{"id":"https://openalex.org/W4200545843","doi":"https://doi.org/10.26650/eor.2022903844","title":"Expression of BMP-4 in dentigerous cyst and ameloblastoma: Is it a differentiation measure?","display_name":"Expression of BMP-4 in dentigerous cyst and ameloblastoma: Is it a differentiation measure?","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200545843","doi":"https://doi.org/10.26650/eor.2022903844","pmid":"https://pubmed.ncbi.nlm.nih.gov/35478708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9012220"},"language":"en","primary_location":{"id":"doi:10.26650/eor.2022903844","doi":"https://doi.org/10.26650/eor.2022903844","is_oa":true,"landing_page_url":"https://doi.org/10.26650/eor.2022903844","pdf_url":"https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/335B3BBA1CE64279A2BCE7B38EE6F7F1","source":{"id":"https://openalex.org/S4306510141","display_name":"European Oral Research","issn_l":"0257-8212","issn":["0257-8212","2147-8716","2630-6158","2651-2823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Oral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/335B3BBA1CE64279A2BCE7B38EE6F7F1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083798202","display_name":"Soudabeh Sargolzaei","orcid":"https://orcid.org/0000-0002-6452-4909","observed_orcids":["https://orcid.org/0000-0002-6452-4909"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Soudabeh Sargolzaei","raw_affiliation_strings":["Department of Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, TehranIran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, TehranIran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075358889","display_name":"Dina Maleki","orcid":"https://orcid.org/0000-0002-8492-618X","observed_orcids":["https://orcid.org/0000-0002-8492-618X"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Dina Maleki","raw_affiliation_strings":["Student Research Committee, School of Dentistry, Guilan University of Medical Sciences, RashtIran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, School of Dentistry, Guilan University of Medical Sciences, RashtIran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018199395","display_name":"Maryam Zohary","orcid":"https://orcid.org/0000-0002-4287-2806","observed_orcids":["https://orcid.org/0000-0002-4287-2806"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Maryam Zohary","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, Guilan University of Medical Sciences, RashtIran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, Guilan University of Medical Sciences, RashtIran","institution_ids":["https://openalex.org/I204331812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018199395"],"corresponding_institution_ids":["https://openalex.org/I204331812"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"56","issue":"1","first_page":"17","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11363","display_name":"Dental Radiography and Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dentigerous-cyst","display_name":"dentigerous cyst","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ameloblastoma","display_name":"ameloblastoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/unicystic-ameloblastoma","display_name":"unicystic ameloblastoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multicystic-ameloblastoma","display_name":"multicystic ameloblastoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/odontogenic-cysts","display_name":"odontogenic cysts","score":0.7649999856948853},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.6740000247955322},{"id":"https://openalex.org/keywords/epithelial-differentiation","display_name":"epithelial differentiation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.5059999823570251},{"id":"https://openalex.org/keywords/mandible","display_name":"mandible","score":0.3959999978542328},{"id":"https://openalex.org/keywords/sex-distribution","display_name":"sex distribution","score":0.6439999938011169},{"id":"https://openalex.org/keywords/lesion-localization","display_name":"lesion localization","score":0.5770000219345093},{"id":"https://openalex.org/keywords/total-score","display_name":"full score","score":0.9520000219345093},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.6230000257492065},{"id":"https://openalex.org/keywords/microvessels","display_name":"microvessels","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2780856748","wikidata":"https://www.wikidata.org/wiki/Q5259492","display_name":"Dentigerous cyst","level":3,"score":0.842859148979187},{"id":"https://openalex.org/C2775876115","wikidata":"https://www.wikidata.org/wiki/Q461857","display_name":"Ameloblastoma","level":3,"score":0.7984338402748108},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6269319653511047},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6089075207710266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.564952552318573},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5417384505271912},{"id":"https://openalex.org/C122246415","wikidata":"https://www.wikidata.org/wiki/Q350956","display_name":"Maxilla","level":2,"score":0.5220125317573547},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.4880460500717163},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4873534142971039},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.4547329545021057},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.4323238730430603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24778082966804504},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2379736304283142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17702698707580566},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.26650/eor.2022903844","doi":"https://doi.org/10.26650/eor.2022903844","is_oa":true,"landing_page_url":"https://doi.org/10.26650/eor.2022903844","pdf_url":"https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/335B3BBA1CE64279A2BCE7B38EE6F7F1","source":{"id":"https://openalex.org/S4306510141","display_name":"European Oral