{"id":"https://openalex.org/W4200537313","doi":"https://doi.org/10.4049/immunohorizons.2100090","title":"Class Ib MHC\u2013Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine","display_name":"Class Ib MHC\u2013Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200537313","doi":"https://doi.org/10.4049/immunohorizons.2100090","pmid":"https://pubmed.ncbi.nlm.nih.gov/34911745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026853"},"language":"en","primary_location":{"id":"doi:10.4049/immunohorizons.2100090","doi":"https://doi.org/10.4049/immunohorizons.2100090","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2100090","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/5/12/953/1485934/ih2100090.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.aai.org/immunohorizons/article-pdf/5/12/953/1485934/ih2100090.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077100355","display_name":"Suryasarathi Dasgupta","orcid":"https://orcid.org/0000-0003-1421-9559","observed_orcids":["https://orcid.org/0000-0003-1421-9559"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suryasarathi Dasgupta","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019987457","display_name":"Igor Maricic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor Maricic","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jay Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Tang","raw_affiliation_strings":["Department of Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073932690","display_name":"Stephen Wandro","orcid":"https://orcid.org/0000-0001-5514-0244","observed_orcids":["https://orcid.org/0000-0001-5514-0244"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Wandro","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027323292","display_name":"Kelly C. Weldon","orcid":"https://orcid.org/0000-0003-1064-8153","observed_orcids":["https://orcid.org/0000-0003-1064-8153"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Weldon","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013102525","display_name":"Carolina S. Carpenter","orcid":"https://orcid.org/0000-0002-5716-3068","observed_orcids":["https://orcid.org/0000-0002-5716-3068"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolina S Carpenter","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007202760","display_name":"Lars Eckmann","orcid":"https://orcid.org/0000-0002-7987-8742","observed_orcids":["https://orcid.org/0000-0002-7987-8742"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lars Eckmann","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-7987-8742","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050920863","display_name":"Jes\u00fas Rivera\u2013Nieves","orcid":"https://orcid.org/0000-0002-7887-7959","observed_orcids":["https://orcid.org/0000-0002-7887-7959"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Rivera-Nieves","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032150391","display_name":"William J. Sandborn","orcid":"https://orcid.org/0000-0002-3314-7960","observed_orcids":["https://orcid.org/0000-0002-3314-7960"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Sandborn","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033881627","display_name":"Rob D. Knight","orcid":"https://orcid.org/0000-0002-0975-9019","observed_orcids":["https://orcid.org/0000-0002-0975-9019","https://orcid.org/0000-0001-7531-0087"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Knight","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Department of Bioengineering, University of California San Diego , La Jolla, CA","Department of Computer Science and Engineering, University of California San Diego , La Jolla, CA","Department of Pediatrics, School of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058155811","display_name":"Peter Dorrestein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Dorrestein","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, CA","Department of Pediatrics, School of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005856984","display_name":"Austin D.-E. Swafford","orcid":"https://orcid.org/0000-0001-5655-8300","observed_orcids":["https://orcid.org/0000-0001-5655-8300"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin D Swafford","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072512711","display_name":"Vipin Kumar","orcid":"https://orcid.org/0000-0002-2838-2472","observed_orcids":["https://orcid.org/0000-0002-2838-2472"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vipin Kumar","raw_affiliation_strings":["Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-2838-2472","affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California San Diego , La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007202760","https://openalex.org/A5019987457","https://openalex.org/A5032150391","https://openalex.org/A5072512711","https://openalex.org/A5077100355"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":1700,"currency":"USD","value_usd":1700},"apc_paid":{"value":1700,"currency":"USD","value_usd":1700},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2002959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"5","issue":"12","first_page":"953","last_page":"971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/qa-1b","display_name":"Qa-1b","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mucosal-homeostasis","display_name":"mucosal