{"id":"https://openalex.org/W4200544214","doi":"https://doi.org/10.3389/fmolb.2021.747493","title":"GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19","display_name":"GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200544214","doi":"https://doi.org/10.3389/fmolb.2021.747493","pmid":"https://pubmed.ncbi.nlm.nih.gov/34988113","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8721193"},"language":"en","primary_location":{"id":"doi:10.3389/fmolb.2021.747493","doi":"https://doi.org/10.3389/fmolb.2021.747493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2021.747493","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmolb.2021.747493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022362972","display_name":"Vesna M. Coric","orcid":"https://orcid.org/0000-0003-0227-821X","observed_orcids":["https://orcid.org/0000-0003-0227-821X"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vesna Coric","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029631462","display_name":"Ivana Milo\u0161evi\u0107","orcid":"https://orcid.org/0000-0002-4331-3328","observed_orcids":["https://orcid.org/0000-0002-4331-3328"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Ivana Milosevic","raw_affiliation_strings":["Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071275942","display_name":"Tatjana I. Djukic","orcid":"https://orcid.org/0000-0003-1959-5115","observed_orcids":["https://orcid.org/0000-0003-1959-5115"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Tatjana Djukic","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034526196","display_name":"Zoran Bukumiri\u0107","orcid":"https://orcid.org/0000-0002-7609-4504","observed_orcids":["https://orcid.org/0000-0002-7609-4504"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Zoran Bukumiric","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical Statistics and Informatics, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical Statistics and Informatics, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053935172","display_name":"Ana R. Savic-Radojevic","orcid":"https://orcid.org/0000-0002-2026-4180","observed_orcids":["https://orcid.org/0000-0002-2026-4180"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Ana Savic-Radojevic","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082713404","display_name":"Marija G. Matic","orcid":"https://orcid.org/0000-0002-1488-3647","observed_orcids":["https://orcid.org/0000-0002-1488-3647"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marija Matic","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028852194","display_name":"Djurdja Jeroti\u0107","orcid":"https://orcid.org/0000-0002-1664-6557","observed_orcids":["https://orcid.org/0000-0002-1664-6557"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Djurdja Jerotic","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101547655","display_name":"Nevena Todorovi\u0107","orcid":"https://orcid.org/0000-0001-9227-1067","observed_orcids":["https://orcid.org/0000-0001-9227-1067","https://orcid.org/0000-0003-3973-5154"]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nevena Todorovic","raw_affiliation_strings":["Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025091518","display_name":"Milika A\u0161anin","orcid":"https://orcid.org/0000-0001-8493-0499","observed_orcids":["https://orcid.org/0000-0001-8493-0499"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Milika Asanin","raw_affiliation_strings":["Clinic of Neurology, Clinical Centre of Serbia, Belgrade, Serbia","Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Neurology, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019141001","display_name":"Marko Ercegovac","orcid":"https://orcid.org/0000-0002-7622-1112","observed_orcids":["https://orcid.org/0000-0002-7622-1112"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marko Ercegovac","raw_affiliation_strings":["Clinic of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia","Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078997052","display_name":"Jovan T. Ranin","orcid":"https://orcid.org/0000-0003-0398-9486","observed_orcids":["https://orcid.org/0000-0003-0398-9486"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Jovan Ranin","raw_affiliation_strings":["Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045343677","display_name":"Goran Stevanovi\u0107","orcid":"https://orcid.org/0000-0002-3621-4882","observed_orcids":["https://orcid.org/0000-0002-3621-4882"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Goran Stevanovic","raw_affiliation_strings":["Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077197176","display_name":"Marija S. Pljesa-Ercegovac","orcid":"https://orcid.org/0000-0001-8969-0594","observed_orcids":["https://orcid.org/0000-0001-8969-0594"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Marija