{"id":"https://openalex.org/W4200548389","doi":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","title":"Investigation of Cytotoxic Effects of Recombinant Human Interferon Lambda-1 and Its Pegylated Form on Human Conjunctival Epithelial Cells","display_name":"Investigation of Cytotoxic Effects of Recombinant Human Interferon Lambda-1 and Its Pegylated Form on Human Conjunctival Epithelial Cells","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W4200548389","doi":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208"},"language":"en","primary_location":{"id":"doi:10.30895/2312-7821-2021-9-4-200-208","doi":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","pdf_url":"https://www.risksafety.ru/jour/article/download/240/379","source":{"id":"https://openalex.org/S4210210648","display_name":"Safety and Risk of Pharmacotherapy","issn_l":"2312-7821","issn":["2312-7821","2619-1164"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Safety and Risk of Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.risksafety.ru/jour/article/download/240/379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082481593","display_name":"\u041d\u0438\u043a\u043e\u043b\u0430\u0439 \u0410\u043d\u0434\u0440\u0435\u0435\u0432\u0438\u0447 \u041a\u0438\u0445\u0442\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-1446-7229","observed_orcids":["https://orcid.org/0000-0003-1446-7229"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Kikhtenko","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0003-1446-7229","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030107423","display_name":"Natalia A. Bondarenko","orcid":"https://orcid.org/0000-0002-8443-656X","observed_orcids":["https://orcid.org/0000-0002-8443-656X"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Bondarenko","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-8443-656X","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090268231","display_name":"Nataliya P. Bgatova","orcid":"https://orcid.org/0000-0002-4507-093X","observed_orcids":["https://orcid.org/0000-0002-4507-093X"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. P. Bgatova","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-4507-093X","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051213349","display_name":"\u041b\u0430\u0440\u0438\u0441\u0430 \u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u043d\u0430 \u041e\u043b\u0435\u0439\u043d\u0438\u043a","orcid":"https://orcid.org/0000-0002-0336-4227","observed_orcids":["https://orcid.org/0000-0002-0336-4227"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. A. Oleynik","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-0336-4227","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035877036","display_name":"\u041e. \u0412. \u041f\u043e\u0432\u0435\u0449\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0001-9956-0056","observed_orcids":["https://orcid.org/0000-0001-9956-0056"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. V. Poveshchenko","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0001-9956-0056","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015007302","display_name":"\u0410. \u0416. \u0424\u0443\u0440\u0441\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6311-5452","observed_orcids":["https://orcid.org/0000-0001-6311-5452"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Zh. Fursova","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0001-6311-5452","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091256995","display_name":"\u041f\u0430\u0432\u0435\u043b \u0413\u0435\u043d\u043d\u0430\u0434\u044c\u0435\u0432\u0438\u0447 \u041c\u0430\u0434\u043e\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-1093-8938","observed_orcids":["https://orcid.org/0000-0002-1093-8938"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P. G. Madonov","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-1093-8938","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4","first_page":"200","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.15449999272823334,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-lambda-1","display_name":"interferon lambda 1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.8479999899864197},{"id":"https://openalex.org/keywords/conjunctival-epithelial-cells","display_name":"conjunctival epithelial cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ocular-surface-infection","display_name":"ocular surface infection","score":0.8500000238418579},{"id":"https://openalex.org/keywords/viral-conjunctivitis","display_name":"viral conjunctivitis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/keratinization","display_name":"keratinization","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ultrastructural-changes","display_name":"ultrastructural changes","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7680026292800903},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.590675413608551},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5166254639625549},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46316301822662354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4545036256313324},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4203706979751587},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41084975004196167},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3916308581829071},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.382554292678833},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3130650520324707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30234280228614807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2946213185787201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28354111313819885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18302911520004272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.30895/2312-7821-2021-9-4-200-208","doi":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","pdf_url":"https://www.risksafety.ru/jour/article/download/240/379","source":{"id":"https://openalex.org/S4210210648","display_name":"Safety