{"id":"https://openalex.org/W4200538228","doi":"https://doi.org/10.2147/ijgm.s341959","title":"Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level","display_name":"Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200538228","doi":"https://doi.org/10.2147/ijgm.s341959","pmid":"https://pubmed.ncbi.nlm.nih.gov/35221711","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8867000"},"language":"en","primary_location":{"id":"doi:10.2147/ijgm.s341959","doi":"https://doi.org/10.2147/ijgm.s341959","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s341959","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77012","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=77012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xinyang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyang Wang","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101007112","display_name":"Dandan Xue","orcid":"https://orcid.org/0000-0003-3392-5598","observed_orcids":["https://orcid.org/0000-0003-3392-5598"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Xue","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058360620","display_name":"Xiaoxia Zhu","orcid":"https://orcid.org/0000-0003-0445-9129","observed_orcids":["https://orcid.org/0000-0003-0445-9129"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I4210139780","display_name":"Yixing People's Hospital","ror":"https://ror.org/049avne82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Zhu","raw_affiliation_strings":["Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China","institution_ids":["https://openalex.org/I115592961","https://openalex.org/I4210139780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036278731","display_name":"Rui Geng","orcid":"https://orcid.org/0000-0001-9028-0031","observed_orcids":["https://orcid.org/0000-0001-9028-0031"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Geng","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I4210139780","display_name":"Yixing People's Hospital","ror":"https://ror.org/049avne82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Bao","raw_affiliation_strings":["Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China","institution_ids":["https://openalex.org/I115592961","https://openalex.org/I4210139780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang 'Anthony' Chen","orcid":"https://orcid.org/0000-0002-2499-8261","observed_orcids":["https://orcid.org/0000-0002-2499-8261"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I4210139780","display_name":"Yixing People's Hospital","ror":"https://ror.org/049avne82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, People's Republic of China","institution_ids":["https://openalex.org/I115592961","https://openalex.org/I4210139780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003246573","display_name":"Tiansong Xia","orcid":"https://orcid.org/0000-0002-2039-3820","observed_orcids":["https://orcid.org/0000-0002-2039-3820","https://orcid.org/0009-0002-7896-665X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiansong Xia","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China","Jiangsu Key Lab of Cancer Biomarkers, Prevention, and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Lab of Cancer Biomarkers, Prevention, and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100441917"],"corresponding_institution_ids":["https://openalex.org/I115592961","https://openalex.org/I4210139780"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.3978,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.47739422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"Volume 14","issue":null,"first_page":"10213","last_page":"10224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plat","display_name":"PLAT","score":0.9649999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6000000238418579},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8566296100616455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.690571129322052},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6345148086547852},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6176842451095581},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5773378014564514},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5005121231079102},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.442581444978714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4412629008293152},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41626471281051636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30452078580856323},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.268837571144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20220094919204712},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19546416401863098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ijgm.s341959","doi":"https://doi.org/10.2147/ijgm.s341959","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s341959","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77012","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8867000","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8867000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Gen Med","raw_type":"Text"},{"id":"pmid:35221711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35221711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of general medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5e351e6288db4dfe99cce18c13ff02a2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e351e6288db4dfe99cce18c13ff02a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of General Medicine, Vol Volume 14, Pp 10213-10224 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/71721","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/low-expression-of-plat-in-breast-cancer-infers-poor-prognosis-and-high-peer-reviewed-fulltext-article-IJGM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijgm.s341959","doi":"https://doi.org/10.2147/ijgm.s341959","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s341959","pdf_url":"https://www.dovepress.com/getfile.php?fileID=77012","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4046712994","display_name":null,"funder_award_id":"BK20171506","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200538228.pdf","grobid_xml":"https://content.openalex.org/works/W4200538228.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1964437080","https://openalex.org/W1966107523","https://openalex.org/W1969361257","https://openalex.org/W1971944129","https://openalex.org/W2018586930","https://openalex.org/W2027726380","https://openalex.org/W2035252444","https://openalex.org/W2035618305","https://openalex.org/W2053367329","https://openalex.org/W2089808841","https://openalex.org/W2123106337","https://openalex.org/W2123879591","https://openalex.org/W2130410032","https://openalex.org/W2132619562","https://openalex.org/W2134878729","https://openalex.org/W2147230623","https://openalex.org/W2159707944","https://openalex.org/W2191127622","https://openalex.org/W2210453860","https://openalex.org/W2220539909","https://openalex.org/W2314057593","https://openalex.org/W2521469434","https://openalex.org/W2521963431","https://openalex.org/W2560367415","https://openalex.org/W2615301036","https://openalex.org/W2767395146","https://openalex.org/W2791482536","https://openalex.org/W2800289222","https://openalex.org/W2811050063","https://openalex.org/W2910493999","https://openalex.org/W2937441321","https://openalex.org/W2971125419","https://openalex.org/W2974078113","https://openalex.org/W3013391308","https://openalex.org/W3027286012","https://openalex.org/W3031508706","https://openalex.org/W3096715224","https://openalex.org/W3128646645"],"related_works":["https://openalex.org/W7203440899","https://openalex.org/W3175535521","https://openalex.org/W3196278560","https://openalex.org/W4390582576","https://openalex.org/W4225254001","https://openalex.org/W7002246487","https://openalex.org/W3194191535","https://openalex.org/W4283740293","https://openalex.org/W4214507324","https://openalex.org/W4387586319"],"abstract_inverted_index":{"PURPOSE:":[0],"Breast":[1],"cancer":[2,26,41,55,73,186,210,251],"accounts":[3],"for":[4,197],"the":[5,15,21,31,46,58,97,155,205,218,222,230,235,257],"highest":[6],"incidence":[7],"of":[8,14,24,33,69,126,208,227,237,259],"tumors":[9],"in":[10,39,53,71,99,184,221],"women.":[11],"Immune":[12],"infiltrating":[13,52],"tumor":[16,223],"microenvironment":[17],"positively":[18],"correlates":[19],"with":[20,74,105,188,204],"overall":[22,100],"survival":[23,101],"breast":[25,40,54,72,127,185,198,209,238,250],"patients.":[27],"PLAT":[28,49,70,120,158,167,179,200,228,241],"can":[29,242],"affect":[30],"development":[32,258],"many":[34,213],"cancers,":[35],"but":[36],"its":[37],"mechanism":[38],"is":[42,121],"unclear.":[43],"We":[44],"assessed":[45],"correlation":[47,156,165,176],"between":[48,103,157,166],"and":[50,66,85,110,133,148,160,169,216,233,253],"immune":[51,162,206,214,219],"based":[56],"on":[57],"TCGA":[59],"database.":[60],"PATIENTS":[61],"AND":[62],"METHODS:":[63],"The":[64,164],"expression":[65,159,168,182,232],"DNA":[67,170,225],"methylation":[68,171,226],"different":[75,106],"clinical":[76,190],"characteristics":[77],"was":[78,93,172],"tested":[79],"by":[80,87,174,211],"Wilcoxon":[81],"signed":[82],"rank":[83],"test":[84],"displayed":[86],"box":[88],"plot.":[89],"Sequentially,":[90],"Kaplan-Meier":[91],"plot":[92],"employed":[94,138],"to":[95,117,139,153,248,256],"compare":[96],"difference":[98],"rates":[102],"patients":[104,187],"expressed":[107],"levels.":[108],"Univariate":[109],"multivariate":[111],"Cox":[112],"regression":[113],"analyses":[114],"were":[115,137,151],"used":[116,152],"validate":[118],"whether":[119],"an":[122,193],"independent":[123,194],"prognostic":[124],"factor":[125,196],"cancer.":[128,239],"After":[129],"that,":[130],"GO,":[131],"KEGG,":[132],"gene-set":[134],"enrichment":[135,142],"analysis":[136],"do":[140],"functional":[141],"analysis.":[143],"Finally,":[144],"TIMER,":[145],"TISIDB":[146],"database,":[147],"ssGSEA":[149],"algorithm":[150],"assess":[154],"various":[161,189],"characteristics.":[163,191],"examined":[173],"Pearson":[175],"coefficient.":[177],"RESULTS:":[178],"displays":[180],"differential":[181],"levels":[183],"As":[192],"protective":[195],"cancer,":[199],"may":[201],"significantly":[202],"correlate":[203],"status":[207],"adjusting":[212],"molecules":[215],"affecting":[217],"infiltration":[220],"microenvironment.":[224],"downregulates":[229],"gene":[231],"affects":[234],"prognosis":[236,252],"CONCLUSION:":[240],"be":[243],"considered":[244],"a":[245],"potential":[246],"biomarker":[247],"predict":[249],"might":[254],"contribute":[255],"immunological":[260],"treatment":[261],"strategies.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-12-31T00:00:00"}