{"id":"https://openalex.org/W4200544872","doi":"https://doi.org/10.3389/fncel.2021.792764","title":"Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy","display_name":"Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4200544872","doi":"https://doi.org/10.3389/fncel.2021.792764","pmid":"https://pubmed.ncbi.nlm.nih.gov/35002629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8733560"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2021.792764","doi":"https://doi.org/10.3389/fncel.2021.792764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.792764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.792764/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.792764/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067356749","display_name":"Guilian Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210106451","display_name":"Jinan Central Hospital","ror":"https://ror.org/01fr19c68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106451"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"GuiLian Yu","raw_affiliation_strings":["Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210106451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386278","display_name":"Ying Zhang","orcid":"https://orcid.org/0009-0002-9613-8903","observed_orcids":["https://orcid.org/0009-0002-9613-8903","https://orcid.org/0000-0002-4448-2051"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210106451","display_name":"Jinan Central Hospital","ror":"https://ror.org/01fr19c68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106451"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210106451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026909840","display_name":"Bin Ning","orcid":"https://orcid.org/0000-0002-7592-9485","observed_orcids":["https://orcid.org/0000-0002-7592-9485"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210106451","display_name":"Jinan Central Hospital","ror":"https://ror.org/01fr19c68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106451"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Ning","raw_affiliation_strings":["Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210106451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026909840"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210106451"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.9618,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.90751634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":null,"first_page":"792764","last_page":"792764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.4542999863624573,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.4542999863624573,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.120899997651577,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/astrocyte-heterogeneity","display_name":"astrocyte heterogeneity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/astrocyte-subpopulations","display_name":"astrocyte subpopulations","score":0.8870000243186951},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":1.0},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glial-scar-formation","display_name":"glial scar formation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/astrocyte-targeted-therapy","display_name":"astrocyte-targeted therapy","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7343054413795471},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7304245233535767},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6468084454536438},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5878846645355225},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5696934461593628},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5370619893074036},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.5346658825874329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48283085227012634},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.44463494420051575},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4330601096153259},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4105488061904907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33297815918922424},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.3228474259376526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28363311290740967},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncel.2021.792764","doi":"https://doi.org/10.3389/fncel.2021.792764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.792764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.792764/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmid:35002629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35002629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8733560","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8733560/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:545342fa7bbe456d86a71bc10bf7092a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/545342fa7bbe456d86a71bc10bf7092a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 15 