and Risk of Pharmacotherapy","issn_l":"2312-7821","issn":["2312-7821","2619-1164"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Safety and Risk of Pharmacotherapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:95492679dd1240b2ad09b411ed82eced","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95492679dd1240b2ad09b411ed82eced","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0411\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0438 \u0440\u0438\u0441\u043a \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u0438, Vol 9, Iss 4, Pp 200-208 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.30895/2312-7821-2021-9-4-200-208","doi":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2312-7821-2021-9-4-200-208","pdf_url":"https://www.risksafety.ru/jour/article/download/240/379","source":{"id":"https://openalex.org/S4210210648","display_name":"Safety and Risk of Pharmacotherapy","issn_l":"2312-7821","issn":["2312-7821","2619-1164"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Safety and Risk of Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200548389.pdf","grobid_xml":"https://content.openalex.org/works/W4200548389.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1575345125","https://openalex.org/W1841904820","https://openalex.org/W1987119060","https://openalex.org/W2082277349","https://openalex.org/W2299487985","https://openalex.org/W2888712616","https://openalex.org/W2903893273","https://openalex.org/W2950049576","https://openalex.org/W2992335147","https://openalex.org/W3040598325","https://openalex.org/W3149930323","https://openalex.org/W3178634699","https://openalex.org/W4210583131"],"related_works":["https://openalex.org/W4210583131","https://openalex.org/W4293812566","https://openalex.org/W3091781701","https://openalex.org/W2983306449","https://openalex.org/W4214543395","https://openalex.org/W1552158380","https://openalex.org/W2143391909","https://openalex.org/W2773251486","https://openalex.org/W2003459674","https://openalex.org/W4405525874"],"abstract_inverted_index":{"Currently,":[0],"there":[1],"are":[2],"no":[3,161],"efficacious,":[4],"all-purpose":[5],"antiviral":[6,54],"medicines":[7,55,256],"for":[8,28,113,257],"the":[9,19,33,70,98,123,147,166,172,188,205,225,233,253,258],"treatment":[10,259],"of":[11,36,69,77,178,197,204,255,260],"ocular":[12],"surface":[13],"infections":[14],"caused":[15],"by":[16,97,131,139,228],"viruses.":[17],"At":[18],"same":[20],"time,":[21],"type":[22],"III":[23],"interferons":[24],"demonstrate":[25],"high":[26],"potency":[27],"histological":[29],"barriers,":[30],"such":[31],"as":[32,230,248],"conjunctiva.":[34],"Modification":[35],"protein":[37],"molecules":[38],"in":[39,187,211,252],"native":[40],"products":[41],"can":[42],"significantly":[43],"improve":[44],"their":[45],"pharmacodynamic":[46],"properties.":[47],"Thus,":[48],"it":[49],"seems":[50],"reasonable":[51],"to":[52,72,121,202,232],"develop":[53],"based":[56],"on":[57,165],"interferon":[58],"lambda":[59],"(IFN-\u03bb1)":[60],"and":[61,81,92,155,171,190,195,200,213,220,242],"its":[62,82],"pegylated":[63,83],"form":[64,84],"(PEG":[65],"IFN-\u03bb1).":[66],"The":[67,116,176],"aim":[68],"studywas":[71],"evaluate":[73],"thein":[74],"vitrocytotoxic":[75],"effect":[76,164],"recombinant":[78],"human":[79,105,167],"IFN-\u03bb1":[80,94,157,183,192,212,215,241,244],"onChang":[85],"conjunctiva":[86,109,168],"clone":[87,110],"1-5c-4human":[88],"conjunctival":[89,106,261],"cells.":[90],"Materials":[91],"methods:PEG":[93],"was":[95,119,129,144],"obtained":[96],"electron":[99,140],"beam":[100],"immobilisation":[101],"method.":[102],"A":[103,208],"normal":[104],"cell":[107,114,169,173,206,226],"lineChang":[108],"1-5c-4was":[111],"used":[112,120,247],"cultivation.":[115],"MTT":[117],"test":[118],"assess":[122],"cytotoxic":[124,163],"effect.":[125],"Cell":[126],"proliferative":[127,174],"activity":[128],"studied":[130],"measuring":[132],"microelectrode":[133],"impedance.":[134],"Ultrastructural":[135],"changes":[136,180],"were":[137],"assessed":[138],"microscopy.":[141],"Statistical":[142],"processing":[143],"performed":[145],"using":[146],"Statistica":[148],"10.0":[149],"software":[150],"package.":[151],"Results:IFN-\u03bb1":[152],"(37":[153],"\u03bcg/mL)":[154,159],"PEG":[156,191,214,243],"(42":[158],"had":[160],"significant":[162],"culture":[170],"activity.":[175],"analysis":[177],"ultrastructural":[179],"demonstrated":[181,239],"that":[182,240],"activated":[184],"metabolic":[185],"processes":[186],"cells,":[189],"promoted":[193],"differentiation":[194],"keratinisation":[196],"epithelial":[198],"cells":[199],"led":[201],"modification":[203],"membrane.":[207],"ten-fold":[209],"increase":[210],"concentration":[216],"(to":[217],"370":[218],"\u03bcg/mL":[219],"420":[221],"\u03bcg/mL,":[222],"respectively)":[223],"reduced":[224],"viability":[227],"15\u201320%":[229],"compared":[231],"intact":[234],"control.":[235],"Conclusions:the":[236],"study":[237],"results":[238],"could":[245],"be":[246],"active":[249],"pharmaceutical":[250],"ingredients":[251],"development":[254],"viral":[262],"infections.":[263]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-31T00:00:00"}