{"id":"https://openalex.org/W4200545780","doi":"https://doi.org/10.1016/j.taap.2021.115817","title":"Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation","display_name":"Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200545780","doi":"https://doi.org/10.1016/j.taap.2021.115817","pmid":"https://pubmed.ncbi.nlm.nih.gov/34890640"},"language":"en","primary_location":{"id":"doi:10.1016/j.taap.2021.115817","doi":"https://doi.org/10.1016/j.taap.2021.115817","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.taap.2021.115817","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041008X2100421X?via%3Dihub","source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/am/pii/S0041008X2100421X?via%3Dihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113625128","display_name":"Shigeki Tashiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Tashiro","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106487310","display_name":"Masatake Tanaka","orcid":"https://orcid.org/0000-0001-7461-0678","observed_orcids":["https://orcid.org/0000-0001-7461-0678"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatake Tanaka","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062696123","display_name":"Takeshi Goya","orcid":"https://orcid.org/0000-0001-9035-8695","observed_orcids":["https://orcid.org/0000-0001-9035-8695"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Goya","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072374079","display_name":"Tomomi Aoyagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Aoyagi","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112667479","display_name":"Miho Kurokawa","orcid":"https://orcid.org/0000-0002-9915-0644","observed_orcids":["https://orcid.org/0000-0002-9915-0644"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miho Kurokawa","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061041268","display_name":"Koji Imoto","orcid":"https://orcid.org/0000-0003-4323-263X","observed_orcids":["https://orcid.org/0000-0003-4323-263X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Imoto","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059278756","display_name":"Akifumi Kuwano","orcid":"https://orcid.org/0000-0001-9397-8056","observed_orcids":["https://orcid.org/0000-0001-9397-8056"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akifumi Kuwano","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Motoi Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoi Takahashi","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028389456","display_name":"Hideo Suzuki","orcid":"https://orcid.org/0000-0002-1469-7449","observed_orcids":["https://orcid.org/0000-0002-1469-7449"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Suzuki","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006276959","display_name":"Motoyuki Kohjima","orcid":"https://orcid.org/0000-0001-5285-3054","observed_orcids":["https://orcid.org/0000-0001-5285-3054"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Motoyuki Kohjima","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kohjima@med.kyushu-u.ac.jp","Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kohjima@med.kyushu-u.ac.jp","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869835","display_name":"Masaki Kato","orcid":"https://orcid.org/0000-0002-8017-7708","observed_orcids":["https://orcid.org/0000-0002-8017-7708"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I63121688","display_name":"Nakamura Gakuen University","ror":"https://ror.org/00qm2vr07","country_code":"JP","type":"education","lineage":["https://openalex.org/I63121688"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Kato","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-ku, Fukuoka 814-0198, Japan","Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-ku, Fukuoka 814-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-ku, Fukuoka 814-0198, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I63121688"]},{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-ku, Fukuoka 814-0198, Japan","institution_ids":["https://openalex.org/I63121688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074060371","display_name":"Yoshihiro Ogawa","orcid":"https://orcid.org/0000-0002-0834-2836","observed_orcids":["https://orcid.org/0000-0002-0834-2836"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ogawa","raw_affiliation_strings":["Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006276959"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":1.9154,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.83258415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"434","issue":null,"first_page":"115817","last_page":"115817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pirfenidone","display_name":"pirfenidone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.8090000152587891},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.871999979019165},{"id":"https://openalex.org/keywords/jnk-phosphorylation","display_name":"JNK phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tunel-staining","display_name":"TUNEL staining","score":0.6579999923706055},{"id":"https://openalex.org/keywords/propidium-iodide-staining","display_name":"propidium iodide staining","score":0.890999972820282},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.8562484979629517},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6804013848304749},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.587864100933075},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5609989762306213},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.5365327596664429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.495138555765152},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4355959892272949},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.414293110370636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3745116591453552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35625070333480835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35237762331962585},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33647263050079346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18051037192344666},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.10279962420463562}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.taap.2021.115817","doi":"https://doi.org/10.1016/j.taap.2021.115817","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.taap.2021.115817","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041008X2100421X?via%3Dihub","source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:34890640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34890640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:catalog.lib.kyushu-u.ac.jp:2324/4784478","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2324/4784478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400832","display_name":"Kyushu