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2021.792764","doi":"https://doi.org/10.3389/fncel.2021.792764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.792764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.792764/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1630472672","display_name":null,"funder_award_id":"2019RC021","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"},{"id":"https://openalex.org/G2641877434","display_name":null,"funder_award_id":"81771346","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G373828242","display_name":null,"funder_award_id":"81771346, 82071383","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4136247940","display_name":null,"funder_award_id":"2019QL025","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G6249249298","display_name":null,"funder_award_id":"ZR2020KH007","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G6699651269","display_name":null,"funder_award_id":"82071383","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8166847509","display_name":null,"funder_award_id":"2019QL025","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200544872.pdf","grobid_xml":"https://content.openalex.org/works/W4200544872.grobid-xml"},"referenced_works_count":293,"referenced_works":["https://openalex.org/W583881585","https://openalex.org/W609521126","https://openalex.org/W640853832","https://openalex.org/W1140975977","https://openalex.org/W1165970735","https://openalex.org/W1480468820","https://openalex.org/W1485665912","https://openalex.org/W1495656315","https://openalex.org/W1502901716","https://openalex.org/W1503617838","https://openalex.org/W1510059371","https://openalex.org/W1519585367","https://openalex.org/W1523932090","https://openalex.org/W1548202935","https://openalex.org/W1551533003","https://openalex.org/W1551535344","https://openalex.org/W1564344417","https://openalex.org/W1818228426","https://openalex.org/W1825604636","https://openalex.org/W1868670079","https://openalex.org/W1908112684","https://openalex.org/W1914809775","https://openalex.org/W1968310639","https://openalex.org/W1968706291","https://openalex.org/W1970727433","https://openalex.org/W1977241912","https://openalex.org/W1977361215","https://openalex.org/W1977838764","https://openalex.org/W1979444094","https://openalex.org/W1980286364","https://openalex.org/W1980829307","https://openalex.org/W1982685163","https://openalex.org/W1983891257","https://openalex.org/W1987126633","https://openalex.org/W1988808659","https://openalex.org/W1989479275","https://openalex.org/W1989591252","https://openalex.org/W1992957286","https://openalex.org/W1996243257","https://openalex.org/W1996778863","https://openalex.org/W1998167315","https://openalex.org/W2000270109","https://openalex.org/W2001419937","https://openalex.org/W2001751013","https://openalex.org/W2001934566","https://openalex.org/W2002336012","https://openalex.org/W2003412986","https://openalex.org/W2007497157","https://openalex.org/W2008952605","https://openalex.org/W2011322035","https://openalex.org/W2011815863","https://openalex.org/W2012928251","https://openalex.org/W2013436204","https://openalex.org/W2015541518","https://openalex.org/W2015551349","https://openalex.org/W2016553428","https://openalex.org/W2018681635","https://openalex.org/W2023654842","https://openalex.org/W2028580069","https://openalex.org/W2029894447","https://openalex.org/W2030190730","https://openalex.org/W2031080649","https://openalex.org/W2036785515","https://openalex.org/W2036924440","https://openalex.org/W2038274440","https://openalex.org/W2038293269","https://openalex.org/W2038567621","https://openalex.org/W2041005555","https://openalex.org/W2041302528","https://openalex.org/W2045220084","https://openalex.org/W2045705413","https://openalex.org/W2047245618","https://openalex.org/W2047585900","https://openalex.org/W2047596225","https://openalex.org/W2049483733","https://openalex.org/W2050105192","https://openalex.org/W2051300373","https://openalex.org/W2052930675","https://openalex.org/W2061517642","https://openalex.org/W2066520425","https://openalex.org/W2068959325","https://openalex.org/W2071696504","https://openalex.org/W2071768383","https://openalex.org/W2073135642","https://openalex.org/W2074131381","https://openalex.org/W2082920313","https://openalex.org/W2083761407","https://openalex.org/W2084226102","https://openalex.org/W2084566588","https://openalex.org/W2084952516","https://openalex.org/W2085196976","https://openalex.org/W2085777461","https://openalex.org/W2085878699","https://openalex.org/W2086436146","https://openalex.org/W2103037576","https://openalex.org/W2104968232","https://openalex.org/W2108438047","https://openalex.org/W2110053523","https://openalex.org/W2110184849","https://openalex.org/W2121860798","https://openalex.org/W2127634810","https://openalex.org/W2128751464","https://openalex.org/W2130198578","https://openalex.org/W2134733089","https://openalex.org/W2135376726","https://openalex.org/W2138910310","https://openalex.org/W2140182398","https://openalex.org/W2140354846","https://openalex.org/W2140660632","https://openalex.org/W2141601862","https://openalex.org/W2141852514","https://openalex.org/W2145695478","https://openalex.org/W2150148667","https://openalex.org/W2153759921","https://openalex.org/W2160500827","https://openalex.org/W2163437443","https://openalex.org/W2163958669","https://openalex.org/W2168056663","https://openalex.org/W2170010756","https://openalex.org/W2170147460","https://openalex.org/W2170921124","https://openalex.org/W2172266256","https://openalex.org/W2181484272","https://openalex.org/W2191292005","https://openalex.org/W2280479084","https://openalex.org/W2323603660","https://openalex.org/W2335534790","https://openalex.org/W2377446316","https://openalex.org/W2401867526","https://openalex.org/W2414352146","https://openalex.org/W2415255606","https://openalex.org/W2528165446","https://openalex.org/W2557387239","https://openalex.org/W2572710398","https://openalex.org/W2588672048","https://openalex.org/W2591708738","https://openalex.org/W2595085771","https://openalex.org/W2612468721","https://openalex.org/W2612808369","https://openalex.org/W2613830934","https://openalex.org/W2618235845","https://openalex.org/W2626078173","https://openalex.org/W2658281240","https://openalex.org/W2700330585","https://openalex.org/W2725932778","https://openalex.org/W2730074009","https://openalex.org/W2736485888","https://openalex.org/W2744662591","https://openalex.org/W2751534020","https://openalex.org/W2765083364","https://openalex.org/W2765953433","https://openalex.org/W2767813783","https://openalex.org/W2770869008","https://openalex.org/W2770950271","https://openalex.org/W2771853756","https://openalex.org/W2777525962","https://openalex.org/W2782274120","https://openalex.org/W2784015117","https://openalex.org/W2786949584","https://openalex.org/W2788807220","https://openalex.org/W2790139801","https://openalex.org/W2794351872","https://openalex.org/W2796054699","https://openalex.org/W2799817820","https://openalex.org/W2807238564","https://openalex.org/W2807256450","https://openalex.org/W2807425198","https://openalex.org/W2807705689","https://openalex.org/W2808800285","https://openalex.org/W2810570053","https://openalex.org/W2885532750","https://openalex.org/W2886651460","https://openalex.org/W2888922379","https://openalex.org/W2889719632","https://openalex.org/W2891775731","https://openalex.org/W2891897651","https://openalex.org/W2895015842","https://openalex.org/W2899237238","https://openalex.org/W2899927624","https://openalex.org/W2901448111","https://openalex.org/W2902279932","https://openalex.org/W2903325146","https://openalex.org/W2910556324","https://openalex.org/W2912583212","https://openalex.org/W2912925231","https://openalex.org/W2916936852","https://openalex.org/W2917730612","https://openalex.org/W2921258905","https://openalex.org/W2922587668","https://openalex.org/W2927790284","https://openalex.org/W2936110531","https://openalex.org/W2937076564","https://openalex.org/W2937715612","https://openalex.org/W2939200041","https://openalex.org/W2943226123","https://openalex.org/W2943664567","https://openalex.org/W2945131148","https://openalex.org/W2945182885","https://openalex.org/W2951427869","https://openalex.org/W2954120469","https://openalex.org/W2957073165","https://openalex.org/W2957424123","https://openalex.org/W2969768224","https://openalex.org/W2970959902","https://openalex.org/W2972293044","https://openalex.org/W2974865755","https://openalex.org/W2976701790","https://openalex.org/W2984832447","https://openalex.org/W2994955146","https://openalex.org/W2998520357","https://openalex.org/W2999662108","https://openalex.org/W2999761222","https://openalex.org/W3002173750","https://openalex.org/W3002288130","https://openalex.org/W3006328684","https://openalex.org/W3008223617","https://openalex.org/W3010171238","https://openalex.org/W3011193172","https://openalex.org/W3011825821","https://openalex.org/W3013584175","https://openalex.org/W3013857818","https://openalex.org/W3014118429","https://openalex.org/W3015511259","https://openalex.org/W3015698727","https://openalex.org/W3015712342","https://openalex.org/W3022539327","https://openalex.org/W3023328654","https://openalex.org/W3025175405","https://openalex.org/W3025713031","https://openalex.org/W3027101465","https://openalex.org/W3033231305","https://openalex.org/W3035935860","https://openalex.org/W3036279865","https://openalex.org/W3043201977","https://openalex.org/W3045238854","https://openalex.org/W3045459208","https://openalex.org/W3046615650","https://openalex.org/W3053159770","https://openalex.org/W3067269879","https://openalex.org/W3082558175","https://openalex.org/W3083733923","https://openalex.org/W3089158540","https://openalex.org/W3091794069","https://openalex.org/W3092307174","https://openalex.org/W3093378191","https://openalex.org/W3093494259","https://openalex.org/W3096585599","https://openalex.org/W3096853844","https://openalex.org/W3102539200","https://openalex.org/W3103183473","https://openalex.org/W3104332815","https://openalex.org/W3107005782","https://openalex.org/W3108918132","https://openalex.org/W3108990613","https://openalex.org/W3108995625","https