{"id":"https://openalex.org/W4200548214","doi":"https://doi.org/10.1186/s11658-021-00293-6","title":"Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?","display_name":"Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200548214","doi":"https://doi.org/10.1186/s11658-021-00293-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/34911439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8903693"},"language":"en","primary_location":{"id":"doi:10.1186/s11658-021-00293-6","doi":"https://doi.org/10.1186/s11658-021-00293-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11658-021-00293-6","pdf_url":"https://cmbl.biomedcentral.com/counter/pdf/10.1186/s11658-021-00293-6","source":{"id":"https://openalex.org/S97575921","display_name":"Cellular & Molecular Biology Letters","issn_l":"1425-8153","issn":["1425-8153","1689-1392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular &amp; Molecular Biology Letters","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cmbl.biomedcentral.com/counter/pdf/10.1186/s11658-021-00293-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032257555","display_name":"Lucia H\u00e1ron\u00edkov\u00e1","orcid":"https://orcid.org/0000-0002-4903-2404","observed_orcids":["https://orcid.org/0000-0002-4903-2404"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Lucia Haronikova","raw_affiliation_strings":["RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. lucia.haronikova@mou.cz","RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. lucia.haronikova@mou.cz","institution_ids":["https://openalex.org/I4210115043"]},{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069991357","display_name":"Ond\u0159ej Bonczek","orcid":"https://orcid.org/0000-0003-0745-3136","observed_orcids":["https://orcid.org/0000-0003-0745-3136"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["CZ","SE"],"is_corresponding":false,"raw_author_name":"Ondrej Bonczek","raw_affiliation_strings":["Department of Medical Biosciences, Umea University, 901 87, Umea, Vasterbotten, Sweden","RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biosciences, Umea University, 901 87, Umea, Vasterbotten, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077077420","display_name":"Pavl\u00edna Zatloukalov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Pavlina Zatloukalova","raw_affiliation_strings":["RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086454101","display_name":"Filip Zavadil Kokas","orcid":"https://orcid.org/0000-0003-3902-9444","observed_orcids":["https://orcid.org/0000-0003-3902-9444"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Filip Kokas-Zavadil","raw_affiliation_strings":["RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020228165","display_name":"Martina Kucerikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martina Kucerikova","raw_affiliation_strings":["National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic","RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012430901","display_name":"Philip John Coates","orcid":"https://orcid.org/0000-0003-1518-6306","observed_orcids":["https://orcid.org/0000-0003-1518-6306"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Philip J. Coates","raw_affiliation_strings":["RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013133434","display_name":"Robin F\u00e5hr\u00e6us","orcid":"https://orcid.org/0000-0003-0402-8492","observed_orcids":["https://orcid.org/0000-0003-0402-8492"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4403928344","display_name":"H\u00e9matopo\u00ef\u00e8se normale et pathologique : Emergence, environnement et recherche translationnelle","ror":"https://ror.org/02cypx016","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403928344"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["CZ","FR","SE"],"is_corresponding":false,"raw_author_name":"Robin Fahraeus","raw_affiliation_strings":["Department of Medical Biosciences, Umea University, 901 87, Umea, Vasterbotten, Sweden","Inserm UMRS1131, Institut de G\u00e9n\u00e9tique Mol\u00e9culaire, Universit\u00e9 Paris 7, H\u00f4pital St. Louis, 75010, Paris, France","RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biosciences, Umea University, 901 87, Umea, Vasterbotten, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Inserm UMRS1131, Institut de G\u00e9n\u00e9tique Mol\u00e9culaire, Universit\u00e9 Paris 7, H\u00f4pital St. Louis, 75010, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610","https://openalex.org/I4403928344"]},{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017937179","display_name":"Bo\u0159ivoj Vojt\u011b\u0161ek","orcid":"https://orcid.org/0000-0001-6194-3705","observed_orcids":["https://orcid.org/0000-0001-6194-3705"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Borivoj Vojtesek","raw_affiliation_strings":["RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. vojtesek@mou.cz","RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0001-6194-3705","affiliations":[{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. vojtesek@mou.cz","institution_ids":["https://openalex.org/I4210115043"]},{"raw_affiliation_string":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5017937179","https://openalex.org/A5032257555"],"corresponding_institution_ids":["https://openalex.org/I4210115043"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.1364,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.79286789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"26","issue":"1","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p53-mdm2-interaction","display_name":"p53-MDM2 