University Institutional Repository (QIR) (Kyushu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135598925","host_organization_name":"Kyushu University","host_organization_lineage":["https://openalex.org/I135598925"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"doi:10.1016/j.taap.2021.115817","doi":"https://doi.org/10.1016/j.taap.2021.115817","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.taap.2021.115817","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041008X2100421X?via%3Dihub","source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1608315289","display_name":null,"funder_award_id":"TKDS20190416055","funder_id":"https://openalex.org/F4320309807","funder_display_name":"Takeda Science Foundation"},{"id":"https://openalex.org/G1647740241","display_name":null,"funder_award_id":"JP20H04949","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1898262280","display_name":"The resesarch on platicity and heterogeneity of hepatocyte in acute liver injury","funder_award_id":"20K22877","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2574104860","display_name":"Elucidation of the mechanism of non-alcoholic steatohepatitis focusing on the metabolic zonation in the liver.","funder_award_id":"19K17496","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5591292482","display_name":"Development and progression mechanism of NASH from the viewpoint of cell-cell interaction and medical application","funder_award_id":"19H01054","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5932286632","display_name":"The change of glucose and lipid metabolism in hepatocellular carcinoma and the involvement to tumor dedifferntiation","funder_award_id":"17K09430","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6312633290","display_name":null,"funder_award_id":"2018G015","funder_id":"https://openalex.org/F4320322555","funder_display_name":"Smoking Research Foundation"},{"id":"https://openalex.org/G8451559873","display_name":"The effect of smoking on hepatocyte plasticity and heterogeneity in liver failure","funder_award_id":"2021Y010","funder_id":"https://openalex.org/F4320322555","funder_display_name":"Smoking Research Foundation"},{"id":"https://openalex.org/G877852359","display_name":null,"funder_award_id":"JP18H05039","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320322555","display_name":"Smoking Research Foundation","ror":"https://ror.org/04q4hbm31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200545780.pdf","grobid_xml":"https://content.openalex.org/works/W4200545780.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W7512181","https://openalex.org/W103448961","https://openalex.org/W1859746580","https://openalex.org/W1935580014","https://openalex.org/W1963094384","https://openalex.org/W1972465938","https://openalex.org/W1975892042","https://openalex.org/W1983576933","https://openalex.org/W1988582067","https://openalex.org/W2013054179","https://openalex.org/W2025562293","https://openalex.org/W2039818533","https://openalex.org/W2041465430","https://openalex.org/W2041841526","https://openalex.org/W2047177695","https://openalex.org/W2052530964","https://openalex.org/W2056309362","https://openalex.org/W2057942179","https://openalex.org/W2059655597","https://openalex.org/W2061854287","https://openalex.org/W2078036072","https://openalex.org/W2079118329","https://openalex.org/W2085159051","https://openalex.org/W2085604666","https://openalex.org/W2086709875","https://openalex.org/W2086714780","https://openalex.org/W2091404523","https://openalex.org/W2093684206","https://openalex.org/W2114111268","https://openalex.org/W2117807235","https://openalex.org/W2120180999","https://openalex.org/W2124308362","https://openalex.org/W2129070184","https://openalex.org/W2134586772","https://openalex.org/W2139884774","https://openalex.org/W2139941417","https://openalex.org/W2146326470","https://openalex.org/W2160141634","https://openalex.org/W2164605770","https://openalex.org/W2164887116","https://openalex.org/W2166874505","https://openalex.org/W2267777024","https://openalex.org/W2337103164","https://openalex.org/W2409474453","https://openalex.org/W2531043166","https://openalex.org/W2546580079","https://openalex.org/W2561594797","https://openalex.org/W2597078743","https://openalex.org/W2613163105","https://openalex.org/W2726302169","https://openalex.org/W2737518257","https://openalex.org/W2774641438","https://openalex.org/W2800221622","https://openalex.org/W2808993218","https://openalex.org/W2913407408","https://openalex.org/W2936799906","https://openalex.org/W2952112680","https://openalex.org/W2980544582","https://openalex.org/W2981384529","https://openalex.org/W3007341831","https://openalex.org/W3008188366","https://openalex.org/W3014331104","https://openalex.org/W3027740287","https://openalex.org/W4211036490","https://openalex.org/W4211193493","https://openalex.org/W4235551585","https://openalex.org/W4313333714","https://openalex.org/W4406056548"],"related_works":["https://openalex.org/W7146295997","https://openalex.org/W2587531375","https://openalex.org/W4311532748","https://openalex.org/W2087275438","https://openalex.org/W2084441247","https://openalex.org/W2999612460","https://openalex.org/W2099655521","https://openalex.org/W4220962108","https://openalex.org/W4392788663","https://openalex.org/W1992543987"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}