://openalex.org/W3113127439","https://openalex.org/W3113127697","https://openalex.org/W3114256325","https://openalex.org/W3115760280","https://openalex.org/W3118618632","https://openalex.org/W3123657625","https://openalex.org/W3126989622","https://openalex.org/W3129441528","https://openalex.org/W3130261914","https://openalex.org/W3130667204","https://openalex.org/W3132240972","https://openalex.org/W3133103360","https://openalex.org/W3133559173","https://openalex.org/W3134057982","https://openalex.org/W3134994269","https://openalex.org/W3135183493","https://openalex.org/W3135348615","https://openalex.org/W3135823144","https://openalex.org/W3137080682","https://openalex.org/W3137707505","https://openalex.org/W3138609033","https://openalex.org/W3139889986","https://openalex.org/W3146109077","https://openalex.org/W3154828597","https://openalex.org/W3155626809","https://openalex.org/W3156139198","https://openalex.org/W3158424265","https://openalex.org/W3159760213","https://openalex.org/W3159810068","https://openalex.org/W3166301930","https://openalex.org/W3171167854","https://openalex.org/W3172062908","https://openalex.org/W3184731772","https://openalex.org/W3194004635","https://openalex.org/W3195131727","https://openalex.org/W3200945945","https://openalex.org/W3201931145","https://openalex.org/W3217640824"],"related_works":["https://openalex.org/W3004611199","https://openalex.org/W4401112746","https://openalex.org/W2700330585","https://openalex.org/W3181046365","https://openalex.org/W6943654525","https://openalex.org/W4410019683","https://openalex.org/W3112163795","https://openalex.org/W2806510144","https://openalex.org/W2304707465","https://openalex.org/W2006289803"],"abstract_inverted_index":{"Traumatic":[0],"central":[1],"nervous":[2],"system":[3],"(CNS)":[4],"injury,":[5,82,195,248,258],"which":[6],"includes":[7],"both":[8,70,144],"traumatic":[9],"brain":[10,72],"injury":[11,16],"(TBI)":[12],"and":[13,26,73,86,103,124,149,175,214,282],"spinal":[14,75],"cord":[15],"(SCI),":[17],"is":[18],"associated":[19,191],"with":[20,54,117],"irreversible":[21],"loss":[22,99],"of":[23,40,47,60,90,100,106,147,156,184,190,217,232,246,271,280],"neurological":[24],"function":[25],"high":[27],"medical":[28],"care":[29],"costs.":[30],"Currently,":[31],"no":[32],"effective":[33,185],"treatment":[34,189],"exists":[35],"to":[36,119,243],"improve":[37],"the":[38,44,51,55,58,71,74,98,104,135,154,169,182,188,197,230,244,261,269,277],"prognosis":[39],"patients.":[41],"Astrocytes":[42],"comprise":[43],"largest":[45],"population":[46],"glial":[48],"cells":[49],"in":[50,57,69,94,150,167,220,228,234,265],"CNS":[52,173,194,247,257],"and,":[53],"advancements":[56],"field":[59],"neurology,":[61],"are":[62,114],"increasingly":[63],"recognized":[64],"as":[65,145,196],"having":[66],"key":[67],"functions":[68,270],"cord.":[76],"When":[77],"stimulated":[78],"by":[79],"disease":[80,198],"or":[81,162],"astrocytes":[83,113,139,158,233],"become":[84],"activated":[85,138],"undergo":[87,202],"a":[88,141,178,212,240],"series":[89],"changes,":[91],"including":[92],"alterations":[93],"gene":[95,121],"expression,":[96],"hypertrophy,":[97],"inherent":[101],"functions,":[102],"acquisition":[105],"new":[107],"ones.":[108],"Studies":[109],"have":[110],"shown":[111],"that":[112,159],"highly":[115],"heterogeneous":[116],"respect":[118],"their":[120,129],"expression":[122],"profiles,":[123],"this":[125,237,266],"heterogeneity":[126],"accounts":[127],"for":[128,181,187],"observed":[130],"context-dependent":[131],"phenotypic":[132],"diversity.":[133],"In":[134,236],"inured":[136],"CNS,":[137],"play":[140],"dual":[142],"role":[143],"regulators":[146],"neuroinflammation":[148],"scar":[151],"formation.":[152],"Identifying":[153],"subpopulations":[155,219],"reactive":[157],"exert":[160],"beneficial":[161],"harmful":[163],"effects":[164],"will":[165],"aid":[166,227],"deciphering":[168],"pathological":[170,222],"mechanisms":[171],"underlying":[172],"injuries":[174],"ultimately":[176],"provide":[177],"theoretical":[179],"basis":[180],"development":[183],"strategies":[186],"conditions.":[192],"Following":[193],"progresses,":[199],"astrocyte":[200,218,254,273],"phenotypes":[201],"continuous":[203],"changes.":[204],"Although":[205],"current":[206,251],"research":[207],"methods":[208],"do":[209],"not":[210],"allow":[211],"comprehensive":[213],"accurate":[215],"classification":[216,279],"complex":[221],"contexts,":[223],"they":[224],"can":[225],"nonetheless":[226],"understanding":[229],"roles":[231],"disease.":[235],"review,":[238],"after":[239],"brief":[241],"introduction":[242],"pathology":[245],"we":[249],"summarize":[250],"knowledge":[252],"regarding":[253],"activation":[255],"following":[256],"including:":[259],"(a)":[260],"regulatory":[262],"factors":[263],"involved":[264],"process;":[267],"(b)":[268],"different":[272],"subgroups":[274],"based":[275],"on":[276],"existing":[278],"astrocytes;":[281],"(c)":[283],"attempts":[284],"at":[285],"astrocyte-targeted":[286],"therapy.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-12-31T00:00:00"}