/W2215718728","https://openalex.org/W2216341974","https://openalex.org/W2253760272","https://openalex.org/W2256481109","https://openalex.org/W2257520046","https://openalex.org/W2263613603","https://openalex.org/W2315243978","https://openalex.org/W2331667420","https://openalex.org/W2337230445","https://openalex.org/W2341044585","https://openalex.org/W2344189616","https://openalex.org/W2404527505","https://openalex.org/W2407627822","https://openalex.org/W2440111950","https://openalex.org/W2467346023","https://openalex.org/W2469788238","https://openalex.org/W2487348170","https://openalex.org/W2488603650","https://openalex.org/W2501557717","https://openalex.org/W2513990794","https://openalex.org/W2522630089","https://openalex.org/W2526747727","https://openalex.org/W2530135307","https://openalex.org/W2533763458","https://openalex.org/W2551893887","https://openalex.org/W2557222435","https://openalex.org/W2557607078","https://openalex.org/W2560367415","https://openalex.org/W2560396365","https://openalex.org/W2566052798","https://openalex.org/W2572174216","https://openalex.org/W2581279204","https://openalex.org/W2586407709","https://openalex.org/W2586679548","https://openalex.org/W2587816384","https://openalex.org/W2592785733","https://openalex.org/W2596133050","https://openalex.org/W2603666401","https://openalex.org/W2603969536","https://openalex.org/W2605607341","https://openalex.org/W2606111706","https://openalex.org/W2611270905","https://openalex.org/W2616374826","https://openalex.org/W2625169067","https://openalex.org/W2625600561","https://openalex.org/W2625859437","https://openalex.org/W2625891699","https://openalex.org/W2640380310","https://openalex.org/W2648296251","https://openalex.org/W2726460771","https://openalex.org/W2729948572","https://openalex.org/W2734740032","https://openalex.org/W2738996050","https://openalex.org/W2741183042","https://openalex.org/W2741389799","https://openalex.org/W2742865544","https://openalex.org/W2744578405","https://openalex.org/W2746147763","https://openalex.org/W2750434008","https://openalex.org/W2753432434","https://openalex.org/W2753490666","https://openalex.org/W2754995492","https://openalex.org/W2760780444","https://openalex.org/W2764326999","https://openalex.org/W2768338741","https://openalex.org/W2781945015","https://openalex.org/W2781947653","https://openalex.org/W2783370150","https://openalex.org/W2786031287","https://openalex.org/W2789078890","https://openalex.org/W2791238394","https://openalex.org/W2793124274","https://openalex.org/W2793277547","https://openalex.org/W2793755888","https://openalex.org/W2794022348","https://openalex.org/W2795616169","https://openalex.org/W2796582438","https://openalex.org/W2797208961","https://openalex.org/W2803810965","https://openalex.org/W2805354595","https://openalex.org/W2808109470","https://openalex.org/W2809263068","https://openalex.org/W2810086371","https://openalex.org/W2815290681","https://openalex.org/W2847139828","https://openalex.org/W2870890742","https://openalex.org/W2884691005","https://openalex.org/W2885239461","https://openalex.org/W2887245816","https://openalex.org/W2888554859","https://openalex.org/W2889523320","https://openalex.org/W2889570909","https://openalex.org/W2889781468","https://openalex.org/W2891884133","https://openalex.org/W2892640821","https://openalex.org/W2894451493","https://openalex.org/W2894759458","https://openalex.org/W2895390950","https://openalex.org/W2895949406","https://openalex.org/W2896652675","https://openalex.org/W2898435366","https://openalex.org/W2898526755","https://openalex.org/W2899783716","https://openalex.org/W2900489118","https://openalex.org/W2905006914","https://openalex.org/W2906932524","https://openalex.org/W2908198004","https://openalex.org/W2908683838","https://openalex.org/W2911526204","https://openalex.org/W2912349490","https://openalex.org/W2912696928","https://openalex.org/W2912740498","https://openalex.org/W2913599997","https://openalex.org/W2913745075","https://openalex.org/W2914524806","https://