{"id":"https://openalex.org/W4200548855","doi":"https://doi.org/10.3389/fphar.2021.749945","title":"Nanocarrier-Based Approaches for the Efficient Delivery of Anti-Tubercular Drugs and Vaccines for Management of Tuberculosis","display_name":"Nanocarrier-Based Approaches for the Efficient Delivery of Anti-Tubercular Drugs and Vaccines for Management of Tuberculosis","publication_year":2021,"publication_date":"2021-12-21","ids":{"openalex":"https://openalex.org/W4200548855","doi":"https://doi.org/10.3389/fphar.2021.749945","pmid":"https://pubmed.ncbi.nlm.nih.gov/34992530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8724553"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2021.749945","doi":"https://doi.org/10.3389/fphar.2021.749945","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.749945","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.749945/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.749945/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020048496","display_name":"Amarjitsing Rajput","orcid":"https://orcid.org/0000-0003-2103-2127","observed_orcids":["https://orcid.org/0000-0003-2103-2127"]},"institutions":[{"id":"https://openalex.org/I887998513","display_name":"Bharati Vidyapeeth (Deemed to be University)","ror":"https://ror.org/0052mmx10","country_code":"IN","type":"education","lineage":["https://openalex.org/I887998513"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amarjitsing Rajput","raw_affiliation_strings":["Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India","institution_ids":["https://openalex.org/I887998513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039919339","display_name":"Satish K. Mandlik","orcid":"https://orcid.org/0000-0003-4699-2167","observed_orcids":["https://orcid.org/0000-0003-4699-2167"]},"institutions":[{"id":"https://openalex.org/I887998513","display_name":"Bharati Vidyapeeth (Deemed to be University)","ror":"https://ror.org/0052mmx10","country_code":"IN","type":"education","lineage":["https://openalex.org/I887998513"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satish Mandlik","raw_affiliation_strings":["Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India","institution_ids":["https://openalex.org/I887998513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088183107","display_name":"Varsha Pokharkar","orcid":"https://orcid.org/0000-0001-5464-9620","observed_orcids":["https://orcid.org/0000-0001-5464-9620","https://orcid.org/0000-0003-1185-0847","https://orcid.org/0000-0001-5438-0297"]},"institutions":[{"id":"https://openalex.org/I887998513","display_name":"Bharati Vidyapeeth (Deemed to be University)","ror":"https://ror.org/0052mmx10","country_code":"IN","type":"education","lineage":["https://openalex.org/I887998513"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Varsha Pokharkar","raw_affiliation_strings":["Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune, India","institution_ids":["https://openalex.org/I887998513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088183107"],"corresponding_institution_ids":["https://openalex.org/I887998513"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.2161,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.14787701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"749945","last_page":"749945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.8740000128746033},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7229999899864197},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tuberculosis-vaccine","display_name":"tuberculosis vaccine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/macrophage-targeting","display_name":"macrophage targeting","score":0.8700000047683716},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.9758782386779785},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.758133053779602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6082393527030945},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5838724374771118},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5622764825820923},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.5352180004119873},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.4768066108226776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4760339558124542},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3664170503616333},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11639341711997986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05729752779006958}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2021.749945","doi":"https://doi.org/10.3389/fphar.2021.749945","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.749945","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.749945/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:34992530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34992530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8724553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8724553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ea449eeee9244382ad1a7d563a7d401c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea449eeee9244382ad1a7d563a7d401c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2021.749945","doi":"https://doi.org/10.3389/fphar.2021.749945","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.749945","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.749945/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200548855.pdf","grobid_xml":"https://content.openalex.org/works/W4200548855.