interaction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nutlin-3a","display_name":"Nutlin-3a","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p53-independent-pathway","display_name":"p53-independent pathway","score":0.9679999947547913},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7639999985694885},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.8871352672576904},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.5035011172294617},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5025007724761963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4833754897117615},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.44824960827827454},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4264407753944397},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40789365768432617},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37314677238464355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37125730514526367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36840060353279114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3208634853363037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1674043834209442},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.11336579918861389},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09777623414993286},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s11658-021-00293-6","doi":"https://doi.org/10.1186/s11658-021-00293-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11658-021-00293-6","pdf_url":"https://cmbl.biomedcentral.com/counter/pdf/10.1186/s11658-021-00293-6","source":{"id":"https://openalex.org/S97575921","display_name":"Cellular & Molecular Biology Letters","issn_l":"1425-8153","issn":["1425-8153","1689-1392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular &amp; Molecular Biology Letters","raw_type":"journal-article"},{"id":"pmid:34911439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34911439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular & molecular biology letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8903693","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8903693/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Biol Lett","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:umu-190854","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190854","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d1e17d5c51ce4f04a150f6d6747e8079","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1e17d5c51ce4f04a150f6d6747e8079","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-33 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s11658-021-00293-6","doi":"https://doi.org/10.1186/s11658-021-00293-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11658-021-00293-6","pdf_url":"https://cmbl.biomedcentral.com/counter/pdf/10.1186/s11658-021-00293-6","source":{"id":"https://openalex.org/S97575921","display_name":"Cellular & Molecular Biology Letters","issn_l":"1425-8153","issn":["1425-8153","1689-1392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular &amp; Molecular Biology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G12500569","display_name":null,"funder_award_id":"CZ.02.1.01/0.0","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G1455966332","display_name":null,"funder_award_id":"MMCI, 00209805","funder_id":"https://openalex.org/F4320321798","funder_display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky"},{"id":"https://openalex.org/G176604203","display_name":null,"funder_award_id":"02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2039240949","display_name":null,"funder_award_id":".02.1.01/0.0/0.0/16_019/0000868","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G291036901","display_name":null,"funder_award_id":"CZ.02","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3051851884","display_name":null,"funder_award_id":"00209805)","funder_id":"https://openalex.org/F4320321798","funder_display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky"},{"id":"https://openalex.org/G310317919","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16_019 /0000868","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3293029808","display_name":null,"funder_award_id":"00209805","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3490171961","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4131035492","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G5273185502","display_name":null,"funder_award_id":"MMCI, 00209805","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5916014575","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6090963825","display_name":"Mechanism of non-mutational p53 inactivation in human cancers and its implication for cancer therapy","funder_award_id":"GJ19-18177Y","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G7363506711","display_name":null,"funder_award_id":"/16_019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7519213876","display_name":null,"funder_award_id":"No. CZ.02.1.01/0.0/0.0/16_019/0000868","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7649738552","display_name":null,"funder_award_id":"1900073","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"}],"funders":[{"id":"https://openalex.org/F4320315060","display_name":"Wenner-Gren