openalex.org/W2914619843","https://openalex.org/W2918050559","https://openalex.org/W2918171974","https://openalex.org/W2918494696","https://openalex.org/W2921982580","https://openalex.org/W2932807328","https://openalex.org/W2936557674","https://openalex.org/W2939856144","https://openalex.org/W2940057770","https://openalex.org/W2941109595","https://openalex.org/W2941548908","https://openalex.org/W2943740372","https://openalex.org/W2943922648","https://openalex.org/W2945629214","https://openalex.org/W2946860111","https://openalex.org/W2947165726","https://openalex.org/W2954196577","https://openalex.org/W2960078024","https://openalex.org/W2962221292","https://openalex.org/W2963568636","https://openalex.org/W2964143382","https://openalex.org/W2964168587","https://openalex.org/W2964876593","https://openalex.org/W2965794029","https://openalex.org/W2967026559","https://openalex.org/W2967278186","https://openalex.org/W2967713987","https://openalex.org/W2967880518","https://openalex.org/W2968361635","https://openalex.org/W2969511990","https://openalex.org/W2970237571","https://openalex.org/W2971701160","https://openalex.org/W2972005444","https://openalex.org/W2972480782","https://openalex.org/W2973041084","https://openalex.org/W2973169637","https://openalex.org/W2975736787","https://openalex.org/W2976432085","https://openalex.org/W2977511465","https://openalex.org/W2979519501","https://openalex.org/W2979972034","https://openalex.org/W2979979888","https://openalex.org/W2981563963","https://openalex.org/W2981815608","https://openalex.org/W2984717591","https://openalex.org/W2986438911","https://openalex.org/W2986930487","https://openalex.org/W2987385271","https://openalex.org/W2987834130","https://openalex.org/W2991932560","https://openalex.org/W2992258096","https://openalex.org/W2995440672","https://openalex.org/W2995643897","https://openalex.org/W2995646856","https://openalex.org/W2996435406","https://openalex.org/W2996952632","https://openalex.org/W2999417355","https://openalex.org/W3000361261","https://openalex.org/W3003599806","https://openalex.org/W3003977949","https://openalex.org/W3004108195","https://openalex.org/W3006096871","https://openalex.org/W3007902813","https://openalex.org/W3008601088","https://openalex.org/W3010839046","https://openalex.org/W3011557100","https://openalex.org/W3011604393","https://openalex.org/W3012033976","https://openalex.org/W3013347515","https://openalex.org/W3014209163","https://openalex.org/W3016275977","https://openalex.org/W3016840787","https://openalex.org/W3018758687","https://openalex.org/W3021653703","https://openalex.org/W3022527720","https://openalex.org/W3022711511","https://openalex.org/W3025990150","https://openalex.org/W3026499341","https://openalex.org/W3028703234","https://openalex.org/W3034422358","https://openalex.org/W3035033806","https://openalex.org/W3037638848","https://openalex.org/W3039384063","https://openalex.org/W3041271367","https://openalex.org/W3042467660","https://openalex.org/W3043464740","https://openalex.org/W3043916743","https://openalex.org/W3046395306","https://openalex.org/W3047170875","https://openalex.org/W3048942453","https://openalex.org/W3049152128","https://openalex.org/W3060747957","https://openalex.org/W3080850044","https://openalex.org/W3082212681","https://openalex.org/W3085860981","https://openalex.org/W3088473918","https://openalex.org/W3090329944","https://openalex.org/W3092966039","https://openalex.org/W3093270998","https://openalex.org/W3093708469","https://openalex.org/W3093892656","https://openalex.org/W3094330219","https://openalex.org/W3094711595","https://openalex.org/W3095002745","https://openalex.org/W3095015438","https://openalex.org/W3095022149","https://openalex.org/W3096836913","https://openalex.org/W3104812339","https://openalex.org/W3106021040","https://openalex.org/W3106439440","https://openalex.org/W3108001384","https://openalex.org/W3109064276","https://openalex.org/W3109418138","https://openalex.org/W3109741298","https://openalex.org/W3110