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W808915020","https://openalex.org/W911267903","https://openalex.org/W1689426281","https://openalex.org/W1975361143","https://openalex.org/W1975845832","https://openalex.org/W1976180415","https://openalex.org/W1980802044","https://openalex.org/W1985966294","https://openalex.org/W1989882741","https://openalex.org/W2026969625","https://openalex.org/W2031525198","https://openalex.org/W2044020341","https://openalex.org/W2054273338","https://openalex.org/W2065781730","https://openalex.org/W2071588478","https://openalex.org/W2076452452","https://openalex.org/W2092363851","https://openalex.org/W2093255846","https://openalex.org/W2105121917","https://openalex.org/W2108538024","https://openalex.org/W2117487911","https://openalex.org/W2132960805","https://openalex.org/W2134675926","https://openalex.org/W2146140226","https://openalex.org/W2147467826","https://openalex.org/W2150820813","https://openalex.org/W2166739260","https://openalex.org/W2170563097","https://openalex.org/W2182642564","https://openalex.org/W2248088237","https://openalex.org/W2256320267","https://openalex.org/W2290665348","https://openalex.org/W2295582201","https://openalex.org/W2339064579","https://openalex.org/W2340931467","https://openalex.org/W2343130116","https://openalex.org/W2403525468","https://openalex.org/W2493233200","https://openalex.org/W2497869800","https://openalex.org/W2567913317","https://openalex.org/W2582631698","https://openalex.org/W2590208789","https://openalex.org/W2599030549","https://openalex.org/W2601160133","https://openalex.org/W2602767127","https://openalex.org/W2607225440","https://openalex.org/W2608602136","https://openalex.org/W2735481791","https://openalex.org/W2740681594","https://openalex.org/W2774563372","https://openalex.org/W2775200831","https://openalex.org/W2780354128","https://openalex.org/W2787531087","https://openalex.org/W2788163636","https://openalex.org/W2789910838","https://openalex.org/W2791214549","https://openalex.org/W2792297294","https://openalex.org/W2800348675","https://openalex.org/W2805332531","https://openalex.org/W2806900749","https://openalex.org/W2888074562","https://openalex.org/W2888821025","https://openalex.org/W2888961376","https://openalex.org/W2902379251","https://openalex.org/W2903281005","https://openalex.org/W2907536090","https://openalex.org/W2908034698","https://openalex.org/W2910454105","https://openalex.org/W2913528827","https://openalex.org/W2939501018","https://openalex.org/W2946853123","https://openalex.org/W2950204807","https://openalex.org/W2981632193","https://openalex.org/W2983120443","https://openalex.org/W3007794598","https://openalex.org/W3008526463","https://openalex.org/W3009599329","https://openalex.org/W3010950869","https://openalex.org/W3012464373","https://openalex.org/W3013711543","https://openalex.org/W3014341034","https://openalex.org/W3016566873","https://openalex.org/W3036101776","https://openalex.org/W3040151936","https://openalex.org/W3048391154","https://openalex.org/W3087733506","https://openalex.org/W3094036894","https://openalex.org/W3097058738","https://openalex.org/W3124894219","https://openalex.org/W3128171957","https://openalex.org/W3133860377","https://openalex.org/W3140110910","https://openalex.org/W3155551263","https://openalex.org/W3194006354","https://openalex.org/W4382398930"],"related_works":["https://openalex.org/W4401735097","https://openalex.org/W3094036894","https://openalex.org/W4368374137","https://openalex.org/W3025863412","https://openalex.org/W2045335324","https://openalex.org/W3200284420","https://openalex.org/W3136714910","https://openalex.org/W7218133328","https://openalex.org/W3114586540","https://openalex.org/W3131430042"],"abstract_inverted_index":{"Drug-resistant":[0],"species":[1],"of":[2,24,56,63,103,122],"tuberculosis":[3,25],"(TB),":[4],"which":[5,111],"spread":[6],"faster":[7],"than":[8],"traditiona":[9],"TB,":[10],"is":[11,106],"a":[12,85],"severely":[13],"infectious":[14],"disease.":[15],"The":[16,101],"conventional":[17,134],"drug":[18,114],"therapy":[19],"used":[20,59],"in":[21,60,142],"the":[22,61,104,119],"management":[23,62],"has":[26],"several":[27,57],"challenges":[28,131],"linked":[29],"with":[30,44,74,108,133],"adverse":[31],"effects.":[32],"Hence,":[33],"nanotherapeutics":[34],"served":[35],"as":[36,88,91],"an":[37],"emerging":[38],"technique":[39],"to":[40,49,66],"overcome":[41,50],"problems":[42],"associated":[43,132],"current":[45,128],"treatment.":[46],"Nanotherapeutics":[47],"helps":[48],"toxicity":[51],"and":[52,69,96,117,139],"poor":[53],"solubility":[54],"issues":[55],"drugs":[58,76],"tuberculosis.":[64],"Due":[65],"their":[67],"diameter":[68],"surface":[70,102],"chemistry,":[71],"nanocarriers":[72,105],"encapsulated":[73],"antimicrobial":[75],"are":[77],"readily":[78],"taken":[79],"up":[80],"by":[81],"macrophages.":[82],"Macrophages":[83],"play":[84],"crucial":[86],"role":[87],"they":[89],"serve":[90],"target":[92],"sites":[93],"for":[94,99],"active":[95],"passive":[97],"targeting":[98],"nanocarriers.":[100,123],"coated":[107],"ligand-specific":[109],"receptors,":[110],"further":[112],"enhances":[113],"concentration":[115],"locally":[116],"indicates":[118],"therapeutic":[120],"potential":[121],"This":[124],"review":[125],"highlights":[126],"tuberculosis's":[127],"facts,":[129],"figures,":[130],"treatment,":[135],"different":[136],"nanocarrier-based":[137],"systems,":[138],"its":[140],"application":[141],"vaccine":[143],"development.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}