Stiftelserna","ror":"https://ror.org/033b0v780"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320321798","display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","ror":"https://ror.org/00y6khe77"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200548214.pdf","grobid_xml":"https://content.openalex.org/works/W4200548214.grobid-xml"},"referenced_works_count":243,"referenced_works":["https://openalex.org/W81266651","https://openalex.org/W656288512","https://openalex.org/W754307957","https://openalex.org/W1199549464","https://openalex.org/W1483486462","https://openalex.org/W1578847946","https://openalex.org/W1591281137","https://openalex.org/W1637251086","https://openalex.org/W1637381432","https://openalex.org/W1726030378","https://openalex.org/W1734797913","https://openalex.org/W1865917776","https://openalex.org/W1963878229","https://openalex.org/W1967382879","https://openalex.org/W1969044026","https://openalex.org/W1973288117","https://openalex.org/W1976261939","https://openalex.org/W1981067307","https://openalex.org/W1983751803","https://openalex.org/W1985567682","https://openalex.org/W1985683054","https://openalex.org/W1986250681","https://openalex.org/W1986252082","https://openalex.org/W1987444567","https://openalex.org/W1987585655","https://openalex.org/W1989064116","https://openalex.org/W1989607823","https://openalex.org/W1990054550","https://openalex.org/W1991167758","https://openalex.org/W1992947288","https://openalex.org/W1992975954","https://openalex.org/W1993263392","https://openalex.org/W1993864973","https://openalex.org/W1996523330","https://openalex.org/W1997800761","https://openalex.org/W2001089793","https://openalex.org/W2001184319","https://openalex.org/W2003463790","https://openalex.org/W2003525712","https://openalex.org/W2004928820","https://openalex.org/W2004968694","https://openalex.org/W2005173284","https://openalex.org/W2006099686","https://openalex.org/W2007249806","https://openalex.org/W2007852946","https://openalex.org/W2011250979","https://openalex.org/W2011361940","https://openalex.org/W2016543925","https://openalex.org/W2017058074","https://openalex.org/W2019619416","https://openalex.org/W2021570316","https://openalex.org/W2022070430","https://openalex.org/W2022431825","https://openalex.org/W2026104514","https://openalex.org/W2029283387","https://openalex.org/W2029631901","https://openalex.org/W2029865335","https://openalex.org/W2033485885","https://openalex.org/W2034042949","https://openalex.org/W2034333242","https://openalex.org/W2034417337","https://openalex.org/W2034954692","https://openalex.org/W2035248522","https://openalex.org/W2035294512","https://openalex.org/W2036092325","https://openalex.org/W2036521316","https://openalex.org/W2040068538","https://openalex.org/W2040486656","https://openalex.org/W2043478931","https://openalex.org/W2046135777","https://openalex.org/W2047680964","https://openalex.org/W2048981268","https://openalex.org/W2049133549","https://openalex.org/W2052516738","https://openalex.org/W2052715855","https://openalex.org/W2053601921","https://openalex.org/W2054311839","https://openalex.org/W2059698904","https://openalex.org/W2060473115","https://openalex.org/W2060513486","https://openalex.org/W2064676609","https://openalex.org/W2067381505","https://openalex.org/W2068427129","https://openalex.org/W2068912983","https://openalex.org/W2070933716","https://openalex.org/W2072435450","https://openalex.org/W2072610461","https://openalex.org/W2074244064","https://openalex.org/W2074778020","https://openalex.org/W2076147908","https://openalex.org/W2077423253","https://openalex.org/W2081953771","https://openalex.org/W2082912215","https://openalex.org/W2082979850","https://openalex.org/W2085065223","https://openalex.org/W2085875005","https://openalex.org/W2086956752","https://openalex.org/W2088205139","https://openalex.org/W2090240238","https://openalex.org/W2091151265","https://openalex.org/W2093846525","https://openalex.org/W2096428863","https://openalex.org/W2096695840","https://openalex.org/W2097305792","https://openalex.org/W2097933346","https://openalex.org/W2098412103","https://openalex.org/W2104715465","https://openalex.org/W2106718280","https://openalex.org/W2108068107","https://openalex.org/W2108491241","https://openalex.org/W2111689885","https://openalex.org/W2113588690","https://openalex.org/W2114649348","https://openalex.org/W2115078294","https://openalex.org/W2116009473","https://openalex.org/W2116416768","https://openalex.org/W2116565198","https://openalex.org/W2116787167","https://openalex.org/W2116994638","https://openalex.org/W2120132028","https://openalex.org/W2120447464","https://openalex.org/W2123184912","https://openalex.org/W2126166557","https://openalex.org/W2127423053","https://openalex.org/W2129244035","https://openalex.org/W2132888849","https://openalex.org/W2135658143","https://openalex.org/W2139466852","https://openalex.org/W2142605244","https://openalex.org/W2143351237","https://openalex.org/W2149581245","https://openalex.org/W2151686058","https://openalex.org/W2152988906","https://openalex.org/W2154563079","https://openalex.org/W2155786178","https://openalex.org/W2155906069","https://openalex.org/W2156807398","https://openalex.org/W2157459126","https://openalex.org/W2158485828","https://openalex.org/W2159347835","https://openalex.org/W2160340008","https://openalex.org/W2161472990","https://openalex.org/W2161694936","https://openalex.org/W2161919140","https://openalex.org/W2162369786","https://openalex.org/W2162795905","https://openalex.org/W2162899430","https://openalex.org/W2163