629027","https://openalex.org/W3110807933","https://openalex.org/W3112393471","https://openalex.org/W3116467632","https://openalex.org/W3118120466","https://openalex.org/W3118567642","https://openalex.org/W3123371217","https://openalex.org/W3125466252","https://openalex.org/W3128133748","https://openalex.org/W3129406766","https://openalex.org/W3130256567","https://openalex.org/W3131063362","https://openalex.org/W3133035964","https://openalex.org/W3134421888","https://openalex.org/W3134615780","https://openalex.org/W3135376681","https://openalex.org/W3135497466","https://openalex.org/W3136229381","https://openalex.org/W3153686217","https://openalex.org/W3157087909","https://openalex.org/W3160773213","https://openalex.org/W3161652808","https://openalex.org/W3162463291","https://openalex.org/W3164524213","https://openalex.org/W3165355169","https://openalex.org/W3165395145","https://openalex.org/W3171073588","https://openalex.org/W3173064115","https://openalex.org/W3173614841","https://openalex.org/W3176314022","https://openalex.org/W3177026414","https://openalex.org/W3178699757","https://openalex.org/W3180038303","https://openalex.org/W3181897264","https://openalex.org/W3185458922","https://openalex.org/W3185875607","https://openalex.org/W3192345244","https://openalex.org/W3208188115","https://openalex.org/W4234756224","https://openalex.org/W4245503015","https://openalex.org/W4255724971","https://openalex.org/W6646686076"],"related_works":["https://openalex.org/W4401280276","https://openalex.org/W2619715073","https://openalex.org/W4416676658","https://openalex.org/W4386356325","https://openalex.org/W4407652716","https://openalex.org/W2022233074","https://openalex.org/W4401267040","https://openalex.org/W2093821311","https://openalex.org/W7140140961","https://openalex.org/W2055878176"],"abstract_inverted_index":{"Cancer":[0,40],"metastasis":[1,41,155,169],"is":[2,42,141],"responsible":[3],"for":[4,180],"the":[5,19,24,27,30,34,52,62,73,83,102,129,138,154,158,165,175],"vast":[6],"majority":[7],"of":[8,26,33,61,69,105,153,170],"cancer-related":[9],"deaths":[10],"worldwide.":[11],"In":[12,99,146],"contrast":[13],"to":[14,23,76,101],"numerous":[15],"discoveries":[16],"that":[17],"reveal":[18],"detailed":[20],"mechanisms":[21,162],"leading":[22],"formation":[25],"primary":[28,53],"tumor,":[29,54],"biological":[31],"underpinnings":[32],"metastatic":[35,126],"disease":[36],"remain":[37],"poorly":[38],"understood.":[39],"a":[43],"complex":[44],"process":[45],"in":[46,82,96,123,164,178],"which":[47],"cancer":[48,91,130,171,181],"cells":[49,71,92],"escape":[50],"from":[51,144],"settle,":[55],"and":[56,66,79,86,110,118,160,167,173],"grow":[57],"at":[58],"other":[59],"parts":[60],"body.":[63],"Epithelial-mesenchymal":[64],"transition":[65],"anoikis":[67],"resistance":[68],"tumor":[70,84,106],"are":[72,93],"main":[74],"forces":[75],"promote":[77],"metastasis,":[78],"multiple":[80],"components":[81],"microenvironment":[85],"their":[87],"complicated":[88],"crosstalk":[89],"with":[90,125],"closely":[94],"involved":[95,163],"distant":[97,168],"metastasis.":[98,182],"addition":[100],"three":[103],"cornerstones":[104],"treatment,":[107],"surgery,":[108],"chemotherapy,":[109],"radiotherapy,":[111],"novel":[112],"treatment":[113],"approaches":[114],"including":[115],"targeted":[116],"therapy":[117],"immunotherapy":[119],"have":[120],"been":[121,134],"established":[122],"patients":[124],"cancer.":[127],"Although":[128],"survival":[131],"rate":[132],"has":[133],"greatly":[135],"improved":[136],"over":[137],"years,":[139],"it":[140],"still":[142],"far":[143],"satisfactory.":[145],"this":[147],"review,":[148],"we":[149],"provided":[150],"an":[151],"overview":[152],"process,":[156],"summarized":[157],"cellular":[159],"molecular":[161],"dissemination":[166],"cells,":[172],"reviewed":[174],"important":[176],"advances":[177],"interventions":[179]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":11}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-12-31T00:00:00"}