homeostasis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/t-cell-mediated-colitis","display_name":"T cell-mediated colitis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/batf3","display_name":"Batf3","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cdc1","display_name":"cDC1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7260000109672546},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hla-e","display_name":"HLA-E","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/innate-like-t-cells","display_name":"innate-like T cells","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6071792244911194},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.5859251022338867},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.585002064704895},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5485435724258423},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5060026049613953},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.480468213558197},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.47857287526130676},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.46856003999710083},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4520809054374695},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4386085867881775},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.434937983751297},{"id":"https://openalex.org/C152605822","wikidata":"https://www.wikidata.org/wiki/Q17100626","display_name":"Intraepithelial lymphocyte","level":3,"score":0.42103007435798645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.375919908285141},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.19261160492897034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039001","descriptor_name":"Integrin alpha Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/immunohorizons.2100090","doi":"https://doi.org/10.4049/immunohorizons.2100090","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2100090","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/5/12/953/1485934/ih2100090.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},{"id":"pmid:34911745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34911745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10026853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026853","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10026853/pdf/nihms-1868228.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunohorizons","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt42w7q55j","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/42w7q55j","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ImmunoHorizons, vol 5, iss 12","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4049/immunohorizons.2100090","doi":"https://doi.org/10.4049/immunohorizons.2100090","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2100090","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/5/12/953/1485934/ih2100090.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1933053112","display_name":"High Dimensional Mass Cytometry Analysis of the Effects of Vedolizumab in Intestinal Cellular Subsets and its Correlation with Clinical Parameters","funder_award_id":"R21DK118927","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2789603418","display_name":null,"funder_award_id":"I01 BX005951","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3242224074","display_name":"Novel Traffic-targeted Therapies for IBD","funder_award_id":"R01DK108670","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3687871348","display_name":null,"funder_award_id":"I01 BX003436","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5210262051","display_name":"Regulatory CD4/CD8 T cells in autoimmune demyelination","funder_award_id":"R01AI052227","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5845333174","display_name":"A novel population of PLZF+CD8+ regulatory T cells: phenotype and function","funder_award_id":"R56AI146071","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6196018718","display_name":"University of California San Diego Neuroscience Microscopy Imaging Core","funder_award_id":"P30NS047101","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6288296096","display_name":"Interplay Among NKT Cell Subsets in Alcoholic Liver Disease","funder_award_id":"R01AA020864","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000875062","display_name":"San Diego Digestive Diseases Research Center","funder_award_id":"P30DK120515","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000875984","display_name":"Integrin \u03b1E\u03b27-dependent IgA transcytosis during homeostasis and IBD","funder_award_id":"R01DK132242","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200537313.pdf","grobid_xml":"https://content.openalex.org/works/W4200537313.