861438","https://openalex.org/W2167264988","https://openalex.org/W2168062283","https://openalex.org/W2170494099","https://openalex.org/W2176265001","https://openalex.org/W2182708897","https://openalex.org/W2196605452","https://openalex.org/W2210752693","https://openalex.org/W2212199746","https://openalex.org/W2256505962","https://openalex.org/W2276735096","https://openalex.org/W2284498907","https://openalex.org/W2313406933","https://openalex.org/W2333374528","https://openalex.org/W2340120319","https://openalex.org/W2342884001","https://openalex.org/W2345930915","https://openalex.org/W2382465108","https://openalex.org/W2396141880","https://openalex.org/W2402029297","https://openalex.org/W2413306547","https://openalex.org/W2429205724","https://openalex.org/W2460207510","https://openalex.org/W2472035483","https://openalex.org/W2475353358","https://openalex.org/W2522678060","https://openalex.org/W2557390939","https://openalex.org/W2561177551","https://openalex.org/W2575594193","https://openalex.org/W2586562686","https://openalex.org/W2593361213","https://openalex.org/W2593682768","https://openalex.org/W2600231982","https://openalex.org/W2666136463","https://openalex.org/W2679430764","https://openalex.org/W2735186197","https://openalex.org/W2740931579","https://openalex.org/W2742460321","https://openalex.org/W2744254482","https://openalex.org/W2759444489","https://openalex.org/W2765688171","https://openalex.org/W2765689834","https://openalex.org/W2770733439","https://openalex.org/W2776946053","https://openalex.org/W2777457443","https://openalex.org/W2788097887","https://openalex.org/W2794314159","https://openalex.org/W2797049355","https://openalex.org/W2807521243","https://openalex.org/W2872716351","https://openalex.org/W2883445384","https://openalex.org/W2886803370","https://openalex.org/W2887286471","https://openalex.org/W2888012200","https://openalex.org/W2890773677","https://openalex.org/W2890791082","https://openalex.org/W2894539085","https://openalex.org/W2894951547","https://openalex.org/W2895357007","https://openalex.org/W2895467863","https://openalex.org/W2898148116","https://openalex.org/W2899500794","https://openalex.org/W2900444294","https://openalex.org/W2902854367","https://openalex.org/W2920380346","https://openalex.org/W2922464326","https://openalex.org/W2947426144","https://openalex.org/W2951587879","https://openalex.org/W2953054644","https://openalex.org/W2955077735","https://openalex.org/W2964867254","https://openalex.org/W2965547724","https://openalex.org/W2967855006","https://openalex.org/W2969561067","https://openalex.org/W2981704846","https://openalex.org/W2987081466","https://openalex.org/W2987425716","https://openalex.org/W2990863896","https://openalex.org/W2990943232","https://openalex.org/W2995468433","https://openalex.org/W3009145316","https://openalex.org/W3014338272","https://openalex.org/W3036121585","https://openalex.org/W3040650435","https://openalex.org/W3043396902","https://openalex.org/W3082524855","https://openalex.org/W3097145107","https://openalex.org/W3101489001","https://openalex.org/W3106508262","https://openalex.org/W3110734874","https://openalex.org/W3112097879","https://openalex.org/W3141926258","https://openalex.org/W3162867299","https://openalex.org/W3170127104","https://openalex.org/W3172574127","https://openalex.org/W4323966467"],"related_works":["https://openalex.org/W3204277805","https://openalex.org/W2062745242","https://openalex.org/W2594386026","https://openalex.org/W1981067307","https://openalex.org/W1987830924","https://openalex.org/W2527510194","https://openalex.org/W2925921690","https://openalex.org/W4409150843","https://openalex.org/W2030738890","https://openalex.org/W4223995297"],"abstract_inverted_index":{"Since":[0],"the":[1,4,14,32,41,49,62,78,114,134,149],"discovery":[2],"of":[3,17,35,43,52,54,64,74,125,128,151],"first":[5],"MDM2":[6,18,27,36,44,56,67,86,91,115,131],"inhibitors,":[7,57],"we":[8,24],"have":[9],"gained":[10],"deeper":[11],"insights":[12],"into":[13],"cellular":[15],"roles":[16],"and":[19,37,71,76,82,94,121],"p53.":[20,46],"In":[21],"this":[22],"review,":[23],"focus":[25],"on":[26,140],"inhibitors":[28],"that":[29],"bind":[30],"to":[31,39,45,66,85,130,143],"p53-binding":[33],"domain":[34],"aim":[38],"disrupt":[40],"binding":[42],"We":[47,112],"describe":[48],"basic":[50],"mechanism":[51],"action":[53],"these":[55,141],"such":[58],"as":[59],"nutlin-3a,":[60],"summarise":[61],"determinants":[63],"sensitivity":[65],"inhibition":[68],"from":[69],"p53-dependent":[70],"p53-independent":[72],"points":[73],"view":[75],"discuss":[77],"problems":[79],"with":[80],"innate":[81],"acquired":[83],"resistance":[84,129],"inhibition.":[87],"Despite":[88],"progress":[89],"in":[90,101,108,118],"inhibitor":[92,116],"design":[93],"ongoing":[95],"clinical":[96,119,146],"trials,":[97],"their":[98],"broad":[99],"use":[100,150],"cancer":[102],"treatment":[103],"is":[104],"not":[105],"fulfilling":[106],"expectations":[107],"heterogenous":[109],"human":[110],"cancers.":[111],"assess":[113],"types":[117],"trials":[120],"provide":[122],"an":[123],"overview":[124],"possible":[126],"sources":[127],"inhibition,":[132],"underlining":[133],"need":[135],"for":[136,154],"patient":[137],"stratification":[138],"based":[139],"aspects":[142],"gain":[144],"better":[145],"responses,":[147],"including":[148],"combination":[152],"therapies":[153],"personalised":[155],"medicine.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-12-31T00:00:00"}
