{"id":"https://openalex.org/W4200546355","doi":"https://doi.org/10.1002/cnr2.1492","title":"Unified model involving genomics, magnetic resonance imaging and prostate\u2010specific antigen density outperforms individual co\u2010variables at predicting biopsy upgrading in patients on active surveillance for low risk prostate cancer","display_name":"Unified model involving genomics, magnetic resonance imaging and prostate\u2010specific antigen density outperforms individual co\u2010variables at predicting biopsy upgrading in patients on active surveillance for low risk prostate cancer","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200546355","doi":"https://doi.org/10.1002/cnr2.1492","pmid":"https://pubmed.ncbi.nlm.nih.gov/34931468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8955055"},"language":"en","primary_location":{"id":"doi:10.1002/cnr2.1492","doi":"https://doi.org/10.1002/cnr2.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1492","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071632973","display_name":"Alp Tuna Beksac","orcid":"https://orcid.org/0000-0001-6742-0040","observed_orcids":["https://orcid.org/0000-0001-6742-0040"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alp Tuna Beksac","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054214324","display_name":"Parita Ratnani","orcid":"https://orcid.org/0000-0002-4153-1014","observed_orcids":["https://orcid.org/0000-0002-4153-1014"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parita Ratnani","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113333196","display_name":"Zachary S. Dovey","orcid":"https://orcid.org/0000-0002-2231-8429","observed_orcids":["https://orcid.org/0000-0002-2231-8429"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Dovey","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-2231-8429","affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023611204","display_name":"Sneha V. Parekh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sneha Parekh","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009040855","display_name":"Ugo Giovanni Falagario","orcid":"https://orcid.org/0000-0002-1152-3005","observed_orcids":["https://orcid.org/0000-0002-1152-3005"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ugo Falagario","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-1152-3005","affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029066570","display_name":"Reza Roshandel","orcid":"https://orcid.org/0000-0001-6342-2989","observed_orcids":["https://orcid.org/0000-0001-6342-2989"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Roshandel","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-6342-2989","affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079763596","display_name":"Stanis\u0142aw Sob\u00f3tka","orcid":"https://orcid.org/0000-0003-0200-5078","observed_orcids":["https://orcid.org/0000-0003-0200-5078"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislaw Sobotka","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088676413","display_name":"Deepshikha Kewlani","orcid":"https://orcid.org/0000-0002-4033-3614","observed_orcids":["https://orcid.org/0000-0002-4033-3614"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepshikha Kewlani","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022309971","display_name":"Avery Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avery Davis","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090263966","display_name":"Rachel Weil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Weil","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052757074","display_name":"Hafis Bashorun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hafis Bashorun","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043984769","display_name":"Ivan Jambor","orcid":"https://orcid.org/0000-0001-6305-3570","observed_orcids":["https://orcid.org/0000-0001-6305-3570"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Jambor","raw_affiliation_strings":["Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073612543","display_name":"Sara C. Lewis","orcid":"https://orcid.org/0000-0002-4713-6453","observed_orcids":["https://orcid.org/0000-0002-4713-6453"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Lewis","raw_affiliation_strings":["Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113762164","display_name":"Kenneth Haines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Haines","raw_affiliation_strings":["Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068285584","display_name":"Ashutosh