Research","issn_l":"0257-8212","issn":["0257-8212","2147-8716","2630-6158","2651-2823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Oral Research","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/903844","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/eor/article/903844","pdf_url":null,"source":{"id":"https://openalex.org/S4306510141","display_name":"European Oral Research","issn_l":"0257-8212","issn":["0257-8212","2147-8716","2630-6158","2651-2823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:35478708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35478708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European oral research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9012220","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9012220/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Oral Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6e42d85ca0a64bf78037092718680bbb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6e42d85ca0a64bf78037092718680bbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Oral Research, Vol 56, Iss 1, Pp 17-22 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26650/eor.2022903844","doi":"https://doi.org/10.26650/eor.2022903844","is_oa":true,"landing_page_url":"https://doi.org/10.26650/eor.2022903844","pdf_url":"https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/335B3BBA1CE64279A2BCE7B38EE6F7F1","source":{"id":"https://openalex.org/S4306510141","display_name":"European Oral Research","issn_l":"0257-8212","issn":["0257-8212","2147-8716","2630-6158","2651-2823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Oral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200545843.pdf","grobid_xml":"https://content.openalex.org/works/W4200545843.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1971705850","https://openalex.org/W1993472634","https://openalex.org/W2054325055","https://openalex.org/W2064264544","https://openalex.org/W2082411055","https://openalex.org/W2105904579","https://openalex.org/W2123895079","https://openalex.org/W2125403662","https://openalex.org/W2129781357","https://openalex.org/W2156616416","https://openalex.org/W2520983101","https://openalex.org/W2538917862","https://openalex.org/W2876850598","https://openalex.org/W2892269955","https://openalex.org/W2903650068","https://openalex.org/W2909861143","https://openalex.org/W2914772872","https://openalex.org/W2956009102","https://openalex.org/W3046045194","https://openalex.org/W3098220515","https://openalex.org/W3111910895","https://openalex.org/W6678467452"],"related_works":["https://openalex.org/W2123895079","https://openalex.org/W4297186038","https://openalex.org/W2538917862","https://openalex.org/W4301123212","https://openalex.org/W7019667681","https://openalex.org/W7207265906","https://openalex.org/W7161974760","https://openalex.org/W4410982528","https://openalex.org/W2087066544","https://openalex.org/W2133189455"],"abstract_inverted_index":{"Purpose:":[0],"This":[1,35],"study":[2,36],"aimed":[3],"to":[4,142,147,159,270,277,300],"determine":[5],"the":[6,47,51,55,64,68,78,87,125,156,160,197,213,263,294,301],"expression":[7,259],"of":[8,50,77,128,218,260,281,288],"Bone":[9],"Morphogenic":[10],"Protein-4":[11],"(BMP-4)":[12],"in":[13,144,155,180,200,212,247,262,267],"dentigerous":[14,284],"cyst":[15],"(DC),":[16],"unicystic-ameloblastoma":[17],"(UA),":[18],"and":[19,22,33,42,58,63,67,75,96,105,118,136,151,154,164,184,187,203,207,215,221,228,240,251,254,283],"Multicysticameloblastoma":[20],"(MA),":[21],"assess":[23],"whether":[24],"this":[25,132],"marker":[26,93],"can":[27],"be":[28],"a":[29,139,274],"differentiation":[30,287],"measure.":[31],"Materials":[32],"methods:":[34],"included":[37],"30":[38,40,43],"DC,":[39,219,238],"UA,":[41,135,220,239],"MA":[44,137,181,222,241,250],"blocks":[45],"if":[46],"histopathologic":[48],"diagnosis":[49],"lesion":[52,79],"was":[53,94,170,178,192,234,245,265],"definitive,":[54],"clinical":[56],"information":[57],"medical":[59],"records":[60],"were":[61,71,80,84,111,122],"complete,":[62],"microscopic":[65],"slides":[66],"paraffin":[69],"block":[70],"available.":[72],"Age,":[73],"gender,":[74],"location":[76],"recorded.":[81],"The":[82,109,167,190,210,231,243,258,286],"samples":[83],"analyzed":[85,112],"after":[86],"immunohistochemical":[88],"staining":[89],"(Envision":[90],"technique).":[91],"BMP-4":[92,261,272],"evaluated":[95],"reported":[97],"using":[98,113],"Intensity":[99],"Score":[100,103],"(IS),":[101],"Proportional":[102],"(PS),":[104],"Total":[106],"score":[107],"(TS).":[108],"data":[110],"SPSS":[114],"version":[115],"21.0.":[116],"Kruskal-Wallis":[117],"Mann-Whitney":[119],"U":[120],"tests":[121],"applied":[123],"at":[124],"significance":[126],"level":[127],"0.05.":[129],"Results:":[130],"In":[131],"study,":[133],"DCs,":[134],"had":[138,223],"significant":[140],"tendency":[141],"occur":[143],"males":[145],"compared":[146,158,269],"females":[148],"(p<0.001,":[149],"p<0.001,":[150],"p<0.001":[152,255],"respectively),":[153],"mandible":[157],"maxilla":[161],"(p=0.02,":[162],"p=0.024,":[163],"p=0.02":[165],"respectively).":[166,189,209,230,256],"epithelial":[168,232],"IS":[169,177,191],"significantly":[171,194],"different":[172,195,236,279],"among":[173,196,237],"three":[174,198],"lesions":[175,199,290],"(p<0.001).":[176,242],"higher":[179,246,266],"than":[182,249],"UA":[183,248],"DC":[185,252],"(p<0.001":[186],"p=0.006,":[188],"not":[193],"connective":[201,216],"tissue":[202,217],"around":[204],"micro-vessels":[205],"(p=0.3":[206],"p=0.26":[208],"PS":[211],"epithelium":[214,264],"no":[224],"statistical":[225],"difference":[226],"(p=0.549":[227],"p=0.540":[229],"TS":[233,244],"statistically":[235],"(p=0.004":[253],"Conclusion:":[257],"ameloblastoma":[268,282],"DCs.":[271],"is":[273,291],"potential":[275],"measure":[276],"differentiate":[278],"types":[280],"cyst.":[285],"these":[289],"important":[292],"as":[293],"right":[295],"treatment":[296],"plan":[297],"changes":[298],"according":[299],"diagnosis.":[302]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-12-31T00:00:00"}