Pljesa-Ercegovac","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007134818","display_name":"Tatjana P. Simic","orcid":"https://orcid.org/0000-0001-8683-5129","observed_orcids":["https://orcid.org/0000-0001-8683-5129"]},"institutions":[{"id":"https://openalex.org/I1338511612","display_name":"Serbian Academy of Sciences and Arts","ror":"https://ror.org/05m1y4204","country_code":"RS","type":"government","lineage":["https://openalex.org/I1338511612"]},{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Tatjana Simic","raw_affiliation_strings":["Faculty of Medicine, University of Belgrade, Belgrade, Serbia","Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","Serbian Academy of Sciences and Arts, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Institute of Medical and Clinical Biochemistry, Belgrade, Serbia","institution_ids":[]},{"raw_affiliation_string":"Serbian Academy of Sciences and Arts, Belgrade, Serbia","institution_ids":["https://openalex.org/I1338511612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007134818","https://openalex.org/A5077197176"],"corresponding_institution_ids":["https://openalex.org/I1338511612","https://openalex.org/I4068193"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.3283,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.79657523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"747493","last_page":"747493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.902999997138977},{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.953000009059906},{"id":"https://openalex.org/keywords/gstm3","display_name":"GSTM3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gst-polymorphisms","display_name":"GST polymorphisms","score":0.7540000081062317},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.722000002861023},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cumulative-genetic-risk","display_name":"cumulative genetic risk","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.7959617376327515},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6683530211448669},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6494134068489075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.540256679058075},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5046631097793579},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4939132332801819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47069692611694336},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4685229957103729},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3940768539905548},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37875571846961975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29463714361190796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23737838864326477},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11244314908981323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09869840741157532},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.07626831531524658},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.06228908896446228},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmolb.2021.747493","doi":"https://doi.org/10.3389/fmolb.2021.747493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2021.747493","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8721193","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8721193/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8721193/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Biosci","raw_type":"Text"},{"id":"pmid:34988113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34988113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular biosciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:708ea75b0f5e4740a7ec5943ddf2d3fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/708ea75b0f5e4740a7ec5943ddf2d3fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Biosciences, Vol 8 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmolb.2021.747493","doi":"https://doi.org/10.3389/fmolb.2021.747493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2021.747493","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1895699150","display_name":null,"funder_award_id":"200110","funder_id":"https://openalex.org/F4320322729","funder_display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja"},{"id":"https://openalex.org/G1968264819","display_name":null,"funder_award_id":"200110","funder_id":"https://openalex.org/F4320329307","funder_display_name":"Science Fund of the Republic of Serbia"},{"id":"https://openalex.org/G8155812708","display_name":null,"funder_award_id":"No7546803","funder_id":"https://openalex.org/F4320329307","funder_display_name":"Science Fund of the Republic of Serbia"}],"funders":[{"id":"https://openalex.org/F4320322729","display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","ror":"https://ror.org/01znas443"},{"id":"https://openalex.org/F4320329307","display_name":"Science Fund of the Republic of Serbia","ror":"https://ror.org/02r531a15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200544214.pdf","grobid_xml":"https://content.openalex.org/works/W4200544214.