Kumar Tewari","orcid":"https://orcid.org/0000-0002-3146-4524","observed_orcids":["https://orcid.org/0000-0002-3146-4524"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashutosh K. Tewari","raw_affiliation_strings":["Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068285584"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.9703,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76385938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"3","first_page":"e1492","last_page":"e1492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-risk-prostate-cancer","display_name":"low-risk prostate cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/active-surveillance","display_name":"active surveillance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/biopsy-upgrading","display_name":"biopsy upgrading","score":0.9539999961853027},{"id":"https://openalex.org/keywords/psa-density","display_name":"PSA density","score":0.8859999775886536},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.777999997138977},{"id":"https://openalex.org/keywords/gps","display_name":"GPS","score":0.4620000123977661},{"id":"https://openalex.org/keywords/pi-rads-v2-1","display_name":"PI-RADS v2.1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6700000166893005},{"id":"https://openalex.org/keywords/gleason-grade-upgrading","display_name":"Gleason score upgrading","score":0.44999998807907104},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.48399999737739563},{"id":"https://openalex.org/keywords/prostate-cancer-risk-stratification","display_name":"prostate cancer risk stratification","score":0.35199999809265137},{"id":"https://openalex.org/keywords/risk-overestimation","display_name":"risk overestimation","score":0.3440000116825104},{"id":"https://openalex.org/keywords/underestimation-of-risk","display_name":"risk underestimation","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8131614923477173},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6895878314971924},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6367352604866028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5269145369529724},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43066850304603577},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4253348112106323},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.41306114196777344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3855913281440735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34257519245147705},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2981661558151245}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057832","descriptor_name":"Watchful Waiting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061705","descriptor_name":"Image-Guided Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cnr2.1492","doi":"https://doi.org/10.1002/cnr2.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1492","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8955055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8955055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Rep (Hoboken)","raw_type":"Text"},{"id":"pmid:34931468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34931468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer reports (Hoboken, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c4591c2304804f61bac1de0086369898","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c4591c2304804f61bac1de0086369898","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Reports, Vol 5, Iss 3, Pp n/a-n/a (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cnr2.1492","doi":"https://doi.org/10.1002/cnr2.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1492","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200546355.pdf","grobid_xml":"https://content.openalex.org/works/W4200546355.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2131988302","https://openalex.org/W2135546504","https://openalex.org/W2150095882","https://openalex.org/W2284433611","https://openalex.org/W2475267864","https://openalex.org/W2511949746","https://openalex.org/W2512180612","https://openalex.org/W2518676577","https://openalex.org/W2577453388","https://openalex.org/W2735211627","https://openalex.org/W2763351477","https://openalex.org/W2763709490","https://openalex.org/W2770723187","https://openalex.org/W2810729393","https://openalex.org/W2885220860","https://openalex.org/W2898746949","https://openalex.org/W2905011711","https://openalex.org/W2906542507","https://openalex.org/W2939438597","https://openalex.org/W2941047079","https://openalex.org/W2941281880","https://openalex.org/W2984399591","https://openalex.org/W3009200944","https://openalex.org/W3048873723","https://openalex.org/W3090168712","https://openalex.org/W3090551147","https://openalex.org/W3092454626","https://openalex.org/W3111361234","https://openalex.org/W4200546355"],"related_works":["https://openalex.org/W2584921086","https://openalex.org/W3007344616","https://openalex.org/W4408347437","https://openalex.org/W3205754916","https://openalex.org/W2889316592","https://openalex.org/W2922201531","https://openalex.org/W2795564485","https://openalex.org/W3164639994","https://openalex.org/W2947717950","https://openalex.org/W3215527334"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Active":[2],"surveillance":[3,77],"(AS)":[4,78],"is":[5],"the":[6,11,41,54,63,70,132,159,179,201,224,322,342,359],"reference":[7],"standard":[8],"treatment":[9,32],"for":[10,57,69,197,321,341],"management":[12,79],"of":[13,21,33,65,72,80,134,168,230,319,324,344,352,367],"low":[14],"risk":[15,37,43,229],"prostate":[16,81],"cancer":[17,82],"(PCa).":[18,83],"Accurate":[19],"assessment":[20],"tumor":[22],"aggressiveness":[23],"guides":[24],"recruitment":[25],"to":[26,29,94,99,115,130],"AS":[27,95],"programs":[28],"avoid":[30],"conservative":[31],"intermediate":[34],"and":[35,53,67,141,147,252,281,313,338,355],"higher":[36,177,253,332],"patients.":[38],"Nevertheless,":[39],"underestimating":[40],"disease":[42],"may":[44],"occur":[45],"in":[46,178,200],"some":[47],"patients":[48,92,180],"recruited,":[49],"with":[50,162,227,295,363],"biopsy":[51,73,116,231],"upgrading":[52,74,114,169,209,232,346],"concomitant":[55],"potential":[56],"delayed":[58],"treatment.":[59],"Aim":[60],"To":[61],"evaluate":[62],"accuracy":[64,333],"mpMRI":[66],"GPS":[68,148,199,206,339,354],"prediction":[71,323,343],"during":[75,347],"active":[76],"Method":[84],"A":[85,297],"retrospective":[86],"analysis":[87],"was":[88,104,111,128,156,170,176,195],"performed":[89],"on":[90,120,149],"144":[91],"recruited":[93],"from":[96],"October":[97],"2013":[98],"December":[100],"2020.":[101],"Median":[102],"follow":[103,121],"4.8":[105],"(IQR":[106],"3.6,":[107],"6.3)":[108],"years.":[109],"Upgrading":[110],"defined":[112,153],"as":[113,154],"grade":[117],"group":[118],"\u22652":[119],"up":[122],"biopsies.":[123],"Cox":[124],"proportional":[125,220,267],"hazard":[126,221,268],"regression":[127,222,269,299],"used":[129],"investigate":[131],"effect":[133],"PSA":[135,234],"density":[136],"(PSAD),":[137],"baseline":[138,335],"Prostate":[139],"Imaging\u2010Reporting":[140],"Data":[142],"System":[143],"(PI\u2010RADS)":[144],"v2.1":[145],"score":[146,255,284,337,340],"upgrading.":[150,296,325],"Time\u2010to\u2010event":[151],"outcome,":[152],"upgrading,":[155,213],"estimated":[157],"using":[158],"Kaplan\u2013Meier":[160],"method":[161],"log\u2010rank":[163],"test.":[164],"Results":[165],"Overall":[166],"rate":[167],"31.9%":[171],"(n":[172],"=":[173,189,215,236,241,245,250,257,262,274,279,286,291],"46).":[174],"PSAD":[175,243,272,330],"who":[181],"were":[182,233,293],"upgraded":[183],"(0.12":[184],"vs.":[185,210],"0.08":[186],"ng/ml2,":[187],"p":[188,214,240,249,261,278,290],".005),":[190],"while":[191],"no":[192,212],"significant":[193],"difference":[194],"present":[196],"median":[198,205],"overall":[202],"cohort":[203],"(overall":[204],"21;":[207],"22":[208],"20":[211],".2044).":[216],"On":[217,264],"univariable":[218],"cox":[219,266,298],"analysis,":[223,270],"factors":[225],"associated":[226,294],"increased":[228],"(HR":[235,244,256,273,285],"1.30,":[237],"CI":[238,247,259,276,288],"1.16\u20131.47,":[239],"<.0001),":[242],"1.08,":[246],"1.05\u20131.12,":[248],"<.0001)":[251],"PI\u2010RADS":[254,283,311,336,356],"3.51,":[258],"1.56\u20137.91,":[260],".0024).":[263],"multivariable":[265],"only":[271],"1.10,":[275],"1.06\u20131.14,":[277],"<.001)":[280],"high":[282],"4.11,":[287],"1.79\u20139.44,":[289],".0009)":[292],"model":[300],"combining":[301],"these":[302],"three":[303],"clinical":[304],"features":[305],"(PSAD":[306],"\u22650.15":[307],"ng/ml2":[308],"at":[309],"baseline,":[310],"Score":[312,357],"GPS)":[314],"yielded":[315,358],"a":[316,364],"concordance":[317,365],"index":[318,366],"0.71":[320],"Conclusion":[326],"In":[327],"this":[328],"study":[329],"has":[331],"over":[334],"PCa":[345],"AS.":[348],"However,":[349],"combined":[350],"use":[351],"PSAD,":[353],"highest":[360],"predictive":[361],"ability":[362],"0.71.":[368]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}