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1533566241","https://openalex.org/W1564070119","https://openalex.org/W1582112095","https://openalex.org/W1727877696","https://openalex.org/W1742769645","https://openalex.org/W1882298650","https://openalex.org/W1929299962","https://openalex.org/W1967217097","https://openalex.org/W1968106422","https://openalex.org/W1968820656","https://openalex.org/W1973486131","https://openalex.org/W1975521617","https://openalex.org/W1984127959","https://openalex.org/W1986775143","https://openalex.org/W2009042953","https://openalex.org/W2024255214","https://openalex.org/W2032625166","https://openalex.org/W2043659905","https://openalex.org/W2046505430","https://openalex.org/W2049850873","https://openalex.org/W2052179475","https://openalex.org/W2057843379","https://openalex.org/W2060621234","https://openalex.org/W2066935464","https://openalex.org/W2106896953","https://openalex.org/W2108449579","https://openalex.org/W2121635719","https://openalex.org/W2122096954","https://openalex.org/W2125171141","https://openalex.org/W2136798761","https://openalex.org/W2147244516","https://openalex.org/W2148708580","https://openalex.org/W2149848289","https://openalex.org/W2161702641","https://openalex.org/W2162450383","https://openalex.org/W2162750254","https://openalex.org/W2168028214","https://openalex.org/W2190545194","https://openalex.org/W2191493147","https://openalex.org/W2206854629","https://openalex.org/W2319211023","https://openalex.org/W2334209689","https://openalex.org/W2504691963","https://openalex.org/W2515473451","https://openalex.org/W2529705542","https://openalex.org/W2593591803","https://openalex.org/W2749078265","https://openalex.org/W2752299790","https://openalex.org/W2758183934","https://openalex.org/W2766358903","https://openalex.org/W2772206425","https://openalex.org/W2778672167","https://openalex.org/W2787897791","https://openalex.org/W2792358501","https://openalex.org/W2794480084","https://openalex.org/W2800036554","https://openalex.org/W2809392121","https://openalex.org/W2887944446","https://openalex.org/W2892206041","https://openalex.org/W2894528081","https://openalex.org/W2897407482","https://openalex.org/W2905460912","https://openalex.org/W2905622537","https://openalex.org/W2914348147","https://openalex.org/W2916244827","https://openalex.org/W2951061751","https://openalex.org/W2958197323","https://openalex.org/W2963276645","https://openalex.org/W2963622568","https://openalex.org/W2966549733","https://openalex.org/W2975130305","https://openalex.org/W2982535496","https://openalex.org/W2989260998","https://openalex.org/W3003481949","https://openalex.org/W3007415664","https://openalex.org/W3008005014","https://openalex.org/W3011922312","https://openalex.org/W3018595823","https://openalex.org/W3047453719","https://openalex.org/W3063997159","https://openalex.org/W3087096410","https://openalex.org/W3165018664"],"related_works":["https://openalex.org/W4385686214","https://openalex.org/W7160275542","https://openalex.org/W175636617","https://openalex.org/W1881516554","https://openalex.org/W3012095940","https://openalex.org/W1571096646","https://openalex.org/W1989863073","https://openalex.org/W4385687088","https://openalex.org/W4313373516","https://openalex.org/W1544177950"],"abstract_inverted_index":{"Abstract":[0],"Lymphocytes":[1],"within":[2],"the":[3,18,25,30,55,81,127,135,139,144,162,220],"intestinal":[4],"epithelial":[5],"layer":[6],"(IEL)":[7],"in":[8,17,40,99,114,134,159,169,177,184,194,198,217],"mammals":[9],"have":[10,43],"unique":[11],"composition":[12],"compared":[13],"with":[14,90,200,212],"their":[15,88],"counterparts":[16],"lamina":[19],"propria.":[20],"Little":[21],"is":[22,149],"known":[23],"about":[24],"role":[26],"of":[27,29,103,107,130,143,153,207,222],"some":[28],"key":[31],"colonic":[32,82,136],"IEL":[33,83],"subsets,":[34],"such":[35],"as":[36],"TCR\u03b1\u03b2+CD8+":[37],"T":[38,50,66,76,132],"cells,":[39,51],"inflammation.":[41],"We":[42],"recently":[44],"described":[45],"liver-enriched":[46],"innate-like":[47],"TCR\u03b1\u03b2+CD8\u03b1\u03b1":[48,75,131],"regulatory":[49,224],"partly":[52],"controlled":[53],"by":[54],"non-classical":[56],"MHC":[57],"molecule,":[58],"Qa-1b,":[59],"that":[60,74,87,118],"upon":[61,151],"adoptive":[62],"transfer":[63],"protect":[64],"from":[65],"cell\u2013induced":[67],"colitis.":[68,104],"In":[69,138],"this":[70,223],"study,":[71],"we":[72,204],"found":[73,168,205],"cells":[77,125,133],"are":[78],"reduced":[79],"among":[80],"during":[84,109],"inflammation,":[85],"and":[86,111,180,187,214],"activation":[89],"an":[91,100],"agonistic":[92,156],"peptide":[93],"leads":[94],"to":[95,190],"significant":[96],"Qa-1b\u2013dependent":[97],"protection":[98,116],"acute":[101],"model":[102],"Cellular":[105],"expression":[106,142],"Qa-1b":[108,155,195,210],"inflammation":[110,213],"corresponding":[112],"dependency":[113],"peptide-mediated":[115],"suggest":[117],"Batf3-dependent":[119],"CD103+CD11b\u2212":[120],"type":[121],"1":[122],"conventional":[123],"dendritic":[124],"control":[126],"protective":[128],"function":[129],"epithelium.":[137],"colitis":[140],"model,":[141],"potential":[145],"barrier-protective":[146],"gene,":[147],"Muc2,":[148],"enhanced":[150,188],"administration":[152],"a":[154,174,209],"peptide.":[157],"Notably,":[158],"steady":[160],"state,":[161],"mucin":[163],"metabolizing":[164],"Akkermansia":[165],"muciniphila":[166],"was":[167],"significantly":[170],"lower":[171],"abundance":[172],"amid":[173],"dramatic":[175],"change":[176],"overall":[178],"microbiome":[179],"metabolome,":[181],"increased":[182],"IL-6":[183],"explant":[185],"culture,":[186],"sensitivity":[189],"dextran":[191],"sulfate":[192],"sodium":[193],"deficiency.":[196],"Finally,":[197],"patients":[199],"inflammatory":[201],"bowel":[202],"disease,":[203],"upregulation":[206],"HLA-E,":[208],"analog":[211],"biologic":[215],"non-response,":[216],"silico,":[218],"suggesting":[219],"importance":[221],"mechanism":[225],"across":[226],"species.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}