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1505135936","https://openalex.org/W1532431009","https://openalex.org/W1567493178","https://openalex.org/W1594684968","https://openalex.org/W1698280398","https://openalex.org/W1868880553","https://openalex.org/W1964596126","https://openalex.org/W1967303559","https://openalex.org/W1967468829","https://openalex.org/W1976346227","https://openalex.org/W1978911141","https://openalex.org/W1984115286","https://openalex.org/W1984978318","https://openalex.org/W1986346646","https://openalex.org/W1989941629","https://openalex.org/W1995584424","https://openalex.org/W2002681738","https://openalex.org/W2015484641","https://openalex.org/W2016275477","https://openalex.org/W2032477983","https://openalex.org/W2041401488","https://openalex.org/W2045914675","https://openalex.org/W2046916239","https://openalex.org/W2058017659","https://openalex.org/W2070862181","https://openalex.org/W2097254418","https://openalex.org/W2147243248","https://openalex.org/W2149846806","https://openalex.org/W2150081412","https://openalex.org/W2161202365","https://openalex.org/W2162212201","https://openalex.org/W2167206319","https://openalex.org/W2195676082","https://openalex.org/W2291246210","https://openalex.org/W2316699811","https://openalex.org/W2340994381","https://openalex.org/W2412769416","https://openalex.org/W2506002793","https://openalex.org/W2625854732","https://openalex.org/W2738546566","https://openalex.org/W2771117380","https://openalex.org/W2772018329","https://openalex.org/W2784225913","https://openalex.org/W2790095993","https://openalex.org/W2902917344","https://openalex.org/W3027188341","https://openalex.org/W3091177070","https://openalex.org/W3094228497","https://openalex.org/W3095990083","https://openalex.org/W3117241864","https://openalex.org/W3122657532","https://openalex.org/W3158180637","https://openalex.org/W3160478003","https://openalex.org/W3163946711","https://openalex.org/W4238581030"],"related_works":["https://openalex.org/W3163946711","https://openalex.org/W4321457930","https://openalex.org/W7221988683","https://openalex.org/W4378574240","https://openalex.org/W4403466598","https://openalex.org/W4220910095","https://openalex.org/W4388570970","https://openalex.org/W3091177070","https://openalex.org/W3027188341","https://openalex.org/W4362028076"],"abstract_inverted_index":{"Based":[0],"on":[1],"the":[2,24,31,98,155,163,169],"premise":[3],"that":[4,21,102],"oxidative":[5],"stress":[6],"plays":[7],"an":[8],"important":[9],"role":[10],"in":[11,23,46,52,58,73,87,168],"severe":[12],"acute":[13],"respiratory":[14],"syndrome":[15],"coronavirus":[16],"(SARS-CoV-2)":[17],"infection,":[18],"we":[19],"speculated":[20],"variations":[22],"antioxidant":[25],"activities":[26],"of":[27,30,35,43,50,109,118,158],"different":[28],"members":[29],"glutathione":[32,54,160],"S-transferase":[33],"family":[34],"enzymes":[36],"might":[37],"modulate":[38],"individual":[39,69],"susceptibility":[40],"towards":[41],"development":[42,75,111],"clinical":[44],"manifestations":[45],"COVID-19.":[47,96],"The":[48],"distribution":[49],"polymorphisms":[51],"cytosolic":[53],"S-transferasesGSTA1,GSTM1,GSTM3,GSTP1(rs1695andrs1138272),":[55],"andGSTT1were":[56],"assessed":[57],"207":[59],"COVID-19":[60,110,125,137,140],"patients":[61],"and":[62,70,76,139],"252":[63],"matched":[64],"healthy":[65],"individuals,":[66],"emphasizing":[67],"their":[68],"cumulative":[71,133],"effect":[72],"disease":[74],"severity.GSTpolymorphisms":[77],"were":[78],"determined":[79],"by":[80],"appropriate":[81],"PCR":[82],"methods.":[83],"Among":[84],"sixGSTpolymorphisms":[85],"analyzed":[86],"this":[88],"study,GSTP1rs1695":[89],"andGSTM3were":[90],"found":[91],"to":[92,116,153],"be":[93],"associated":[94],"with":[95],"Indeed,":[97],"data":[99],"obtained":[100],"showed":[101],"individuals":[103],"carrying":[104],"variantGSTP1-Valallele":[105],"exhibit":[106],"lower":[107],"odds":[108,123],"(p":[112,126,142],"=":[113,127,143,146],"0.002),":[114],"contrary":[115],"carriers":[117],"variantGSTM3-CCgenotype":[119],"which":[120],"have":[121],"higher":[122],"for":[124],"0.024).":[128],"Moreover,":[129],"combinedGSTP1(rs1138272andrs1695)":[130],"andGSTM3genotype":[131],"exhibited":[132],"risk":[134],"regarding":[135],"both":[136],"occurrence":[138],"severity":[141],"0.001":[144],"andp":[145],"0.025,":[147],"respectively).":[148],"Further":[149],"studies":[150],"are":[151],"needed":[152],"clarify":[154],"exact":[156],"roles":[157],"specific":[159],"S-transferases":[161],"once":[162],"SARS-CoV-2":[164],"infection":[165],"is":[166],"initiated":[167],"host":[170],"cell.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-12-31T00:00:00"}
